LOCUS       NM_001160163            1722 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus neuraminidase 2 (Neu2), transcript variant 1, mRNA.
ACCESSION   NM_001160163
VERSION     NM_001160163.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1722)
  AUTHORS   Oh M, Ha DI, Son C, Kang JG, Hwang H, Moon SB, Kim M, Nam J, Kim
            JS, Song SY, Kim YS, Park S, Yoo JS, Ko JH and Park K.
  TITLE     Defect in cytosolic Neu2 sialidase abrogates lipid metabolism and
            impairs muscle function in vivo
  JOURNAL   Sci Rep 12 (1), 3216 (2022)
   PUBMED   35217678
  REMARK    GeneRIF: Defect in cytosolic Neu2 sialidase abrogates lipid
            metabolism and impairs muscle function in vivo.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1722)
  AUTHORS   Kijimoto-Ochiai S, Doi N, Fujii M, Go S, Kabayama K, Moriya S,
            Miyagi T and Koda T.
  TITLE     Possible association of Neu2 with plasma membrane fraction from
            mouse thymus exhibited sialidase activity with fetuin at pH 7.0 but
            not at pH 4.5
  JOURNAL   Microbiol Immunol 57 (8), 569-582 (2013)
   PUBMED   23750721
  REMARK    GeneRIF: Neu2 from thymus exhibited sialidase activity with fetuin
            at pH 7.0.
REFERENCE   3  (bases 1 to 1722)
  AUTHORS   Kakani S, Yardeni T, Poling J, Ciccone C, Niethamer T, Klootwijk
            ED, Manoli I, Darvish D, Hoogstraten-Miller S, Zerfas P, Tian E,
            Ten Hagen KG, Kopp JB, Gahl WA and Huizing M.
  TITLE     The Gne M712T mouse as a model for human glomerulopathy
  JOURNAL   Am J Pathol 180 (4), 1431-1440 (2012)
   PUBMED   22322304
REFERENCE   4  (bases 1 to 1722)
  AUTHORS   Koda T, Kijimoto-Ochiai S, Uemura S and Inokuchi J.
  TITLE     Specific expression of Neu2 type B in mouse thymus and the
            existence of a membrane-bound form in COS cells
  JOURNAL   Biochem Biophys Res Commun 387 (4), 729-735 (2009)
   PUBMED   19632200
  REMARK    GeneRIF: 30-40% of B and C forms of Neu2 activity was located in
            the crude membrane-fraction, and hydrolyzed ganglioside
            effectively, while both soluble fraction showed particular behavior
            with substrate specificity.
REFERENCE   5  (bases 1 to 1722)
  AUTHORS   Shiozaki K, Koseki K, Yamaguchi K, Shiozaki M, Narimatsu H and
            Miyagi T.
  TITLE     Developmental change of sialidase neu4 expression in murine brain
            and its involvement in the regulation of neuronal cell
            differentiation
  JOURNAL   J Biol Chem 284 (32), 21157-21164 (2009)
   PUBMED   19506080
REFERENCE   6  (bases 1 to 1722)
  AUTHORS   Fanzani A, Colombo F, Giuliani R, Preti A and Marchesini S.
  TITLE     Insulin-like growth factor 1 signaling regulates cytosolic
            sialidase Neu2 expression during myoblast differentiation and
            hypertrophy
  JOURNAL   FEBS J 273 (16), 3709-3721 (2006)
   PUBMED   16869890
  REMARK    GeneRIF: Our data demonstrate that IGF-1-induced myoblast
            differentiation and hypertrophy are driven, at least in part, by
            Neu2 upregulation and further support the significant role of
            cytosolic sialidase in myoblasts.
REFERENCE   7  (bases 1 to 1722)
  AUTHORS   Vyas A, Saha B, Lai E and Tole S.
  TITLE     Paleocortex is specified in mice in which dorsal telencephalic
            patterning is severely disrupted
  JOURNAL   J Comp Neurol 466 (4), 545-553 (2003)
   PUBMED   14566948
REFERENCE   8  (bases 1 to 1722)
  AUTHORS   Kotani K, Kuroiwa A, Saito T, Matsuda Y, Koda T and Kijimoto-Ochiai
            S.
  TITLE     Cloning, chromosomal mapping, and characteristic 5'-UTR sequence of
            murine cytosolic sialidase
  JOURNAL   Biochem Biophys Res Commun 286 (2), 250-258 (2001)
   PUBMED   11500029
REFERENCE   9  (bases 1 to 1722)
  AUTHORS   Hasegawa T, Yamaguchi K, Wada T, Takeda A, Itoyama Y and Miyagi T.
  TITLE     Molecular cloning of mouse ganglioside sialidase and its increased
            expression in Neuro2a cell differentiation
  JOURNAL   J Biol Chem 275 (11), 8007-8015 (2000)
   PUBMED   10713120
  REMARK    Erratum:[J Biol Chem 2000 May 12;275(19):14778]
REFERENCE   10 (bases 1 to 1722)
  AUTHORS   Fronda CL, Zeng G, Gao L and Yu RK.
