LOCUS       NM_001037906            2812 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus NEL-like 1 (Nell1), mRNA.
ACCESSION   NM_001037906 XR_000494
VERSION     NM_001037906.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2812)
  AUTHORS   Ni,C., Liao,W., Nie,H., Ge,R., Liu,R., Zou,X., Yuan,Z. and Yan,F.
  TITLE     Neural epidermal growth factor-like 1 protein (Nell-1) alleviates
            periodontal tissue destruction in periodontitis by regulating the
            ratio of M2/M1 macrophage phenotypes
  JOURNAL   Int Immunopharmacol 137, 112522 (2024)
   PUBMED   38908089
  REMARK    GeneRIF: Neural epidermal growth factor-like 1 protein (Nell-1)
            alleviates periodontal tissue destruction in periodontitis by
            regulating the ratio of M2/M1 macrophage phenotypes.
REFERENCE   2  (bases 1 to 2812)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2812)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   4  (bases 1 to 2812)
  AUTHORS   Qin,Q., Gomez-Salazar,M., Tower,R.J., Chang,L., Morris,C.D.,
            McCarthy,E.F., Ting,K., Zhang,X. and James,A.W.
  TITLE     NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression
  JOURNAL   Cancer Res 82 (15), 2734-2747 (2022)
   PUBMED   35700263
REFERENCE   5  (bases 1 to 2812)
  AUTHORS   Koppes,E., Shaffer,B., Sadovsky,E., Himes,K., Barak,Y., Sadovsky,Y.
            and Chaillet,J.R.
  TITLE     Klf14 is an imprinted transcription factor that regulates placental
            growth
  JOURNAL   Placenta 88, 61-67 (2019)
   PUBMED   31675530
REFERENCE   6  (bases 1 to 2812)
  AUTHORS   Bouma,G.J., Hudson,Q.J., Washburn,L.L. and Eicher,E.M.
  TITLE     New candidate genes identified for controlling mouse gonadal sex
            determination and the early stages of granulosa and Sertoli cell
            differentiation
  JOURNAL   Biol Reprod 82 (2), 380-389 (2010)
   PUBMED   19864314
REFERENCE   7  (bases 1 to 2812)
  AUTHORS   Aghaloo,T., Cowan,C.M., Chou,Y.F., Zhang,X., Lee,H., Miao,S.,
            Hong,N., Kuroda,S., Wu,B., Ting,K. and Soo,C.
  TITLE     Nell-1-induced bone regeneration in calvarial defects
  JOURNAL   Am J Pathol 169 (3), 903-915 (2006)
   PUBMED   16936265
  REMARK    GeneRIF: Nell-1 reduced osterix-producing cells and increased bone
            sialoprotein, osteocalcin, and BMP-7 expression.
REFERENCE   8  (bases 1 to 2812)
  AUTHORS   Zhang,X., Cowan,C.M., Jiang,X., Soo,C., Miao,S., Carpenter,D.,
            Wu,B., Kuroda,S. and Ting,K.
  TITLE     Nell-1 induces acrania-like cranioskeletal deformities during mouse
            embryonic development
  JOURNAL   Lab Invest 86 (7), 633-644 (2006)
   PUBMED   16652108
REFERENCE   9  (bases 1 to 2812)
  AUTHORS   Desai,J., Shannon,M.E., Johnson,M.D., Ruff,D.W., Hughes,L.A.,
            Kerley,M.K., Carpenter,D.A., Johnson,D.K., Rinchik,E.M. and
            Culiat,C.T.
  TITLE     Nell1-deficient mice have reduced expression of extracellular
            matrix proteins causing cranial and vertebral defects
  JOURNAL   Hum Mol Genet 15 (8), 1329-1341 (2006)
   PUBMED   16537572
  REMARK    GeneRIF: Nell1-deficient mice have reduced expression of
            extracellular matrix proteins causing cranial and vertebral defects
            GeneRIF: A recessive, neonatal-lethal point mutation in the Nell1
            gene causes cranial and skeletal defects.
