LOCUS       NM_001408274            7234 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus neogenin (Neo1), transcript variant 8, mRNA.
ACCESSION   NM_001408274 XM_006510846
VERSION     NM_001408274.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7234)
  AUTHORS   Quilez,S., Dumontier,E., Baim,C., Kam,J. and Cloutier,J.F.
  TITLE     Loss of Neogenin alters branchial arch development and leads to
            craniofacial skeletal defects
  JOURNAL   Front Cell Dev Biol 12, 1256465 (2024)
   PUBMED   38404688
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7234)
  AUTHORS   Wang,X.F., Vigouroux,R., Syonov,M., Baglaenko,Y.,
            Nikolakopoulou,A.M., Ringuette,D., Rus,H., DiStefano,P.V.,
            Dufour,S., Shabanzadeh,A.P., Lee,S., Mueller,B.K., Charish,J.,
            Harada,H., Fish,J.E., Wither,J., Walchli,T., Cloutier,J.F.,
            Zlokovic,B.V., Carlen,P.L. and Monnier,P.P.
  TITLE     The liver and muscle secreted HFE2-protein maintains central
            nervous system blood vessel integrity
  JOURNAL   Nat Commun 15 (1), 1037 (2024)
   PUBMED   38310100
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7234)
  AUTHORS   Luo,P.M., Gu,X., Chaney,C., Carroll,T. and Cleaver,O.
  TITLE     Stromal netrin 1 coordinates renal arteriogenesis and mural cell
            differentiation
  JOURNAL   Development 150 (22) (2023)
   PUBMED   37823339
REFERENCE   4  (bases 1 to 7234)
  AUTHORS   Zhang,J., Xu,Y., Wei,C., Yin,Z., Pan,W., Zhao,M., Ding,W., Xu,S.,
            Liu,J., Yu,J., Ye,J., Ye,D., Qin,J.J., Wan,J. and Wang,M.
  TITLE     Macrophage neogenin deficiency exacerbates myocardial remodeling
            and inflammation after acute myocardial infarction through
            JAK1-STAT1 signaling
  JOURNAL   Cell Mol Life Sci 80 (11), 324 (2023)
   PUBMED   37824022
  REMARK    GeneRIF: Macrophage neogenin deficiency exacerbates myocardial
            remodeling and inflammation after acute myocardial infarction
            through JAK1-STAT1 signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7234)
  AUTHORS   Gannoun,L., De Schrevel,C., Belle,M., Dauguet,N., Achouri,Y.,
            Loriot,A., Vanderaa,C., Cordi,S., Dili,A., Heremans,Y., Rooman,I.,
            Leclercq,I.A., Jacquemin,P., Gatto,L. and Lemaigre,F.P.
  TITLE     Axon guidance genes control hepatic artery development
  JOURNAL   Development 150 (16) (2023)
   PUBMED   37497580
REFERENCE   6  (bases 1 to 7234)
  AUTHORS   Alcantara,S., Ruiz,M., De Castro,F., Soriano,E. and Sotelo,C.
  TITLE     Netrin 1 acts as an attractive or as a repulsive cue for distinct
            migrating neurons during the development of the cerebellar system
  JOURNAL   Development 127 (7), 1359-1372 (2000)
   PUBMED   10704383
REFERENCE   7  (bases 1 to 7234)
  AUTHORS   Salbaum,J.M. and Kappen,C.
  TITLE     Cloning and expression of nope, a new mouse gene of the
            immunoglobulin superfamily related to guidance receptors
  JOURNAL   Genomics 64 (1), 15-23 (2000)
   PUBMED   10708514
REFERENCE   8  (bases 1 to 7234)
  AUTHORS   Bloch-Gallego,E., Ezan,F., Tessier-Lavigne,M. and Sotelo,C.
