LOCUS       NM_001408276            7174 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus neogenin (Neo1), transcript variant 10, mRNA.
ACCESSION   NM_001408276 XM_006510847
VERSION     NM_001408276.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7174)
  AUTHORS   Quilez,S., Dumontier,E., Baim,C., Kam,J. and Cloutier,J.F.
  TITLE     Loss of Neogenin alters branchial arch development and leads to
            craniofacial skeletal defects
  JOURNAL   Front Cell Dev Biol 12, 1256465 (2024)
   PUBMED   38404688
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7174)
  AUTHORS   Wang,X.F., Vigouroux,R., Syonov,M., Baglaenko,Y.,
            Nikolakopoulou,A.M., Ringuette,D., Rus,H., DiStefano,P.V.,
            Dufour,S., Shabanzadeh,A.P., Lee,S., Mueller,B.K., Charish,J.,
            Harada,H., Fish,J.E., Wither,J., Walchli,T., Cloutier,J.F.,
            Zlokovic,B.V., Carlen,P.L. and Monnier,P.P.
  TITLE     The liver and muscle secreted HFE2-protein maintains central
            nervous system blood vessel integrity
  JOURNAL   Nat Commun 15 (1), 1037 (2024)
   PUBMED   38310100
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7174)
  AUTHORS   Luo,P.M., Gu,X., Chaney,C., Carroll,T. and Cleaver,O.
  TITLE     Stromal netrin 1 coordinates renal arteriogenesis and mural cell
            differentiation
  JOURNAL   Development 150 (22) (2023)
   PUBMED   37823339
REFERENCE   4  (bases 1 to 7174)
  AUTHORS   Zhang,J., Xu,Y., Wei,C., Yin,Z., Pan,W., Zhao,M., Ding,W., Xu,S.,
            Liu,J., Yu,J., Ye,J., Ye,D., Qin,J.J., Wan,J. and Wang,M.
  TITLE     Macrophage neogenin deficiency exacerbates myocardial remodeling
            and inflammation after acute myocardial infarction through
            JAK1-STAT1 signaling
  JOURNAL   Cell Mol Life Sci 80 (11), 324 (2023)
   PUBMED   37824022
  REMARK    GeneRIF: Macrophage neogenin deficiency exacerbates myocardial
            remodeling and inflammation after acute myocardial infarction
            through JAK1-STAT1 signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7174)
  AUTHORS   Gannoun,L., De Schrevel,C., Belle,M., Dauguet,N., Achouri,Y.,
            Loriot,A., Vanderaa,C., Cordi,S., Dili,A., Heremans,Y., Rooman,I.,
            Leclercq,I.A., Jacquemin,P., Gatto,L. and Lemaigre,F.P.
  TITLE     Axon guidance genes control hepatic artery development
  JOURNAL   Development 150 (16) (2023)
   PUBMED   37497580
REFERENCE   6  (bases 1 to 7174)
  AUTHORS   Alcantara,S., Ruiz,M., De Castro,F., Soriano,E. and Sotelo,C.
  TITLE     Netrin 1 acts as an attractive or as a repulsive cue for distinct
            migrating neurons during the development of the cerebellar system
  JOURNAL   Development 127 (7), 1359-1372 (2000)
   PUBMED   10704383
REFERENCE   7  (bases 1 to 7174)
  AUTHORS   Salbaum,J.M. and Kappen,C.
  TITLE     Cloning and expression of nope, a new mouse gene of the
            immunoglobulin superfamily related to guidance receptors
  JOURNAL   Genomics 64 (1), 15-23 (2000)
   PUBMED   10708514
REFERENCE   8  (bases 1 to 7174)
  AUTHORS   Bloch-Gallego,E., Ezan,F., Tessier-Lavigne,M. and Sotelo,C.
