LOCUS       NM_025441               3737 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus nuclear export mediator factor (Nemf), mRNA.
ACCESSION   NM_025441
VERSION     NM_025441.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3737)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3737)
  AUTHORS   Thrun,A., Garzia,A., Kigoshi-Tansho,Y., Patil,P.R., Umbaugh,C.S.,
            Dallinger,T., Liu,J., Kreger,S., Patrizi,A., Cox,G.A., Tuschl,T.
            and Joazeiro,C.A.P.
  TITLE     Convergence of mammalian RQC and C-end rule proteolytic pathways
            via alanine tailing
  JOURNAL   Mol Cell 81 (10), 2112-2122 (2021)
   PUBMED   33909987
REFERENCE   3  (bases 1 to 3737)
  AUTHORS   Udagawa,T., Seki,M., Okuyama,T., Adachi,S., Natsume,T., Noguchi,T.,
            Matsuzawa,A. and Inada,T.
  TITLE     Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal
            Morphogenesis and Cell Survival
  JOURNAL   Cell Rep 34 (1), 108599 (2021)
   PUBMED   33406423
REFERENCE   4  (bases 1 to 3737)
  AUTHORS   Martin,P.B., Kigoshi-Tansho,Y., Sher,R.B., Ravenscroft,G.,
            Stauffer,J.E., Kumar,R., Yonashiro,R., Muller,T., Griffith,C.,
            Allen,W., Pehlivan,D., Harel,T., Zenker,M., Howting,D., Schanze,D.,
            Faqeih,E.A., Almontashiri,N.A.M., Maroofian,R., Houlden,H.,
            Mazaheri,N., Galehdari,H., Douglas,G., Posey,J.E., Ryan,M.,
            Lupski,J.R., Laing,N.G., Joazeiro,C.A.P. and Cox,G.A.
  TITLE     NEMF mutations that impair ribosome-associated quality control are
            associated with neuromuscular disease
  JOURNAL   Nat Commun 11 (1), 4625 (2020)
   PUBMED   32934225
  REMARK    GeneRIF: NEMF mutations that impair ribosome-associated quality
            control are associated with neuromuscular disease.
            Erratum:[Nat Commun. 2020 Oct 1;11(1):5022. doi:
            10.1038/s41467-020-18941-4.. PMID: 33004807]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3737)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3737)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   7  (bases 1 to 3737)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 3737)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY241581.1, AK039497.1, CB524482.1, AK149005.1 and BC039647.1.
            
            On Oct 8, 2011 this sequence version replaced NM_025441.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.1845733.1,
                                           SRR13948564.4274493.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BY241581.1         1-34
            35-1898             AK039497.1         2-1865
            1899-2389           CB524482.1         1-491
            2390-2926           AK149005.1         2-538
            2927-3737           BC039647.1         26-836
FEATURES             Location/Qualifiers
     source          1..3737
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 28.78 cM"
     gene            1..3737
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /note="nuclear export mediator factor"
                     /db_xref="GeneID:66244"
                     /db_xref="MGI:MGI:1918305"
     exon            1..126
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..3262
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /note="serologically defined colon cancer antigen 1
                     homolog; nuclear export mediator factor Nemf"
                     /codon_start=1
                     /product="ribosome quality control complex subunit NEMF"
                     /protein_id="NP_079717.2"
                     /db_xref="CCDS:CCDS25951.1"
                     /db_xref="GeneID:66244"
                     /db_xref="MGI:MGI:1918305"
                     /translation="MKSRFSTVDLRAVLAELNASLLGMRVNNVYDVDNKTYLIRLQKP
                     DFKATLLLESGIRIHTTEFEWPKNMMPSSFAMKCRKHLKSRRLVSAKQLGVDRIVDFQ
                     FGSDEAAYHLIIELYDRGNIVLTDYEYLILNILRFRTDEADDVKFAVRERYPIDHARA
                     AEPLLTLERLTEVIAAAPKGEVLKRVLNPLLPYGPALIEHCLIESGFSGNAKVDEKLE