  TITLE     Floor plate and netrin-1 are involved in the migration and survival
            of inferior olivary neurons
  JOURNAL   J Neurosci 19 (11), 4407-4420 (1999)
   PUBMED   10341242
REFERENCE   9  (bases 1 to 7234)
  AUTHORS   Gad,J.M., Keeling,S.L., Wilks,A.F., Tan,S.S. and Cooper,H.M.
  TITLE     The expression patterns of guidance receptors, DCC and Neogenin,
            are spatially and temporally distinct throughout mouse
            embryogenesis
  JOURNAL   Dev Biol 192 (2), 258-273 (1997)
   PUBMED   9441666
REFERENCE   10 (bases 1 to 7234)
  AUTHORS   Keeling,S.L., Gad,J.M. and Cooper,H.M.
  TITLE     Mouse Neogenin, a DCC-like molecule, has four splice variants and
            is expressed widely in the adult mouse and during embryogenesis
  JOURNAL   Oncogene 15 (6), 691-700 (1997)
   PUBMED   9264410
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT033754.8 and AC110530.10.
            
            On Jun 14, 2022 this sequence version replaced XM_006510846.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.54184.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-482               CT033754.8         73126-73607         c
            483-800             CT033754.8         27351-27668         c
            801-1076            CT033754.8         22761-23036         c
            1077-1230           CT033754.8         19236-19389         c
            1231-1367           CT033754.8         15785-15921         c
            1368-1522           AC110530.10        18113-18267
            1523-1643           AC110530.10        20086-20206
            1644-1863           AC110530.10        44990-45209
            1864-2018           AC110530.10        50249-50403
            2019-2167           AC110530.10        54250-54398
            2168-2306           AC110530.10        54865-55003
            2307-2356           AC110530.10        57509-57558
            2357-2504           AC110530.10        59059-59206
            2505-2615           AC110530.10        61801-61911
            2616-2810           AC110530.10        62823-63017
            2811-2906           AC110530.10        67666-67761
            2907-3130           AC110530.10        69071-69294
            3131-3269           AC110530.10        69377-69515
            3270-3377           AC110530.10        71614-71721
            3378-3572           AC110530.10        73057-73251
            3573-3605           AC110530.10        74050-74082
            3606-3674           AC110530.10        76932-77000
            3675-3822           AC110530.10        82143-82290
            3823-4061           AC110530.10        86945-87183
            4062-4154           AC110530.10        87672-87764
            4155-4418           AC110530.10        95310-95573
            4419-4555           AC110530.10        98001-98137
            4556-7234           AC110530.10        98808-101486
FEATURES             Location/Qualifiers
     source          1..7234
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.81 cM"
     gene            1..7234
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /note="neogenin"
                     /db_xref="GeneID:18007"
                     /db_xref="MGI:MGI:1097159"
     exon            1..482
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..4639
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /note="isoform 8 precursor is encoded by transcript
