LOCUS       NM_173772               4524 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus sialidase 4 (Neu4), transcript variant 2, mRNA.
ACCESSION   NM_173772
VERSION     NM_173772.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4524)
  AUTHORS   Xiao,P.T., Hao,J.H., Kuang,Y.J., Dai,C.X., Rong,X.L., Jiang,L.L.,
            Xie,Z.S., Zhang,L., Chen,Q.Q. and Liu,E.H.
  TITLE     Targeting Neuraminidase 4 Attenuates Kidney Fibrosis in Mice
  JOURNAL   Adv Sci (Weinh) 11 (39), e2406936 (2024)
   PUBMED   39136142
  REMARK    GeneRIF: Targeting Neuraminidase 4 Attenuates Kidney Fibrosis in
            Mice.
REFERENCE   2  (bases 1 to 4524)
  AUTHORS   Howlader,M.A., Demina,E.P., Samarani,S., Guo,T., Caillon,A.,
            Ahmad,A., Pshezhetsky,A.V. and Cairo,C.W.
  TITLE     The Janus-like role of neuraminidase isoenzymes in inflammation
  JOURNAL   FASEB J 36 (5), e22285 (2022)
   PUBMED   35363389
REFERENCE   3  (bases 1 to 4524)
  AUTHORS   Timur,Z.K., Inci,O.K., Demir,S.A. and Seyrantepe,V.
  TITLE     Sialidase neu4 deficiency is associated with neuroinflammation in
            mice
  JOURNAL   Glycoconj J 38 (6), 649-667 (2021)
   PUBMED   34686927
  REMARK    GeneRIF: Sialidase neu4 deficiency is associated with
            neuroinflammation in mice.
REFERENCE   4  (bases 1 to 4524)
  AUTHORS   Oliveira,R., Hermo,L., Pshezhetsky,A.V. and Morales,C.R.
  TITLE     Presence of aberrant epididymal tubules revealing undifferentiated
            epithelial cells and absence of spermatozoa in a combined
            neuraminidase-3 and -4 deficient adult mouse model
  JOURNAL   PLoS One 13 (10), e0206173 (2018)
   PUBMED   30359429
  REMARK    GeneRIF: Absence of Neu3 and Neu4 leads to defects in cell adhesion
            and differentiation of epithelial cells resulting in aberrant
            tubular offshoots that fail to remain connected with the main duct
            and male infertility. Hence Neu3 and Neu 4 play an essential role
            in the guidance of epithelial cells during early embryonic
            formation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4524)
  AUTHORS   Pan,X., De Aragao,C.B.P., Velasco-Martin,J.P., Priestman,D.A.,
            Wu,H.Y., Takahashi,K., Yamaguchi,K., Sturiale,L., Garozzo,D.,
            Platt,F.M., Lamarche-Vane,N., Morales,C.R., Miyagi,T. and
            Pshezhetsky,A.V.
  TITLE     Neuraminidases 3 and 4 regulate neuronal function by catabolizing
            brain gangliosides
  JOURNAL   FASEB J 31 (8), 3467-3483 (2017)
   PUBMED   28442549
  REMARK    GeneRIF: These results provide the first in vivo evidence that
            neuraminidases 3 and 4 have important roles in CNS function by
            catabolizing gangliosides and preventing their storage in
            lipofuscin bodies.
REFERENCE   6  (bases 1 to 4524)
  AUTHORS   Seyrantepe,V., Lema,P., Caqueret,A., Dridi,L., Bel Hadj,S.,
            Carpentier,S., Boucher,F., Levade,T., Carmant,L., Gravel,R.A.,
            Hamel,E., Vachon,P., Di Cristo,G., Michaud,J.L., Morales,C.R. and
            Pshezhetsky,A.V.
  TITLE     Mice doubly-deficient in lysosomal hexosaminidase A and
            neuraminidase 4 show epileptic crises and rapid neuronal loss
  JOURNAL   PLoS Genet 6 (9), e1001118 (2010)
   PUBMED   20862357
  REMARK    GeneRIF: Neu4 is not the only sialidase contributing to the
            metabolic bypass in Hexa(-/-) mice.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4524)
  AUTHORS   Shiozaki,K., Koseki,K., Yamaguchi,K., Shiozaki,M., Narimatsu,H. and
            Miyagi,T.
