LOCUS       NM_010893               3850 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus neuraminidase 1 (Neu1), mRNA.
ACCESSION   NM_010893
VERSION     NM_010893.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3850)
  AUTHORS   Fremuth,L.E., Hu,H., van de Vlekkert,D., Annunziata,I.,
            Weesner,J.A. and Alessandra,d.'.Azzo.
  TITLE     Neuraminidase 1 regulates neuropathogenesis by governing the
            cellular state of microglia via modulation of Trem2 sialylation
  JOURNAL   Cell Rep 44 (1), 115204 (2025)
   PUBMED   39817909
REFERENCE   2  (bases 1 to 3850)
  AUTHORS   Toussaint,K., Appert-Collin,A., Vanalderwiert,L., Bour,C.,
            Terryn,C., Spenle,C., Van Der Heyden,M., Roumieux,M., Maurice,P.,
            Romier-Crouzet,B., Sartelet,H., Duca,L., Blaise,S. and
            Bennasroune,A.
  TITLE     Inhibition of neuraminidase-1 sialidase activity by interfering
            peptides impairs insulin receptor activity in vitro and glucose
            homeostasis in vivo
  JOURNAL   J Biol Chem 300 (6), 107316 (2024)
   PUBMED   38663826
  REMARK    GeneRIF: Inhibition of neuraminidase-1 sialidase activity by
            interfering peptides impairs insulin receptor activity in vitro and
            glucose homeostasis in vivo.
REFERENCE   3  (bases 1 to 3850)
  AUTHORS   Itoh,K. and Tsukimoto,J.
  TITLE     Lysosomal sialidase NEU1, its intracellular properties, deficiency,
            and use as a therapeutic agent
  JOURNAL   Glycoconj J 40 (6), 611-619 (2023)
   PUBMED   38147151
  REMARK    GeneRIF: Lysosomal sialidase NEU1, its intracellular properties,
            deficiency, and use as a therapeutic agent.
            Review article
REFERENCE   4  (bases 1 to 3850)
  AUTHORS   Kho,I., Demina,E.P., Pan,X., Londono,I., Cairo,C.W., Sturiale,L.,
            Palmigiano,A., Messina,A., Garozzo,D., Ung,R.V., Mac-Way,F.,
            Bonneil,E., Thibault,P., Lemaire,M., Morales,C.R. and
            Pshezhetsky,A.V.
  TITLE     Severe kidney dysfunction in sialidosis mice reveals an essential
            role for neuraminidase 1 in reabsorption
  JOURNAL   JCI Insight 8 (20), e166470 (2023)
   PUBMED   37698928
  REMARK    GeneRIF: Severe kidney dysfunction in sialidosis mice reveals an
            essential role for neuraminidase 1 in reabsorption.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3850)
  AUTHORS   Gorelik,A., Illes,K., Mazhab-Jafari,M.T. and Nagar,B.
  TITLE     Structure of the immunoregulatory sialidase NEU1
  JOURNAL   Sci Adv 9 (20), eadf8169 (2023)
   PUBMED   37205763
  REMARK    GeneRIF: Structure of the immunoregulatory sialidase NEU1.
REFERENCE   6  (bases 1 to 3850)
  AUTHORS   Frankel,W.N., Lee,B.K., Stoye,J.P., Coffin,J.M. and Eicher,E.M.
  TITLE     Characterization of the endogenous nonecotropic murine leukemia
            viruses of NZB/B1NJ and SM/J inbred strains
  JOURNAL   Mamm Genome 2 (2), 110-122 (1992)
   PUBMED   1311971
REFERENCE   7  (bases 1 to 3850)
  AUTHORS   Levan,G., Szpirer,J., Szpirer,C., Klinga,K., Hanson,C. and
            Islam,M.Q.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
REFERENCE   8  (bases 1 to 3850)
  AUTHORS   Potier,M., Lu Shun Yan,D. and Womack,J.E.
  TITLE     Neuraminidase deficiency in the mouse
  JOURNAL   FEBS Lett 108 (2), 345-348 (1979)
   PUBMED   520573
REFERENCE   9  (bases 1 to 3850)
  AUTHORS   Dizik,M. and Elliott,R.W.