  TITLE     Molecular cloning and expression of mouse brain sialidase
  JOURNAL   Biochem Biophys Res Commun 258 (3), 727-731 (1999)
   PUBMED   10329453
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145284.1, FJ613504.1, AC102564.7 and AB028023.1.
            
            [WARNING] On May 3, 2023 this sequence was replaced by
            NM_001160163.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ613504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AK145284.1         2-64
            64-106              FJ613504.1         46-88
            107-174             AC102564.7         108815-108882       c
            175-442             FJ613504.1         158-425
            443-1704            AB028023.1         311-1572
            1705-1722           AC102564.7         90477-90494         c
FEATURES             Location/Qualifiers
     source          1..1722
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..1722
                     /gene="Neu2"
                     /gene_synonym="MBS; MSS; MTS"
                     /note="neuraminidase 2"
                     /db_xref="GeneID:23956"
                     /db_xref="MGI:MGI:1344417"
     exon            1..100
                     /gene="Neu2"
                     /gene_synonym="MBS; MSS; MTS"
                     /inference="alignment:Splign:2.1.0"
     exon            101..202
                     /gene="Neu2"
                     /gene_synonym="MBS; MSS; MTS"
                     /inference="alignment:Splign:2.1.0"
     exon            203..414
                     /gene="Neu2"
                     /gene_synonym="MBS; MSS; MTS"
                     /inference="alignment:Splign:2.1.0"
     exon            415..1722
                     /gene="Neu2"
                     /gene_synonym="MBS; MSS; MTS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacatgaccc aaacggcccc tggctgcaag gtaatatcgg aagttgacta agaatggacg
       61 ccccaccact gactgacccg ccccctgagt ctgagattgg acttgtctct ggatacagtc
      121 atactttgag gtactacaag ttagaaactg ttaggttact cagttcagtc catgacagtc
      181 caaccttctc catggttttc cgatctcagg cccatggcga cctgccctgt cctgcagaag
      241 gagacactgt tccgcacagg cgtccatgct tacagaatcc ctgctctgct ctacctgaag
      301 aagcagaaga ccctgctggc ctttgcggaa aagcgagcca gcaagacgga tgagcacgca
      361 gagttgattg tcctgagaag aggaagctac aacgaagcca ccaaccgtgt caagtggcag
      421 cctgaggaag tggtgaccca agcccagctg gaaggccacc gctccatgaa tccatgtccc
      481 ttgtatgaca agcaaacaaa gaccctcttc cttttcttca tcgctgtccc tgggcgtgta
      541 tcagaacatc atcagctcca cactaaggtt aatgtcacac ggctgtgctg tgtcagcagc
      601 actgaccatg ggaggacctg gagccccatc caggacctca cagagaccac cattggcagc
      661 actcatcagg aatgggccac atttgctgtg ggtcctgggc attgtctgca gctgcggaac
      721 ccagctggga gcctgctggt acctgcttat gcctaccgga aactgcaccc tgctcagaag
      781 cctaccccct ttgccttctg cttcatcagc cttgaccatg ggcacacatg gaaactaggc
      841 aactttgtgg ctgaaaactc actggagtgc caggtggctg aggttggcac tggagctcag
      901 aggatggtat atctcaatgc taggagcttc ctgggagcca gggtccaggc acaaagtcct
      961 aatgatggtc tggatttcca ggacaaccgg gtagtgagta agcttgtaga gcccccccac
     1021 gggtgtcatg gaagtgtggt tgccttccac aaccccatct ctaagccaca tgccttagac
     1081 acatggcttc tttatacaca ccctacagac tccaggaata gaaccaacct gggtgtgtac
     1141 ctaaaccaga tgccactaga tcccacagcc tggtcagagc ccaccctgct ggccatgggc
     1201 atctgtgcct actcagactt acagaacatg gggcaaggcc ctgatggctc cccacagttt
     1261 gggtgtctgt atgaatcagg taactatgaa gagatcattt tcctcatatt caccctgaag
     1321 caagctttcc ccactgtatt tgatgcccag tgatctcagt gcacgtggcc caaagggctt
     1381 ccttgtgctt caaaacaccc atctctcttt gcttccagca tcctctggac tcttgagtcc
     1441 agctcttggg taacttcctc aggaggatgc agagaatttg gtctcttgac tctctgcagg
     1501 ccttattgtt tcagcctctg gttctctttt cagcccagaa atcaaaggag cctggctttc
     1561 ctcagcctgt tggcagggca ggtggggaca gtatatatag aggctgccat tctgcatgtc
     1621 ggttgtcact atgctagttt aacctgcctg tttccccatg cctagtgttt gaatgagtat
     1681 taataaaata tccaacccag cccatttctt cctggaaaaa aa
//