REFERENCE   10 (bases 1 to 2812)
  AUTHORS   Rinchik,E.M., Carpenter,D.A. and Johnson,D.K.
  TITLE     Functional annotation of mammalian genomic DNA sequence by chemical
            mutagenesis: a fine-structure genetic mutation map of a 1- to 2-cM
            segment of mouse chromosome 7 corresponding to human chromosome
            11p14-p15
  JOURNAL   Proc Natl Acad Sci U S A 99 (2), 844-849 (2002)
   PUBMED   11792855
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC116694.9,
            AC163402.5, AC115080.13, AC161929.4, AC110036.8, AC116734.14,
            AC128699.4 and AC171557.7.
            
            On Nov 17, 2006 this sequence version replaced NM_001037906.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY622226.1, SRR1660811.47430.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC116694.9         61920-62013
            95-223              AC116694.9         69246-69374
            224-374             AC116694.9         149188-149338
            375-545             AC163402.5         148246-148416       c
            546-642             AC163402.5         92625-92721         c
            643-715             AC163402.5         49292-49364         c
            716-798             AC163402.5         48610-48692         c
            799-933             AC163402.5         40020-40154         c
            934-1036            AC163402.5         38688-38790         c
            1037-1110           AC163402.5         19232-19305         c
            1111-1210           AC163402.5         10681-10780         c
            1211-1339           AC115080.13        52131-52259
            1340-1465           AC161929.4         107896-108021
            1466-1588           AC110036.8         166459-166581
            1589-1684           AC116734.14        170946-171041
            1685-1825           AC128699.4         123884-124024
            1826-2019           AC128699.4         146107-146300
            2020-2196           AC128699.4         151453-151629
            2197-2421           AC171557.7         23682-23906
            2422-2812           AC171557.7         30377-30767
FEATURES             Location/Qualifiers
     source          1..2812
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 31.79 cM"
     gene            1..2812
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /note="NEL-like 1"
                     /db_xref="GeneID:338352"
                     /db_xref="MGI:MGI:2443902"
     exon            1..94
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            95..223
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            224..374
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            375..545
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            546..642
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            643..715
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            716..798
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            799..933
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1036
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1110
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1210
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1339
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1465
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1588
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1684
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1825
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..2019
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2196
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2421
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2812