  TITLE     A second gene affecting the sialylation of lysosomal
            alpha-mannosidase in mouse liver
  JOURNAL   Biochem Genet 16 (3-4), 247-260 (1978)
   PUBMED   678293
REFERENCE   10 (bases 1 to 3850)
  AUTHORS   Womack,J.E. and Eicher,E.M.
  TITLE     Liver-specific lysosomal acid phosphatase deficiency (Apl) on mouse
            chromosome 17
  JOURNAL   Mol Gen Genet 155 (3), 315-317 (1977)
   PUBMED   600262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY281600.1, AK077444.1, AK145680.1, CT025759.14 and AK138332.1.
            
            On Jul 31, 2009 this sequence version replaced NM_010893.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145680.1, BC004666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                BY281600.1         3-76
            75-116              AK077444.1         15-56
            117-2474            AK145680.1         11-2368
            2475-2493           CT025759.14        163950-163968
            2494-3850           AK138332.1         61-1417
FEATURES             Location/Qualifiers
     source          1..3850
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.48 cM"
     gene            1..3850
                     /gene="Neu1"
                     /gene_synonym="Aglp; Apl; Bat-7; Bat7; G9; Map-2; Neu;
                     Neu-1"
                     /note="neuraminidase 1"
                     /db_xref="GeneID:18010"
                     /db_xref="MGI:MGI:97305"
     exon            1..295
                     /gene="Neu1"
                     /gene_synonym="Aglp; Apl; Bat-7; Bat7; G9; Map-2; Neu;
                     Neu-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1384
                     /gene="Neu1"
                     /gene_synonym="Aglp; Apl; Bat-7; Bat7; G9; Map-2; Neu;
                     Neu-1"
                     /EC_number="3.2.1.18"
                     /note="sialidase-1; N-acetyl-alpha-neuraminidase 1; G9
                     sialidase; HLA-B-associated transcript 7; lysosomal
                     sialidase"
                     /codon_start=1
                     /product="sialidase-1 precursor"
                     /protein_id="NP_035023.3"
                     /db_xref="CCDS:CCDS28668.1"
                     /db_xref="GeneID:18010"
                     /db_xref="MGI:MGI:97305"
                     /translation="MVGADPTRPRGPLSYWAGRRGQGLAAIFLLLVSAAESEARAEDD
                     FSLVQPLVTMEQLLWVSGKQIGSVDTFRIPLITATPRGTLLAFAEARKKSASDEGAKF
                     IAMRRSTDQGSTWSSTAFIVDDGEASDGLNLGAVVNDVDTGIVFLIYTLCAHKVNCQV
                     ASTMLVWSKDDGISWSPPRNLSVDIGTEMFAPGPGSGIQKQREPGKGRLIVCGHGTLE
                     RDGVFCLLSDDHGASWHYGTGVSGIPFGQPKHDHDFNPDECQPYELPDGSVIINARNQ
                     NNYHCRCRIVLRSYDACDTLRPRDVTFDPELVDPVVAAGALATSSGIVFFSNPAHPEF
                     RVNLTLRWSFSNGTSWQKERVQVWPGPSGYSSLTALENSTDGKKQPPQLFVLYEKGLN
                     RYTESISMVKISVYGTL"
     exon            296..488
                     /gene="Neu1"
                     /gene_synonym="Aglp; Apl; Bat-7; Bat7; G9; Map-2; Neu;
                     Neu-1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..751