                     variant 8"
                     /codon_start=1
                     /product="neogenin isoform 8 precursor"
                     /protein_id="NP_001395203.1"
                     /db_xref="GeneID:18007"
                     /db_xref="MGI:MGI:1097159"
                     /translation="MAAEREAGRLLCTSSSRRCCPPPPLLLLLPLLLLLGRPASGAAA
                     TKSGSPPQSAGASVRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPNIEWKKDGT
                     FLNLESDDRRQLLPDGSLFISNVVHSKHNKPDEGFYQCVATVDNLGTIVSRTAKLTVA
                     GLPRFTSQPEPSSVYVGNSAILNCEVNADLVPFVRWEQNRQPLLLDDRIVKLPSGTLV
                     ISNATEGDGGLYRCIVESGGPPKFSDEAELKVLQDPEEIVDLVFLMRPSSMMKVTGQS
                     AVLPCVVSGLPAPVVRWMKNEEVLDTESSGRLVLLAGGCLEISDVTEDDAGTYFCIAD
                     NGNKTVEAQAELTVQVPPGFLKQPANIYAHESMDIVFECEVTGKPTPTVKWVKNGDVV
                     IPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHDVAIPTLPP
                     TSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFY
                     TKEGVARERVENTSQPGEMQVTIQNLMPATVYIFKVMAQNKHGSGESSAPLRVETQPE
                     VQLPGPAPNIRAYATSPTSITVTWETPLSGNGEIQNYKLYYMEKGTDKEQDIDVSSHS
                     YTINGLKKYTEYSFRVVAYNKHGPGVSTQDVAVRTLSDVPSAAPQNLSLEVRNSKSIV
                     IHWQPPSSTTQNGQITGYKIRYRKASRKSDVTETLVTGTQLSQLIEGLDRGTEYNFRV
                     AALTVNGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIV
                     VRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESA
                     VTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQ
                     KITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTW
                     SMTAHGATFELVPTSPPKDVTVVSKEGKPRTIIVNWQPPSEANGKITGYIIYYSTDVN
                     AEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSS
                     DKMPNDQALGSAGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVI
                     TIVVVVVIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNCKDVKPPDLWIHHERLELK
                     PIDKSPDPNPVMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRR
                     GMRPKMMMPFDSQPPQQSVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEE
                     DSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPLYDPALPSTPLLSQQALNHHIHSVKTA
                     SIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAHLEGLMKDLNAI
                     TTA"
     exon            483..800
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1076
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1230
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1367
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1522
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1643
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1863
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2018
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2167
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2306
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2356
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2504
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2615
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2810
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2906
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3130
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3269
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3377