                     SKDIEKILVCVQRAEDYLRKTSNFNGKGYIIQKREAKPSLDADKPAEDILTYEEFHPF
                     LFSQHLQCPYIEFESFDKAVDEFYSKIEGQKIDLKALQQEKQALKKLDNVRKDHENRL
                     EALQQAQEIDKLKGELIEMNLQIVDRAIQVVRSALANQIDWTEIGVIVKEAQAQGDPV
                     ACAIKELKLQTNHVTMLLRNPYLLSEEEDGDGDASIENSDAEAPKGKKKKQKNKQLQK
                     PQKNKPLLVDVDLSLSAYANAKKYYDHKRYAAKKTQRTVEAAEKAFKSAEKKTKQTLK
                     EVQTVTSIQKARKVYWFEKFLWFISSENYLIIGGRDQQQNEIIVKRYLTPGDIYVHAD
                     LHGATSCVIKNPTGEPIPPRTLTEAGTMALCYSAAWDARVITSAWWVYHHQVSKTAPT
                     GEYLTTGSFMIRGKKNFLPPSYLMMGFSFLFKVDESCVWRHRGERKVRVQDEDMETLT
                     SCTSELMAEEMEQLEGGDSSEEETEELHGMPGDVELMTQVDQEDIAVHSGRDELSSED
                     GEAKAVTKDQEPIGEMKEEEEDTFEYPDTTIDLSHLQSQRPLQKLAPREESLNSNDSK
                     SQGRRHLSAKERREMKKKKLPCESGDLEVIEEKDKERESAVHTEAYQNTSKNVAAGQP
                     MKRGQKSKMKKMKEKYKDQDDEDRELIMKLLASAGSNKEEKGKKGKKGKPKDEPVKKP
                     PQKPRGGQRVLDVVKEPPSLQVLAHDLQDLAVDDPHDDKEEHDLDQQGNEENLFDSLT
                     GQPHPEDVLMFAIPICAPYTIMTNYKYKVKLTPGVQKKGKAAKTALNSFMHSKEATAR
                     EKDLFRSVKDTDLSRNIPGKVKVSAPNLLHVKRK"
     exon            127..195
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            196..298
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            299..424
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            425..573
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..641
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..728
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..802
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..873
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..949
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1012
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1090
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1299
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1485
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1549
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1638
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1742
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1805
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1918
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..1976
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2035
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2156
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2406
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2449
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2499
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2653
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2731
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2926
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..2959
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3060
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3061..3104
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3184
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..3722
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3643..3648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /note="hexamer: ATTAAA"
     polyA_site      3670
                     /gene="Nemf"
                     /gene_synonym="1500011I12Rik; 4933405E14Rik; Sdccag1"
                     /note="major polyA site"
ORIGIN      
        1 agaagcatag tggtcctgcg tcggctcagt ccctgaaagg actgcggtag cgacacgcag
       61 cctagccatg aagagccggt tcagcacggt tgacctccgc gcagtgctcg cggaactgaa
      121 tgcgagcttg ctaggaatga gagtaaacaa cgtttatgat gtggataaca agacatatct
      181 tattcggctt caaaaacctg attttaaagc tacactgtta cttgagtctg gtatacgtat
      241 tcatacaaca gaatttgagt ggcctaagaa catgatgccg tcgagttttg ccatgaagtg
      301 tcgaaaacat ttgaagagtc ggagattagt cagtgcaaaa cagcttggtg tggacagaat
      361 tgtggatttc cagtttggaa gtgacgaagc tgcttatcac ttaatcattg agctctatga
      421 cagggggaac attgttctta cagattatga gtacctaatt ttaaatatcc taaggtttcg
      481 aactgatgaa gcagatgatg ttaagtttgc tgttcgtgaa cgctatccca tagatcatgc
