LOCUS       NM_010894               2510 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus neurogenic differentiation 1 (Neurod1), mRNA.
ACCESSION   NM_010894
VERSION     NM_010894.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2510)
  AUTHORS   Wutikeli,H., Yu,Y., Zhang,T., Cao,J., Nawy,S. and Shen,Y.
  TITLE     Role of Elavl-like RNA-binding protein in retinal development and
            signal transduction
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167518 (2025)
   PUBMED   39307290
REFERENCE   2  (bases 1 to 2510)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2510)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   4  (bases 1 to 2510)
  AUTHORS   Ohyama,K., Shinohara,H.M., Takayama,N., Ogawa,R., Omura,S.,
            Hayashida,M. and Takahashi,T.
  TITLE     Differentiation stage-specific expression of transcriptional
            regulators for epithelial mesenchymal transition in dentate granule
            progenitors
  JOURNAL   Front Neurosci 18, 1425849 (2024)
   PUBMED   39268037
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2510)
  AUTHORS   Talifu,Z., Zhang,C., Xu,X., Pan,Y., Ke,H., Li,Z., Liu,W., Du,H.,
            Wang,X., Gao,F., Yang,D., Jing,Y., Yu,Y., Du,L. and Li,J.
  TITLE     Neuronal repair after spinal cord injury by in vivo astrocyte
            reprogramming mediated by the overexpression of NeuroD1 and
            Neurogenin-2
  JOURNAL   Biol Res 57 (1), 53 (2024)
   PUBMED   39135103
  REMARK    GeneRIF: Neuronal repair after spinal cord injury by in vivo
            astrocyte reprogramming mediated by the overexpression of NeuroD1
            and Neurogenin-2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2510)
  AUTHORS   McCormick,M.B., Tamimi,R.M., Snider,L., Asakura,A., Bergstrom,D.
            and Tapscott,S.J.
  TITLE     NeuroD2 and neuroD3: distinct expression patterns and
            transcriptional activation potentials within the neuroD gene family
  JOURNAL   Mol Cell Biol 16 (10), 5792-5800 (1996)
   PUBMED   8816493
REFERENCE   7  (bases 1 to 2510)
  AUTHORS   Tamimi,R., Steingrimsson,E., Copeland,N.G., Dyer-Montgomery,K.,
            Lee,J.E., Hernandez,R., Jenkins,N.A. and Tapscott,S.J.
  TITLE     The NEUROD gene maps to human chromosome 2q32 and mouse chromosome
            2
  JOURNAL   Genomics 34 (3), 418-421 (1996)
   PUBMED   8786144
REFERENCE   8  (bases 1 to 2510)
  AUTHORS   Kawakami,H., Maruyama,H., Yasunami,M., Ohkubo,H., Hara,H.,
            Saida,T., Nakanishi,S. and Nakamura,S.
  TITLE     Cloning and expression of a rat brain basic helix-loop-helix factor
  JOURNAL   Biochem Biophys Res Commun 221 (1), 199-204 (1996)
   PUBMED   8660336
REFERENCE   9  (bases 1 to 2510)
  AUTHORS   Lee,J.E., Hollenberg,S.M., Snider,L., Turner,D.L., Lipnick,N. and
            Weintraub,H.
  TITLE     Conversion of Xenopus ectoderm into neurons by NeuroD, a basic
            helix-loop-helix protein
  JOURNAL   Science 268 (5212), 836-844 (1995)
   PUBMED   7754368
REFERENCE   10 (bases 1 to 2510)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005073.1 and BC094611.1.
            
            On Apr 24, 2018 this sequence version replaced NM_010894.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB610830.1, AK005073.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2216              AK005073.1         2-2217
            2217-2510           BC094611.1         1799-2092
FEATURES             Location/Qualifiers
     source          1..2510
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 47.58 cM"
     gene            1..2510
                     /gene="Neurod1"
                     /gene_synonym="BETA2; BHF-1; bHLHa3; Nd1; Neurod"
                     /note="neurogenic differentiation 1"
                     /db_xref="GeneID:18012"
                     /db_xref="MGI:MGI:1339708"
     exon            1..86
                     /gene="Neurod1"
                     /gene_synonym="BETA2; BHF-1; bHLHa3; Nd1; Neurod"
                     /inference="alignment:Splign:2.1.0"
     exon            87..2498
                     /gene="Neurod1"
                     /gene_synonym="BETA2; BHF-1; bHLHa3; Nd1; Neurod"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1171
                     /gene="Neurod1"
                     /gene_synonym="BETA2; BHF-1; bHLHa3; Nd1; Neurod"
                     /note="beta-cell E-box transcriptional activator 2"
