LOCUS       NM_020580               2254 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus negative elongation factor complex member C/D, Th1l
            (Nelfcd), mRNA.
ACCESSION   NM_020580
VERSION     NM_020580.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2254)
  AUTHORS   Abe,K., Schauer,T. and Torres-Padilla,M.E.
  TITLE     Distinct patterns of RNA polymerase II and transcriptional
            elongation characterize mammalian genome activation
  JOURNAL   Cell Rep 41 (13), 111865 (2022)
   PUBMED   36577375
REFERENCE   2  (bases 1 to 2254)
  AUTHORS   Pan,H., Zhao,X., Zhang,X., Abouelsoud,M., Sun,J., April,C.,
            Amleh,A., Fan,J.B., Hu,Y. and Li,R.
  TITLE     Translational Initiation at a Non-AUG Start Codon for Human and
            Mouse Negative Elongation Factor-B
  JOURNAL   PLoS One 10 (5), e0127422 (2015)
   PUBMED   26010750
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2254)
  AUTHORS   Campbell,G.R., Baudhuin,A., Vranizan,K. and Ngai,J.
  TITLE     Transcription factors expressed in olfactory bulb local progenitor
            cells revealed by genome-wide transcriptome profiling
  JOURNAL   Mol Cell Neurosci 46 (2), 548-561 (2011)
   PUBMED   21194568
REFERENCE   4  (bases 1 to 2254)
  AUTHORS   Yang,Y., Zou,W., Kong,X., Wang,H., Zong,H., Jiang,J., Wang,Y.,
            Hong,Y., Chi,Y., Xie,J. and Gu,J.
  TITLE     Trihydrophobin 1 attenuates androgen signal transduction through
            promoting androgen receptor degradation
  JOURNAL   J Cell Biochem 109 (5), 1013-1024 (2010)
   PUBMED   20069563
  REMARK    GeneRIF: These results indicate that TH1 is a novel regulator to
            control the duration and magnitude of androgen signal transduction
            and might be directly involved in androgen-related developmental,
            physiological, and pathological processes.
REFERENCE   5  (bases 1 to 2254)
  AUTHORS   Kikuchi,N., Ishii,Y., Morishima,Y., Yageta,Y., Haraguchi,N.,
            Itoh,K., Yamamoto,M. and Hizawa,N.
  TITLE     Nrf2 protects against pulmonary fibrosis by regulating the lung
            oxidant level and Th1/Th2 balance
  JOURNAL   Respir Res 11 (1), 31 (2010)
   PUBMED   20298567
  REMARK    GeneRIF: results indicated that Nrf2 protects against the
            development of pulmonary fibrosis by regulating the cellular redox
            level and lung Th1/Th2 balance.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2254)
  AUTHORS   Martucci,C., Franchi,S., Lattuada,D., Panerai,A.E. and Sacerdote,P.
  TITLE     Differential involvement of RelB in morphine-induced modulation of
            chemotaxis, NO, and cytokine production in murine macrophages and
            lymphocytes
  JOURNAL   J Leukoc Biol 81 (1), 344-354 (2007)
   PUBMED   17023558
  REMARK    GeneRIF: In conclusion, our data suggest that RelB is an important
            target for morphine modulation of proinflammatory and Th1
            cytokines. They also indicate that morphine uses multiple
            intracellular pathways to exert its generalized immunosuppression.
REFERENCE   7  (bases 1 to 2254)
  AUTHORS   Guan,X., Liu,J., Ding,F., Gu,J. and Gu,X.
  TITLE     Expression and distribution of trihydrophobin 1 in postnatal
            developing mouse testis
  JOURNAL   Mol Cell Biochem 292 (1-2), 179-187 (2006)
   PUBMED   16786193
  REMARK    GeneRIF: The gene expression of TH1 in mouse testis and changes of
            TH1 protein during postnatal development, were analyzed.
REFERENCE   8  (bases 1 to 2254)
  AUTHORS   Zanoni,I., Foti,M., Ricciardi-Castagnoli,P. and Granucci,F.
  TITLE     TLR-dependent activation stimuli associated with Th1 responses
            confer NK cell stimulatory capacity to mouse dendritic cells
  JOURNAL   J Immunol 175 (1), 286-292 (2005)
   PUBMED   15972660
REFERENCE   9  (bases 1 to 2254)
  AUTHORS   Bonthron,D.T., Hayward,B.E., Moran,V. and Strain,L.
