LOCUS       NM_010895               3137 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus neurogenic differentiation 2 (Neurod2), mRNA.
ACCESSION   NM_010895
VERSION     NM_010895.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3137)
  AUTHORS   Pang,Y., Ruan,X., Liu,W., Hou,L., Yin,B., Shu,P. and Peng,X.
  TITLE     MicroRNA-495 Modulates Neuronal Layer Fate Determination by
            Targeting Tcf4
  JOURNAL   Int J Biol Sci 20 (15), 6207-6221 (2024)
   PUBMED   39664574
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3137)
  AUTHORS   Ma,Q., Yang,Z., Yang,C., Lin,M., Gong,M., Deng,P., He,M., Lu,Y.,
            Zhang,K., Pi,H., Qu,M., Yu,Z., Zhou,Z. and Chen,C.
  TITLE     A single-cell transcriptomic landscape of cadmium-hindered brain
            development in mice
  JOURNAL   Commun Biol 7 (1), 997 (2024)
   PUBMED   39147853
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3137)
  AUTHORS   Lin,L., Zhao,J., Kubota,N., Li,Z., Lam,Y.L., Nguyen,L.P., Yang,L.,
            Pokharel,S.P., Blue,S.M., Yee,B.A., Chen,R., Yeo,G.W., Chen,C.W.,
            Chen,L. and Zheng,S.
  TITLE     Epistatic interactions between NMD and TRP53 control progenitor
            cell maintenance and brain size
  JOURNAL   Neuron 112 (13), 2157-2176 (2024)
   PUBMED   38697111
REFERENCE   4  (bases 1 to 3137)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3137)
  AUTHORS   Alderman,P.J., Saxon,D., Torrijos-Saiz,L.I., Sharief,M., Page,C.E.,
            Baroudi,J.K., Biagiotti,S.W., Butyrkin,V.A., Melamed,A., Kuo,C.T.,
            Vicini,S., Garcia-Verdugo,J.M., Herranz-Perez,V., Corbin,J.G. and
            Sorrells,S.F.
  TITLE     Delayed maturation and migration of excitatory neurons in the
            juvenile mouse paralaminar amygdala
  JOURNAL   Neuron 112 (4), 574-592 (2024)
   PUBMED   38086370
REFERENCE   6  (bases 1 to 3137)
  AUTHORS   Tamimi,R.M., Steingrimsson,E., Montgomery-Dyer,K., Copeland,N.G.,
            Jenkins,N.A. and Tapscott,S.J.
  TITLE     NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and
            5q23-q31 and mouse chromosomes 11 and 13, respectively
  JOURNAL   Genomics 40 (2), 355-357 (1997)
   PUBMED   9119405
REFERENCE   7  (bases 1 to 3137)
  AUTHORS   Kandil,E., Kohda,K., Ishibashi,T., Tanaka,K. and Kasahara,M.
  TITLE     PA28 subunits of the mouse proteasome: primary structures and
            chromosomal localization of the genes
  JOURNAL   Immunogenetics 46 (4), 337-344 (1997)
   PUBMED   9218537
REFERENCE   8  (bases 1 to 3137)
  AUTHORS   Isaka,F., Shimizu,C., Nakanishi,S. and Kageyama,R.
  TITLE     Genetic mapping of four mouse bHLH genes related to Drosophila
            proneural gene atonal
  JOURNAL   Genomics 37 (3), 400-402 (1996)
   PUBMED   8938455
REFERENCE   9  (bases 1 to 3137)
  AUTHORS   McCormick,M.B., Tamimi,R.M., Snider,L., Asakura,A., Bergstrom,D.
            and Tapscott,S.J.
  TITLE     NeuroD2 and neuroD3: distinct expression patterns and
            transcriptional activation potentials within the neuroD gene family
  JOURNAL   Mol Cell Biol 16 (10), 5792-5800 (1996)
   PUBMED   8816493
REFERENCE   10 (bases 1 to 3137)
  AUTHORS   Yasunami,M., Suzuki,K., Maruyama,H., Kawakami,H., Nagai,Y.,
            Hagiwara,M. and Ohkubo,H.
  TITLE     Molecular cloning and characterization of a cDNA encoding a novel
            basic helix-loop-helix protein structurally related to Neuro-D/BHF1
  JOURNAL   Biochem Biophys Res Commun 220 (3), 754-758 (1996)
   PUBMED   8607837
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158767.1, CJ237767.1, CJ063668.1, CJ237963.1 and CD741852.1.
