LOCUS       NM_001081656            6273 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus neuralized E3 ubiquitin protein ligase 1B (Neurl1b),
            mRNA.
ACCESSION   NM_001081656 XM_139844 XM_915023 XM_989681
VERSION     NM_001081656.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6273)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6273)
  AUTHORS   Rullinkov,G., Tamme,R., Sarapuu,A., Lauren,J., Sepp,M., Palm,K. and
            Timmusk,T.
  TITLE     Neuralized-2: expression in human and rodents and interaction with
            Delta-like ligands
  JOURNAL   Biochem Biophys Res Commun 389 (3), 420-425 (2009)
   PUBMED   19723503
REFERENCE   3  (bases 1 to 6273)
  AUTHORS   Koo,B.K., Yoon,M.J., Yoon,K.J., Im,S.K., Kim,Y.Y., Kim,C.H.,
            Suh,P.G., Jan,Y.N. and Kong,Y.Y.
  TITLE     An obligatory role of mind bomb-1 in notch signaling of mammalian
            development
  JOURNAL   PLoS One 2 (11), e1221 (2007)
   PUBMED   18043734
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6273)
  AUTHORS   Song,R., Koo,B.K., Yoon,K.J., Yoon,M.J., Yoo,K.W., Kim,H.T.,
            Oh,H.J., Kim,Y.Y., Han,J.K., Kim,C.H. and Kong,Y.Y.
  TITLE     Neuralized-2 regulates a Notch ligand in cooperation with Mind
            bomb-1
  JOURNAL   J Biol Chem 281 (47), 36391-36400 (2006)
   PUBMED   17003037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157598.4.
            
            On Jun 24, 2019 this sequence version replaced NM_001081656.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ414760.1, DQ839448.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AC157598.4         37062-37198         c
            138-683             AC157598.4         19725-20270         c
            684-1376            AC157598.4         12698-13390         c
            1377-1502           AC157598.4         10854-10979         c
            1503-6273           AC157598.4         5736-10506          c
FEATURES             Location/Qualifiers
     source          1..6273
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.18 cM"
     gene            1..6273
                     /gene="Neurl1b"
                     /gene_synonym="C230078M08Rik; EG240055"
                     /note="neuralized E3 ubiquitin protein ligase 1B"
                     /db_xref="GeneID:240055"
                     /db_xref="MGI:MGI:3643092"
     exon            1..137
                     /gene="Neurl1b"
                     /gene_synonym="C230078M08Rik; EG240055"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1747
                     /gene="Neurl1b"
                     /gene_synonym="C230078M08Rik; EG240055"
                     /EC_number="2.3.2.27"
                     /note="neuralized-like protein 1B; neuralized homolog 1b;
                     RING-type E3 ubiquitin transferase NEURL1B"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase NEURL1B"
                     /protein_id="NP_001075125.1"
                     /db_xref="CCDS:CCDS37513.1"
                     /db_xref="GeneID:240055"
                     /db_xref="MGI:MGI:3643092"
                     /translation="MGNTVHRTLPDSSPPARLLATRPCYGPGPERRAVLGEAPRFHAQ
                     AKGKNVRLDGHSRRATRRNSFCNGVTFTQRPIRLYEQVRLRLVAVRPGWSGALRFGFT
