LOCUS       NM_001113211            6001 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus nuclear envelope integral membrane protein 1 (Nemp1),
            transcript variant 1, mRNA.
ACCESSION   NM_001113211
VERSION     NM_001113211.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6001)
  AUTHORS   Suzuki,A., Yabuta,N., Shimada,K., Mashiko,D., Tokuhiro,K.,
            Oyama,Y., Miyata,H., Garcia,T.X., Matzuk,M.M. and Ikawa,M.
  TITLE     Individual disruption of 12 testis-enriched genes via the
            CRISPR/Cas9 system does not affect the fertility of male mice
  JOURNAL   J Reprod Immunol 163, 104252 (2024)
   PUBMED   38697008
REFERENCE   2  (bases 1 to 6001)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6001)
  AUTHORS   Hodzic,D., Wu,J., Krchma,K., Jurisicova,A., Tsatskis,Y., Liu,Y.,
            Ji,P., Choi,K. and McNeill,H.
  TITLE     The inner nuclear membrane protein NEMP1 supports nuclear envelope
            openings and enucleation of erythroblasts
  JOURNAL   PLoS Biol 20 (10), e3001811 (2022)
   PUBMED   36215313
  REMARK    GeneRIF: The inner nuclear membrane protein NEMP1 supports nuclear
            envelope openings and enucleation of erythroblasts.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6001)
  AUTHORS   Tsatskis,Y., Rosenfeld,R., Pearson,J.D., Boswell,C., Qu,Y., Kim,K.,
            Fabian,L., Mohammad,A., Wang,X., Robson,M.I., Krchma,K., Wu,J.,
            Goncalves,J., Hodzic,D., Wu,S., Potter,D., Pelletier,L.,
            Dunham,W.H., Gingras,A.C., Sun,Y., Meng,J., Godt,D., Schedl,T.,
            Ciruna,B., Choi,K., Perry,J.R.B., Bremner,R., Schirmer,E.C.,
            Brill,J.A., Jurisicova,A. and McNeill,H.
  TITLE     The NEMP family supports metazoan fertility and nuclear envelope
            stiffness
  JOURNAL   Sci Adv 6 (35), eabb4591 (2020)
   PUBMED   32923640
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6001)
  AUTHORS   Shibano,T., Mamada,H., Hakuno,F., Takahashi,S. and Taira,M.
  TITLE     The Inner Nuclear Membrane Protein Nemp1 Is a New Type of
            RanGTP-Binding Protein in Eukaryotes
  JOURNAL   PLoS One 10 (5), e0127271 (2015)
   PUBMED   25946333
  REMARK    GeneRIF: Nemp1 represents a new type of RanGTP-binding protein.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6001)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   7  (bases 1 to 6001)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 6001)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160970.7 and AK129110.1.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129110.1, SRR10223970.12809.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC160970.7         138105-138107
            4-6001              AK129110.1         1-5998
FEATURES             Location/Qualifiers
     source          1..6001
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.6 cM"
     gene            1..6001
                     /gene="Nemp1"
                     /gene_synonym="Tmem194; Tmem194a"
                     /note="nuclear envelope integral membrane protein 1"
                     /db_xref="GeneID:210035"
                     /db_xref="MGI:MGI:2446113"
     exon            1..163
                     /gene="Nemp1"
                     /gene_synonym="Tmem194; Tmem194a"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1347
                     /gene="Nemp1"