  TITLE     Characterization of TH1 and CTSZ, two non-imprinted genes
            downstream of GNAS1 in chromosome 20q13
  JOURNAL   Hum Genet 107 (2), 165-175 (2000)
   PUBMED   11030415
REFERENCE   10 (bases 1 to 2254)
  AUTHORS   Deussing,J., von Olshausen,I. and Peters,C.
  TITLE     Murine and human cathepsin Z: cDNA-cloning, characterization of the
            genes and chromosomal localization
  JOURNAL   Biochim Biophys Acta 1491 (1-3), 93-106 (2000)
   PUBMED   10760573
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844534.4.
            
            On Jan 10, 2023 this sequence version replaced NM_020580.3.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006959.1, AJ238743.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AL844534.4         59667-59793
            128-246             AL844534.4         63864-63982
            247-356             AL844534.4         64161-64270
            357-466             AL844534.4         65547-65656
            467-574             AL844534.4         66404-66511
            575-727             AL844534.4         66889-67041
            728-858             AL844534.4         67213-67343
            859-1024            AL844534.4         67820-67985
            1025-1159           AL844534.4         68443-68577
            1160-1299           AL844534.4         68951-69090
            1300-1414           AL844534.4         69750-69864
            1415-1510           AL844534.4         70154-70249
            1511-1651           AL844534.4         70326-70466
            1652-1781           AL844534.4         70654-70783
            1782-2254           AL844534.4         70868-71340
FEATURES             Location/Qualifiers
     source          1..2254
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 97.93 cM"
     gene            1..2254
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /note="negative elongation factor complex member C/D,
                     Th1l"
                     /db_xref="GeneID:57314"
                     /db_xref="MGI:MGI:1926424"
     exon            1..127
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1816
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /note="TH1 homolog; TH1-like homolog; trihydrophobin 1
                     homolog; TH1-like protein"
                     /codon_start=1
                     /product="negative elongation factor D"
                     /protein_id="NP_065605.3"
                     /db_xref="CCDS:CCDS38358.1"
                     /db_xref="GeneID:57314"
                     /db_xref="MGI:MGI:1926424"
                     /translation="MGEDYFGNASEWGEEADGGQHQEDDSGEGEDDAEVQQECLHKFS
                     TRDYIMEPSIFNTLKRYFQAGGSPENVIQLLSENYTAVAQTVNLLAEWLIQTGVEPVQ
                     VQETVENHLKSLLIKHFDPRKADSIFTEEGETPAWLEQMIAHTTWRDLFYKLAEAHPD
                     CLMLNFTVKLISDAGYQGEITSVSTACQQLEVFSRVLRTSLATILDGGEENLEKNLPE
                     FAKMVCHGEHTYLFAQAMMSVLAQEEQGGSAVRRVAQEVQRFAQEKGHDASQITLALG
                     TAASYPRACQALGAMLSRGALNPADITVLFKMFTSMDPPPVELIRVPAFLDLFMQSLF
                     KPGAKINQDHKHKYIHILAYAASVVETWKKNKRVSIGKDELKSTSKAIETVHNLCCNE
                     NKGASELVAELSTLYQCIRFPVVAMGVLKWVDWTVSEPRYFQLQTDHTPVHLALLDEI
                     STCHQLLHPQVLQLLVKLFETEHSQLDVMEQLELKKTLLDRMVHLLSRGYVLPVVSYI
                     RKCLEKLDTDISLIRYFVTEVLDVIAPPYTSDFVQLFLPILENDSIAGTIKAEGEHDP
                     VTEFIAHCKSNFIVVN"
     exon            128..246
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /inference="alignment:Splign:2.1.0"
     exon            247..356
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /inference="alignment:Splign:2.1.0"
     exon            357..466
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /inference="alignment:Splign:2.1.0"
     exon            467..574
