LOCUS       NM_001357288            5646 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus neuropilin (NRP) and tolloid (TLL)-like 2 (Neto2),
            transcript variant 2, mRNA.
ACCESSION   NM_001357288 XM_006531439
VERSION     NM_001357288.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5646)
  AUTHORS   Cesari,E., Farini,D., Medici,V., Ehrmann,I., Guerra,M., Testa,E.,
            Naro,C., Geloso,M.C., Pagliarini,V., La Barbera,L., D'Amelio,M.,
            Orsini,T., Vecchioli,S.F., Tamagnone,L., Fort,P., Viscomi,M.T.,
            Elliott,D.J. and Sette,C.
  TITLE     Differential expression of paralog RNA binding proteins establishes
            a dynamic splicing program required for normal cerebral cortex
            development
  JOURNAL   Nucleic Acids Res 52 (8), 4167-4184 (2024)
   PUBMED   38324473
REFERENCE   2  (bases 1 to 5646)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5646)
  AUTHORS   Xu,J.C., Chen,T.Y., Liao,L.T., Chen,T., Li,Q.L., Xu,J.X., Hu,J.W.,
            Zhou,P.H. and Zhang,Y.Q.
  TITLE     NETO2 promotes esophageal cancer progression by inducing
            proliferation and metastasis via PI3K/AKT and ERK pathway
  JOURNAL   Int J Biol Sci 17 (1), 259-270 (2021)
   PUBMED   33390848
  REMARK    GeneRIF: NETO2 promotes esophageal cancer progression by inducing
            proliferation and metastasis via PI3K/AKT and ERK pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5646)
  AUTHORS   Mennesson,M., Orav,E., Gigliotta,A., Kulesskaya,N., Saarnio,S.,
            Kirjavainen,A., Kesaf,S., Winkel,F., Llach Pou,M., Umemori,J.,
            Voikar,V., Risbrough,V., Partanen,J., Castren,E., Lauri,S.E. and
            Hovatta,I.
  TITLE     Kainate Receptor Auxiliary Subunit NETO2-Related Cued Fear
            Conditioning Impairments Associate with Defects in Amygdala
            Development and Excitability
  JOURNAL   eNeuro 7 (4) (2020)
   PUBMED   32788298
  REMARK    GeneRIF: Kainate Receptor Auxiliary Subunit NETO2-Related Cued Fear
            Conditioning Impairments Associate with Defects in Amygdala
            Development and Excitability.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5646)
  AUTHORS   Orav,E., Dowavic,I., Huupponen,J., Taira,T. and Lauri,S.E.
  TITLE     NETO1 Regulates Postsynaptic Kainate Receptors in CA3 Interneurons
            During Circuit Maturation
  JOURNAL   Mol Neurobiol 56 (11), 7473-7489 (2019)
   PUBMED   31044365
REFERENCE   6  (bases 1 to 5646)
  AUTHORS   Tang,M., Pelkey,K.A., Ng,D., Ivakine,E., McBain,C.J., Salter,M.W.
            and McInnes,R.R.
  TITLE     Neto1 is an auxiliary subunit of native synaptic kainate receptors
  JOURNAL   J Neurosci 31 (27), 10009-10018 (2011)
   PUBMED   21734292
REFERENCE   7  (bases 1 to 5646)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   8  (bases 1 to 5646)
  AUTHORS   Chen,B., Schaevitz,L.R. and McConnell,S.K.
  TITLE     Fezl regulates the differentiation and axon targeting of layer 5
            subcortical projection neurons in cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 102 (47), 17184-17189 (2005)
   PUBMED   16284245
REFERENCE   9  (bases 1 to 5646)
  AUTHORS   Michishita,M., Ikeda,T., Nakashiba,T., Ogawa,M., Tashiro,K.,
            Honjo,T., Doi,K., Itohara,S. and Endo,S.
  TITLE     Expression of Btcl2, a novel member of Btcl gene family, during
            development of the central nervous system
  JOURNAL   Brain Res Dev Brain Res 153 (1), 135-142 (2004)
   PUBMED   15464227
  REMARK    GeneRIF: Btcl2 mRNA was observed restrictively in brain throughout
            embryonic and postnatal stages; expressed in the pontine nucleus
            and subplate, which are required for establishing the neuronal
            circuit formation.
REFERENCE   10 (bases 1 to 5646)
  AUTHORS   Stohr,H., Berger,C., Frohlich,S. and Weber,B.H.
  TITLE     A novel gene encoding a putative transmembrane protein with two
            extracellular CUB domains and a low-density lipoprotein class A
            module: isolation of alternatively spliced isoforms in retina and
            brain
  JOURNAL   Gene 286 (2), 223-231 (2002)
   PUBMED   11943477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK083512.1, AC122409.4, BC068168.1 and AW544441.1.
