LOCUS       NM_153408               2583 bp    mRNA    linear   ROD 10-JUN-2024
DEFINITION  Mus musculus neuralized E3 ubiquitin protein ligase 3 (Neurl3),
            mRNA.
ACCESSION   NM_153408
VERSION     NM_153408.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2583)
  AUTHORS   Ning,X., Du,J., Gong,Y., Yao,Y., Bai,Z., Ni,Y., Li,Y., Li,Z.,
            Zhao,H., Zhou,J., Liu,B., Lan,Y. and Hou,S.
  TITLE     Divergent expression of Neurl3 from hemogenic endothelial cells to
            hematopoietic stem progenitor cells during development
  JOURNAL   J Genet Genomics 50 (9), 661-675 (2023)
   PUBMED   37230320
  REMARK    GeneRIF: Divergent expression of Neurl3 from hemogenic endothelial
            cells to hematopoietic stem progenitor cells during development.
REFERENCE   2  (bases 1 to 2583)
  AUTHORS   Qi,F., Zhang,X., Wang,L., Ren,C., Zhao,X., Luo,J. and Lu,D.
  TITLE     E3 ubiquitin ligase NEURL3 promotes innate antiviral response
            through catalyzing K63-linked ubiquitination of IRF7
  JOURNAL   FASEB J 36 (8), e22409 (2022)
   PUBMED   35792897
  REMARK    GeneRIF: E3 ubiquitin ligase NEURL3 promotes innate antiviral
            response through catalyzing K63-linked ubiquitination of IRF7.
REFERENCE   3  (bases 1 to 2583)
  AUTHORS   Hou,S., Li,Z., Dong,J., Gao,Y., Chang,Z., Ding,X., Li,S., Li,Y.,
            Zeng,Y., Xin,Q., Wang,B., Ni,Y., Ning,X., Hu,Y., Fan,X., Hou,Y.,
            Li,X., Wen,L., Zhou,B., Liu,B., Tang,F. and Lan,Y.
  TITLE     Heterogeneity in endothelial cells and widespread venous
            arterialization during early vascular development in mammals
  JOURNAL   Cell Res 32 (4), 333-348 (2022)
   PUBMED   35079138
REFERENCE   4  (bases 1 to 2583)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2583)
  AUTHORS   Hou,S., Li,Z., Zheng,X., Gao,Y., Dong,J., Ni,Y., Wang,X., Li,Y.,
            Ding,X., Chang,Z., Li,S., Hu,Y., Fan,X., Hou,Y., Wen,L., Liu,B.,
            Tang,F. and Lan,Y.
  TITLE     Embryonic endothelial evolution towards first hematopoietic stem
            cells revealed by single-cell transcriptomic and functional
            analyses
  JOURNAL   Cell Res 30 (5), 376-392 (2020)
   PUBMED   32203131
REFERENCE   6  (bases 1 to 2583)
  AUTHORS   Londhe,V.A., Tomi,T., Nguyen,T.T., Lopez,B. and Smith,J.B.
  TITLE     Overexpression of LINCR in the developing mouse lung epithelium
            inhibits distal differentiation and induces cystic changes
  JOURNAL   Dev Dyn 244 (7), 827-838 (2015)
   PUBMED   25904058
  REMARK    GeneRIF: LINCR may exert its effects on distal lung development in
            this model through activation of the Notch signaling pathway.
REFERENCE   7  (bases 1 to 2583)
  AUTHORS   Hu,Y., Nguyen,T.T., Bui,K.C., Demello,D.E. and Smith,J.B.
  TITLE     A novel inflammation-induced ubiquitin E3 ligase in alveolar type
            II cells
  JOURNAL   Biochem Biophys Res Commun 333 (1), 253-263 (2005)
   PUBMED   15936721
REFERENCE   8  (bases 1 to 2583)
  AUTHORS   Smith,J.B., Nguyen,T.T., Hughes,H.J., Herschman,H.R., Widney,D.P.,
            Bui,K.C. and Rovai,L.E.
  TITLE     Glucocorticoid-attenuated response genes induced in the lung during
            endotoxemia
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 283 (3), L636-L647 (2002)
   PUBMED   12169584
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC132456.5 and
            AC133102.4.