  TITLE     Developmental change of sialidase neu4 expression in murine brain
            and its involvement in the regulation of neuronal cell
            differentiation
  JOURNAL   J Biol Chem 284 (32), 21157-21164 (2009)
   PUBMED   19506080
  REMARK    GeneRIF: mouse Neu4 plays an important regulatory role in neurite
            formation, possibly through desialylation of glycoproteins
REFERENCE   8  (bases 1 to 4524)
  AUTHORS   Seyrantepe,V., Canuel,M., Carpentier,S., Landry,K., Durand,S.,
            Liang,F., Zeng,J., Caqueret,A., Gravel,R.A., Marchesini,S.,
            Zwingmann,C., Michaud,J., Morales,C.R., Levade,T. and
            Pshezhetsky,A.V.
  TITLE     Mice deficient in Neu4 sialidase exhibit abnormal ganglioside
            catabolism and lysosomal storage
  JOURNAL   Hum Mol Genet 17 (11), 1556-1568 (2008)
   PUBMED   18270209
  REMARK    GeneRIF: Neu4 is a functional component of the
            ganglioside-metabolizing system, contributing to the postnatal
            development of the brain and other vital organs.
REFERENCE   9  (bases 1 to 4524)
  AUTHORS   Ngamukote,S., Yanagisawa,M., Ariga,T., Ando,S. and Yu,R.K.
  TITLE     Developmental changes of glycosphingolipids and expression of
            glycogenes in mouse brains
  JOURNAL   J Neurochem 103 (6), 2327-2341 (2007)
   PUBMED   17883393
REFERENCE   10 (bases 1 to 4524)
  AUTHORS   Comelli,E.M., Amado,M., Lustig,S.R. and Paulson,J.C.
  TITLE     Identification and expression of Neu4, a novel murine sialidase
  JOURNAL   Gene 321, 155-161 (2003)
   PUBMED   14637003
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070438.1.
            
            On May 16, 2004 this sequence version replaced NM_173772.2.
            
            Transcript Variant: This variant (2) lacks an alternate exon
            compared to variant 1, which causes translation initiation at a
            downstream AUG. The resulting isoform (2) is shorter at the
            N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070438.1, AK034236.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..4524
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 47.46 cM"
     gene            1..4524
                     /gene="Neu4"
                     /gene_synonym="9330166I04"
                     /note="sialidase 4"
                     /db_xref="GeneID:241159"
                     /db_xref="MGI:MGI:2661364"
     exon            1..124
                     /gene="Neu4"
                     /gene_synonym="9330166I04"
                     /inference="alignment:Splign:2.1.0"
     exon            125..357
                     /gene="Neu4"
                     /gene_synonym="9330166I04"
                     /inference="alignment:Splign:2.1.0"
     exon            358..613
                     /gene="Neu4"
                     /gene_synonym="9330166I04"
                     /inference="alignment:Splign:2.1.0"
     exon            614..4511
                     /gene="Neu4"
                     /gene_synonym="9330166I04"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2285..2290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neu4"
                     /gene_synonym="9330166I04"
                     /note="hexamer: ATTAAA"
     polyA_site      2304