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /inference="alignment:Splign:2.1.0"
     exon            575..727
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /inference="alignment:Splign:2.1.0"
     exon            728..858
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1024
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1159
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1299
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1414
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1510
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1651
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1781
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..2254
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2228..2233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /note="hexamer: AATAAA"
     polyA_site      2254
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /note="major polyA site"
ORIGIN      
        1 gttgtgtccg gcgcacgcgc agtgaggaga cgcggcagat atggcgggtc cggcgccggg
       61 tacaattatg ggagaagact acttcgggaa tgcctcagag tggggcgaag aggcagacgg
      121 cggccagcat caggaagatg attccggaga aggagaggac gatgctgagg tgcagcagga
      181 atgcctgcat aagttttcca cccgggacta catcatggag ccctccatct tcaacactct
      241 gaagaggtat ttccaggcag gagggtctcc agaaaacgtc atccagctct tatctgagaa
      301 ctacacggca gtggcccaga cagtgaacct gctggctgag tggctcattc agacaggcgt
      361 tgagcctgtg caggtgcagg agactgtgga aaaccacttg aagagtttgc tgatcaagca
      421 cttcgaccct cggaaagcag attctatttt cactgaagaa ggagagaccc cagcttggct
      481 tgagcagatg atcgcacaca caacatggag agatctgttt tataagttgg ccgaggccca
      541 tcctgactgt ttgatgctca acttcactgt gaagctcatt tctgatgcgg ggtaccaagg
      601 ggagatcacc agcgtgtcca cagcctgcca gcagttggaa gtgttctcca gagtgcttcg
      661 gacctctcta gccacgatct tggatggggg agaagaaaac cttgagaaaa atctccctga
      721 gtttgcaaag atggtatgcc atggcgagca cacgtacctg tttgcacagg ccatgatgtc
      781 cgtgctggca caggaggaac agggtggttc tgcagtgcgc agggtcgctc aggaagtcca
      841 gcgcttcgcc caggagaagg gccatgatgc cagtcagatc acgctggcct tgggcacagc
      901 tgcctcctac ccccgagcct gccaagcgct tggcgccatg ctgtccagag gagccctgaa
      961 tcctgcagac atcacggtct tgttcaagat gttcaccagc atggaccctc ctcccgtgga
     1021 actcatccgg gtgccggcct tcctggacct gttcatgcag tcgctcttca agccaggggc
     1081 caagatcaac caggaccaca aacacaagta catccacatc ctggcttacg ctgccagtgt
     1141 ggttgagacc tggaagaaga acaagcgggt cagcattggc aaagacgagc tcaagtccac
     1201 gtcaaaggct atcgagactg tccacaacct gtgctgcaac gagaacaaag gggcctctga
     1261 gctggtggct gagctgagca cactttatca gtgcattcgg tttccagtgg tggcgatggg
     1321 cgtgctcaag tgggtagatt ggaccgtatc ggagccaagg tacttccagc tgcagactga
     1381 tcacactcca gttcacctgg ccttgttgga tgagatcagc acctgccacc agctcctgca
     1441 cccccaggtt ctgcagctgc ttgttaagct ttttgagaca gagcactccc agctagacgt
     1501 gatggagcag ctcgagttga aaaagaccct gctggacagg atggtgcacc tgctgagccg
     1561 cggctacgtc ctgccggtgg tcagttatat ccgcaaatgt ctggagaagc tggacacgga
     1621 catctccctc atccgctact ttgtcactga ggttctggat gtcatcgccc ctccgtacac
     1681 ctcagacttt gtgcagcttt tcctccccat cttggaaaat gacagcatcg cgggcaccat
     1741 caaggcagag ggcgagcatg accccgtgac ggagttcatt gctcactgca agtcgaactt
     1801 catcgtggtg aactgagcgc atctgtaact gaagccgaaa cttccatgcc agcctggggt
     1861 ggggggacca gaggactcgt tcagaaagct gctctgtgaa gaggctcaac cagcctcctg
     1921 gaagcagggt ctgctgggaa gaagcaggca actcttctca aaggtagctt ctgtggcaga
     1981 cagcccccct gtgtcgcagt gtggctctgt gctacatgtc acatcccagg cgtgtgccac
     2041 ctctgaacag ggacccagtg ggcctctggg tagtgggaat ctagcagctg ggacacttca
     2101 tgaagggttt atgtaagttt ccttcctatg acccagatgg tcagttactt taagtttcca
     2161 agagtaatgt tgagttgtat gtgtgtgtgt gggagtgtgc gtgtgttgtg tgtgctagtc
     2221 tcgtgtaaat aaagtacaca agcgtgggaa gcca
//