            
            On Oct 25, 2017 this sequence version replaced XM_006531439.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083512.1, BC151050.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-528               AK083512.1         1-528
            529-529             AC122409.4         41778-41778
            530-2301            AK083512.1         530-2301
            2302-5076           BC068168.1         2348-5122
            5077-5646           AW544441.1         1-570               c
FEATURES             Location/Qualifiers
     source          1..5646
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.61 cM"
     gene            1..5646
                     /gene="Neto2"
                     /gene_synonym="5530601C23Rik; BTCL2"
                     /note="neuropilin (NRP) and tolloid (TLL)-like 2"
                     /db_xref="GeneID:74513"
                     /db_xref="MGI:MGI:1921763"
     exon            1..284
                     /gene="Neto2"
                     /gene_synonym="5530601C23Rik; BTCL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..1828
                     /gene="Neto2"
                     /gene_synonym="5530601C23Rik; BTCL2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; neuropilin and tolloid-like protein 2;
                     brain-specific transmembrane protein containing 2 CUB and
                     1 LDL-receptor class A domains protein 2"
                     /codon_start=1
                     /product="neuropilin and tolloid-like protein 2 isoform 2
                     precursor"
                     /protein_id="NP_001344217.1"
                     /db_xref="CCDS:CCDS90432.1"
                     /db_xref="GeneID:74513"
                     /db_xref="MGI:MGI:1921763"
                     /translation="MALEQLCAVLKVLLITVLVVEGIAVAQKTQDGQNIGIKHIPATQ
                     CGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDERYYIEPSFECRF
                     DHLEIRDGPFGFSPLIDRYCGMKSPALIRSTGRFMWIKFSSDEELEGLGFRAKYSFIP
                     DPDFTYLGGILNPIPDCQFELSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAK
                     IYLRFLDYQMEHSNECKRNFVAVYDGSSAIENLKAKFCSTVANDVMLKTGVGVIRMWA
                     DEGSRLSRFRMLFTSFVEPPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDENHCKEK
                     KKAGLFEQITKTHGTIIGITSGIVLVLLIISILVQVKQPRKKVMACKTAFNKTGFQEV
                     FDPPHYELFSLREKEISADLADLSEELDNYQKLRRSSTASRCIHDHHCGSQASSVKQS
                     RTNLSSMELPFRNDFAQPQPMKTFNSTFKKSSYTFKQAHECPEQALEDRVMEEIPCEI
                     YVRGRDDSAQASISIDF"
     exon            285..341
                     /gene="Neto2"
                     /gene_synonym="5530601C23Rik; BTCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            342..482
                     /gene="Neto2"
                     /gene_synonym="5530601C23Rik; BTCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..731
                     /gene="Neto2"
                     /gene_synonym="5530601C23Rik; BTCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            732..776
                     /gene="Neto2"
                     /gene_synonym="5530601C23Rik; BTCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            777..904
                     /gene="Neto2"
                     /gene_synonym="5530601C23Rik; BTCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1133
                     /gene="Neto2"
                     /gene_synonym="5530601C23Rik; BTCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1247
                     /gene="Neto2"
                     /gene_synonym="5530601C23Rik; BTCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..5646
                     /gene="Neto2"
                     /gene_synonym="5530601C23Rik; BTCL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5256..5261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neto2"