                     /gene_synonym="Tmem194; Tmem194a"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; transmembrane protein 194A"
                     /codon_start=1
                     /product="nuclear envelope integral membrane protein 1
                     isoform 1 precursor"
                     /protein_id="NP_001106682.1"
                     /db_xref="CCDS:CCDS48720.1"
                     /db_xref="GeneID:210035"
                     /db_xref="MGI:MGI:2446113"
                     /translation="MAGGIKVSVWSAVGPGPRCWGAGGGGGATWLLLVVAGCVVCGSA
                     DVNVVMLQESQVDMNSSQQFCYKNVLIPKWHDIWTRIQVRVNSSKLVRVTQVDNEEKL
                     KELEQFSIWNFFSSFLKEKLNDTYVNVGLYSTKTCLKVEMIEKDTTYSVTVTRRFDPK
                     LFLVFLLGLTLFFCGDLLSRSQIFYYSTGMSVGIVASLLIVIFMISKFMPKRSPIYVI
                     LVGGWSFSLYLIQLVFKNLQEIWRSYWHYLLSYILTVGFMSFAVCYKYGPLENERSIN
                     LLTWTLQLLGLGLMYSSIQIPHVAFALIVIALCTKNLEYPIHWLCSTYRRMCKASGKP
                     VPPRLLTEEEYRIQGEVETQKALQELREFCNSPECSAWKTISRIQSPKRFADFVEGSF
                     HLTPNEVSVHEQEYGLGSIFTQDEELSSEEEGSEYPTFTQNNFLT"
     exon            164..279
                     /gene="Nemp1"
                     /gene_synonym="Tmem194; Tmem194a"
                     /inference="alignment:Splign:2.1.0"
     exon            280..499
                     /gene="Nemp1"
                     /gene_synonym="Tmem194; Tmem194a"
                     /inference="alignment:Splign:2.1.0"
     exon            500..572
                     /gene="Nemp1"
                     /gene_synonym="Tmem194; Tmem194a"
                     /inference="alignment:Splign:2.1.0"
     exon            573..666
                     /gene="Nemp1"
                     /gene_synonym="Tmem194; Tmem194a"
                     /inference="alignment:Splign:2.1.0"
     exon            667..781
                     /gene="Nemp1"
                     /gene_synonym="Tmem194; Tmem194a"
                     /inference="alignment:Splign:2.1.0"
     exon            782..1007
                     /gene="Nemp1"
                     /gene_synonym="Tmem194; Tmem194a"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1181
                     /gene="Nemp1"
                     /gene_synonym="Tmem194; Tmem194a"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..6001
                     /gene="Nemp1"
                     /gene_synonym="Tmem194; Tmem194a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcacgcga ggaggaggcg gtgtgaggca tccatggcgg gaggaatcaa agtgtcggtg
       61 tggtcggcgg ttggtccagg gccccggtgc tggggggccg ggggcggcgg cggcgccaca
      121 tggctgctct tggtcgtcgc cggctgcgtg gtctgcggct cagctgatgt aaatgtggtc
      181 atgcttcagg aatcccaagt tgatatgaat tccagtcaac aattctgtta taaaaatgtg
      241 cttatcccaa agtggcatga tatatggaca cggatacagg ttcgggtaaa tagttccaag
      301 ttggtccgag ttacccaggt ggacaatgag gagaagctga aggagctaga gcagtttagt
      361 atctggaact ttttttcttc ttttttaaaa gagaaattga atgacaccta tgttaacgtg
      421 ggtctgtaca gcactaaaac ctgcctcaag gttgagatga tagagaagga caccacgtac
      481 agtgtcactg tgacccggag atttgacccc aaactcttcc ttgttttcct cctcggactg
      541 acactgtttt tttgtggaga cttgttgagc aggagtcaaa ttttctacta ttccactggg
      601 atgagtgtgg gaatcgtggc ctctctctta atcgtcattt ttatgatctc taagtttatg
      661 cccaagagaa gccccattta cgtcatcctg gtaggaggct ggtccttctc tctgtacctc
