LOCUS       NM_021360               4168 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus neuralized E3 ubiquitin protein ligase 1A (Neurl1a),
            transcript variant 1, mRNA.
ACCESSION   NM_021360 XM_918020 XM_925439 XM_925441 XM_925442
VERSION     NM_021360.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4168)
  AUTHORS   Lee,J., Yoon,K.J., Park,P., Lee,C., Kim,M.J., Han,D.H., Kim,J.I.,
            Kim,S., Lee,H.R., Lee,Y., Jang,E.H., Ko,H.G., Kong,Y.Y. and
            Kaang,B.K.
  TITLE     Neur1 and Neur2 are required for hippocampus-dependent spatial
            memory and synaptic plasticity
  JOURNAL   Hippocampus 30 (11), 1158-1166 (2020)
   PUBMED   32644222
  REMARK    GeneRIF: Neur1 and Neur2 are required for hippocampus-dependent
            spatial memory and synaptic plasticity.
REFERENCE   2  (bases 1 to 4168)
  AUTHORS   Ha,T., Moon,K.H., Dai,L., Hatakeyama,J., Yoon,K., Park,H.S.,
            Kong,Y.Y., Shimamura,K. and Kim,J.W.
  TITLE     The Retinal Pigment Epithelium Is a Notch Signaling Niche in the
            Mouse Retina
  JOURNAL   Cell Rep 19 (2), 351-363 (2017)
   PUBMED   28402857
  REMARK    Erratum:[Cell Rep. 2022 Sep 27;40(13):111449. doi:
            10.1016/j.celrep.2022.111449.. PMID: 36170829]
REFERENCE   3  (bases 1 to 4168)
  AUTHORS   Lee,H.J., Yoon,J.H., Ahn,J.S., Jo,E.H., Kim,M.Y., Lee,Y.C.,
            Kim,J.W., Ann,E.J. and Park,H.S.
  TITLE     Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1
            protein stability through the E3 ligase Neuralized-like 1
  JOURNAL   Biochim Biophys Acta 1853 (11 Pt A), 2918-2928 (2015)
   PUBMED   26276215
  REMARK    GeneRIF: Fe65 negatively regulates Jagged1 signaling by decreasing
            Jagged1 protein stability through the E3 ligase Neuralized-like 1.
REFERENCE   4  (bases 1 to 4168)
  AUTHORS   Moayedi,Y., Basch,M.L., Pacheco,N.L., Gao,S.S., Wang,R.,
            Harrison,W., Xiao,N., Oghalai,J.S., Overbeek,P.A., Mardon,G. and
            Groves,A.K.
  TITLE     The candidate splicing factor Sfswap regulates growth and
            patterning of inner ear sensory organs
  JOURNAL   PLoS Genet 10 (1), e1004055 (2014)
   PUBMED   24391519
REFERENCE   5  (bases 1 to 4168)
  AUTHORS   Pavlopoulos,E., Trifilieff,P., Chevaleyre,V., Fioriti,L.,
            Zairis,S., Pagano,A., Malleret,G. and Kandel,E.R.
  TITLE     Neuralized1 activates CPEB3: a function for nonproteolytic
            ubiquitin in synaptic plasticity and memory storage
  JOURNAL   Cell 147 (6), 1369-1383 (2011)
   PUBMED   22153079
  REMARK    GeneRIF: These results suggest a model whereby
            Neuralized1-dependent ubiquitination facilitates hippocampal
            plasticity and hippocampal-dependent memory storage by modulating
            the activity of CPEB3 and CPEB3-dependent protein synthesis and
            synapse formation.
REFERENCE   6  (bases 1 to 4168)
  AUTHORS   Nastasi,T., Bongiovanni,A., Campos,Y., Mann,L., Toy,J.N.,
            Bostrom,J., Rottier,R., Hahn,C., Conaway,J.W., Harris,A.J. and
            D'Azzo,A.
  TITLE     Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin
            degradation during myogenesis
  JOURNAL   Dev Cell 6 (2), 269-282 (2004)
   PUBMED   14960280
REFERENCE   7  (bases 1 to 4168)
  AUTHORS   Timmusk,T., Palm,K., Belluardo,N., Mudo,G. and Neuman,T.
  TITLE     Dendritic localization of mammalian neuralized mRNA encoding a
            protein with transcription repression activities
  JOURNAL   Mol Cell Neurosci 20 (4), 649-668 (2002)
   PUBMED   12213446
REFERENCE   8  (bases 1 to 4168)
  AUTHORS   Pavlopoulos,E., Kokkinaki,M., Koutelou,E., Mitsiadis,T.A.,
            Prinos,P., Delidakis,C., Kilpatrick,M.W., Tsipouras,P. and
            Moschonas,N.K.