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..3572
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3573..3605
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3606..3674
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3675..3822
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3823..4061
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4062..4154
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4155..4418
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4419..4555
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4556..7234
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7055..7060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /note="hexamer: AATACA"
     polyA_site      7074
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /note="major polyA site"
     regulatory      7208..7213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /note="hexamer: AAGAAA"
     polyA_site      7234
                     /gene="Neo1"
                     /gene_synonym="2610028H22Rik; D930014N22Rik; Igdcc2"
                     /note="major polyA site"
ORIGIN      
        1 gtctccgccc ccctcgctct accgtgagga gcccgagtcg gcggcgggtg gcggcgcctg
       61 gaacctggag agaccgagcc accccccggc tctcggccgg aatgtactga ttctcctctg
      121 ctctcctccc cgccccgctg caggagggag gcgcccggag tctttccccc tgggcgcgcg
      181 agggggccgc gcgggccggg ccgggccggg ctggagccga gccctgcggc gcagagaccg
      241 gctgaggcgc gctgagggaa gggcgcgagc gctccgcggc gctatcgccg ccgccgccgc
      301 cgccactcgt ggggtagaga tggcggcgga gcgcgaagcc gggcgactcc tctgcacctc
      361 ctcctcccgg cgctgctgtc cgccaccgcc gctgctgctg ttgctgccgc tgctgctgct
      421 gctcggacgc ccggcgtccg gcgccgcggc cacgaagagc ggctccccgc cgcagtccgc
      481 aggagccagt gttcgaacat tcactccgtt ttattttctg gtggagccag tagacaccct
      541 ctcagttaga ggctcttctg ttatattaaa ttgctcggca tattctgagc cctctccaaa
      601 cattgaatgg aagaaagatg ggactttttt aaacttagaa tcagatgatc gacgccagct
      661 actcccagat ggatctttat tcatcagcaa cgtggtgcat tccaaacaca ataagcctga
      721 cgaaggtttc tatcagtgtg tagccactgt ggataatctt ggaaccattg tcagcagaac
      781 agccaagctc acagtagcag gtcttccaag atttaccagc caaccagaac cttcttcagt
      841 ctatgttgga aacagtgcaa ttctgaattg tgaagttaat gcagatttgg tcccatttgt
      901 taggtgggaa cagaatcgac agccccttct tctagatgac aggattgtca aacttccaag
      961 tggaacactg gttatcagca atgctactga aggagatggg ggactctacc gctgcattgt
     1021 tgaaagtggt gggccaccaa agtttagtga cgaagctgaa ttgaaagttc ttcaagatcc
     1081 tgaggaaatt gtagacttgg tatttctgat gcgaccatct tctatgatga aagtcactgg
     1141 tcagagtgca gtgttgccat gtgttgtctc agggcttcct gctccagttg ttagatggat
     1201 gaaaaacgaa gaagtgcttg acacagaaag ctctggcagg ttggtcttgc tagcaggagg
     1261 ttgcttggag atcagtgatg tcactgagga tgatgctggg acttattttt gcatagctga
     1321 taatggaaat aagacagttg aagctcaggc ggagcttact gtgcaagtgc cacctggatt
     1381 cctgaaacaa cctgctaaca tatatgctca cgaatccatg gacattgtat ttgaatgtga
     1441 agtcactggg aagccaactc caactgtgaa gtgggtcaag aatggggatg tggttatccc
     1501 cagtgattac tttaaaattg taaaggaaca taatcttcaa gttttgggtc tggtgaaatc
     1561 agatgaaggg ttctatcaat gcattgctga gaatgatgtt ggaaatgcac aagctggagc
     1621 ccagctgata atccttgagc atgatgttgc catcccaaca ttacctccca cttcactgac
     1681 cagtgccact actgaccatc tagcaccagc cacaacggga ccattacctt cagctcctcg
     1741 agacgtcgtg gcctccctgg tctctactcg cttcattaaa ttgacatggc gtacacctgc