                     /codon_start=1
                     /product="neurogenic differentiation factor 1"
                     /protein_id="NP_035024.1"
                     /db_xref="CCDS:CCDS16169.1"
                     /db_xref="GeneID:18012"
                     /db_xref="MGI:MGI:1339708"
                     /translation="MTKSYSESGLMGEPQPQGPPSWTDECLSSQDEEHEADKKEDELE
                     AMNAEEDSLRNGGEEEEEDEDLEEEEEEEEEEEDQKPKRRGPKKKKMTKARLERFKLR
                     RMKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSG
                     KSPDLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNPDMPPHLPTASASFPVHP
                     YSYQSPGLPSPPYGTMDSSHVFHVKPPPHAYSAALEPFFESPLTDCTSPSFDGPLSPP
                     LSINGNFSFKHEPSAEFEKNYAFTMHYPAATLAGPQSHGSIFSSGAAAPRCEIPIDNI
                     MSFDSHSHHERVMSAQLNAIFHD"
     regulatory      2473..2478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neurod1"
                     /gene_synonym="BETA2; BHF-1; bHLHa3; Nd1; Neurod"
                     /note="hexamer: AATAAA"
     polyA_site      2498
                     /gene="Neurod1"
                     /gene_synonym="BETA2; BHF-1; bHLHa3; Nd1; Neurod"
                     /note="major polyA site"
ORIGIN      
        1 acgaggaatt cgcccacgca gaaggcaagg tgtcccgagg ctccagggtt atgagatcgt
       61 cactattcag aaccttttaa caacaggaag tggaaacatg accaaatcat acagcgagag
      121 cgggctgatg ggcgagcctc agccccaagg tcccccaagc tggacagatg agtgtctcag
      181 ttctcaggac gaggaacacg aggcagacaa gaaagaggac gagcttgaag ccatgaatgc
      241 agaggaggac tctctgagaa acgggggaga ggaggaggag gaagatgagg atctagagga
      301 agaggaggaa gaagaagagg aggaggagga tcaaaagccc aagagacggg gtcccaaaaa
      361 gaaaaagatg accaaggcgc gcctagaacg ttttaaatta aggcgcatga aggccaacgc
      421 ccgcgagcgg aaccgcatgc acgggctgaa cgcggcgctg gacaacctgc gcaaggtggt
      481 accttgctac tccaagaccc agaaactgtc taaaatagag acactgcgct tggccaagaa
      541 ctacatctgg gctctgtcag agatcctgcg ctcaggcaaa agccctgatc tggtctcctt
      601 cgtacagacg ctctgcaaag gtttgtccca gcccactacc aatttggtcg ccggctgcct
      661 gcagctcaac cctcggactt tcttgcctga gcagaacccg gacatgcccc cgcatctgcc
      721 aaccgccagc gcttccttcc cggtgcatcc ctactcctac cagtcccctg gactgcccag
      781 cccgccctac ggcaccatgg acagctccca cgtcttccac gtcaagccgc cgccacacgc
      841 ctacagcgca gctctggagc ccttctttga aagcccccta actgactgca ccagcccttc
      901 ctttgacgga cccctcagcc cgccgctcag catcaatggc aacttctctt tcaaacacga
      961 accatccgcc gagtttgaaa aaaattatgc ctttaccatg cactaccctg cagcgacgct
     1021 ggcagggccc caaagccacg gatcaatctt ctcttccggt gccgctgccc ctcgctgcga
     1081 gatccccata gacaacatta tgtctttcga tagccattcg catcatgagc gagtcatgag
     1141 tgcccagctt aatgccatct ttcacgatta gaggcacgtc agtttcacta ttcccgggaa
     1201 acgaatccac tgtgcgtaca gtgactgtcc tgtttacaga aggcagccct tttgctaaga
     1261 ttgctgcaaa gtgcaaatac tcaaagcttc aagtgatata tgtatttatt gtcgttactg
     1321 cctttggaag aaacagggga tcaaagttcc tgttcacctt atgtattgtt ttctatagct
     1381 cttctatttt aaaaataata atacagtaaa gtaaaaaaga aaatgtgtac cacgaatttc
     1441 gtgtagctgt attcagatcg tattaattat ctgatcggga taaaaaaaat cacaagcaat
     1501 aattaggatc tatgcaattt ttaaactagt aatgggccaa ttaaaatata tataaatata
     1561 tatttttcaa ccagcatttt actacctgtg acctttccca tgctgaatta ttttgttgtg
     1621 attttgtaca gaatttttaa tgacttttta taacgtggat ttcctatttt aaaaccatgc
     1681 agcttcatca atttttatac atatcagaaa agtagaatta tatctaattt atacaaaata
     1741 atttaactaa tttaaaccag cagaaaagtg cttagaaagt tattgcgttg ccttagcact
     1801 tctttcttct ctaattgtaa aaaagaaaag aaaagaaaaa aaaccaacaa attgcacaat
     1861 ttgagcaatt catctcactt taaagttttt cctgctcgct ccctaaaata gaaaccagac
     1921 ccataacact caagaggatg aaaaccgaaa tgcattcctt atcaaaacac atcaattcat
     1981 tacttgcaca agcttgtaaa tacatattat aaataaatgc caacacacac tcctttaaat
     2041 caaaagctgc ttgactatca catacaattt gcactctttc tttttagtct tttacttctt
     2101 tgaattccat gattttacgg agtgtttgaa gatattgatg tttccagaaa atataaatgc
     2161 atgattttat acatagtcaa acaaatggtg gtttgtcatc tattcatgta ataaatctga
     2221 gcctaaattt attcaggttg ttaatgttgg gtttttatac ctgtgtagtc agttagtaca
     2281 gtagtttaaa taaaattcaa accatcgaat tcataattag aacaatagct gttgcatgta
     2341 aaatgcagtc cagaataagt gctgtttgag atgtgatgct ggtactactg gaattgacat
     2401 gtactgtaat cttgtttgta atcctgtgta ttatggtgta atgcacaatt tagaaaactc
     2461 ccatgcagtt gcaataaaaa tagtatggaa aatcaaaaaa aaaaaaaaaa
//