      721 attcagctag tttttaagaa tttacaggag atatggagga gttactggca ttatcttcta
      781 agctacatcc tcacagttgg attcatgagt tttgcagtgt gctacaaata tgggcccctg
      841 gaaaatgaac gaagcattaa cctgctgacc tggacgctgc agctgctggg cctgggactc
      901 atgtattcca gtatccagat cccgcacgtt gcctttgctc tcatcgtcat tgcactgtgc
      961 actaagaacc tggaataccc tatccactgg ctgtgcagca cctacagaag gatgtgtaag
     1021 gcatcaggaa agcctgtccc ccctcgcctc ctgacagaag aagagtatcg gatacaagga
     1081 gaggtggaga cccaaaaggc tttacaggaa ctccgagaat tttgtaacag tccggagtgc
     1141 tctgcctgga agaccatatc tcgaattcag tctccaaaaa gatttgctga ctttgtggaa
     1201 ggttctttcc acctcacgcc aaatgaagtt tctgttcacg aacaggagta tggattaggg
     1261 agcatcttta cccaggatga ggagctgtcc tcagaagagg agggctcaga gtaccccact
     1321 ttcacacaga acaatttctt gacttaaata gcagtctgtt gttttcatat agactggcat
     1381 ggtaccttgg tgtggccaca ttgtaagtgc tgtgtgattc tcccaggctt ttataagagc
     1441 ctggagcggg tgcaggagtt ctgctggaat gaggggctga gtgggttacc ctctggcagt
     1501 acttttggtg tgtacctcag gctggtcctc ttcgaggaaa gagtggcgga ggcactgagg
     1561 gctgcggcag ctcgcttctg acatttgagc acttggccca ctttgcggtt cctgaagtca
     1621 ttgtttgccc acaacagtct agctcctgtt taaaagtttg ctgagttctg gcaactctgt
     1681 cactgtgaca gacccttaaa aatgagtatt aagtgcagta atgcattcaa atggaggctg
     1741 catcttttaa agagaatcta taagtctgag ccatttttta cttctgtctg ctctatttca
     1801 ctggatcctt ataataatcc tgaatgattt aaatattgaa gaaaaaatag attgttacct
     1861 atcttgtttt ttaaacaaat atattttttt aagtgcaaga aagtcatgtt ctttacccaa
     1921 taagtgctcc agagtacaaa ccctactgac cccagatatt tattacctgt gaaacccctg
     1981 gagctgctgc tgttgagcct tgaatgctca cagtctgatt tttagtttgc ttgcatttag
     2041 gagaacgtct gctgcccttc tgtaggtttg gtttcctaag ctttttatta tatttgatat
     2101 tggctttttt tcttgccgtt tctcaccatt gacttttccc actcaggaat ggtgtgtccc
     2161 ctttcctgta gagtgtgcac agttgagaat ttgtctcatt tgccgctgcc ttcttcctaa
     2221 cactgaggtt cttccatatc tcctactgtg tacctcagac ttgagagtcc ctgagcatct
     2281 ggtatttctg ttttgacttt tccttctggg ttggggcctg ctgctgtacc tcaggttgat
     2341 cctttcacct tcgcctttac actgctagaa ttttaagcct gtgctggtat accaagcttc
     2401 tttttttctt ctgttttggt tttcgagaca cattttctct gcatagccct tgctgtcgta
     2461 gaacttgctc tagagagcac attggcctgg aactcacaga gatgcctctg cctctgcctc
     2521 tgcctctgcc tctgcctctg cctctgccaa agtatgttac cactggctgg catgtcaaat
     2581 ttcttgtttc ttatatataa atgttcccct taccttgatt cctacattat ggctaggcag
     2641 agaagtctta tttacaccct tctcccccct agtcagatca cataccttct gagttactat
     2701 agtcaggaaa ctgttccagg gctgggcata tagctcagtg gtagaatgct tactggttca
     2761 gcatgcaagg ccctgattgg gtcgctatcg ccacaacaaa atcaacctta tctccttgtt
     2821 ccttgtcttc tttttatgta ctcattctat tcattcagcc ttcctaacca ccagcatgct
     2881 cccagatctt atcatttata agccctaaac aaccatctgt taagtttctt tctatgcaat
     2941 tttagttttg taactgccac gcttttccac ggcagagaac agaccttcag gtgtactgcc
     3001 tgcctctggt gcccattcag ctgttagcat cagctacatc ccctgagttt actctactta
     3061 cttacagttc catttctgta gagacgctgc ctctgcagtg atgttagctt ccgaatccct
     3121 tgcctttgca gatctcttag aagctggcag gatcatttac gagggacaga ctctcaagtt
     3181 tctgccgttt gcttggttct ttcattgtga tcttcaccac tgcactggag gaagtgtgta
     3241 atgtgtgtaa ttccttcagc cagggaggtc ggtgctcact caggaataca gcatcagact
     3301 cattgtctta ggatcatcga ggaggaaggt ggtattttca ggaagctctt agggcttctt
