LOCUS       NM_001418463            3306 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus neuraminidase 3 (Neu3), transcript variant 2, mRNA.
ACCESSION   NM_001418463 XM_030242761
VERSION     NM_001418463.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3306)
  AUTHORS   Wu,G., Cao,B., Zhai,H., Liu,B., Huang,Y., Chen,X., Ling,H.,
            Ling,S., Jin,S., Yang,X. and Wang,J.
  TITLE     EPO promotes the progression of rheumatoid arthritis by inducing
            desialylation via increasing the expression of neuraminidase 3
  JOURNAL   Ann Rheum Dis 83 (5), 564-575 (2024)
   PUBMED   38272667
  REMARK    GeneRIF: EPO promotes the progression of rheumatoid arthritis by
            inducing desialylation via increasing the expression of
            neuraminidase 3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3306)
  AUTHORS   Allende,M.L., Lee,Y.T., Byrnes,C., Li,C., Tuymetova,G., Bakir,J.Y.,
            Nicoli,E.R., James,V.K., Brodbelt,J.S., Tifft,C.J. and Proia,R.L.
  TITLE     Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1
            gangliosidosis
  JOURNAL   J Lipid Res 64 (12), 100463 (2023)
   PUBMED   37871851
  REMARK    GeneRIF: Sialidase NEU3 action on GM1 ganglioside is
            neuroprotective in GM1 gangliosidosis.
REFERENCE   3  (bases 1 to 3306)
  AUTHORS   Deschenes,N.M., Cheng,C., Khanal,P., Quinville,B.M., Ryckman,A.E.,
            Mitchell,M., Pshezhetsky,A.V. and Walia,J.S.
  TITLE     Characterization of a phenotypically severe animal model for human
            AB-Variant GM2 gangliosidosis
  JOURNAL   Front Mol Neurosci 16, 1242814 (2023)
   PUBMED   38098938
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3306)
  AUTHORS   Yang,W.H., Aziz,P.V., Heithoff,D.M., Kim,Y., Ko,J.Y., Cho,J.W.,
            Mahan,M.J., Sperandio,M. and Marth,J.D.
  TITLE     Innate mechanism of mucosal barrier erosion in the pathogenesis of
            acquired colitis
  JOURNAL   iScience 26 (10), 107883 (2023)
   PUBMED   37752945
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3306)
  AUTHORS   Sengul,T., Can,M., Ates,N. and Seyrantepe,V.
  TITLE     Autophagic flux is impaired in the brain tissue of Tay-Sachs
            disease mouse model
  JOURNAL   PLoS One 18 (3), e0280650 (2023)
   PUBMED   36928510
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3306)
  AUTHORS   Garrison,W.D., Battle,M.A., Yang,C., Kaestner,K.H., Sladek,F.M. and
            Duncan,S.A.
  TITLE     Hepatocyte nuclear factor 4alpha is essential for embryonic
            development of the mouse colon
  JOURNAL   Gastroenterology 130 (4), 1207-1220 (2006)
   PUBMED   16618389
REFERENCE   7  (bases 1 to 3306)
  AUTHORS   Papini,N., Anastasia,L., Tringali,C., Croci,G., Bresciani,R.,
            Yamaguchi,K., Miyagi,T., Preti,A., Prinetti,A., Prioni,S.,
            Sonnino,S., Tettamanti,G., Venerando,B. and Monti,E.
  TITLE     The plasma membrane-associated sialidase MmNEU3 modifies the
            ganglioside pattern of adjacent cells supporting its involvement in
            cell-to-cell interactions
  JOURNAL   J Biol Chem 279 (17), 16989-16995 (2004)
   PUBMED   14970224
  REMARK    GeneRIF: MmNEU3 is able to hydrolyze ganglioside substrates in
            intact living cells at a neutral pH, mainly through cell-to-cell
            interactions
REFERENCE   8  (bases 1 to 3306)
  AUTHORS   Sasaki,A., Hata,K., Suzuki,S., Sawada,M., Wada,T., Yamaguchi,K.,
            Obinata,M., Tateno,H., Suzuki,H. and Miyagi,T.
  TITLE     Overexpression of plasma membrane-associated sialidase attenuates
            insulin signaling in transgenic mice
  JOURNAL   J Biol Chem 278 (30), 27896-27902 (2003)
   PUBMED   12730204
  REMARK    GeneRIF: NEU3 participates in the control of insulin signaling via
            modulation of gangliosides and interaction with Grb2
REFERENCE   9  (bases 1 to 3306)
  AUTHORS   Li,S.C., Li,Y.T., Moriya,S. and Miyagi,T.