  TITLE     Floor plate and netrin-1 are involved in the migration and survival
            of inferior olivary neurons
  JOURNAL   J Neurosci 19 (11), 4407-4420 (1999)
   PUBMED   10341242
REFERENCE   9  (bases 1 to 7174)
  AUTHORS   Gad,J.M., Keeling,S.L., Wilks,A.F., Tan,S.S. and Cooper,H.M.
  TITLE     The expression patterns of guidance receptors, DCC and Neogenin,
            are spatially and temporally distinct throughout mouse
            embryogenesis
  JOURNAL   Dev Biol 192 (2), 258-273 (1997)
   PUBMED   9441666
REFERENCE   10 (bases 1 to 7174)
  AUTHORS   Keeling,S.L., Gad,J.M. and Cooper,H.M.
  TITLE     Mouse Neogenin, a DCC-like molecule, has four splice variants and
            is expressed widely in the adult mouse and during embryogenesis
  JOURNAL   Oncogene 15 (6), 691-700 (1997)
   PUBMED   9264410
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT033754.8 and AC110530.10.
            
            On Jun 14, 2022 this sequence version replaced XM_006510847.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.156058.1,
                                           SRR9219380.76901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-482               CT033754.8         73126-73607         c
            483-800             CT033754.8         27351-27668         c
            801-1076            CT033754.8         22761-23036         c
            1077-1230           CT033754.8         19236-19389         c
            1231-1367           CT033754.8         15785-15921         c
            1368-1522           AC110530.10        18113-18267
            1523-1643           AC110530.10        20086-20206
            1644-1803           AC110530.10        45050-45209
            1804-1958           AC110530.10        50249-50403
            1959-2107           AC110530.10        54250-54398
            2108-2246           AC110530.10        54865-55003
            2247-2296           AC110530.10        57509-57558
            2297-2444           AC110530.10        59059-59206
            2445-2555           AC110530.10        61801-61911
            2556-2750           AC110530.10        62823-63017
            2751-2846           AC110530.10        67666-67761
            2847-3070           AC110530.10        69071-69294
            3071-3209           AC110530.10        69377-69515
            3210-3317           AC110530.10        71614-71721
            3318-3512           AC110530.10        73057-73251
            3513-3545           AC110530.10        74050-74082
            3546-3614           AC110530.10        76932-77000
            3615-3762           AC110530.10        82143-82290
            3763-4001           AC110530.10        86945-87183
            4002-4094           AC110530.10        87672-87764
            4095-4358           AC110530.10        95310-95573
            4359-4495           AC110530.10        98001-98137
            4496-7174           AC110530.10        98808-101486
FEATURES             Location/Qualifiers
     source          1..7174
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.81 cM"
     gene            1..7174
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /note="neogenin"
                     /db_xref="GeneID:18007"
                     /db_xref="MGI:MGI:1097159"
     exon            1..482
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..4579
