LOCUS       NM_007501               3375 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus neurogenic differentiation 4 (Neurod4), transcript
            variant 3, mRNA.
ACCESSION   NM_007501
VERSION     NM_007501.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3375)
  AUTHORS   Manuel,M., Tan,K.B., Kozic,Z., Molinek,M., Marcos,T.S.,
            Razak,M.F.A., Dobolyi,D., Dobie,R., Henderson,B.E.P.,
            Henderson,N.C., Chan,W.K., Daw,M.I., Mason,J.O. and Price,D.J.
  TITLE     Pax6 limits the competence of developing cerebral cortical cells to
            respond to inductive intercellular signals
  JOURNAL   PLoS Biol 20 (9), e3001563 (2022)
   PUBMED   36067211
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3375)
  AUTHORS   Stallings,C.E., Kapali,J., Evans,B.W., McGee,S.R. and
            Ellsworth,B.S.
  TITLE     FOXO Transcription Factors Are Required for Normal Somatotrope
            Function and Growth
  JOURNAL   Endocrinology 163 (2) (2022)
   PUBMED   34971379
REFERENCE   3  (bases 1 to 3375)
  AUTHORS   Moreau,M.X., Saillour,Y., Cwetsch,A.W., Pierani,A. and Causeret,F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (bases 1 to 3375)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3375)
  AUTHORS   Yang,L., Ge,D., Chen,X., Jiang,C. and Zheng,S.
  TITLE     miRNA-544a Regulates the Inflammation of Spinal Cord Injury by
            Inhibiting the Expression of NEUROD4
  JOURNAL   Cell Physiol Biochem 51 (4), 1921-1931 (2018)
   PUBMED   30513512
  REMARK    GeneRIF: The expression of miR-544a was significantly decreased
            after spinal cord injury. High expression of miR-544a could
            alleviate the inflammation caused by spinal cord injury and promote
            the recovery of spinal cord via the inhibition of NEUROD4.
REFERENCE   6  (bases 1 to 3375)
  AUTHORS   Tsuda,H., Takebayashi,K., Nakanishi,S. and Kageyama,R.
  TITLE     Structure and promoter analysis of Math3 gene, a mouse homolog of
            Drosophila proneural gene atonal. Neural-specific expression by
            dual promoter elements
  JOURNAL   J Biol Chem 273 (11), 6327-6333 (1998)
   PUBMED   9497361
REFERENCE   7  (bases 1 to 3375)
  AUTHORS   Ma,Q., Chen,Z., del Barco Barrantes,I., de la Pompa,J.L. and
            Anderson,D.J.
  TITLE     neurogenin1 is essential for the determination of neuronal
            precursors for proximal cranial sensory ganglia
  JOURNAL   Neuron 20 (3), 469-482 (1998)
   PUBMED   9539122
REFERENCE   8  (bases 1 to 3375)
  AUTHORS   Takebayashi,K., Takahashi,S., Yokota,C., Tsuda,H., Nakanishi,S.,
            Asashima,M. and Kageyama,R.
  TITLE     Conversion of ectoderm into a neural fate by ATH-3, a vertebrate
            basic helix-loop-helix gene homologous to Drosophila proneural gene
            atonal
  JOURNAL   EMBO J 16 (2), 384-395 (1997)
   PUBMED   9029157
REFERENCE   9  (bases 1 to 3375)
  AUTHORS   Isaka,F., Shimizu,C., Nakanishi,S. and Kageyama,R.
  TITLE     Genetic mapping of four mouse bHLH genes related to Drosophila
            proneural gene atonal
  JOURNAL   Genomics 37 (3), 400-402 (1996)
   PUBMED   8938455
REFERENCE   10 (bases 1 to 3375)
  AUTHORS   Sommer,L., Ma,Q. and Anderson,D.J.
  TITLE     neurogenins, a novel family of atonal-related bHLH transcription
            factors, are putative mammalian neuronal determination genes that
            reveal progenitor cell heterogeneity in the developing CNS and PNS
  JOURNAL   Mol Cell Neurosci 8 (4), 221-241 (1996)
   PUBMED   9000438
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CO431699.1, CN526913.1,
            BC054391.1 and AI846749.1.
            
            On Jul 16, 2016 this sequence version replaced NM_007501.4.