                     /gene="Neu1"
                     /gene_synonym="Aglp; Apl; Bat-7; Bat7; G9; Map-2; Neu;
                     Neu-1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..934
                     /gene="Neu1"
                     /gene_synonym="Aglp; Apl; Bat-7; Bat7; G9; Map-2; Neu;
                     Neu-1"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1157
                     /gene="Neu1"
                     /gene_synonym="Aglp; Apl; Bat-7; Bat7; G9; Map-2; Neu;
                     Neu-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..3850
                     /gene="Neu1"
                     /gene_synonym="Aglp; Apl; Bat-7; Bat7; G9; Map-2; Neu;
                     Neu-1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1874
                     /gene="Neu1"
                     /gene_synonym="Aglp; Apl; Bat-7; Bat7; G9; Map-2; Neu;
                     Neu-1"
                     /note="major polyA site"
     regulatory      3131..3136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neu1"
                     /gene_synonym="Aglp; Apl; Bat-7; Bat7; G9; Map-2; Neu;
                     Neu-1"
                     /note="hexamer: AATAGA"
     polyA_site      3150
                     /gene="Neu1"
                     /gene_synonym="Aglp; Apl; Bat-7; Bat7; G9; Map-2; Neu;
                     Neu-1"
ORIGIN      
        1 gggtcacatg ctgatggact aattggagtc gcggcagcgc gggctgcggc ccccaagggg
       61 aggggtcgga gtgacgtgcg cgcttttaaa gggccgaggt cagctgacgg cttgccaccg
      121 gtgaccagtt cctggacagg gatcgccggg agctatggtg ggggcagacc cgaccagacc
      181 ccggggaccg ctgagctatt gggcgggccg tcggggtcag gggctcgcag cgatcttcct
      241 gctcctggtg tccgcggcgg aatccgaggc cagggcagag gatgacttca gcctggtgca
      301 gccgctggtg accatggagc agctgctgtg ggtgagcggg aagcagatcg gctctgtaga
      361 cactttccgc atcccgctca tcacagccac ccctcggggc acgctcctgg ccttcgctga
      421 ggccaggaaa aaatctgcat ccgatgaggg ggccaagttc atcgccatga ggaggtccac
      481 ggaccagggt agcacgtggt cctctacagc cttcatcgta gacgatgggg aggcctccga
      541 tggcctgaac ctgggcgctg tggtgaacga tgtagacaca gggatagtgt tccttatcta
      601 taccctctgt gctcacaagg tcaactgcca ggtggcctct accatgttgg tttggagtaa
      661 ggacgacggc atttcctgga gcccaccccg gaatctctct gtggatattg gcacagagat
      721 gtttgcccct ggacctggct caggcattca gaaacagcgg gagcctggga agggccggct
      781 cattgtgtgt ggacacggga cgctggagcg agatggggtc ttctgtctcc tcagtgatga
      841 ccacggtgcc tcctggcact acggcactgg agtgagcggc attccctttg gccagcccaa
      901 acacgatcac gatttcaacc ccgacgagtg ccagccctac gagcttccag atggctcggt
      961 catcatcaac gcccggaacc agaataacta ccattgccgc tgcaggatcg tcctccgcag
     1021 ctatgacgcc tgtgacaccc tcaggccccg ggatgtgacc ttcgaccctg agctcgtgga
     1081 ccctgtggta gctgcaggag cactagccac cagctccggc attgtcttct tctccaatcc
     1141 agcccaccct gagttccgag tgaacctgac cctgcgctgg agtttcagca atggtacatc
     1201 ctggcagaag gagagggtcc aggtgtggcc gggacccagc ggctactcgt ccctgacagc
     1261 cctggaaaac agcacggatg gaaagaagca gcccccgcag ctgttcgttc tgtacgagaa
     1321 aggcctgaac cggtacaccg agagcatctc catggtcaaa atcagcgtct acggcacgct