            
            On Nov 17, 2006 this sequence version replaced NM_153408.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF321278.1, BC056622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AC132456.5         165753-165840
            89-577              AC133102.4         2367-2855
            578-631             AC133102.4         3359-3412
            632-2583            AC133102.4         5515-7466
FEATURES             Location/Qualifiers
     source          1..2583
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 15.18 cM"
     gene            1..2583
                     /gene="Neurl3"
                     /gene_synonym="2010300P06Rik; Lincr"
                     /note="neuralized E3 ubiquitin protein ligase 3"
                     /db_xref="GeneID:214854"
                     /db_xref="MGI:MGI:2429944"
     exon            1..88
                     /gene="Neurl3"
                     /gene_synonym="2010300P06Rik; Lincr"
                     /inference="alignment:Splign:2.1.0"
     exon            89..577
                     /gene="Neurl3"
                     /gene_synonym="2010300P06Rik; Lincr"
                     /inference="alignment:Splign:2.1.0"
     exon            578..631
                     /gene="Neurl3"
                     /gene_synonym="2010300P06Rik; Lincr"
                     /inference="alignment:Splign:2.1.0"
     exon            632..2583
                     /gene="Neurl3"
                     /gene_synonym="2010300P06Rik; Lincr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2507..2512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neurl3"
                     /gene_synonym="2010300P06Rik; Lincr"
                     /note="hexamer: ATTAAA"
     polyA_site      2528
                     /gene="Neurl3"
                     /gene_synonym="2010300P06Rik; Lincr"
                     /note="major polyA site"
     regulatory      2559..2564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neurl3"
                     /gene_synonym="2010300P06Rik; Lincr"
                     /note="hexamer: AGTAAA"
     polyA_site      2583
                     /gene="Neurl3"
                     /gene_synonym="2010300P06Rik; Lincr"
                     /note="major polyA site"
ORIGIN      
        1 actggccttc acagacatct tcagacccag ggacttgtgc cccaggagga gctcaggctg
       61 atgggttctc tcctcagccc tgaggccaat gccgaggtgc cccgcgaggc ccttagtttc
      121 cacgggaacg ccacgggcgc acaggtgcat ctggacgatc agcggagcac agcgcgcagg
      181 cgctcgacgt tccacgatgg tatcgtgttc agccagaggc cggtctggcc gggtgagcgt
      241 gttgctctgc gcgtcctgcg acatgaagaa ggctggtgcg gtggcctccg cgtgggcttc
      301 acgcgcctgg accctgcgca agtggccgcg tcctgcctgc cacccttcgt gtgcccggac
      361 ctggaggagc agagtcccac gtgggcagcg ttgcttccag agggcttcgt tcgtgcgggg
      421 aatgtggtct gcttctgggt gaaccgtaga gggtggctct tcgccaaggt caacgctggc
      481 cgccccctct tgctgcgcaa agacgtgctg gtccagggcg ccccgctctg ggcggtgatg
      541 gatgtgtacg ggaccacgaa agccattgag cttctggatc ccaaagccaa cgcctggatt
      601 cgtagtggtg agcctgtgcc agagtctgaa gtcatatcag gagaggagtg tgtcatctgc
      661 ttccacaaca ctgccaacac ccgcctcatg ccctgtggcc actcacactt ctgtggctcc
      721 tgtgcctggc acatcttcaa agacacggcc aggtgcccca tatgtcgctg gcagatcgag
      781 gaggtggctg tagtgtcttc actgaaggct gaggaaggct cctgagaaga tgacttcttg
      841 ggcagatggg acctggctct gaccacactg gccttacatt aaggactgga tggggctctg
      901 gcaggtccct ggactctagt tactgaacat ggcaggattc agtcaacatt cccagctctg
      961 agtctgaaga ctttgccctt ccagttgaat tctggggact tcaggaggtt ctgacatggg
     1021 tggaaggcag gtattaatat tagttaagga agccccaact tggggctttt ctatgtagga
     1081 acccctatgc ccaacatatt tgtcaaattt aatcagttta tagtgtttaa actgagactg
     1141 gggaaccaaa aacctttatc cttgatgtag gtgatggcta tgttccattc tatttgtggg
     1201 agctcaatct cacagtccaa caagattggt tcattggtgt gaaggggaag gtcgggggct
     1261 gagttcttgc caggcaaagt ggtagaaaaa atggccttgt gacagagcac tgaccccacc
     1321 tacgtctact ggcagacgct gagagtttgc tgactatggt tgaggggttc ctggccatgg
     1381 caagccactt gaagacctct ttacacccag ttttataaac ctgtggccag aggaggtcag
     1441 agaacctcca accagtgagt cctggaaggg tctgcctggg ggtggggagc agggagcttg
     1501 gcccagagaa gcaaggcaaa gctcccagcc tgatggaggt tcagagcagg aagcctctgt
     1561 atccagaagc tgtgtgtggc cgccttcacc cagcaaccac tgtggtgatt ggtgattggc
     1621 tgcaatcatc agcttgcaga atcttggatc acctggaaac ggatactcag taagggagtg
     1681 tctcctggcg gttggccttt ggggatgcct atgaggaatt tcctgattgg gttaattgag
     1741 ttgtaaaccc accttgaatg tggctggcac catttcatga gctgggcctc tagagcaatg
     1801 gttctcagcc ttcctaatgc tgtgaccctt tcatacagtt ccttatgttg cggtgacccc
     1861 caactataaa attattttgt tccctacttc ataactgtaa ttttgctact gttatgaatc
     1921 ataatgtaaa tatctgatac tcaggacagc tggtatgtgg cccctgttga gaaacactgc
     1981 tctagactga gagggacaga gagcccaggg cacaggcatt cagtggtctg cttctagaca
     2041 atgggcacac tttgaccagt tgtctcaagc tctgacttcc tggaaatgat ggactgggac
     2101 tcggaattgt ggggtaaaat aagctcttgc ttccttaagt tgatttggtt gagatatttt
     2161 gtcacaggtt aggaatagtt ctgagatcac aaaaaagaga ccgccattat aattgtgagg
     2221 gtttgtatat gctcagccca gggagtggca ctattagaag gtttggcctc cttggagtag
     2281 gtgtggcctt gttggagtag gtgtgacctt gttggagtag gtgtatcact gttggtgtgg
     2341 gctataagac cctcatccta actgcctgga agtcagtctt ccactagccg acttcagatg
     2401 aagatgtaga actctcagct ccccctgcac cacgcctgcc tggatgctgt cgttttcctg
     2461 ctttgatgat aatggactga acctctcacc ctgtaagcca tccccaatta aatgttgtcc
     2521 ttataagagt tgccttggtc atggtgtctc ttcacagcag taaaatccta actaaggcaa
     2581 taa
//