            
            Summary: This gene belongs to the neurogenic differentiation factor
            family and encodes a basic helix-loop-helix (bHLH) transcription
            factor which is expressed in the developing nervous system with
            high levels of expression in the brain, retina and cranial
            ganglions. Expression gradually becomes restricted to the neural
            retina. It is a key gene in the Ngn2-regulated neuronal
            differentiation pathway, coordinating the onset of cortical gene
            transcription. This gene also regulates amacrine cell fate
            determination in the retina. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054391.1, AK012183.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02146467, SAMN02146468
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 CO431699.1         1-8
            9-14                CN526913.1         1-6
            15-3358             BC054391.1         1-3344
            3359-3375           AI846749.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..3375
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 77.81 cM"
     gene            1..3375
                     /gene="Neurod4"
                     /gene_synonym="ATH-3; Atoh3; bHLHa4; MATH-3; Math3"
                     /note="neurogenic differentiation 4"
                     /db_xref="GeneID:11923"
                     /db_xref="MGI:MGI:108055"
     exon            1..98
                     /gene="Neurod4"
                     /gene_synonym="ATH-3; Atoh3; bHLHa4; MATH-3; Math3"
                     /inference="alignment:Splign:2.1.0"
     exon            99..3359
                     /gene="Neurod4"
                     /gene_synonym="ATH-3; Atoh3; bHLHa4; MATH-3; Math3"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1100
                     /gene="Neurod4"
                     /gene_synonym="ATH-3; Atoh3; bHLHa4; MATH-3; Math3"
                     /note="helix-loop-helix protein mATH-3; atonal homolog 3"
                     /codon_start=1
                     /product="neurogenic differentiation factor 4"
                     /protein_id="NP_031527.1"
                     /db_xref="CCDS:CCDS24353.1"
                     /db_xref="GeneID:11923"
                     /db_xref="MGI:MGI:108055"
                     /translation="MAKMYMKSKDMVELVNTQSWMDKGLSSQNEMKEQERRPGSYGML
                     GTLTEEHDSIEEDEEEEEDGDKPKRRGPKKKKMTKARLERFRARRVKANARERTRMHG
                     LNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSEVLETGQTLEGKGFVEMLCK
                     GLSQPTSNLVAGCLQLGPQSTLLEKHEEKSSICDSTISVHSFNYQSPGLPSPPYGHME
                     THSLHLKPQPFKSLGDSFGSHPPDCSTPPYEGPLTPPLSISGNFSLKQDGSPDLEKSY
                     NFMPHYTSASLSSGHVHSTPFQTGTPRYDVPVDLSYDSYSHHSIGTQLNTIFSD"
     regulatory      3338..3343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neurod4"
                     /gene_synonym="ATH-3; Atoh3; bHLHa4; MATH-3; Math3"
                     /note="hexamer: AATAAA"
     polyA_site      3359
                     /gene="Neurod4"
                     /gene_synonym="ATH-3; Atoh3; bHLHa4; MATH-3; Math3"
                     /note="major polyA site"
ORIGIN      
        1 aaacggcggc aagtcagaag ctccagtcag atcacaggag ctgcccagag actgtggtac
       61 tgaaagaact actcgcggga gctgaccccg ggaaagagaa tctatacatg gcaaaaatgt
      121 atatgaaatc caaggacatg gtggagctgg tcaacacaca atcctggatg gacaaaggtc
      181 tgagctctca aaatgagatg aaggagcaag agagaagacc gggctcttat ggaatgctcg
      241 gaaccttaac tgaagagcat gacagtattg aggaggatga agaagaggaa gaagatggag
      301 ataaacctaa aagaagaggt cccaagaaaa agaagatgac taaagctcgc cttgaaagat
      361 tcagggctcg aagagtcaag gccaatgcta gagaacggac ccggatgcat ggcctgaatg