     1801 atcagaccct catggagaca atctcaccta ctctgtgttc tacaccaagg aaggggttgc
     1861 tagggagcgt gttgagaata ccagccagcc aggagagatg caggtgacta ttcaaaactt
     1921 gatgccagca actgtgtaca tcttcaaagt tatggctcaa aataagcatg gctctggaga
     1981 aagttcagct cctcttcgag tagagacaca gcctgaggtt cagctccctg gcccagcacc
     2041 taatatccgt gcttatgcaa cgtcacctac ttctatcact gtcacctggg aaacaccgtt
     2101 atctggcaat ggggaaattc aaaattacaa attgtactac atggaaaaag gaactgataa
     2161 agaacaggat attgatgttt caagtcactc ctacaccatt aatggactga agaaatacac
     2221 agaatacagt ttccgagtgg tggcctacaa taaacatggt cctggagttt ctacacaaga
     2281 tgttgctgtt cgaacattat cagatgttcc cagtgctgct cctcagaatc tgtccttaga
     2341 agtgagaaat tcaaagagta tagtgatcca ctggcagccc ccttcctcaa ccacacaaaa
     2401 tgggcagata actggctaca agattcgata tcgaaaggcc tcccgaaaaa gtgatgtcac
     2461 tgagaccttg gtaactggga cacagctgtc tcagctgatt gaaggtcttg atcgggggac
     2521 agaatataac ttccgagtcg ctgctctcac agtcaatggt acaggtccag caactgattg
     2581 gctgtctgct gaaacttttg aaagcgacct agatgaaact cgtgttcctg aagtgcccag
     2641 ctctcttcat gtccgtccgc tcgtcactag cattgtagtg agctggactc ctccagagaa
     2701 ccagaacatt gtggtccgag gttatgccat cggttacggc attggcagcc ctcatgccca
     2761 gaccatcaaa gtggactata aacaacgtta ttacaccatc gaaaacttgg atccaagctc
     2821 tcattacgtg attaccttga aagcatttaa caatgttggc gaaggcatcc ccctttatga
     2881 gagtgctgtg accagacctc acacagacac ttctgaagtt gatttatttg ttattaatgc
     2941 tccatacact ccagtgccag atcccactcc catgatgcca ccagtgggag ttcaggcttc
     3001 cattctgagt cacgacacca taaggattac ctgggcagac aactccctgc ccaaacacca
     3061 gaagattaca gactcccgct actacacagt ccggtggaag accaacatcc cagcaaacac
     3121 gaagtacaag aatgcaaatg caacgacgtt aagctatttg gttactggtt taaagccaaa
     3181 tacgctctat gagttctctg tgatggtgac caaaggcaga aggtcaagca cgtggagtat
     3241 gacagctcat ggcgctacct ttgaattagt tcctacttct ccacctaagg atgtgacagt
     3301 tgtgagtaag gaaggaaaac ctagaaccat catagtgaat tggcagcctc cctctgaagc
     3361 taacggcaag attacaggtt acatcatcta ttacagcacg gatgtgaatg cagagataca
     3421 tgactgggtt attgaaccag ttgtgggaaa cagactgact caccagattc aagagttaac
     3481 acttgatacg ccatactact tcaaaatcca ggcccggaac tcaaagggca tggggcccat
     3541 gtctgaagct gtacagttca gaacacctaa agcggactcc tctgataaaa tgcctaatga
     3601 ccaagcctta gggtcagcag gaaaaggaag ccgactacca gacctgggat ctgactacaa
     3661 acctccaatg agtggcagca acagccctca cgggagcccc acctcccctc tggacagcaa
     3721 catgctgctg gtcatcattg tctctgttgg cgtcatcact atcgtggtgg ttgtggtcat
     3781 tgctgtcttt tgtacccggc gcaccacctc tcaccagaag aagaaacgag ctgcgtgcaa
     3841 atcagtgaat ggctcccata agtacaaggg caattgcaaa gatgtgaagc ctccagacct
     3901 atggatccat cacgagagac tagagttgaa gcctattgac aagtctccag atcctaaccc
     3961 tgtcatgact gatactccaa tccctcgaaa ctctcaagat atcacaccag tggacaattc
     4021 catggatagc aatatccatc aaaggcggaa ttcatacaga gggcatgagt cagaggacag
     4081 catgtctaca ctggctggaa ggaggggaat gagaccaaaa atgatgatgc cctttgactc
     4141 tcagccacct cagcaatctg ttcgaaatac ccccagcacg gacaccatgc cagcgtcctc
     4201 gtctcagacg tgctgcactg accatcagga ccctgagggt gctactagct cctcttactt
     4261 ggccagctcc caagaggaag actcaggcca gagtcttccc acagcccatg tccgcccttc
     4321 ccaccctctg aagagcttcg ctgtgccagc aatcccaccc ccaggacctc ctctctatga
     4381 tcctgcactg ccaagcacac cattactgtc ccagcaagct ctgaaccatc acattcactc
     4441 agtgaaaaca gcctccatcg ggacgttagg aaggagccgg cctcctatgc cagtggttgt
     4501 tccgagtgcc cctgaagtac aggagaccac caggatgctg gaagactccg agagtagcta