  TITLE     Cloning, chromosomal organization and expression analysis of Neurl,
            the mouse homolog of Drosophila melanogaster neuralized gene
  JOURNAL   Biochim Biophys Acta 1574 (3), 375-382 (2002)
   PUBMED   11997106
  REMARK    GeneRIF: molecular cloning, base sequence, amino acid sequence, and
            embryo tissue localization
REFERENCE   9  (bases 1 to 4168)
  AUTHORS   Vollrath,B., Pudney,J., Asa,S., Leder,P. and Fitzgerald,K.
  TITLE     Isolation of a murine homologue of the Drosophila neuralized gene,
            a gene required for axonemal integrity in spermatozoa and terminal
            maturation of the mammary gland
  JOURNAL   Mol Cell Biol 21 (21), 7481-7494 (2001)
   PUBMED   11585928
REFERENCE   10 (bases 1 to 4168)
  AUTHORS   Ruan,Y., Tecott,L., Jiang,M.M., Jan,L.Y. and Jan,Y.N.
  TITLE     Ethanol hypersensitivity and olfactory discrimination defect in
            mice lacking a homolog of Drosophila neuralized
  JOURNAL   Proc Natl Acad Sci U S A 98 (17), 9907-9912 (2001)
   PUBMED   11481456
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC099702.1 and BC058386.1.
            
            On Jul 31, 2009 this sequence version replaced NM_021360.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099702.1, BC058386.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               BC099702.1         1-175
            176-2742            BC058386.1         1-2567
            2743-4168           BC099702.1         2743-4168
FEATURES             Location/Qualifiers
     source          1..4168
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 39.39 cM"
     gene            1..4168
                     /gene="Neurl1a"
                     /gene_synonym="2410129E16Rik; Neu1; Neur1; Neurl; Neurl1;
                     Nlz; Rnf67"
                     /note="neuralized E3 ubiquitin protein ligase 1A"
                     /db_xref="GeneID:18011"
                     /db_xref="MGI:MGI:1334263"
     exon            1..732
                     /gene="Neurl1a"
                     /gene_synonym="2410129E16Rik; Neu1; Neur1; Neurl; Neurl1;
                     Nlz; Rnf67"
                     /inference="alignment:Splign:2.1.0"
     CDS             648..2372
                     /gene="Neurl1a"
                     /gene_synonym="2410129E16Rik; Neu1; Neur1; Neurl; Neurl1;
                     Nlz; Rnf67"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neuralized-like protein 1; neuralized-like protein 1A;
                     m-neu1; m-neuralized 1; neuralized-like homolog;
                     neuralized1; E3 ubiquitin-protein ligase NEURL1;
                     neuralized homolog 1A; RING-type E3 ubiquitin transferase
                     NEURL1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase NEURL1 isoform 1"
                     /protein_id="NP_067335.4"
                     /db_xref="CCDS:CCDS29890.1"
                     /db_xref="GeneID:18011"
                     /db_xref="MGI:MGI:1334263"
                     /translation="MGNNFSSVSSLQRGNPSRASRGHPQNLKDSIGGSFPVPSHRCHH
                     KQKHCPPTLSGGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLI
                     YEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEE
                     FANEGNIIAFWVDKKGRVFYRINESAAMLFFSGVRTVDPLWALVDVYGLTRGVQLLDS
                     ELVLPDCLRPRSFTALRRPSLRCEADEARLSVSLCDLNVPGADGDDGAPPAGCPIPQN
                     SLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARLEHGRDERALVFTSRPVRV
                     AETIFIKVTRSGGGRAGALSFGVTTCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGP
