LOCUS       NM_025424                681 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus neuron derived neurotrophic factor (Nenf), mRNA.
ACCESSION   NM_025424
VERSION     NM_025424.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 681)
  AUTHORS   Nakayama,Y., Masuda,Y., Mukae,T., Mikami,T., Shimizu,R., Kondo,N.,
            Kitagawa,H., Itoh,N. and Konishi,M.
  TITLE     A secretory protein neudesin regulates splenic red pulp macrophages
            in erythrophagocytosis and iron recycling
  JOURNAL   Commun Biol 7 (1), 129 (2024)
   PUBMED   38272969
  REMARK    GeneRIF: A secretory protein neudesin regulates splenic red pulp
            macrophages in erythrophagocytosis and iron recycling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 681)
  AUTHORS   Hasegawa,H., Kondo,M., Nakayama,K., Okuno,T., Itoh,N. and
            Konishi,M.
  TITLE     Testicular Hypoplasia with Normal Fertility in Neudesin-Knockout
            Mice
  JOURNAL   Biol Pharm Bull 45 (12), 1791-1797 (2022)
   PUBMED   36450531
  REMARK    GeneRIF: Testicular Hypoplasia with Normal Fertility in
            Neudesin-Knockout Mice.
REFERENCE   3  (bases 1 to 681)
  AUTHORS   Moutaoufik,M.T., Malty,R., Amin,S., Zhang,Q., Phanse,S.,
            Gagarinova,A., Zilocchi,M., Hoell,L., Minic,Z., Gagarinova,M.,
            Aoki,H., Stockwell,J., Jessulat,M., Goebels,F., Broderick,K.,
            Scott,N.E., Vlasblom,J., Musso,G., Prasad,B., Lamantea,E.,
            Garavaglia,B., Rajput,A., Murayama,K., Okazaki,Y., Foster,L.J.,
            Bader,G.D., Cayabyab,F.S. and Babu,M.
  TITLE     Rewiring of the Human Mitochondrial Interactome during Neuronal
            Reprogramming Reveals Regulators of the Respirasome and
            Neurogenesis
  JOURNAL   iScience 19, 1114-1132 (2019)
   PUBMED   31536960
REFERENCE   4  (bases 1 to 681)
  AUTHORS   Novais,A., Silva,A., Ferreira,A.C., Falcao,A.M., Sousa,N.,
            Palha,J.A., Marques,F. and Sousa,J.C.
  TITLE     Adult Hippocampal Neurogenesis Modulation by the
            Membrane-Associated Progesterone Receptor Family Member Neudesin
  JOURNAL   Front Cell Neurosci 12, 463 (2018)
   PUBMED   30534059
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 681)
  AUTHORS   Ohta,H., Konishi,M., Kobayashi,Y., Kashio,A., Mochiyama,T.,
            Matsumura,S., Inoue,K., Fushiki,T., Nakao,K., Kimura,I. and Itoh,N.
  TITLE     Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced
            Obesity by Increased Sympathetic Activity
  JOURNAL   Sci Rep 5, 10049 (2015)
   PUBMED   25955136
  REMARK    GeneRIF: neudesin, which may be a negative regulator of sympathetic
            activity, could represent a novel regulator of the development of
            obesity and obesity-related metabolic dysfunctions.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 681)
  AUTHORS   Byerly,M.S., Swanson,R.D., Semsarzadeh,N.N., McCulloh,P.S.,
            Kwon,K., Aja,S., Moran,T.H., Wong,G.W. and Blackshaw,S.
  TITLE     Identification of hypothalamic neuron-derived neurotrophic factor
            as a novel factor modulating appetite
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 304 (12), R1085-R1095 (2013)
   PUBMED   23576617
  REMARK    GeneRIF: Neuron-derived neurotrophic factor (NENF) is an important
            central modulator of food intake.
REFERENCE   7  (bases 1 to 681)
  AUTHORS   Kimura,I., Konishi,M., Asaki,T., Furukawa,N., Ukai,K., Mori,M.,
            Hirasawa,A., Tsujimoto,G., Ohta,M., Itoh,N. and Fujimoto,M.
  TITLE     Neudesin, an extracellular heme-binding protein, suppresses
            adipogenesis in 3T3-L1 cells via the MAPK cascade
  JOURNAL   Biochem Biophys Res Commun 381 (1), 75-80 (2009)
   PUBMED   19351598
  REMARK    GeneRIF: These findings suggest that neudesin plays a critical role
            in the early stage of adipocyte differentiation in which C/EBPbeta
            induces PPARgamma and C/EBPalpha expressions, by controlling the
            MAPK pathway.
REFERENCE   8  (bases 1 to 681)
  AUTHORS   Kimura,I., Nakayama,Y., Yamauchi,H., Konishi,M., Miyake,A.,
            Mori,M., Ohta,M., Itoh,N. and Fujimoto,M.