      421 atgccttgga taatcttagg agagtcatgc catgttactc taaaactcaa aagctttcca
      481 agatagagac tcttcgactg gcaaggaact acatctgggc cttgtctgaa gtcctggaga
      541 ctggtcagac acttgaaggg aagggatttg tagagatgct atgtaaaggt ctctctcaac
      601 ccacaagcaa cctggttgct ggatgcctcc aactggggcc tcaatctacc ctcctggaga
      661 agcatgagga aaaatcttca atttgtgact ctactatctc tgtccacagc ttcaactatc
      721 agtctccagg gctccccagc cctccttatg gccatatgga aacacattct ctccatctca
      781 agcctcaacc atttaagagt ttgggtgact cttttgggag ccatccacct gactgcagta
      841 ccccccctta tgagggtcca ctcacaccac ccctgagcat tagtggcaac ttctccttaa
      901 agcaagacgg ctcccctgat ttggaaaaat cctacaattt catgccacat tatacctctg
      961 caagtctaag ttcagggcat gtgcattcaa ctccctttca gactggcact ccccgctatg
     1021 atgttcctgt agacctgagc tatgattcct actcccacca tagcattgga actcagctca
     1081 atacgatctt ctctgattag agcaataaga taagcaccaa tatttcagag aatgaagtgg
     1141 agattttttt cacatttcta gtggctgagc taaactctca gaaaatttaa aagaaccttt
     1201 ggatatgcat caaacataat agtcctagtt tgttcagaac ttcctgtacc tgctaacttt
     1261 cttcccatta acttctcaca ttggaccagt cctacatttg gtaaacttaa gtgaatatat
     1321 ttgatggttt gaggccacat ggtaatagaa cagaaagaaa gcccaggccc tgttccaatg
     1381 gtgccaaaga ttaattgaat gctctgccaa ttaactttcc atttccagtg tttttattgc
     1441 tttctgataa acatgaagca actgttccaa atcaacatat acctttcacc tcccacacat
     1501 ttttaaattt aaaagcaatc aaagcaaata gcaaaaatgg aatgattata cagaactgga
     1561 aggagcatca agtacatgtc tgttggctta tagaatacaa aatttgtgtg aatttgacaa
     1621 atcatctttg tgtctattta aatataactt ccagagccta aaataataac ttggatgtta
     1681 ccataaataa ccagtatgtt ctttaagaga tcagctctac ttattactgt gctgaaaggt
     1741 atacacacct tttttagtga ttggagaacc atgatagaag cctcacacaa actttattct
     1801 ttatactatt taaaaaacaa ctgtcttagt actaggagac aagcaagaaa gacattgaaa
     1861 tttctcttct ggcacacaga aatatcacct agctcatttc ttagcttccg tgactatagg
     1921 gctgtagaat tttgcaggta ttcaggtgct tcagttagaa tcagaactca gccaggttca
     1981 tactgtagag caataaaatg gtggttggct gctatcccaa ctaacacagt taaagaactc
     2041 tgcctcacac atagccactg gaaaaatgtg gatattctcc agcaagatga atttcactgt
     2101 ttaaagcaat gcaattaaag ccatagagtt tcgtccactc cagtatcata tattccagaa
     2161 ctgttgtaat caatcttgaa ttcttacaac ataaatgcaa ctccttactt cccacctaac
     2221 actgattgtt atattgtctt caattccaag atattatgca attatatgca aaattttgat
     2281 tagaatcaaa attaagagtc aatgaatctg tctgtatctt caggacgggt tttgatcagt
     2341 tttaagaaag tttattttcc tttatgtggc atctcttttc tttgtaacca cactggttca
     2401 gccaagtttc tcttctccag agaaattagc tctgagaaat tttactatca tgatccatct
     2461 tccacagcaa ttatttaggt tcaactcaag agtatacata gtttatttat agtgggtgag
     2521 gatacacctc caagaataaa ttttaacaac attaatgaca tatgaatatg ccattttatc
     2581 taccaaacta tatatgtatc tcttttcttt attgccctta tttatttctt cacactgaga
     2641 gttattttgt gtccatctta ttgcagcact tactctgctc tactttgcac ctttggatta
     2701 taaatatgtt taaaagtctg taaagacgtc ttaaacaact cgtgacagta attcaccacc
     2761 cctaagacct tgaatcaccc tagtggaaat aggcaaggag aattatttat agaatcatcc
     2821 tatgtaattt tttttgagaa tttgctctac ctagcattta tgtttataga taattgctat
     2881 ctgcattatt tattaggttc tatttattta atttatcttt ctttcttttt atgtaaacat
     2941 ttgtgcccca tagatatagc ctcaaagctt cactgggaaa ctagcttata tgtttggagt
     3001 gagagaaaag gagaaaatca gttcttgatt gcttgcaatg gttttataaa acagagcaat
     3061 aatttgaata gatatgcaac ttaatggttt tagatttttt tcctttaagg tgcaacagag
     3121 ttacattatt atttatgact ttggagaatg tagtacatgt gaaccaggac tgtaggcttg
     3181 tgaagagaga ttttataatt aaatacaaat ttagtactgt actatgcttg gaaagaactt
     3241 gttctttaaa taatgtttag tcttctggga gtgttttcag ataaaatgaa gcaattgttt
     3301 aaaagaaatg gctgttttcc ctcccttttc cagtagcaat aaagctttga gtgttattaa
     3361 aaaaaaaaaa aaaaa
//