     4561 tgaaccagat gagctgacca aagagatggc ccacctggaa ggactaatga aggacctaaa
     4621 tgccatcaca acagcctgat gaccttcgcc tggacatgac tccaagcctg agtctacaag
     4681 tctcggaact taaccttgaa aacaaggaat tgtacagagt acgagaggac agcacttgag
     4741 agcaggagcc agcaaaccag ccagtgcctc catgtggggt tggctccagg cacagccacc
     4801 tgccttctcc tggtcagcct ggattacact tgtgtggagg cagcttccct ttgcctgctg
     4861 agagcctgca ggactgggca ctatgggcca aaattttgtg tccagggaag aggcaagaag
     4921 tacgacctgc cttttgcttt gtggtcagtg gcttgtgtct ttgtgctgca actgcatcac
     4981 ttttatggag tgtagacatt ggcatttatg tacaattttg tgtcctattt tattttacct
     5041 taaaacacta tcagaagcca agggagtctg tgatgttctc tcaagcagtt gacacttgac
     5101 tgtggttcca gttacttacg gaaagtcatc aacagtgagg ttgtttgaca ccactgacag
     5161 gcattggctt gttgtgggtt tcatttttat tcttaattct gagacattgc atcctctgcc
     5221 agctgttaat ccatcacttt gaggggagga catgttgcat tgctgtttgt aagctttttt
     5281 attatttttt tattataatt attaaaggcc tgactttctc ctctcatcac tgtgagatta
     5341 cagatctatt tgaatgaaat gtaacattga aaagacttgt ttgttgcttt ctgtgcagat
     5401 tcagtattgg ggtgggattg gggattggga ataggaaatg gaggggctgc tgaggccctg
     5461 tgaatgtttc tgtcaatgta ctttgttcca gaagcctgcc gagaatgaaa gcagcatctt
     5521 tagtgtcctt tcctggcatt tccatcttcg tgtcactgca tagcaactgg agttttgttt
     5581 ggatctggtt ataaattctt gtacagtgga tgactttggt gatttagctg ccctggtatc
     5641 ttggtcattt cctctttgga gtgtccacac tgaggtctct atcaatgtat gtttaattgc
     5701 ttgagagatg ccaagtagaa ccagagcctg actgtgctct gagaagctac aaagcacagg
     5761 gtggagactc cctttgtgtt gctagtattg gttctctctg gaaggttaaa atctaaggca
     5821 ggatcttggt ttcctattcc aaataggatg cctgcttctc tgggcaccag tcctcagcca
     5881 ggcagctctc gtggcattgc agaggctctc ctgaaaaaca tcaaccaggg tgagagccaa
     5941 gatggggtgg cacccatgac gcttccccac atgtttcttc aaggagcaga ggacagagat
     6001 agtggaaaga gggtcagcag aagcaggtgc cttcatctat cccagcagct cagccaaacc
     6061 ccagttagaa tgaggcagca ggagattcca ggtgtgctga gggttcagcc acacgcagaa
     6121 gacgttgcag agtgttaaag aggtaagctg aggtgtgtat ttggttggct ttgttgttgt
     6181 tgttaatgta taatgaaaag tataagacta accctcaggc ctcatgttct ccaatagatc
     6241 cctggaagac agtatagaaa gtcagtcggg cttgggctcc ttagccagtg agactactca
     6301 gaccaccagt ggctagccta gcctacctgt ccttgaacat gggtgatttt acccctttga
     6361 ggtcttaacc ctttttttac tttcaacaag atgagctctt tgtatgattg cgggcggggg
     6421 atatgaaaat gcaatgatct aactcctgtt gctcttctag ctggtcacat gacggcacca
     6481 ggcagggttc tgggacaccc ggtgtgcttt gactgttcta caaaaagctg tcagagcgtt
     6541 ctggcctcct ggaggctaga ttcctcagaa actgtctagc ctttgcccac agagcatgct
     6601 atgtaattag agcactcctt cccatgaacc ccagcacttg tgttacctca gggccttggt
     6661 acctggatac tgccacagaa tttccatggg gcgggaaggg atgtattttt aaataaagta
     6721 acttaaaagt tggggaaatt ttttaaattc agaaaatgca aagctattct gtattacacc
     6781 atttcacaat ttaatatgtc ttatattttc ctgtgactct ggaaactaaa ccattgtgtg
     6841 tcttgtcgtg tcctagttga gctggggcct agcagcttcc ttccagtggg tgtggagcaa
     6901 acgtgtatgt cgcctcgcta cctgcttgag gggtccgaag ggctgctggg actgagttct
     6961 gtacacactt gtttggcctt ttctgtagtt gatgctgtaa aactctatgg ctttttaaaa
     7021 acaatttcat gtttttattt tgtattggaa gtccaataca cttttttaat ccaatcaaac
     7081 tggtctggtc aaaaagttct ttcccttaaa agttcagggg ctcctacttc cagcttccga
     7141 tgacttctct gtggctctca ctgctataaa gcaggattta gaatggcaat ctgggcagag
     7201 gtaataaaag aaatgtctga ctgccagccc caaa
//