            
            On Sep 14, 2007 this sequence version replaced NM_010895.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158767.1, BC058965.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1529              AK158767.1         133-1661
            1530-2015           CJ237767.1         2-487
            2016-2027           AK158767.1         2148-2159
            2028-2160           AK158767.1         2161-2293
            2161-2495           CJ063668.1         274-608
            2496-2586           CJ237963.1         46-136
            2587-3137           CD741852.1         18-568              c
FEATURES             Location/Qualifiers
     source          1..3137
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.75 cM"
     gene            1..3137
                     /gene="Neurod2"
                     /gene_synonym="bHLHa1; Ndrf"
                     /note="neurogenic differentiation 2"
                     /db_xref="GeneID:18013"
                     /db_xref="MGI:MGI:107755"
     exon            1..212
                     /gene="Neurod2"
                     /gene_synonym="bHLHa1; Ndrf"
                     /inference="alignment:Splign:2.1.0"
     exon            213..3137
                     /gene="Neurod2"
                     /gene_synonym="bHLHa1; Ndrf"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1369
                     /gene="Neurod2"
                     /gene_synonym="bHLHa1; Ndrf"
                     /note="neuroD-related factor"
                     /codon_start=1
                     /product="neurogenic differentiation factor 2"
                     /protein_id="NP_035025.3"
                     /db_xref="CCDS:CCDS25343.1"
                     /db_xref="GeneID:18013"
                     /db_xref="MGI:MGI:107755"
                     /translation="MLTRLFSEPGLLSDVPKFASWGDGDDDEPRSDKGDAPPQPPPAP
                     GSGAPGPARAAKPVSLRGGEEIPEPTLAEVKEEGELGGEEEEEEEEEEGLDEAEGERP
                     KKRGPKKRKMTKARLERSKLRRQKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSK
                     IETLRLAKNYIWALSEILRSGKRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLT
                     EQGADGAGRFHGSGGPFAMHPYPYPCSRLAGAQCQAAGGLGGGAAHALRTHGYCAAYE
                     TLYAAAGGGGASPDYNSSEYEGPLSPPLCLNGNFSLKQDSSPDHEKSYHYSMHYSALP
                     GSRPTGHGLVFGSSAVRGGVHSENLLSYDMHLHHDRGPMYEELNAFFHN"
     regulatory      3106..3111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neurod2"
                     /gene_synonym="bHLHa1; Ndrf"
                     /note="hexamer: AATAAA"
     polyA_site      3128
                     /gene="Neurod2"
                     /gene_synonym="bHLHa1; Ndrf"
                     /note="major polyA site"
ORIGIN      
        1 aggctggtac cccgcctggt agagatgcca cactcgctcc gcggctcgca tggcgctctg
       61 aagacgccgg cgcccgccgc cttgaggaac cgctgccccc gctccctgaa gatgggggaa
      121 caatgaaata agcgagaaga ttcctcttct cccccctctc tctcttgccc cctcccccct
      181 cccctcccct ctccccttga ctcctctctg aggcaccatg ctgacccgcc tgttcagcga
      241 gcccggcctc ctctcggacg tgcccaagtt cgccagctgg ggcgacggcg acgacgacga
      301 gccgaggagc gacaagggcg acgcgccgcc gcagcctcct cctgctcccg ggtcgggggc
      361 tccaggaccc gcccgggccg ccaagccagt gtctcttcgt ggaggagaag agatccctga
      421 acccacgttg gctgaggtca aggaggaagg agagctgggc ggcgaggagg aggaggaaga