                     /gene="Nell1"
                     /gene_synonym="B230343H07Rik; l7R6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgttggtgc gccctgcttg gcggggggcc tccggagcga tgccgatgga tgtgatttta
       61 gttttgtggt tctgtgtgtg caccgccagg acagtgctgg gctttgggat ggaccctgac
      121 cttcagatgg acatcatcac tgaacttgac cttgtgaaca ccaccctggg cgtcactcag
      181 gtggctggac tacacaatgc cagtaaggca tttctgtttc aagatgtaca gagagagatc
      241 cactcagccc ctcatgtgag tgagaagctg atccagctat tccggaataa gagtgagttt
      301 acctttttgg ctacagtgca gcagaagccg tccacctcag gggtgatact gtcgatccgg
      361 gagctggaac acagctattt tgaactggag agcagtggcc caagagaaga gatacgctat
      421 cattacatcc atggcggcaa gcccaggact gaggcccttc cctaccgcat ggccgatgga
      481 cagtggcaca aggtcgcgct gtctgtgagc gcctctcacc tcctactcca tgtcgactgc
      541 aataggattt atgagcgtgt gatagatcct ccggagacca accttcctcc aggaagcaat
      601 ctatggcttg ggcaacgtaa tcaaaagcat ggctttttca aaggaatcat ccaagatggc
      661 aagatcatct tcatgccgaa cggcttcatc acacagtgcc ccaacctaaa tcgcacttgc
      721 ccaacatgca gtgatttcct gagcctggtt caaggaataa tggatttgca agagcttttg
      781 gccaagatga ctgcaaaact gaattatgca gagacgagac ttggtcaact ggaaaattgc
      841 cactgtgaga agacctgcca agtgagtggg ctgctctaca gggaccaaga ctcctgggta
      901 gatggtgaca actgcaggaa ctgcacatgc aaaagtggtg ctgtggagtg ccgaaggatg
      961 tcctgtcccc cactcaactg ttccccagac tcacttcctg tgcatatttc tggccaatgt
     1021 tgtaaagttt gcagaccaaa atgtatctat ggaggaaaag ttcttgctga gggccagcgg
     1081 attttaacca agacctgccg ggaatgtcga ggtggagtct tggtaaaaat cacagaagct
     1141 tgccctcctt tgaactgctc agagaaggat catattcttc cggagaacca gtgctgcagg
     1201 gtctgccgag gtcataactt ctgtgcagaa gcacctaagt gtggagaaaa ctcggaatgc
     1261 aaaaattgga atacaaaagc gacttgtgag tgcaagaatg gatacatctc tgtccagggc
     1321 aactctgcat actgtgaaga tatcgatgag tgtgcagcaa agatgcacta ctgtcatgcc
     1381 aacacggtgt gtgtcaactt gccggggtta tatcgctgtg actgcatccc aggatacatc
     1441 cgtgtggatg acttctcttg tacggagcat gatgattgtg gcagcggaca acacaactgt
     1501 gacaaaaatg ccatctgtac caacacagtc cagggacaca gctgtacctg ccagccaggc
     1561 tacgtgggaa atggtactgt ctgcaaagca ttctgtgaag agggttgcag atacggaggt
     1621 acctgtgtgg cccctaacaa atgtgtctgt ccttctggat tcacaggaag ccactgtgag
     1681 aaagatattg atgaatgtgc agagggattc gttgagtgcc acaaccactc ccgctgcgtt
     1741 aaccttccag ggtggtacca ctgtgagtgc agaagcggtt tccatgacga tgggacctat
     1801 tcactgtccg gggagtcctg cattgatatt gatgaatgtg ccttaagaac tcacacttgt
     1861 tggaatgact ctgcctgcat caacttagca ggaggatttg actgcctgtg tccctctggg
     1921 ccctcctgct ctggtgactg tccccacgaa ggggggctga agcataatgg gcaggtgtgg
     1981 attctgagag aagacaggtg ttcagtctgt tcctgtaagg atgggaagat attctgccgg
     2041 cggacagctt gtgattgcca gaatccaaat gttgaccttt tctgctgccc agagtgtgac
     2101 accagggtca ctagccaatg tttagatcaa agcggacaga agctctatcg aagtggagac
     2161 aactggaccc acagctgcca gcagtgccga tgtctggaag gagaggcaga ctgctggcct
     2221 ctagcttgcc ctagtttgag ctgtgaatac acagccatct ttgaaggaga gtgttgtccc
     2281 cgctgtgtca gtgacccctg cctggctgat aatattgcct atgacatcag aaaaacttgc
     2341 ctggacagct ctggtatttc gaggctgagc ggcgcagtgt ggacaatggc tggatctccc
     2401 tgtacaacct gtcaatgcaa gaatgggaga gtctgctgct ctgtggatct ggtgtgtctt
     2461 gagaataact gaagatttta aatggactca tcacatgaga aaatggacaa aatgaccatc
     2521 caacctgagg aagaggaggg gctgatttct ttttcttttt aaccacagtc aattaccaaa
     2581 gtctccatca gaggaaggcg tttgggttgc ctttaccact ttgctcatcc ttgctgacct
     2641 agtctagatg cctgcagtac cgtgtatttc ggtcgatggt tgttgagtct ccgtgctgta
     2701 aatcacattt cccttgtcag atcatttaca gatacattta aaggattcca tgataaatgt
     2761 taaagtacct tttgtttatt ttgtgtacca acataataga gacttggcac ca
//