                     /gene_synonym="5530601C23Rik; BTCL2"
                     /note="hexamer: ATTAAA"
     polyA_site      5275
                     /gene="Neto2"
                     /gene_synonym="5530601C23Rik; BTCL2"
     regulatory      5622..5627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neto2"
                     /gene_synonym="5530601C23Rik; BTCL2"
                     /note="hexamer: AATAAA"
     polyA_site      5646
                     /gene="Neto2"
                     /gene_synonym="5530601C23Rik; BTCL2"
                     /note="major polyA site"
ORIGIN      
        1 gcttaaatga gccggggctc ccggcgcgcg ccacttcaag ggagcccgcc gcgggagcgt
       61 ccgccgctgg ctttcctcag cccgccgaga ggcggcggcc gtcggggacc cggcacggcg
      121 ggccgaggcg ctgcgcccgc tgctaggaag cggcggcggc cggcgatggg gacggagcga
      181 agctaccccg ccgggccgtg accaccgcgc cgccgcctcg ggcgctctcg gagcgccgac
      241 gctgaggaac atggccctgg agcagctctg cgcggtcctc aaagtgttgc tgataacagt
      301 acttgtcgtg gaagggattg ctgtggccca aaaaacccaa gatggacaaa atattggaat
      361 caagcacatt cctgcaaccc agtgtggtat ttgggttcga accagcaatg gaggtcattt
      421 tgcttcacca aattatcctg actcatatcc accaaacaag gagtgtatct atattttgga
      481 agctgctcct cgtcaacgaa tagagctgac ctttgatgaa cgctattata tagagccatc
      541 attcgaatgt cggtttgatc acttggaaat tcgagacggg ccatttggtt tttctcctct
      601 tatagatcgt tactgtggca tgaaaagccc tgcattaatt aggtcaacgg gaagattcat
      661 gtggattaaa tttagttctg atgaagaact tgaaggacta ggatttcgag caaaatactc
      721 attcatccca gatccagact ttacttacct tggaggtatt ttaaatccca ttccagattg
      781 ccagtttgag ctctctggag ctgatggaat agtacggtct agccaagtag agcaagaaga
      841 gaaaacaaag cctggccaag cagttgattg catatggaca attaaagcta ctccaaaagc
      901 taagatttat ttgaggttcc tagattacca aatggaacac tcaaatgaat gcaaaagaaa
      961 ttttgtggca gtctatgatg gaagcagtgc tatcgaaaat ctgaaggcca agttctgcag
     1021 cactgtggct aatgatgtca tgttgaaaac aggagtcgga gtgatccgga tgtgggcaga
     1081 cgaaggcagt cggcttagca ggtttaggat gctcttcact tcctttgtgg aacctccctg
     1141 tacaagcagc actttctttt gccatagcaa catgtgcatc aacaattctt tagtctgtaa
     1201 tggtgttcaa aactgtgcat acccttggga tgagaatcac tgtaaagaaa agaaaaaagc
     1261 tggactattt gaacaaatca ctaaaactca tgggacaatt attggcatta catcaggaat
     1321 tgtcttggtc cttctcatta tttctatttt agtacaagtg aaacagcccc ggaaaaaggt
     1381 tatggcttgc aaaactgcat ttaataaaac tgggttccag gaagtatttg atcctcctca
     1441 ttatgaacta ttttcactaa gagagaaaga gatttctgca gatctggcag atttgtcaga
     1501 agaacttgac aactaccaga agttgcggcg ctcctccacg gcctcccggt gcattcacga
     1561 ccaccactgt ggatcacaag catccagtgt gaaacaaagc aggaccaacc tcagttccat
     1621 ggaacttccc ttccgaaatg attttgcaca accacagcca atgaaaacat ttaatagcac
     1681 cttcaaaaaa agcagctaca ctttcaaaca agctcatgag tgccctgaac aggctctaga
     1741 ggacagagtg atggaggaga ttccctgtga aatttatgtc agagggcgag acgattctgc
     1801 acaagcatcc atatccatcg acttttaatt gctgactaaa ggcattattg ttaagtgtgt
     1861 atgcagccta caccaacact cattctatct ccgcatccaa tcttgttcta tcaaatttag
     1921 aaagcccttc ataacttatc ataatgctga tgattttatt atctcaggca atctatatat
     1981 gtgaaaccaa ctaagaaact taaatgtatt cagtggaaag aaggcatcat ctgttgctgg
     2041 tatcttaacc tgtaaaacac caccagtgca atagcagctg aggagcaggt catgcatgtt
     2101 aagtcaggca gagcagcccg gtgctgtgaa caccaggcac tgtgcgtgtc tgcacagccc
     2161 catcaacttg atctcacagt aaatttaaaa gttttttctt tatattcctt ttgtccttct
     2221 tttttctgtt atgttttctt tgcctgtggt tttaccattt cagtttcctg cagacgggga
     2281 taatatgtca ctcaattcag catggccatg catttgctcc taaatgagtg taatacggct
     2341 agtactgtaa taagtggcag tttaagatgc agtcatattt catttcttcc tgactgattt
     2401 ctacactgtt gtctttaata actgcatctt tagttctgct tttctatggg aagtaggact
     2461 tatcaccttt aatcatgttt catcttagtt atactaaaaa agtaagaatc ctagggtata
     2521 ttattaccag atacacatga acagaatttt gagaaagatt aaaaacttgt agcaacctct