                     AHDPSLMSAQDIPKYACPDLVTRPGYWAKALPENLALRDTVLAYWADRHGRVFYSVND
                     GEPVLFHCGVAVGGPLWALIDVYGITDEVQLLESTFADTLTPLRLGQARLSACPPPGS
                     HDAANFDNNELENNQVVAKLGHLALGRPDAAVPCVARERPRPASSPALLDAELRFHAT
                     RGPDVSLSADRRLACAPRPDGGRTLVFSERPLRPGESLCVEVGRPGLAAPAAVAFGIT
                     SCDPGALRPSELPADPAALLDRKEYWVVARAGPVPSGGDALSFTLRPGGDVLLAVNGR
                     PRGRLLCVDTSQALWAFFAVRGGVAGQLRLLGTLQSSSETMTPSGSFSGSQDDSDSDM
                     TFGVNQSSSASESSLVTAPSSPLSPPVSPAFSAPEPTGSRNGECTVCFDSEVDTVIYT
                     CGHMCLCHGCGLRLRRQARACCPICRRPIKDVIKIYRP"
     exon            138..683
                     /gene="Neurl1b"
                     /gene_synonym="C230078M08Rik; EG240055"
                     /inference="alignment:Splign:2.1.0"
     exon            684..1376
                     /gene="Neurl1b"
                     /gene_synonym="C230078M08Rik; EG240055"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1502
                     /gene="Neurl1b"
                     /gene_synonym="C230078M08Rik; EG240055"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..6273
                     /gene="Neurl1b"
                     /gene_synonym="C230078M08Rik; EG240055"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6249..6254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neurl1b"
                     /gene_synonym="C230078M08Rik; EG240055"
                     /note="hexamer: CATAAA"
     polyA_site      6273
                     /gene="Neurl1b"
                     /gene_synonym="C230078M08Rik; EG240055"
                     /note="major polyA site"
ORIGIN      
        1 gcccatctgc cgcccgccgg tcgccggtgc agcggcaatg ccccgcagcc cggccgcggc
       61 ccccggcccg cccagctagc cccgcgccgc gagtctcgga gtagcgatgg gcaacacggt
      121 gcaccggacc ctgccagact ccagccctcc tgcacgcctc ctggccaccc ggccttgcta
      181 cggcccgggc ccagagaggc gagcggtcct gggcgaggcg ccgcgcttcc atgcgcaggc
      241 taagggcaag aacgtgcgtc tggacggcca ctcgcgcagg gccacgcggc ggaacagctt
      301 ctgcaacgga gtcaccttca cgcagcgccc cattcgcctg tacgagcagg tgcggctgcg
      361 cctggtggcc gtgcgtcccg gctggagcgg tgctctgcgc ttcggcttca ctgcgcacga
      421 cccgtctctc atgagcgcac aggatatccc caagtacgcc tgccccgacc tggttacgcg
      481 gcctggttac tgggccaagg cgctgcccga gaacctggcg ctgcgggaca cagtgctggc
      541 ctactgggcc gatcgccacg gtcgcgtctt ctacagtgtc aacgatggtg agccagtgct
      601 gttccactgc ggcgtggctg tgggcggccc actctgggca ctcatcgacg tctatggcat
      661 cacggacgaa gtacagcttc tggaaagcac cttcgctgac acgctgaccc ccctgcgcct
      721 gggtcaggct cgcctcagcg cctgcccccc tcctggcagc cacgacgctg ccaacttcga
      781 caacaacgag ctggagaaca accaggtggt ggccaagctg ggtcacctgg ctctcggccg
      841 tcccgacgcc gcggtcccgt gcgtggcccg cgaacgcccg aggcccgcct catcgcccgc
      901 gctgctggac gccgagctgc gcttccacgc cacgcgcgga cccgacgtga gcttgtccgc
      961 cgaccgcagg ctagcctgcg cgccccgccc cgacggcggc cgcacgctcg tgttctccga
     1021 gcggccgctg cggccagggg agagcctgtg cgtggaagtg gggcgcccgg ggctggcggc
     1081 acccgcggct gtggccttcg gcatcacgtc ctgcgatcct ggcgcgctgc ggccatccga
     1141 gctgcccgcc gatcccgctg cgctgctgga ccgcaaggaa tactgggtgg tggctcgcgc