      481 ggaggaggag gaaggactgg acgaggcgga aggcgagcgg cccaagaagc gcgggccgaa
      541 gaaacgcaag atgaccaagg cgcgtctgga gcgctccaag ctgcggcgac agaaggccaa
      601 cgcgcgggag cgcaaccgca tgcacgacct gaacgcggct ctggacaacc tgcgcaaggt
      661 ggtgccctgc tactccaaga cgcagaagct gtccaagatc gagaccctgc gcctggccaa
      721 gaactacatc tgggctctct cggagatctt gcgctccggg aagcggccgg atctggtgtc
      781 ctacgtgcag actctgtgca aggggctgtc acagcccacc acgaatctgg tggccggctg
      841 cctgcagcta aactctcgta acttcctcac ggagcagggc gcggacggcg ccggccgctt
      901 tcacggctcg ggtggcccgt tcgccatgca tccgtaccca tacccgtgct cccgcctggc
      961 aggcgcacag tgtcaggcgg ctggcggcct gggcggaggc gcggcgcacg ccctgcggac
     1021 ccacggctac tgcgccgcct acgagacgct gtacgcggcg gccggtggcg gcggcgctag
     1081 cccggactac aacagctccg agtacgaggg tccactcagt cccccgctct gtctcaacgg
     1141 caacttctcg ctcaagcagg actcgtcccc cgatcacgag aagagctacc actactctat
     1201 gcactactcg gcgctgcccg gctcacggcc cacgggccac gggctggtct tcggctcgtc
     1261 ggccgtgcgc gggggcgtcc actccgagaa tctcttgtct tacgatatgc accttcacca
     1321 cgatcggggc cccatgtacg aggagctcaa cgcatttttc cataactgag acctcgcgcc
     1381 gacccctttc tttttctttg cctttgtccg gccccttagc cccagcccca cgagctcagg
     1441 ggctcccacc gactccagag ccgggcgctc gagcgcgggc cgccggttct gcagctctcc
     1501 agagcggcgt gctctcttac ctgtgggtgg cccgtcccag gggcctcgct tgcctctggg
     1561 gactcgcctt ctctctctcc ccagcgggct tcctcctccc ttctctcgtg gagagcatct
     1621 ctggggatct cccgccaggc cctcccaaga gacttcctcc acattcccaa acttgggttt
     1681 tctctcccca cctcccaaca ggccagaggc agttggtaag gggctgctga gtctcgggat
     1741 agtgtctccc ccacttatag ttactttaaa aaaacaaaaa caaaacagac acagagcttc
     1801 ccaggccgaa aagagttggt atctcttcct tctcgaagag gccacagcca gggagcccaa
     1861 acgccttcac cctaacacga atctccgcgt tttttatttt ttattttggt gggaggggat
     1921 gtggattgag aggaaagaga gaggccaagc caatttgtaa ctagaaccat ttttcctttt
     1981 ccctttttaa agaaaacaaa caaacataca aaaggaaaaa aaaaaaagaa agaaagaaag
     2041 aaaaaggaaa aaatactgag aggcaacgga ggccgaactc agagtccgga tcggagagaa
     2101 aacgcattaa gaacttttag aagcaataaa aggcaaataa taataataaa aaatactacc
     2161 aataataatt tttaaaaaga cacaaatatc tatgcaagga ggttctgact gagcctagca
     2221 gcctgacctg ggtgctcctc gggtctgctg gctgccccgc ccacgcgcgg atctgtgcac
     2281 tttggtgaag tgggggcccg cgccgcccct cccccccccc agtttcttac aatcaatgac
     2341 tcggagattt ggaaccccag tgccactgcc ctcctcccgc cctgccccgt tgtgcgtcat
     2401 actgttttct aaaaacctgt ttccaaattt gtatggaatg gcaaactgtt agggggggtc
     2461 ggtttgggga gggagggttt gcatgagaga caccacacac gcacacacac gcgcgcgcgc
     2521 gaacacgcac acacacacac acacacacac acacacacac acaccacacc gcacgcacac
     2581 gcaggccccg ggcgtccggg gacagaagga gctgtctact ggtacctcct ctctataggc
     2641 actctggtcc gtcccctctt ggggtaaggt ggaggagccc agacctggga acagccttac
     2701 ccttgtccag actgtgcctc cgtgggcgcc aagctcctgg tgatttctgg tggctagaga
     2761 gggttgtttt gggtttttgt ttgtttgttt gttggggggg ttgttgttgc ttttgttttt
     2821 tgttttgttt tgtgtttcgg ttctaggctc ctcctgactt ttgtcatcca gtgagctggg
     2881 agaactgagg gctcctctgg aggttcccct cgcaagaggc aacaggtgaa gctccccccc
     2941 caccggaggc agggaaccag gcacccaaac acacgatgca aaaaacgcaa acccacaggc
     3001 gacacacccc acacacgcaa ttttaccttc ctcttgtagc gaagatgaaa ctcctgtcgg
     3061 acacccgaag tgcattgcgt gtttctgttg agtttaatga cgattaataa atatttatgt
     3121 aaatgagatg caaagca
//