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /note="isoform 10 precursor is encoded by transcript
                     variant 10"
                     /codon_start=1
                     /product="neogenin isoform 10 precursor"
                     /protein_id="NP_001395205.1"
                     /db_xref="GeneID:18007"
                     /db_xref="MGI:MGI:1097159"
                     /translation="MAAEREAGRLLCTSSSRRCCPPPPLLLLLPLLLLLGRPASGAAA
                     TKSGSPPQSAGASVRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPNIEWKKDGT
                     FLNLESDDRRQLLPDGSLFISNVVHSKHNKPDEGFYQCVATVDNLGTIVSRTAKLTVA
                     GLPRFTSQPEPSSVYVGNSAILNCEVNADLVPFVRWEQNRQPLLLDDRIVKLPSGTLV
                     ISNATEGDGGLYRCIVESGGPPKFSDEAELKVLQDPEEIVDLVFLMRPSSMMKVTGQS
                     AVLPCVVSGLPAPVVRWMKNEEVLDTESSGRLVLLAGGCLEISDVTEDDAGTYFCIAD
                     NGNKTVEAQAELTVQVPPGFLKQPANIYAHESMDIVFECEVTGKPTPTVKWVKNGDVV
                     IPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLP
                     SAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGVARERVENTSQPGEMQ
                     VTIQNLMPATVYIFKVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNIRAYATSPTSI
                     TVTWETPLSGNGEIQNYKLYYMEKGTDKEQDIDVSSHSYTINGLKKYTEYSFRVVAYN
                     KHGPGVSTQDVAVRTLSDVPSAAPQNLSLEVRNSKSIVIHWQPPSSTTQNGQITGYKI
                     RYRKASRKSDVTETLVTGTQLSQLIEGLDRGTEYNFRVAALTVNGTGPATDWLSAETF
                     ESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKV
                     DYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPY
                     TPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANT
                     KYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGATFELVPTSPPKDV
                     TVVSKEGKPRTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQI
                     QELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQALGSAGKGSRLPD
                     LGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVVIAVFCTRRTTSHQ
                     KKKRAACKSVNGSHKYKGNCKDVKPPDLWIHHERLELKPIDKSPDPNPVMTDTPIPRN
                     SQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQQSVR
                     NTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSF
                     AVPAIPPPGPPLYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAP
                     EVQETTRMLEDSESSYEPDELTKEMAHLEGLMKDLNAITTA"
     exon            483..800
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1076
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1230
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1367
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1522
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1643
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1803
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1958
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2107
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2246
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2296
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2444
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2555
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2750
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2846
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..3070
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3209