     2581 gaagttttcc ccactgggtc tcaattcagt gacagtaatc agggtcctag aactcacctg
     2641 tgagcagacc tttaattatg gctccatgca gagcttctca gatcttattc cctatcatct
     2701 ttcaaaacga tttctttgtt ctcttggtat tggtttgtct tggacatggc catggttggt
     2761 ggaagcttaa agaaattctc agagaaactg tgttagcctt tacatagctt ctgcttgaaa
     2821 cagtgcattt ttctacccat tatcgagaag agcaatttca actttttttt taagctgcac
     2881 ttttaacctt atgtttttta aagtatataa aacaataatt tataaacacg gtatcaaaac
     2941 tcattgtgtt tttttagact tttgatatta tttgatattg tataaacttt attagatcaa
     3001 gatttaagac atacaagaca atttctttaa gtcttcacag tagtgacttt atatagaaga
     3061 atactgtgat gggactgtac tgtaatttat tataaagacc ttgctcatgg tgatatgtac
     3121 atacattttt ctttcttttg ctgctgtgtt agttggtaat aagtttttca ctgtgtggta
     3181 tttattgttc taaatcacaa cagaaatctt atattagagt atacattaat tcatgatcct
     3241 tcaattatat tatttatagc aggaatcctt tgaataagat atagatgagg aagaattcat
     3301 atatttaatg ataaccaata gagataatgc cattttaaag aagtaaattc tcattttcta
     3361 tattgaacta aatttccaat gaatgaaaag ttgaggtttc actagatttc atttattttt
     3421 ttaagtacta cataaatctg atttctcaga ttactaaaaa ctttgacctt tagtgtgatg
     3481 tactttctga ccaaagtgtg ttttctgtat gacatttttt ttatttttaa aaaggaaatt
     3541 atatcaagaa tattgggaaa acttaccctt ggcataagca tgacttaatt ttttaagtca
     3601 gtagatgttc ctgctttgta aaatagaact tggaaaagta aaaggaatct caaaacatag
     3661 taatcactga actatccaga gaaaaattaa atgttctttc agtaactata agcattttat
     3721 tatgtgactt agaccagcca ccactccaac accatagtaa atacttaaat tgatagctat
     3781 gataccatag tgaaataaaa attaacaatt ttataaatta tatccactat aaaaatagtt
     3841 gtcatattca tcattaattt taagattata gtttatagta tgccttcata catcatgatc
     3901 acttgtaggt gtatttttat ttttaacact attctatttt aaaggaattt gaagggattt
     3961 acaaaacagt tgtttgtaca aaatactgaa cattccaacc atgtaaattt gcatgatctc
     4021 atgcatcagc aagagaaact cgggtgatca tttggttcta aattctctaa ctagaaagtt
     4081 gatccttttc acagtagaaa acacttatat tcagaggcta aagtgaaagc cataaactta
     4141 agcagtaaca aatatgaagt taagctgtct tatgtgagtt attataccct acaaagtacc
     4201 tgtgttaaac acacccttca gtgaaaaatg caaagccaga ggatagtaaa aatctccagt
     4261 gcaagaaagt actaagtaca aactatatga taccaacaca ttgctgtcgt tcatcccaag
     4321 ttcactacaa gctgtcagct cccaagtagc cacagactgc aacctacaca tcccactgtc
     4381 tcaaagacat gggaataaac tgttatttgt ttgcagaaga gagttatcaa tataaatatt
     4441 gaacaaaaac caaaggatgt ttacatttca catcatggat ctgaaaggct cccttagctt
     4501 tgctttagga gagtctttgt cactctccta catgcgtttt gtatcattgc taagcattaa
     4561 ggaactgcag tctgcactga acatttctat actttggata ctacctaatg atggtacttg
     4621 cttgggtcag gaacatatca gctaagatga gaaaaggctg cttgtagttc caggaataat
     4681 taacattcag agattacact ttgttgcaaa atgatgtctg ccatatgccc acttttattt
     4741 actacaagtg ttaagagaaa tgtgcctgaa tcacattgat tgtggacaga aggaacttta
     4801 ttttgttctg tttaaagatc caagagagat gatctagtct agttttgtca atgagaagac
     4861 aaaaccctga tggtgaagta gctccccatg gctccatcct cctagcccag taaccttcct
     4921 tggcttcttc tctccctgct tagcttttaa aagtcacata attccaaaca tcagcctaga
     4981 tgttccatgc aaaacttgtt agttatgctt acttaaaatg taatgctgta attttgtata
     5041 caaagggggt ttcaccctcc ctttttaatt tatataacac tgttatccca tcagttttgt
     5101 taccagactt ccttggcacc tgcagaatat gtaattactg tgaattctta gtaaacagtg
     5161 ctggttagca gcacataggc tgatgccaga aagaaagctc tgtgctttca cgtttgtaat
     5221 ttttttagtt aaaattaaca atgtacatta tagaaattaa atattgggta ctgtatcttg
     5281 agttttgaga attatttgag tctgaaccac tgtaagagaa caagctgacc tgggatatcc
     5341 ttttagcttc ctacaccatc tgttacctgt tatgtatctt tcctagtagt atgttcttct
     5401 tcactcggct ttttaagata cttttgacta tatttctgag attggtttac tggctcaaaa
     5461 agcctccaag ctaatgatga gggtgcacgt atagtgagta ctacctaaac ttgttttttt
     5521 aaggagtaga tttctattag agacaaactt ccagatcatg taagaattct cattgcttaa
     5581 tccagatttg gcactttaaa gtacttaacc cttgaaatgc aaataaaaat tcctcttttg
     5641 attttc
//