     3361 cagacccgct tttaacatgt aattttggaa gaccctgggc tttactgcta gcatccaaaa
     3421 tgtcagctga gacacctctc caggtggcca gttagttatt tcaaccaatg ttccccatag
     3481 ccttaaattg tcctaaagtg acaactacct cacttggtag aaggtgacag aaaaatgagc
     3541 agtatctgag ctgtggttag agctgcaggg tataagaaac tttgtaacgg aacctttttg
     3601 tctttgtgaa ttataaatac agtaaaattt gtctcttttc aaagaacttg aagatcctga
     3661 agaggtggga atgcacctca gaggcagtaa gtgcttgtcc tgggggtgca ggctggccac
     3721 cccccaaaca aagcccacca ctaacaacaa aagccttcag aaatttatac ctagtatatt
     3781 ttactgtaaa ctcagttata caatttttgt aggtcttggg agaccctcat gcctgtttcc
     3841 ccaaatcact ccttacggat ggtagcttgc taaaggggag gaggctcttg acttcttatt
     3901 ttaatgagaa ttcactgtaa gtgactttgc tcttctgtgg gttgactcac tgtgaaagac
     3961 agatttcttt tcaaggccat tttttttaaa actgtatttg aatttggggc gagcaaagca
     4021 agctcatttt cttacccctg cctggtagtt ggagaagtga atgctgagag agctgcttca
     4081 gacagtgaag gacagacggt gcctcttttg tatgctgtgt atccttggcc tgcctgcctg
     4141 cctgcctgcc tgggtggctc cgctggatgc ttctgagcct ctgcgtgccc agacactgct
     4201 tgagtcagct cagtctcatc cctcagaatg agctcatcaa ggaccgaggg agaagtggag
     4261 tgagctggac actggagcca tgagcgctgt gtgccagcaa tcatcgatcc agaagctggt
     4321 tccaggagtg ggggtcttga tggtattgga aatgcattgc ttctaatggg tctgacctga
     4381 gttcataaaa catgactccc gttaatggga acataagagg cagccggcat acaactttac
     4441 agttttcctt tccttatgag aacatactga tcaaagccag gaaaagttta gcaactttga
     4501 taacttggtt accttgaaat gagaaagagc cagttcccca cccacattct tgttttctca
     4561 gcagagggtg gttttgtctg agatggctct ttgggtccca ctgttccatt ttaccatatg
     4621 accgcccatt caagggcata gccctctgtg aatcagttgt gttctcttta gcctacccta
     4681 cttgggtgat tgaggtttgg tgaataaaag gacccaaata ggccagagaa ttcccccagg
     4741 ccttgatacc cgtgaagaat ttggacgggt tacataattg ttgaaaggta tgctgagatg
     4801 gatcccagag ttaaaatgga ccttagctgt gcccacagct cttgtggact gagtggtaca
     4861 agttgaagtg tgcagacagg aaaataatgc cttctagtat tcccatggac tcgggtccaa
     4921 gatgggtgcc tgcatttgca tgctgagagg acaggggcag gtgtacggag ctctcccctt
     4981 aggcaggcac tgaaaccaag ggagaagcac acagagtagc cttgcacttt acaagtgtgt
     5041 ctaaatgttt gtgcttgtag tcttatagca gagagtattt ctttggggga acgtaggcag
     5101 ttgagctaac ccagagctaa cccagtggca tcttcgtgac tcgattatgg attctgttgc
     5161 tgttggagac cagatggtga ctacctcgaa aaggaggttt ggaagtcagg catggtaatt
     5221 agtgtccgcc tgaacttgga aggctgaagc aaggggacca cttgagttgg acattgtcaa
     5281 caatggggac ccatacatgg caggccctag aacccactgg gaataagcaa agcatatgga
     5341 taccctttaa cctcagcggg gacagaagtg gtcacataga ctcagacatg gggctttggg
     5401 ccacaagtgt cttccatgtg tcatttttct ttgacatgct cttatctccc caaggtattg
     5461 tttagatagg gcaccactct gtagcccagg ctgtcctgga attcaattta tttattaccc
     5521 aggcttgcct acaactcaca atagccatgt ctcagcctcc tgagtgctgg gattacaggc
     5581 ttgagccacc cagcccagct tcctttttgc actcttggtg ttaacttaaa aatgtcgagt
     5641 tcatttgctt agaacttgtg ggcagcactg ccatggcaga tcgtccccag cgtgagcctt
     5701 gagccagtta caacctgagc tggccactct ccatgtctgt gggactgttc ctgaaataac
     5761 agggctaaga aactactaga taagttatag cctgtgggta atgccttagt gttatttaga
     5821 taaaatatgt gtcattgata cttaatacat ggtaaggaat gttcagaaag aacaaagttt
     5881 tcagggatgt ctgtttgctg tgagtcttcc acatttgtgt aagaaaatct gatgccatgt
     5941 agttttttat ttctattgtg gcttgtaaat aatccccact ttaataaagt tttatacaat
     6001 t
//