      541 cagagctgct gaacctttgc tgactttgga aaggttgact gaagtaatag ctgctgctcc
      601 taaaggtgaa gtgctgaaga gagttcttaa cccattactt ccctatggac cagctcttat
      661 tgagcactgt cttatagaaa gtggattctc tggcaatgct aaagtggatg aaaaacttga
      721 gagcaaagat attgaaaaga tactggtttg tgtacagagg gcagaagact atttgaggaa
      781 aacatccaac ttcaatggaa agggctatat aattcagaaa agagaggcaa aaccaagcct
      841 ggatgcagat aaaccagctg aagacatact cacgtatgag gagtttcatc ctttcttgtt
      901 ttctcagcat ttacaatgtc catatataga atttgaatca tttgacaagg ccgtggatga
      961 attttattcc aagatagaag ggcagaaaat tgacttaaaa gctttacaac aggaaaaaca
     1021 agcactgaag aaattagata atgtccgaaa ggatcatgaa aacagattag aagctcttca
     1081 gcaggctcag gaaattgata aactgaaagg ggagctcata gagatgaacc tgcagatagt
     1141 ggacagagcc attcaggtag tccgaagtgc gttggccaac cagatagact ggacagaaat
     1201 cggagtgatt gtgaaagaag ctcaagctca aggagacccg gttgcatgtg caatcaaaga
     1261 gctaaaactg caaaccaacc acgttacgat gctgctacga aatccatact tgttatcaga
     1321 ggaggaagat ggtgatggtg atgccagcat tgagaacagt gatgctgaag caccaaaagg
     1381 gaaaaaaaaa aagcaaaaga acaagcagct gcagaagccg cagaagaaca agccgctgct
     1441 tgtagatgtg gatctcagcc tgtcagccta tgccaatgcc aaaaaatatt atgatcataa
     1501 gaggtatgct gctaaaaaaa cccagaggac tgttgaagct gctgagaagg cattcaaatc
     1561 agcagaaaag aaaacaaagc aaaccttaaa agaagtacaa acagttactt ctatccaaaa
     1621 agcaagaaaa gtgtattggt ttgagaaatt tctgtggttc attagttcag agaactattt
     1681 aatcataggt ggtcgggatc agcagcagaa tgagattatt gtgaaaagat acttgacacc
     1741 aggagacatt tatgtgcatg ctgatcttca tggagctacc agctgtgtaa ttaagaatcc
     1801 gacaggcgaa cccatccctc cacggacttt gactgaagca ggcacaatgg cactttgcta
     1861 cagtgctgct tgggatgcac gtgttatcac tagtgcttgg tgggtgtacc atcatcaggt
     1921 gtctaaaaca gcaccaacag gagaatattt aacaacagga agcttcatga taagaggaaa
     1981 aaagaatttc cttcctcctt catacctaat gatggggttt agcttccttt ttaaggtaga
     2041 tgagtcttgt gtctggagac atcgaggtga acgaaaagtc agagtgcagg atgaagacat
     2101 ggaaacactg acaagctgca caagtgaact catggcagaa gaaatggaac aactagaagg
     2161 gggtgatagc agtgaagaag agactgagga attacatgga atgcctggag acgtagaact
     2221 catgactcag gttgatcaag aggacattgc tgtgcacagt gggagagatg aactaagctc
     2281 tgaagatgga gaagccaaag cagttacaaa agatcaggag cccattggtg aaatgaagga
     2341 agaagaggaa gacacctttg aatatcctga tactaccatt gacttgtccc atcttcagtc
     2401 ccaacggcct ctacagaaac tggctccaag agaagagtct ttgaactcaa atgacagtaa
     2461 atcacagggc cgaagacatt tgtcagccaa ggagagaaga gaaatgaaaa agaaaaagct
     2521 cccatgtgag tcaggggatt tagaagtgat agaagaaaag gacaaagaga gagaaagtgc
     2581 tgtgcacact gaagcttacc aaaacacaag caaaaatgtg gcagctggac agccaatgaa
     2641 aagaggacag aagagtaaaa tgaaaaaaat gaaggaaaaa tacaaagacc aggatgatga
     2701 agatcgtgaa cttattatga agttgctggc atctgcaggt tcgaacaaag aagaaaaggg
     2761 gaagaaagga aagaaaggaa aaccaaaaga tgaacctgtg aaaaaacccc cacagaaacc
     2821 aagaggtgga cagcgggttt tagatgttgt taaagaacct ccgtccctgc aggttttagc
     2881 tcatgactta caagacttag ctgtcgatga tccacatgat gacaaggagg aacacgatct
     2941 ggatcagcag gggaatgagg aaaatctatt tgactctttg acagggcagc cacatcctga
     3001 ggatgtactg atgtttgcta ttccaatatg tgccccttac accatcatga caaactataa
     3061 atacaaagtg aaacttacac ctggagttca gaaaaagggg aaagctgcga agacagcctt
     3121 gaacagtttc atgcactcca aagaagccac agcaagagaa aaagacttat tccgaagtgt
     3181 gaaggacaca gatttatcaa gaaacattcc tggaaaagta aaagtgtccg cacctaatct
     3241 tctgcatgtg aagaggaaat agctgggatg agagcctcag cactgaacag ccagtttgta
     3301 gcctttggaa ggtcaacgat gcagacgtgt taacaggact tccactttac aaatgaacat
     3361 actgccttgc tatcaccaaa aggacttaag attttttccc aagttttata tatatctata
     3421 taaactatga tagtatttcc taaaatattt gtgaaaactt aatgatacac atctgtaatt
     3481 gtattgttct acattttatt gaacttcttg aggtttcatt tcatgatgta acgaccctga
     3541 aatagctcaa gtgcataaac tactgacgta gtggtctact gtatataaca tctaatacat
     3601 agtacagcca gtcacgagag gtttcgtttg gttaatggaa caattaaaca tttaagattt
     3661 gtgtcttgaa cactttgcca aattttacat caaatgcaaa aaaaaataac acaagaaaat
     3721 gaaaaaaaaa aaaaaaa
//