     1201 cgggcccgtg cccagcggag gcgacgcgct cagcttcacg ctgcgacccg gcggcgacgt
     1261 cctgctggcg gtgaacgggc gcccgcgggg acgcctgctg tgcgtggaca cctcacaggc
     1321 gctctgggcc ttcttcgcgg tacgcggcgg tgtggcgggc cagctgcgtc tcctgggtac
     1381 cctacagtcc agttctgaga ccatgacgcc atcagggtcc ttcagtggct cccaggatga
     1441 cagcgattca gacatgacct tcggcgtcaa ccagtcgtcc tcagcatcag aatcgtctct
     1501 ggtgacagcc cccagctccc ctctgagtcc cccggtgtcc ccagccttct ccgcacccga
     1561 gccgaccggc agcaggaatg gagagtgcac agtgtgcttc gacagcgagg tggacacggt
     1621 catctacacg tgtggacaca tgtgcctgtg tcatggctgc ggcctgcggc tccgaaggca
     1681 ggcacgggcc tgctgtccca tctgccggcg gcccatcaag gatgttatca agatctacag
     1741 gccgtagctg tgcaactggc tcggccaagg caaggtcacc tttctgaagc ccctgctagg
     1801 tgggcgacac catggctatc agggagcctg gggtcaggag ccatctctcg tctgccactc
     1861 cgcagtgatg agcaaggcag gacaggtatg gagatgaggc cctgggggcc agagcccagg
     1921 caagcacttg ttgcttctgg ctcaaacaca catcaccccc aaaagcctgt cccaggattc
     1981 agctcaggaa ctgcctggca gatcacctgc ctcttggtga ccttcagctg ggaaagggta
     2041 ccctctgtct gtgcaatgct tctttggggt tgggttgagt gtgtgtgtct gggtgggggg
     2101 gtggggagac agcacggaga atgggtgaga gagaatgtgt gaatgtttta tgtagggatc
     2161 catctcctgg agggtattta acactacgga atgtgcaatc tgggcccaac tgttagtgtg
     2221 gttgtccact ttctggggat ttaggttttt ctgcagtgag ctagctttga acacaggagg
     2281 cctgaaccta cacagagctc cctcaatggc gctcagattt tctaagggag agcaaaaata
     2341 actcactgtt tacagctcca gacagcagct cctgctgagg ggagaaggta ggcggagaac
     2401 atcggagaac aggtggcttt cgcgtctcac tcagcctagg agtagccttc ccaaggcagc
     2461 tgaggacagg tgccccagct gtagcaacta gagtccttta tccccagcca ctagaacagt
     2521 aaacacctca gccttgtccc tacttgctgt ggcgttttat gacgtccttg ctgttctcta
     2581 ggacaactcc gtgtctccca aggtagaatt aagagcttag ggcatgtccc agtgagcagc
     2641 tggcagaagc tagaagaccc agacccctac ctcgtccttg tcctgactct cattttcctg
     2701 ttgattatta tggtgttaag tacatcagtt agctactcgt gaggaactga ctgaaaatgc
     2761 tccccactcc tgggcctgtt tgctgccatt tcccaggccc ctggccctgt caccctctca
     2821 ctgggtcact tatgtctgta ggcttccaga ctttgccatt gcggatgctc tggccgtgtg
     2881 tgccacccct cccttctaaa gagccacggg ttgtaccgga tgtgcatcca cctaccctga
     2941 gctgtacctt tagtgaagtt ccttgaccct ccctcttctt tgctcctact tggaagcctg
     3001 gtgccagggc attggtgaga cccgctctgt tgttgttgtt gttgttgttg ttgttgttgt
     3061 tgttgttttg agagaaagct tgagacacct tgccaggagc aactgtttcc tcacagtgcc
     3121 taacctggcc ctctcttgct gtgagggagg gaaaaagagg gcaagagaaa catttaggaa
     3181 gtgaggttca tggaacagat tttgacaagg agccatggaa cacttgagag cagcccaagc
     3241 ccctctcagt gcccctggtg gctggaggcc ttgggcctcc actgctgctc tgaaagagtc
     3301 aggatctgac ctgttcacag ctccgccttc ctctcccagc aagaacctct gagagctcgc
     3361 tttcccttag ggatgtcacg cccacctttt cactttagga tgattctctt cctttttctt
     3421 tttctttttc tttttctttt tctttttctt tttctttttc ttttctttct ttctttcttt
     3481 tttctttttc tttttccttt tcttttcttt tttttttttg tgtgtgtttt ggtttgttgt
     3541 tgttttggtt ttcctggaac tcactctgta gaccaggcta gccccaaact cagaaatctg
     3601 cctcctgagt gctgggacta agggtgtggc accaccactg ccctggtgca gctgactcct
     3661 ttaaggagct agagtaaccc ttgttcgcct cggtgagagt ctgagaatca ggcgctttgg