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3317
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3318..3512
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3513..3545
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..3614
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3615..3762
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3763..4001
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4002..4094
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4095..4358
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4359..4495
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4496..7174
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6995..7000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /note="hexamer: AATACA"
     polyA_site      7014
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /note="major polyA site"
     regulatory      7148..7153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /note="hexamer: AAGAAA"
     polyA_site      7174
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /note="major polyA site"
ORIGIN      
        1 gtctccgccc ccctcgctct accgtgagga gcccgagtcg gcggcgggtg gcggcgcctg
       61 gaacctggag agaccgagcc accccccggc tctcggccgg aatgtactga ttctcctctg
      121 ctctcctccc cgccccgctg caggagggag gcgcccggag tctttccccc tgggcgcgcg
      181 agggggccgc gcgggccggg ccgggccggg ctggagccga gccctgcggc gcagagaccg
      241 gctgaggcgc gctgagggaa gggcgcgagc gctccgcggc gctatcgccg ccgccgccgc
      301 cgccactcgt ggggtagaga tggcggcgga gcgcgaagcc gggcgactcc tctgcacctc
      361 ctcctcccgg cgctgctgtc cgccaccgcc gctgctgctg ttgctgccgc tgctgctgct
      421 gctcggacgc ccggcgtccg gcgccgcggc cacgaagagc ggctccccgc cgcagtccgc
      481 aggagccagt gttcgaacat tcactccgtt ttattttctg gtggagccag tagacaccct
      541 ctcagttaga ggctcttctg ttatattaaa ttgctcggca tattctgagc cctctccaaa
      601 cattgaatgg aagaaagatg ggactttttt aaacttagaa tcagatgatc gacgccagct
      661 actcccagat ggatctttat tcatcagcaa cgtggtgcat tccaaacaca ataagcctga
      721 cgaaggtttc tatcagtgtg tagccactgt ggataatctt ggaaccattg tcagcagaac
      781 agccaagctc acagtagcag gtcttccaag atttaccagc caaccagaac cttcttcagt
      841 ctatgttgga aacagtgcaa ttctgaattg tgaagttaat gcagatttgg tcccatttgt
      901 taggtgggaa cagaatcgac agccccttct tctagatgac aggattgtca aacttccaag
      961 tggaacactg gttatcagca atgctactga aggagatggg ggactctacc gctgcattgt
     1021 tgaaagtggt gggccaccaa agtttagtga cgaagctgaa ttgaaagttc ttcaagatcc
     1081 tgaggaaatt gtagacttgg tatttctgat gcgaccatct tctatgatga aagtcactgg
     1141 tcagagtgca gtgttgccat gtgttgtctc agggcttcct gctccagttg ttagatggat
     1201 gaaaaacgaa gaagtgcttg acacagaaag ctctggcagg ttggtcttgc tagcaggagg
     1261 ttgcttggag atcagtgatg tcactgagga tgatgctggg acttattttt gcatagctga
     1321 taatggaaat aagacagttg aagctcaggc ggagcttact gtgcaagtgc cacctggatt
     1381 cctgaaacaa cctgctaaca tatatgctca cgaatccatg gacattgtat ttgaatgtga
     1441 agtcactggg aagccaactc caactgtgaa gtgggtcaag aatggggatg tggttatccc
     1501 cagtgattac tttaaaattg taaaggaaca taatcttcaa gttttgggtc tggtgaaatc
     1561 agatgaaggg ttctatcaat gcattgctga gaatgatgtt ggaaatgcac aagctggagc
     1621 ccagctgata atccttgagc atgcaccagc cacaacggga ccattacctt cagctcctcg
     1681 agacgtcgtg gcctccctgg tctctactcg cttcattaaa ttgacatggc gtacacctgc
     1741 atcagaccct catggagaca atctcaccta ctctgtgttc tacaccaagg aaggggttgc