  TITLE     Degradation of G(M1) and G(M2) by mammalian sialidases
  JOURNAL   Biochem J 360 (Pt 1), 233-237 (2001)
   PUBMED   11696012
REFERENCE   10 (bases 1 to 3306)
  AUTHORS   Hasegawa,T., Yamaguchi,K., Wada,T., Takeda,A., Itoyama,Y. and
            Miyagi,T.
  TITLE     Molecular cloning of mouse ganglioside sialidase and its increased
            expression in Neuro2a cell differentiation
  JOURNAL   J Biol Chem 275 (11), 8007-8015 (2000)
   PUBMED   10713120
  REMARK    Erratum:[J Biol Chem 2000 May 12;275(19):14778]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115040.7.
            
            On Mar 21, 2023 this sequence version replaced XM_030242761.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861859.2464620.1,
                                           SRR7345562.2997057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AC115040.7         147951-148175       c
            226-437             AC115040.7         143125-143336       c
            438-3306            AC115040.7         131242-134110       c
FEATURES             Location/Qualifiers
     source          1..3306
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.15 cM"
     gene            1..3306
                     /gene="Neu3"
                     /note="neuraminidase 3"
                     /db_xref="GeneID:50877"
                     /db_xref="MGI:MGI:1355305"
     exon            1..225
                     /gene="Neu3"
                     /inference="alignment:Splign:2.1.0"
     exon            226..437
                     /gene="Neu3"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..1487
                     /gene="Neu3"
                     /EC_number="3.2.1.18"
                     /note="N-acetyl-alpha-neuraminidase 3; membrane sialidase;
                     ganglioside sialidase; Sialidase 3 (Membrane sialidase)
                     (Ganglioside sialidase) (N-acetyl-alpha-neuraminidase 3)"
                     /codon_start=1
                     /product="sialidase-3"
                     /protein_id="NP_001405392.1"
                     /db_xref="GeneID:50877"
                     /db_xref="MGI:MGI:1355305"
                     /translation="MEEVPPYSLSSTLFQQEEQSGVTYRIPALLYLPPTHTFLAFAEK
                     RTSVRDEDAACLVLRRGLMKGRSVQWGPQRLLMEATLPGHRTMNPCPVWEKNTGRVYL
                     FFICVRGHVTERCQIVWGKNAARLCFLCSEDAGCSWGEVKDLTEEVIGSEVKRWATFA
                     VGPGHGIQLHSGRLIIPAYAYYVSRWFLCFACSVKPHSLMIYSDDFGVTWHHGKFIEP
                     QVTGECQVAEVAGTAGNPVLYCSARTPSRFRAEAFSTDSGGCFQKPTLNPQLHEPRTG
                     CQGSVVSFRPLKMPNTYQDSIGKGAPATQKCPLLDSPLEVEKGAETPSATWLLYSHPT
                     SKRKRINLGIYYNRNPLEVNCWSRPWILNRGPSGYSDLAVVEEQDLVACLFECGEKNE
                     YERIDFCLFSDHEVLSCEDCTSPSSD"
     exon            438..3306
                     /gene="Neu3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3287..3292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neu3"
                     /note="hexamer: AATAAA"
     polyA_site      3306
                     /gene="Neu3"
                     /note="major polyA site"
ORIGIN      
        1 agacgctgct ctcagtcctc tggcgcctgc tccccagcgc attccttctg ctcctgggat
       61 atttgtctca ttactgccag ttcttgcgca gcggtcactg ggttcgtttc agcgtctgtg
      121 gtttctgtcg ctgttatcca gtctccatcg ccccagctca gcttcaggcc ttcttccgag
      181 actccacggg agagcccaga gagcctccgg agccggtgag ctgggaagcc atggaggaag
      241 tcccacccta ctccctcagc agcaccctgt tccagcagga agaacagagt ggggtgacct
      301 accggatccc agccctgctg taccttcctc ccacccacac cttcctggcc tttgcagaga
      361 agcggacctc agtcagagat gaggatgctg cctgcctggt gctcagacga gggctgatga