                     /gene="Neu4"
                     /gene_synonym="9330166I04"
                     /note="major polyA site"
     regulatory      2331..2336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neu4"
                     /gene_synonym="9330166I04"
                     /note="hexamer: ATTAAA"
     polyA_site      2359
                     /gene="Neu4"
                     /gene_synonym="9330166I04"
                     /note="major polyA site"
     regulatory      2392..2397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neu4"
                     /gene_synonym="9330166I04"
                     /note="hexamer: AGTAAA"
     polyA_site      2412
                     /gene="Neu4"
                     /gene_synonym="9330166I04"
ORIGIN      
        1 ggacagtgtg catcacggag cttgtggccc agactgtgcc tggcagaccc agaggaccta
       61 aggcttggct ctagtggtgg tcagcacagc cctcggtggt ctgcggagcc tgatattgct
      121 ttacactccc tggtaccttg ctcctactgg aaggttatgg ggcccacgcg tgttcccagg
      181 agaacggtgc tcttccagag ggaaaggacg ggcctgacct accgtgtgcc tgcgttactc
      241 tgtgtgcctc ccaggcctac tctgctggcc ttcgcggaac agcgacttag ccctgatgac
      301 tcccatgccc accgcctggt gctacggagg ggcacgctga ccaggggctc agtgcggtgg
      361 ggcactctga gtgtactgga gactgcagta ctggaggagc acaggtctat gaacccttgc
      421 ccggtgctgg atgagcactc tggtaccatc ttcctcttct tcattgccgt gctgggccac
      481 acaccggagg ccgtgcaaat cgccactggc aagaacgctg ctcgcctctg ctgtgtgacc
      541 agctgtgacg ctggcctcac ctggggcagt gttcgagatc tcactgagga agccattggt
      601 gctgcattgc aggactgggc cacctttgct gtgggtccgg gccatggagt tcagctgcgc
      661 tcgggtcgcc tgcttgttcc tgcttacacc tatcatgtgg accgacggga atgttttggc
      721 aagatctgct ggaccagtcc ccactccttg gcattctaca gtgatgatca tgggatctcc
      781 tggcattgtg gaggccttgt gcccaaccta cgctctggag agtgccaact ggctgcggta
      841 gatggagact ttctctactg taatgctcga agccctctgg gtaaccgtgt gcaggcactg
      901 agtgctgatg aaggcacgtc cttcctacca ggggagctgg tgcctacatt ggcagagacg
      961 gctcgtggtt gccagggtag cattgtgggc ttcctagctc caccctcaat cgagcctcag
     1021 gatgaccggt ggacagggag tcctaggaac accccacatt ccccatgctt caatctcaga
     1081 gtacaggagt cttcggggga aggtgccaga ggtcttcttg aacgttggat gcccaggttg
     1141 cctctctgct acccacagtc ccggagccca gagaatcatg gcctagagcc tgggtcagat
     1201 ggagataaga catcctggac tccggaatgt cctatgtcct ctgattccat gcttcagagc
     1261 cccacatggc tactatattc ccacccagca gggcgtagag ctcggctcca catgggaatc
     1321 tacctgagcc gatccccctt ggatccccac agctggacag agccctgggt gatctatgag
     1381 ggccccagtg gctactctga ccttgccttt cttgggccta tgcctggggc atccctggtt
     1441 tttgcctgtc tgtttgagag cgggaccagg acttcctatg aagacatttc tttttgcttg
     1501 ttctcactgg cggatgtcct ggagaatgtg cccactggct tagagatgct aagtctcagg
     1561 gataaggctc aggggcattg ctggccctct tgatggcctc accctctcgt agccgcctgg
     1621 agaggaaggg tagactatat agaggaggtt aggggtaggt cagcatgatg ctaggatgga
     1681 gagagctctg tcccctcgtg gatggtggtg gtgactcacc cggggggcca gctgctttct
     1741 gagtgcaaat gagaaaaata aagagctgcg ctgtgacttt tctttccaca tcaaagcttg
     1801 ggtgtcagtg ctttagcttg atgctctgat caccatgcaa atcttccacc ggcgccttgc
     1861 tcagctttca tatcccaagg gtgcctggga ggaaggcaac agggacagtg gacatcactg
     1921 caccactttc cacgaccctg tgtgccaacc tcagccactt tgaaacatgc tgatgactga