     1801 tagggagcgt gttgagaata ccagccagcc aggagagatg caggtgacta ttcaaaactt
     1861 gatgccagca actgtgtaca tcttcaaagt tatggctcaa aataagcatg gctctggaga
     1921 aagttcagct cctcttcgag tagagacaca gcctgaggtt cagctccctg gcccagcacc
     1981 taatatccgt gcttatgcaa cgtcacctac ttctatcact gtcacctggg aaacaccgtt
     2041 atctggcaat ggggaaattc aaaattacaa attgtactac atggaaaaag gaactgataa
     2101 agaacaggat attgatgttt caagtcactc ctacaccatt aatggactga agaaatacac
     2161 agaatacagt ttccgagtgg tggcctacaa taaacatggt cctggagttt ctacacaaga
     2221 tgttgctgtt cgaacattat cagatgttcc cagtgctgct cctcagaatc tgtccttaga
     2281 agtgagaaat tcaaagagta tagtgatcca ctggcagccc ccttcctcaa ccacacaaaa
     2341 tgggcagata actggctaca agattcgata tcgaaaggcc tcccgaaaaa gtgatgtcac
     2401 tgagaccttg gtaactggga cacagctgtc tcagctgatt gaaggtcttg atcgggggac
     2461 agaatataac ttccgagtcg ctgctctcac agtcaatggt acaggtccag caactgattg
     2521 gctgtctgct gaaacttttg aaagcgacct agatgaaact cgtgttcctg aagtgcccag
     2581 ctctcttcat gtccgtccgc tcgtcactag cattgtagtg agctggactc ctccagagaa
     2641 ccagaacatt gtggtccgag gttatgccat cggttacggc attggcagcc ctcatgccca
     2701 gaccatcaaa gtggactata aacaacgtta ttacaccatc gaaaacttgg atccaagctc
     2761 tcattacgtg attaccttga aagcatttaa caatgttggc gaaggcatcc ccctttatga
     2821 gagtgctgtg accagacctc acacagacac ttctgaagtt gatttatttg ttattaatgc
     2881 tccatacact ccagtgccag atcccactcc catgatgcca ccagtgggag ttcaggcttc
     2941 cattctgagt cacgacacca taaggattac ctgggcagac aactccctgc ccaaacacca
     3001 gaagattaca gactcccgct actacacagt ccggtggaag accaacatcc cagcaaacac
     3061 gaagtacaag aatgcaaatg caacgacgtt aagctatttg gttactggtt taaagccaaa
     3121 tacgctctat gagttctctg tgatggtgac caaaggcaga aggtcaagca cgtggagtat
     3181 gacagctcat ggcgctacct ttgaattagt tcctacttct ccacctaagg atgtgacagt
     3241 tgtgagtaag gaaggaaaac ctagaaccat catagtgaat tggcagcctc cctctgaagc
     3301 taacggcaag attacaggtt acatcatcta ttacagcacg gatgtgaatg cagagataca
     3361 tgactgggtt attgaaccag ttgtgggaaa cagactgact caccagattc aagagttaac
     3421 acttgatacg ccatactact tcaaaatcca ggcccggaac tcaaagggca tggggcccat
     3481 gtctgaagct gtacagttca gaacacctaa agcggactcc tctgataaaa tgcctaatga
     3541 ccaagcctta gggtcagcag gaaaaggaag ccgactacca gacctgggat ctgactacaa
     3601 acctccaatg agtggcagca acagccctca cgggagcccc acctcccctc tggacagcaa
     3661 catgctgctg gtcatcattg tctctgttgg cgtcatcact atcgtggtgg ttgtggtcat
     3721 tgctgtcttt tgtacccggc gcaccacctc tcaccagaag aagaaacgag ctgcgtgcaa
     3781 atcagtgaat ggctcccata agtacaaggg caattgcaaa gatgtgaagc ctccagacct
     3841 atggatccat cacgagagac tagagttgaa gcctattgac aagtctccag atcctaaccc
     3901 tgtcatgact gatactccaa tccctcgaaa ctctcaagat atcacaccag tggacaattc
     3961 catggatagc aatatccatc aaaggcggaa ttcatacaga gggcatgagt cagaggacag
     4021 catgtctaca ctggctggaa ggaggggaat gagaccaaaa atgatgatgc cctttgactc
     4081 tcagccacct cagcaatctg ttcgaaatac ccccagcacg gacaccatgc cagcgtcctc
     4141 gtctcagacg tgctgcactg accatcagga ccctgagggt gctactagct cctcttactt
     4201 ggccagctcc caagaggaag actcaggcca gagtcttccc acagcccatg tccgcccttc
     4261 ccaccctctg aagagcttcg ctgtgccagc aatcccaccc ccaggacctc ctctctatga
     4321 tcctgcactg ccaagcacac cattactgtc ccagcaagct ctgaaccatc acattcactc
     4381 agtgaaaaca gcctccatcg ggacgttagg aaggagccgg cctcctatgc cagtggttgt
     4441 tccgagtgcc cctgaagtac aggagaccac caggatgctg gaagactccg agagtagcta