      421 aggggcgctc tgtacagtgg ggcccccaac ggctactgat ggaggccaca ttacctgggc
      481 atcgcaccat gaacccctgc cctgtgtggg agaaaaatac tggccgtgtg tacctgtttt
      541 tcatctgtgt gcggggccat gttactgaga ggtgccagat tgtgtggggc aaaaatgccg
      601 cccgtctctg cttcctttgc agtgaagatg ccggctgctc ttggggtgaa gtgaaagact
      661 tgaccgagga ggtcattggc tcagaggtga agcgctgggc cacatttgct gtgggcccag
      721 gtcatggcat ccagctacac tcgggaaggc tgatcatccc cgcctatgcc tactatgtct
      781 cacgttggtt tctctgcttt gcgtgttcag tcaagcccca ttccctgatg atctacagtg
      841 atgactttgg agtcacatgg caccatggca agttcattga gccccaggtg acaggggagt
      901 gccaagtggc cgaagtggct gggacggctg gtaaccctgt gctctactgc agtgcccgaa
      961 caccaagccg atttcgagca gaggctttta gtactgatag tggtggctgc tttcagaagc
     1021 caaccctgaa cccacaactc catgagcctc gaaccggctg ccaaggtagt gtagtgagct
     1081 tccggccttt gaagatgcca aatacctatc aagactcaat tggcaaaggt gctcccgcta
     1141 ctcagaagtg ccctctgctg gacagtcctc tggaggtgga gaaaggagct gaaacaccat
     1201 cagcaacatg gctcttgtac tcacatccaa ctagcaagag gaagaggatt aacctaggca
     1261 tctactacaa ccggaacccc ttggaggtga actgctggtc ccgcccgtgg atcttgaacc
     1321 gtgggcccag tggctactct gatctggctg ttgtggaaga acaggacttg gtggcgtgtt
     1381 tgtttgagtg tggggagaag aatgagtatg agcggattga cttctgtctg ttttcagacc
     1441 atgaggtcct gagctgtgaa gactgtacca gccctagtag cgactaaagc caaatcaaga
     1501 cggatgagtg aggcccagct tcccacagaa aggaatggca gctacagcca gggtaacaga
     1561 ggtctctgat gtctagagaa aactctaaaa actaataatc tgctccttga attttttcac
     1621 ttttcccttc aatgagcatg gtgaaaattg tgccatatct tacataacga ggctcttgaa
     1681 ctgggagttt gaatctcttc tcttcccatt aaaaggagag gccatgtgct cgcttcgcgt
     1741 tcgacaaagc ctggattctg atcttgagtg gaagccacag gcttgtcttt tccaatggtt
     1801 cactgctcac ctgagtatta ggtgatgtgt aggtgccttg gccagaagaa agatctgtgt
     1861 tgttgtattt ttttaaattt atttatttac tatatgtaag tacactgcag ctgtcttcag
     1921 acacaccaga agagggcgtc agatctcatt agagatggtt gtgagccacc atgtggttgc
     1981 tgggatttga actcaggacc ttcagaagag cagtcagtgc tcttaactac tgagccatct
     2041 ctcaagcccc gcattgctgt atttttaata agaaaaatgc ccttatcctt ccaataatgc
     2101 ctggagctgt acaaattctc tgtcttagaa gacttgagaa agcagaactg taaggtcaga
     2161 tgctttctcc agccttgatg ctgtgttcca ccttcccttc ctcatccaga aaacagttac
     2221 tagggagaaa atgagaaacc catgccagct gcccttgatg atggttgata acggtgctta
     2281 ttgcttttga tgtcattacc tctgttagag atgaatcaga gtcagaggtc cttagctgca
     2341 tccacccatt tccaggggga cattctaaca ctgctgaaca gtcagctaaa atgagagctg
     2401 tgtgtcctag cctgattcca ggttagtcat gatgcttcct ggagctgggc ttttatctaa
     2461 tcccaggagc catctagggg aggctcagag ctagcaggtg atcttcctga gatggtttca
     2521 ccgtgacagg tgaaccatga gcccttccaa gcaaggccaa aggacaacat tataggaaag
     2581 atttctagta ttaatatgcc ttttctctgt gtgtgtactg tcttgtagtg atgctatata
     2641 gacaaataga tgatttctta ttttttgttt gtttgtttgt ttttttgttt ttctgtagcc
     2701 ctagctgtcc tggaactcac tttgtaaacc aggctggcct cgatctcaga aatccgcctg
     2761 cctctgcctc ccgagtgctg ggattaaagg tgtgcaccac cacaccttaa tgatgatcct
     2821 ataagtattc ctaaaattat actagtaatt attaactcct ttataatagg actgctatta
     2881 aagccctcgc tgatatgaaa actacagtga gaactctgcc agtcttcaca tgtcataatt
     2941 acttctgaga tagaaagcag gcatttacaa cttagaacac atttcttaga gctgtaaaac
     3001 aattaactag aggtcataaa agggaatgaa agatttattg taggtgctag gacagaacat
     3061 aaaatattga ctgggcttat ctatatgaaa cttcattgtt aacttttaca caagaattat
     3121 ggtttttaac tttcagtgaa cctgcggagc tagtgacaga agagaaatgt ctagttagat
     3181 aactactctt aatggaaatt cacataaaca tctgttgcca tcttcttttt gaatttatgt
     3241 ttaaacttgt gaatgtttga attagacact acgcgagcac atagaaaata aagaactaag
     3301 cgtgaa
//