     3721 ctacacagct caatttacac agccaagcct ttagcttcta tgtgtgctgg gcatggacag
     3781 agcctcctca tcgccagtga tgatggccgg gtttccaggc agccgtggtc ctgtctgaat
     3841 attgtctcta actgccacag tttcagagaa aggggaacaa gttctccttt gcttcttgcc
     3901 ctcccagata gacccttgag gtgtatcagg ggtcacccac agccaccacc aggacatcaa
     3961 cagctgaggt cctagactta ggggtggacc aggcatgatc ctggtgacct gttaccagga
     4021 caaaaaggaa ccacaggcct gtttaacctg ctctgcagct gctataaata gctgccttgt
     4081 ttcccacaga gcaaaggggg tgtttctgtt ctgaaagtcg ggtatttgcc tgtgctctga
     4141 aagacggagt caggccctag agaaagtgtg tatgtgtgtg tttcatctca acaacgggca
     4201 ggagggaaaa gaagccagtg tctttcatac cgtccacatg cctgggcact gagttaaaga
     4261 ggcacctttt ttcaggaccc tgtgtataag ttttagtgcc atattgagtc ccatctgaga
     4321 cttggctcgt tgtaaggctc tccatcttat gggcaacttc aaaagccaca cccaccttag
     4381 catcctgggt ggtcagaagg ctcaccatct tatgggcaac ttcataagcc acacccacct
     4441 tagccgcagg atgctgggat gcagcttcag ttaaaggcca tcagctgcgg gacacaggta
     4501 ctcggggtct aggaaatata acattgtcct catttggcaa atgagctctg agatcctgtg
     4561 agactcttta agtatcacaa aacaggaagt ggcagggttg ggatttcaat ccctgcatct
     4621 caccctggcc tgcctgcctt gcttcttagg aagctcaata cagcctgagt cttctttccc
     4681 tagactcacc tggaaagcct ggcgcccaca cctgtgtagg aagttctggt ccctcactgc
     4741 ccaattgcac tgggacaatg tcatgcaggg ggacgtcatg caggggggcg tcatgcagag
     4801 ctgctctgga gagggacttt aggctgcccc tttctgggac cttgcggcca cccttctcga
     4861 ggagcacccc agccattttc caagcttact gcccatttgt gccctgtgaa cttcaaaagc
     4921 caagattagg atggggaggc cagggcctcc ccctatacat agcagccata tccctgcccc
     4981 ctgggaattt ctggaaaata gttgtttccc aggctaagca ggctcctcct cttactggtt
     5041 ggccctcttg ggcagctgtc ctgtgcaggc tgcgacacac attttcactt gttcagcatc
     5101 cacttaccag catggctcat ggtcagaaca tgaggttgaa gactgggaca aaaggcaagg
     5161 cctgtgggca gctctcaggc aagagatcat aaactgattt gatcactctg gagttggggc
     5221 ttgtgctagc acatagtagg tgctcagtaa aagactgcag atcagatcag gagccaggtt
     5281 aggagtggtc agggggttgg tgaaatagca tccattatat atatatggac acaaagtcac
     5341 tcaacaaaca tttgctgagt gccctcagga tgccagctgc tataaggggc aacagagagc
     5401 aagcacccag ccctgatgcc tgagtggtac cttcagcagg gcaagacagg gtggagcatg
     5461 tgggctttct tgaccattct attgccttgg atccatctaa atagatgccc acaatacttt
     5521 ctgcacctac cttaggggtg ttctttatgg tgagtgagcc cttgccaaac agccaagatc
     5581 ccaccagtta atgaccaccc acagggagtc tctgggcaga aaactccctg ccacttccag
     5641 gcactggaac ggggatgcac aagagccctg aattccagct tcgaatggca ttgtgcagcc
     5701 ttggaacatg ggaagcggta actgctcact gctctgtcca tcctgccctg ctggggacat
     5761 ggctcgggga cactgggcct cccagcgttc cttaatattt tagtgtctca ctgtttcacc
     5821 caagtcccta acagaactat ccatatgaca atctgtctgt gccttatgga agtgtgtgtg
     5881 tgtgtgtgtg tgtgtgtgtg tgtgtgtgca ctttttatcc tttaaaatgc aacccttcaa
     5941 cgtggacaag aagctagcag atgcggttgg gctccagatg ccagcaagga gtccctgaga
     6001 ccctcttgca gtttgcaggt ggaatgatag tgttcacccc cacccatccc cgctacctgt
     6061 gtacagaccc tttgaaacat gtctgtcctt tatgattcaa tactgtgact ctcctatacc
     6121 gtctagtctt tggggaactg tactaaaggc ctgagaactt ggggaggggg gtgagtggga
     6181 agggtttgcg ctagtctttg tgtgttgtgt gttctgatat ttgtctgttt ttatctgttt
     6241 tatattaaca taaatttcct gtttgaaaac aaa
//