                     LHSGDILGLVVNADGELHLSHNGAAAGMQLCVDASQPLWMLFSLHGAITQVRILGSTI
                     MTERGGPSLPCSPASTPTSPSALGIRLSDPLLSTCGSGPLGGSAGGTAPNSPVSLPES
                     PVTPGLGQWSDECTICYEHAVDTVIYTCGHMCLCYSCGLRLKKALHACCPICRRPIKD
                     IIKTYRSS"
     exon            733..974
                     /gene="Neurl1a"
                     /gene_synonym="2410129E16Rik; Neu1; Neur1; Neurl; Neurl1;
                     Nlz; Rnf67"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1296
                     /gene="Neurl1a"
                     /gene_synonym="2410129E16Rik; Neu1; Neur1; Neurl; Neurl1;
                     Nlz; Rnf67"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1986
                     /gene="Neurl1a"
                     /gene_synonym="2410129E16Rik; Neu1; Neur1; Neurl; Neurl1;
                     Nlz; Rnf67"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2133
                     /gene="Neurl1a"
                     /gene_synonym="2410129E16Rik; Neu1; Neur1; Neurl; Neurl1;
                     Nlz; Rnf67"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..4158
                     /gene="Neurl1a"
                     /gene_synonym="2410129E16Rik; Neu1; Neur1; Neurl; Neurl1;
                     Nlz; Rnf67"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4132..4137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neurl1a"
                     /gene_synonym="2410129E16Rik; Neu1; Neur1; Neurl; Neurl1;
                     Nlz; Rnf67"
                     /note="hexamer: AATAAA"
     polyA_site      4152
                     /gene="Neurl1a"
                     /gene_synonym="2410129E16Rik; Neu1; Neur1; Neurl; Neurl1;
                     Nlz; Rnf67"
                     /note="major polyA site"
ORIGIN      
        1 gcagagcggg cgcgcgcgtg tcactaagac gctcattaac ctgcgcagct gtcgccataa
       61 caaccggagc cccggagtcc tggcgacgct agggcggggg ttgggggcgg cggcctcggg
      121 agggacctgg cgggagcggg ggcggtccac acgagccggg cgctgcaagc tcacccgcgg
      181 gcgggagggc gccacgcacg tcgccgcggc cgtccccgcg ggcggggacc gagcccgccg
      241 acgagcctcc gagcagccgc gcgccgagcc ccgactctat ggcccgcggg gagcgcgccg
      301 ccgctgcgcc gcccacccgc agccggaatc cgagctccag caccaggcag agcgcagcgg
      361 ctcgcgccgc gggccggggc ccaggggccg ggccgccccg ggcgcggggc atgggagccc
      421 ggtagccggg tggcgcgagg acccccacgg cgggcaggac ccgccgagcg aagaccgcca
      481 agcccaggga gagccggaga cagcaaaccg cccgcccccg gtcgcagccc cgccagggcc
      541 ctcccctggc agcgcgcacc cgcgcgcgca cacacttgca cacctttcct ccgctcctgc
      601 ccagccttgc ctggctcccg ccggagcacc cccggggggc cgatgccatg ggtaacaact
      661 tctccagtgt ctcctctctg cagcgaggaa acccgagccg cgcgtcgcgg ggccaccccc
      721 agaacctcaa agactccatc gggggctcct tcccggtgcc ctctcaccga tgccatcaca
      781 agcagaagca ttgcccgcct acgctgtcag gtggggggct cccggccacg ccgctgctct
      841 tccatcccca cactaagggc tcccagatcc tcatggacct cagccacaag gccgtcaaga
      901 ggcaggccag cttttgcaat gccatcacct tcagtaaccg cccggtgctc atctacgagc
      961 aagtcaggct gaagatcacc aagaagcaat gctgctggag cggggccctg cgacttggct
     1021 tcaccagcaa ggacccttcc cgcatccacc ccgactcgct gcccaagtac gcctgccctg
     1081 acctggtgtc tcagagtggc ttctgggcca aagcattgcc tgaggagttt gccaacgagg
     1141 gcaacatcat tgccttctgg gtggacaaga agggccgcgt cttctaccgg atcaatgagt
     1201 cagctgctat gcttttcttc agtggggtcc ggacggtgga cccgctctgg gccctggtgg
     1261 acgtctacgg cctcacgcgg ggtgtccagc tgctagacag cgagctggtg ctgcccgact
     1321 gcctgcggcc gcgctccttc accgcgctgc ggcggccgtc gctgcggtgc gaggcggatg