     4501 tgaaccagat gagctgacca aagagatggc ccacctggaa ggactaatga aggacctaaa
     4561 tgccatcaca acagcctgat gaccttcgcc tggacatgac tccaagcctg agtctacaag
     4621 tctcggaact taaccttgaa aacaaggaat tgtacagagt acgagaggac agcacttgag
     4681 agcaggagcc agcaaaccag ccagtgcctc catgtggggt tggctccagg cacagccacc
     4741 tgccttctcc tggtcagcct ggattacact tgtgtggagg cagcttccct ttgcctgctg
     4801 agagcctgca ggactgggca ctatgggcca aaattttgtg tccagggaag aggcaagaag
     4861 tacgacctgc cttttgcttt gtggtcagtg gcttgtgtct ttgtgctgca actgcatcac
     4921 ttttatggag tgtagacatt ggcatttatg tacaattttg tgtcctattt tattttacct
     4981 taaaacacta tcagaagcca agggagtctg tgatgttctc tcaagcagtt gacacttgac
     5041 tgtggttcca gttacttacg gaaagtcatc aacagtgagg ttgtttgaca ccactgacag
     5101 gcattggctt gttgtgggtt tcatttttat tcttaattct gagacattgc atcctctgcc
     5161 agctgttaat ccatcacttt gaggggagga catgttgcat tgctgtttgt aagctttttt
     5221 attatttttt tattataatt attaaaggcc tgactttctc ctctcatcac tgtgagatta
     5281 cagatctatt tgaatgaaat gtaacattga aaagacttgt ttgttgcttt ctgtgcagat
     5341 tcagtattgg ggtgggattg gggattggga ataggaaatg gaggggctgc tgaggccctg
     5401 tgaatgtttc tgtcaatgta ctttgttcca gaagcctgcc gagaatgaaa gcagcatctt
     5461 tagtgtcctt tcctggcatt tccatcttcg tgtcactgca tagcaactgg agttttgttt
     5521 ggatctggtt ataaattctt gtacagtgga tgactttggt gatttagctg ccctggtatc
     5581 ttggtcattt cctctttgga gtgtccacac tgaggtctct atcaatgtat gtttaattgc
     5641 ttgagagatg ccaagtagaa ccagagcctg actgtgctct gagaagctac aaagcacagg
     5701 gtggagactc cctttgtgtt gctagtattg gttctctctg gaaggttaaa atctaaggca
     5761 ggatcttggt ttcctattcc aaataggatg cctgcttctc tgggcaccag tcctcagcca
     5821 ggcagctctc gtggcattgc agaggctctc ctgaaaaaca tcaaccaggg tgagagccaa
     5881 gatggggtgg cacccatgac gcttccccac atgtttcttc aaggagcaga ggacagagat
     5941 agtggaaaga gggtcagcag aagcaggtgc cttcatctat cccagcagct cagccaaacc
     6001 ccagttagaa tgaggcagca ggagattcca ggtgtgctga gggttcagcc acacgcagaa
     6061 gacgttgcag agtgttaaag aggtaagctg aggtgtgtat ttggttggct ttgttgttgt
     6121 tgttaatgta taatgaaaag tataagacta accctcaggc ctcatgttct ccaatagatc
     6181 cctggaagac agtatagaaa gtcagtcggg cttgggctcc ttagccagtg agactactca
     6241 gaccaccagt ggctagccta gcctacctgt ccttgaacat gggtgatttt acccctttga
     6301 ggtcttaacc ctttttttac tttcaacaag atgagctctt tgtatgattg cgggcggggg
     6361 atatgaaaat gcaatgatct aactcctgtt gctcttctag ctggtcacat gacggcacca
     6421 ggcagggttc tgggacaccc ggtgtgcttt gactgttcta caaaaagctg tcagagcgtt
     6481 ctggcctcct ggaggctaga ttcctcagaa actgtctagc ctttgcccac agagcatgct
     6541 atgtaattag agcactcctt cccatgaacc ccagcacttg tgttacctca gggccttggt
     6601 acctggatac tgccacagaa tttccatggg gcgggaaggg atgtattttt aaataaagta
     6661 acttaaaagt tggggaaatt ttttaaattc agaaaatgca aagctattct gtattacacc
     6721 atttcacaat ttaatatgtc ttatattttc ctgtgactct ggaaactaaa ccattgtgtg
     6781 tcttgtcgtg tcctagttga gctggggcct agcagcttcc ttccagtggg tgtggagcaa
     6841 acgtgtatgt cgcctcgcta cctgcttgag gggtccgaag ggctgctggg actgagttct
     6901 gtacacactt gtttggcctt ttctgtagtt gatgctgtaa aactctatgg ctttttaaaa
     6961 acaatttcat gtttttattt tgtattggaa gtccaataca cttttttaat ccaatcaaac
     7021 tggtctggtc aaaaagttct ttcccttaaa agttcagggg ctcctacttc cagcttccga
     7081 tgacttctct gtggctctca ctgctataaa gcaggattta gaatggcaat ctgggcagag
     7141 gtaataaaag aaatgtctga ctgccagccc caaa
//