     1981 ggtctgttca ctttcttaat ttcaagcagg agaagcaggt tggggagcca gcctccccag
     2041 ctagagggga cagaacttga cttgagcagg ggggtacctc ctaggacctg ctccatgtgc
     2101 ctacttcttt acccttctct agagagggct cttgtcctgt cagagctgtt ttctcccttc
     2161 tcttgttttt tctttttcaa gactgtttct ctgtgttagc cctggctgtc ctggatctca
     2221 ctctgtagat caggctgacc ttgagttcaa agctccatct gcctctactt ctcacattac
     2281 tgtgattaaa ggcatatact accactgcct ggtgcccttt tgtatttctt attaaagtcc
     2341 taatgtctga ttataaaaac agtctgtgtg ggctggagtg atggcttact cagtaaagca
     2401 cttgccatgg aatctgggca atctgagttt catttttagc atcctgtaaa aatcccaatt
     2461 tgatggtgta cttgtaatgt cagcatggag aggcagagat aggtaagttc cccaagactc
     2521 tttgaaccga cagcttggcc tcactggcac attccaggtc tcagtgagag accctgcctc
     2581 aaaatacaaa gaaagagctg ctgaagagtg ggtcagagtt gacctctgat ctccggaagt
     2641 atatgataca cacccgtgca tgcactcttc cttacaaaat aaaaagcaaa acaaaacccc
     2701 aacaggtata tggccatttt agaaaaatta gaagatttag aaagctatac ataaaaaaaa
     2761 atgacctaaa gaaaaatctt tactgttctg ggcactatcc ctatcaaacc actgtgttct
     2821 ttggccaagc cttggggtgg acactgtttt gaggtgggtc ctgttatctc cactaggtag
     2881 tggagttttg tgtcagacta actgggtctt aaagctgtct ttaaggccat caggagctac
     2941 tgacttgcct gcctcagcag agcatatcct gaaggtcggg gttaagtctc cttcccgagc
     3001 gagttgcctt ccagtgggcc cctggactcc taggtcctca gcgctcatca gctgccaagg
     3061 actctgaggg aatgtcctct gactgtggcc ccgaaaggta ggggaggggg atgtgcttag
     3121 gcttaggaca gggtcctgtt tcagtctgcc ttcactgtta gtagcactgt gccacatggc
     3181 acagactggg cgagctttaa aggaaggagg ttgatattgg ttcccacttc tggggatcat
     3241 ggttgagcag ccttgtctga tgatggttgt cttgatggta gatcgtgagg tagttgatga
     3301 aggtatgaca tggtgagaaa ctctgtgtgt gtgtgttatt ttctctgtgt tctacctata
     3361 catctatcta tgtatatatg tatctatcta tctacctgga ggctggagag atagcttagt
     3421 ggttaagaac atttgttgtt cttgcatagt cctggattta aattttcagc acccacatgg
     3481 cagctcacaa caacccataa atccagtttc agaggatcca acctctgata taccatgtca
     3541 gccagagcag acacggctga aggtggtttg atccccgtat ggagaggtga caattgggaa
     3601 gagagaaaga tcaacttaac catgcaagga acaggaagtt aaatactgaa cagggaaggt
     3661 aaaggcagga agtagatgta gagggcaaat caatgaaacc caaacatacc caaattacgc
     3721 taaacacaca ctgacatgcc aattaaaagg acaaattggc tccactggca aaaccaaaac
     3781 agacactgaa gatccaaaca gtcacatgcc aactaccgcg gagggagaca gacacagaga
     3841 agaccgtgac agacacttgg acactcttga gagtggatgt gcaggaagag agctctgcca
     3901 gtggagaaga aagcactcag aagaaagtga cagcagctgt aaatttgtat tctgctaatg
     3961 ttatgttcca aagttgaaag caaaattgta ccaattcata agaacaaaca ggctgactct
     4021 cagttgtgac tgaacgtctc tcagtaactg acggggcgag caggccaaag gagagtcggc
     4081 tcagaagggt gcatagccac gccaaatcaa ataagcaagt acaaccggca ggctctattt
     4141 ctagcacaaa ggggtctgtg cctcattctg tgcttgggtc agagcttggg tctctcattt
     4201 ggatgtaagt ggtgtagtgg agaagcagga aataatccgg agcgcatatt ttgattttaa
     4261 cataagtgct gatttgggag ggagttttgt caaattgtgt ttttacaatg tttttttttt
     4321 tttaaatgat gcttttttgt aaagtgtaca aatgtgatat aagattggtt ctgctacatt
     4381 cagtttctat aaaagtggtt ctaaaatatt gtactgtcaa tcatctcatg attattctac
     4441 tgtacacatt actgactttg tatgtaataa ttaatattag aagaaaatat aatttatttg
     4501 aatataaaaa aaaaaaaaaa aaaa
//