     1381 aggcgcgcct gtcggtgagc ctgtgcgacc tcaacgtgcc gggagccgac ggcgacgacg
     1441 gcgcaccgcc tgccggctgc ccgatcccgc agaactcgct caattctcag cacagccgcg
     1501 cgctgccggc gcagctcgac ggcgacctgc gcttccacgc gcttcgcgcc ggcgcgcacg
     1561 tccgcatcct ggacgagcag acggtggcgc gcctggagca cgggcgcgac gagcgcgcgc
     1621 tcgtcttcac cagccggcct gtgcgcgtgg ccgagaccat cttcatcaag gtcacgcgct
     1681 cgggcggggg gcgagcgggc gcgctgtcct tcggggtcac cacgtgtgac cctggcacgc
     1741 tgcggcccgc cgacctgccc ttcagccccg aggccctggt ggaccgcaag gagttctggg
     1801 cggtgtgtcg cgtgcccggg cctctgcaca gcggcgacat cctgggcctg gtggtcaacg
     1861 cggacggaga gctgcacctg agtcacaacg gcgcggcggc cggcatgcag ctgtgcgtgg
     1921 atgcctcgca gcccctctgg atgctcttca gcctgcatgg cgccatcacg caggtccgca
     1981 tcctcggctc caccatcatg actgaacggg gtggcccatc tctcccctgc tcacctgcct
     2041 ccactccaac ctcacccagt gccctgggca tccgcctctc tgaccccctg ctcagcacct
     2101 gcggttctgg gcccctaggt ggctctgctg gagggacagc ccccaactca cctgtgagcc
     2161 tgcccgagtc accggtgacc ccaggtctgg gccagtggag tgatgaatgc accatttgct
     2221 atgaacacgc agtggacaca gtcatctaca cgtgtggcca catgtgcctg tgctactcct
     2281 gtggcctgcg cctcaagaag gccctgcacg cctgctgccc catctgccgt cgccccatca
     2341 aggacatcat caagacctac cgcagctcct agcccactgc agagccccac ctgcacgccc
     2401 acttctgcag actgcagccc agccagcacc agctgagggc aaagccaaca gggtcccttc
     2461 cttctacagt ttgcaaactc ttcctccttt tccattaaac gtgggaaacc aaggtccctg
     2521 gaggattggg ctgaaagagt ttcaggcagg gagatgaggg cacaagcagt gaggggagga
     2581 gggtacccca tatctctctc ctctttaccc agatttctgc atgctgagtg gctggttgcc
     2641 atccctcgag atctcggcag atctctaggt tgtgcagccc ggcagcccgt gcggcatctt
     2701 ggagagagtt agcagacatg tagcttcccc cccggcagct ggggaggagg ccagtggacc
     2761 ttctcccacc ctgggcagct gcaaactgca tgccatgttt ctttctcctt acccaaggca
     2821 gggaaacaga caggctgcag actacaggtc cgaggtcctt gaccttgggc caacctgcca
     2881 tgttcaggat ctcccgtttg ccatgacttt cgccaatcat ctcactggtg ccgtttccca
     2941 gggtgccctt cagtgtaggc tgatgtgagc ctttctgttg tcagggtctc aaaagagcag
     3001 gtccacagcc acacttaagg cctgtcctcc ctcatctcag tgccagtctt ggcctgggct
     3061 gatttgccat tgtgtgccca ggagggacag gaaccctcag tggggtgggg tctccctggc
     3121 ctatggacag cccttttcct taatttattt atttgcttta tgggttatgt tccaacctgg
     3181 ggtctcctga aatgctactg ttgcagggtt gccaggtgaa gggaagcaag gagtagccac
     3241 ttggaatcta tccccaatac aaggctcatg gcagtcctgc taaccccgag gaagaattcc
     3301 aggctggagg cctcccaaga agtggataag cctctcttat gtgggaagtg cccacttcca
     3361 cctgtgtgcc cttcctccct ggatgggagc cctgttactg tggctggttc caggacatcc
     3421 gtctctatag agacatcaga agttctggaa agttgtcaac atgtgggtca gggaccagaa
     3481 tggagacgct tgttagagga gggaagatag accctgaaag ccagcctctg gtcctgctaa
     3541 gggggtgccc cttacttatg ggctgtggcc cctgtattcc tacctgcctt ttttagggtt
     3601 actgtggcgt cttagcctag gctttcccag cctttcagtc cttggccctc atatggctgg
     3661 ttttatatcc tcagaggcgg cttttgcctt gaaaggcagg gtcttggtct ctgtcctggc
     3721 cactggccag tcatgtggct ctagccacag ccctctgccc ctaaaactcc agcttcccct
     3781 gggtaaaagt ttgggggtgg aatactttcc gtgtatttcc tgggagttct tctcaggtgt
     3841 ctctgaggag gaatgtactg gggaggtgtt gagaatggat gccagggtgg gcctttgcct
     3901 gcactgggga atctgggcca ccctcagtct tgcttctcca gtcactggcc ctggtagatg
     3961 ccttcaggct ggagctggta agttgcccca tctagctggg gcttatccta gagatggagc
     4021 aaggtcctag tacagagctg tgtggctgga gttgggaaaa gaagccattg tccattctgc
     4081 tagttcagag gtagcactgc ctcccttgtg aactgggcca ctgtgtttgt gaataaaggt
     4141 gatttcgtac cagcctgaaa aaaaaaaa
//