  TITLE     Neurotrophic activity of neudesin, a novel extracellular
            heme-binding protein, is dependent on the binding of heme to its
            cytochrome b5-like heme/steroid-binding domain
  JOURNAL   J Biol Chem 283 (7), 4323-4331 (2008)
   PUBMED   18056703
  REMARK    GeneRIF: Neudesin is the first extracellular heme-binding protein
            that shows signal transducing activity by itself. The present
            findings may shed new light on the function of extracellular
            heme-binding proteins
REFERENCE   9  (bases 1 to 681)
  AUTHORS   Kimura,I., Konishi,M., Miyake,A., Fujimoto,M. and Itoh,N.
  TITLE     Neudesin, a secreted factor, promotes neural cell proliferation and
            neuronal differentiation in mouse neural precursor cells
  JOURNAL   J Neurosci Res 83 (8), 1415-1424 (2006)
   PUBMED   16547973
  REMARK    GeneRIF: The present findings have revealed new potential roles of
            neudesin in neural cell proliferation and neuronal differentiation.
REFERENCE   10 (bases 1 to 681)
  AUTHORS   Kimura,I., Yoshioka,M., Konishi,M., Miyake,A. and Itoh,N.
  TITLE     Neudesin, a novel secreted protein with a unique primary structure
            and neurotrophic activity
  JOURNAL   J Neurosci Res 79 (3), 287-294 (2005)
   PUBMED   15605373
  REMARK    GeneRIF: identification of neudesin, a novel mouse secreted protein
            showing neurotrophic activity in primary cultured mouse neurons
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115896.9 and AK002413.1.
            
            On Jan 31, 2019 this sequence version replaced NM_025424.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048464.1, AK002413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC115896.9         36705-36717
            14-671              AK002413.1         2-659
            672-681             AC115896.9         48040-48049
FEATURES             Location/Qualifiers
     source          1..681
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 96.28 cM"
     gene            1..681
                     /gene="Nenf"
                     /gene_synonym="1110060M21Rik; SCIRP10; Spuf"
                     /note="neuron derived neurotrophic factor"
                     /db_xref="GeneID:66208"
                     /db_xref="MGI:MGI:1913458"
     exon            1..213
                     /gene="Nenf"
                     /gene_synonym="1110060M21Rik; SCIRP10; Spuf"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..555
                     /gene="Nenf"
                     /gene_synonym="1110060M21Rik; SCIRP10; Spuf"
                     /note="secreted protein of unknown function; neudesin;
                     Spinal cord injury related protein 10; SCIRP10-related
                     protein"
                     /codon_start=1
                     /product="neudesin precursor"
                     /protein_id="NP_079700.1"
                     /db_xref="CCDS:CCDS15618.1"
                     /db_xref="GeneID:66208"
                     /db_xref="MGI:MGI:1913458"
                     /translation="MARPAPWWRLRLLAALVLALALVPVPSAWAGQTPRPAERGPPVR
                     LFTEEELARYGGEEEDQPIYLAVKGVVFDVTSGKEFYGRGAPYNALAGKDSSRGVAKM
                     SLDPADLTHDTTGLTAKELEALDDVFSKVYKAKYPIVGYTARRILNEDGSPNLDFKPE
                     DQPHFDIKDEF"
     exon            214..274
                     /gene="Nenf"
                     /gene_synonym="1110060M21Rik; SCIRP10; Spuf"
                     /inference="alignment:Splign:2.1.0"
     exon            275..378
                     /gene="Nenf"
                     /gene_synonym="1110060M21Rik; SCIRP10; Spuf"
                     /inference="alignment:Splign:2.1.0"
     exon            379..681
                     /gene="Nenf"
                     /gene_synonym="1110060M21Rik; SCIRP10; Spuf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      656..661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nenf"
                     /gene_synonym="1110060M21Rik; SCIRP10; Spuf"
                     /note="hexamer: AATAAA"
     polyA_site      679
                     /gene="Nenf"
                     /gene_synonym="1110060M21Rik; SCIRP10; Spuf"
                     /note="major polyA site"
ORIGIN      
        1 gccccgcccc gccgtcctcc cgcctgctcc tcgctgtcta tggcgcgccc cgcgccctgg
       61 tggcggctgc ggctgctggc ggcgctcgtc ctggcgctgg ctctggtccc agtgccctca
      121 gcctgggctg ggcagacgcc gcgccccgca gagcgcgggc ccccggtgcg gctcttcacc
      181 gaggaggagc tggcccgcta cggcggcgag gaggaggatc agcccatcta cttggcagtg
      241 aagggagtgg tgttcgatgt cacctctggg aaggagtttt atggacgagg agccccctac
      301 aatgccttgg ccgggaagga ctccagcaga ggtgtggcca agatgtcact ggatccagca
      361 gacctcactc acgacactac tggtctcacg gccaaggagc tggaggccct cgatgacgtc
      421 ttcagcaagg tgtacaaagc caagtacccc attgttggct acacagcccg aaggatcctc
      481 aacgaggatg gcagccccaa cctggacttc aagcctgaag accagcccca ttttgacata
      541 aaggacgaat tctgatgtct agctgagaag cagccggttc tagggagaag tgaggggaca
      601 ggagttaagt gtccctcgga acaagcggag gaagcctccg agtgccctgc agctgaataa
      661 agcgaatgtt taactgggag a
//
