LOCUS       NM_001082974            1156 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus neuralized E3 ubiquitin protein ligase 2 (Neurl2),
            mRNA.
ACCESSION   NM_001082974
VERSION     NM_001082974.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1156)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1156)
  AUTHORS   Lee,J., Yoon,K.J., Park,P., Lee,C., Kim,M.J., Han,D.H., Kim,J.I.,
            Kim,S., Lee,H.R., Lee,Y., Jang,E.H., Ko,H.G., Kong,Y.Y. and
            Kaang,B.K.
  TITLE     Neur1 and Neur2 are required for hippocampus-dependent spatial
            memory and synaptic plasticity
  JOURNAL   Hippocampus 30 (11), 1158-1166 (2020)
   PUBMED   32644222
  REMARK    GeneRIF: Neur1 and Neur2 are required for hippocampus-dependent
            spatial memory and synaptic plasticity.
REFERENCE   3  (bases 1 to 1156)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   4  (bases 1 to 1156)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1156)
  AUTHORS   Bongiovanni,A., Romancino,D.P., Campos,Y., Paterniti,G., Qiu,X.,
            Moshiach,S., Di Felice,V., Vergani,N., Ustek,D. and d'Azzo,A.
  TITLE     Alix protein is substrate of Ozz-E3 ligase and modulates actin
            remodeling in skeletal muscle
  JOURNAL   J Biol Chem 287 (15), 12159-12171 (2012)
   PUBMED   22334701
  REMARK    GeneRIF: the Ozz-E3 ligase regulates Alix at sites where the actin
            cytoskeleton undergoes remodeling.
REFERENCE   6  (bases 1 to 1156)
  AUTHORS   Koo,B.K., Yoon,M.J., Yoon,K.J., Im,S.K., Kim,Y.Y., Kim,C.H.,
            Suh,P.G., Jan,Y.N. and Kong,Y.Y.
  TITLE     An obligatory role of mind bomb-1 in notch signaling of mammalian
            development
  JOURNAL   PLoS One 2 (11), e1221 (2007)
   PUBMED   18043734
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1156)
  AUTHORS   Song,R., Koo,B.K., Yoon,K.J., Yoon,M.J., Yoo,K.W., Kim,H.T.,
            Oh,H.J., Kim,Y.Y., Han,J.K., Kim,C.H. and Kong,Y.Y.
  TITLE     Neuralized-2 regulates a Notch ligand in cooperation with Mind
            bomb-1
  JOURNAL   J Biol Chem 281 (47), 36391-36400 (2006)
   PUBMED   17003037
  REMARK    GeneRIF: Neuralized-2 regulates a Notch ligand in cooperation with
            Mind bomb-1
REFERENCE   8  (bases 1 to 1156)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   9  (bases 1 to 1156)
  AUTHORS   Nastasi,T., Bongiovanni,A., Campos,Y., Mann,L., Toy,J.N.,
            Bostrom,J., Rottier,R., Hahn,C., Conaway,J.W., Harris,A.J. and
            D'Azzo,A.
  TITLE     Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin
            degradation during myogenesis
  JOURNAL   Dev Cell 6 (2), 269-282 (2004)
   PUBMED   14960280
REFERENCE   10 (bases 1 to 1156)
  AUTHORS   Rottier,R.J. and D'Azzo,A.
  TITLE     Identification of the promoters for the human and murine protective
            protein/cathepsin A genes
  JOURNAL   DNA Cell Biol 16 (5), 599-610 (1997)
   PUBMED   9174165
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591495.12.
            
            On Oct 3, 2009 this sequence version replaced NM_001082974.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004524.1, CO039719.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-898               AL591495.12        15318-16215         c
            899-1156            AL591495.12        13349-13606         c
FEATURES             Location/Qualifiers
     source          1..1156
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.27 cM"
     gene            1..1156
                     /gene="Neurl2"
                     /gene_synonym="Neur2; Ozz; Ozz-E3"
                     /note="neuralized E3 ubiquitin protein ligase 2"
                     /db_xref="GeneID:415115"
                     /db_xref="MGI:MGI:3043305"
     exon            1..898
                     /gene="Neurl2"
                     /gene_synonym="Neur2; Ozz; Ozz-E3"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1014
                     /gene="Neurl2"
                     /gene_synonym="Neur2; Ozz; Ozz-E3"
                     /note="neuralized-like 2"
                     /codon_start=1
                     /product="neuralized-like protein 2"
                     /protein_id="NP_001076443.1"
                     /db_xref="CCDS:CCDS38330.1"
                     /db_xref="GeneID:415115"
                     /db_xref="MGI:MGI:3043305"
                     /translation="MAAPSEHVGLGGPRSPARPEPPPTRFHQVHGANIRMDPSGTRAT
                     RVESFAHGVCFSREPLAPGQVFLVEIEEKELGWCGHLRLGLTALDPASLAAVPEFSLP
                     DLVSLGHSWVFAITRHHNRVPREGQPEAEAAVPSGPQALLVEPYLRIEQFRIPRDRLV
                     GRSRPGLYSHLLDQLYEQNVLPPTARRSRLGVLFCPREDGTADMHIIINGEDMGPSAR
                     GLPAAQPLYAVVDVFASTKSVRLVQLEYGLPSLQTLCRLVIQKRVVHRLAIDVLHLPK
                     GLKDFCKYE"
     exon            899..1156
                     /gene="Neurl2"
                     /gene_synonym="Neur2; Ozz; Ozz-E3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaaagcgg cgctaggacc cccaggcaga gctgggggaa gttagagaag ggggaaatgc
       61 cttacatggt tcatccaccc cgcccccgcg gtcacaatct gagcccgctg cccaaaatag
      121 cccttggcat gagctgccct gttgcacggc ttggagatgg ctgctccctc cgaacacgta
      181 ggactgggtg gcccacggag ccctgcgcgc ccagagcccc ctcccacccg cttccaccaa
      241 gtgcatggag ccaacatccg catggacccc tcaggaacgc gagccacacg cgtggagagt
      301 ttcgcccacg gtgtgtgctt cagtcgtgag cccctggccc ccggccaggt atttctagtg
      361 gaaattgagg aaaaagagct gggctggtgc gggcacttac gtcttggcct gaccgctctg
      421 gatcccgcca gtctggccgc tgtacccgag ttttcactgc ctgacttggt cagccttggc
      481 cacagttggg tcttcgctat cacacgccac cacaaccgtg tgccccggga aggtcaacca
      541 gaagcggagg cagcggtccc cagtggtccc caagccctac tggttgaacc ctatctgcgc
      601 atcgagcagt tccgaattcc ccgggaccgt ctggtgggcc gcagccggcc agggctttat
      661 agccacctct tagatcagct ctatgaacaa aacgtgctgc ctcctacagc gcgccgaagc
      721 cgcttgggtg ttctcttctg cccccgtgag gatgggaccg ccgacatgca catcatcatc
      781 aacggggagg acatgggccc tagcgcccgg gggctgccag ctgctcagcc cctctacgct
      841 gtggtagatg tgtttgcttc caccaagagc gtgcgtctgg tccagctgga gtatggcttg
      901 ccatctctgc agactctgtg ccgactagtg atccagaaga gggtggtaca caggctggcc
      961 attgatgtgc tccacctgcc caaaggactg aaggacttct gcaagtacga atgaacgaat
     1021 gaacgcctgt ctgtggccac cagagcaaag tccccggtgg tgcgccctgc ctctagagaa
     1081 gtggctagtc tgaagctggt cgcacagctc acaatcaggg ctggaaataa atagagccga
     1141 tgtggatgtt ctgagc
//