     1381 ctgagccccg tgcccaaagg acaccaagtc ctggtcgctg acttcacagc tctctggacc
     1441 atctgcagag ggtgcctgaa acacagctct tcctctgaac tctgaccttt tgcaacttct
     1501 catcaacagg gaagtctctt cgttatgact taacacccag cttcctctcg gggcaggaag
     1561 tccctccgtc accaagagca cttttttcca gtatgctggg gatggcccct gtccattctc
     1621 ttccaggaca acggagctgt gcctttctgg gacaggatgg gggaggggct ccccctggag
     1681 agatgaacag atacgaactc agggaactga gaaggcccgg tgtcctaggg tacaaaggca
     1741 ggtactagat gtgattgctg aaagtcccca gggcagagtg tcctttcaga gcaaggataa
     1801 gcacacctac gtgtgcacct ttgattattt atgaatcgaa atatttgtaa cttaaaattt
     1861 ttgatgcaga aaaagcgttt gtggagtctg tggttctgtc tgctcacgcc ttcccaattg
     1921 cctcctggag agacaggaag gcagctggaa gaggagccga tgtacttact gggaagcaga
     1981 aacccctaga ttccatcctg gctgctgctg tttgcaagtg tcaaagatgg gggggcgtgt
     2041 ttatatttta tatttctaag atggggtggc ataggaaata gggaacagat gtgtaaaacc
     2101 agatgggaag gacagtctgt gagaaaggag caagcagttg ctgcaggtgt gggagagcaa
     2161 agcccttctc cacgtggaaa gagcccagat ggacgctaag catgttgggc acctgtaacc
     2221 ccgcactcgc tggactgacg gtgtagctca gtggtggagc tagtacttgg aacgcctaag
     2281 actctgggtt cagtccttgg gggggggggt atgtgtttat tgagaggaag gtgtacgtac
     2341 tgtaggtcag aggacagctt actggagttg tctctctcct tcacgctgtg agtcctgtgg
     2401 aatgacctca ggtgtcagag ttgggggcag gtgcctttgc cagctgagcc atcttgctgt
     2461 ctctgcttta atttaaaaaa aaaaaaaaaa aagaatatta aggtctgagg gattcgggct
     2521 gcgttcattt caattagagg gtcatatttc ttttgacatt tcttctctaa gaaatgttaa
     2581 gatcatttgt tctgtgtgat agaggtatag ctccattgta tgtcagcagt gagggatcct
     2641 gtgcatttta tccagagttt gtacggtgtt ctaggggctg ctagtgcagc ccagtgctaa
     2701 acacttcagc atgcacaagg cctcaatcag tgcatgcatg tgcacacaca cacagacaca
     2761 cacgtacaca ctgacacagg tacacaaata cacactggcc cacatgtaca catcgactca
     2821 caggtacaca gacccacttt gacacacata tacacagaca caaacgcact ggcacacaca
     2881 tatacacagg cacacatgga tagatggaca cacgtgtaca catacacaca cacacagaaa
     2941 tacaaatgtt caggttttct aaaaaaaaaa aaattagaga cgtgttgact tcatttttag
     3001 caaaaatcct gtcatgtatc ttaaagtgga ttgaacccac tatgtagccc aggctggcct
     3061 ccaaatgggc atccttctgc ctcagtctcc cgagggctag gataacagga gtatgccatc
     3121 acacctggct aatagaaatt ttcaaaattg tttgtttgaa ggtgactctt actatattgc
     3181 ctaactgatc tccagttcgt gaaatcctcc tgcctcagaa ccaggactgt caatataacc
     3241 caccaagaca ggccaacatt cacaattgat tgttagtttg tggtctgaat caaggtctta
     3301 tactgtagcc caggctagcc cggaatacac gatatctcca gtgcttcaga tcctcagttc
     3361 taactaagca tggccacatc catgtttaac tgcaaatttg atgttaccat ggtttggttt
     3421 ggtttggttt ggtttggttt ggtttggttt ggttttttgg ccattttttt tttctcatgc
     3481 tgaggccttg tgctctcaag ttggggagac agcatggagg gtagctgcaa ctgtaacccc
     3541 agttccaggg gacctgacac cctctggcct ccacaagtat taggcacatc tgtggtgcac
     3601 agacatacaa tcaggcaaaa tattcataca cataaaataa aataatttaa aacaaaagca
     3661 aaaatcagga cctaagaaaa aaatctattc ctgattcttt tatgttttgt ttgtatttta
     3721 tcaagacagg gttgtttctc tgtatagccc tggctgtctt ggaattcact ctgtagacca
     3781 ggctggcctc aaactcagaa atcctcctgc ctttgccttc caagtgctgg aattaaaggc
     3841 atgcgccacc
//
