LOCUS       NP_065605                582 aa            linear   ROD 14-JUN-2024
DEFINITION  negative elongation factor D [Mus musculus].
ACCESSION   NP_065605
VERSION     NP_065605.3
DBSOURCE    REFSEQ: accession NM_020580.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 582)
  AUTHORS   Abe,K., Schauer,T. and Torres-Padilla,M.E.
  TITLE     Distinct patterns of RNA polymerase II and transcriptional
            elongation characterize mammalian genome activation
  JOURNAL   Cell Rep 41 (13), 111865 (2022)
   PUBMED   36577375
REFERENCE   2  (residues 1 to 582)
  AUTHORS   Pan,H., Zhao,X., Zhang,X., Abouelsoud,M., Sun,J., April,C.,
            Amleh,A., Fan,J.B., Hu,Y. and Li,R.
  TITLE     Translational Initiation at a Non-AUG Start Codon for Human and
            Mouse Negative Elongation Factor-B
  JOURNAL   PLoS One 10 (5), e0127422 (2015)
   PUBMED   26010750
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 582)
  AUTHORS   Campbell,G.R., Baudhuin,A., Vranizan,K. and Ngai,J.
  TITLE     Transcription factors expressed in olfactory bulb local progenitor
            cells revealed by genome-wide transcriptome profiling
  JOURNAL   Mol Cell Neurosci 46 (2), 548-561 (2011)
   PUBMED   21194568
REFERENCE   4  (residues 1 to 582)
  AUTHORS   Yang,Y., Zou,W., Kong,X., Wang,H., Zong,H., Jiang,J., Wang,Y.,
            Hong,Y., Chi,Y., Xie,J. and Gu,J.
  TITLE     Trihydrophobin 1 attenuates androgen signal transduction through
            promoting androgen receptor degradation
  JOURNAL   J Cell Biochem 109 (5), 1013-1024 (2010)
   PUBMED   20069563
  REMARK    GeneRIF: These results indicate that TH1 is a novel regulator to
            control the duration and magnitude of androgen signal transduction
            and might be directly involved in androgen-related developmental,
            physiological, and pathological processes.
REFERENCE   5  (residues 1 to 582)
  AUTHORS   Kikuchi,N., Ishii,Y., Morishima,Y., Yageta,Y., Haraguchi,N.,
            Itoh,K., Yamamoto,M. and Hizawa,N.
  TITLE     Nrf2 protects against pulmonary fibrosis by regulating the lung
            oxidant level and Th1/Th2 balance
  JOURNAL   Respir Res 11 (1), 31 (2010)
   PUBMED   20298567
  REMARK    GeneRIF: results indicated that Nrf2 protects against the
            development of pulmonary fibrosis by regulating the cellular redox
            level and lung Th1/Th2 balance.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 582)
  AUTHORS   Martucci,C., Franchi,S., Lattuada,D., Panerai,A.E. and Sacerdote,P.
  TITLE     Differential involvement of RelB in morphine-induced modulation of
            chemotaxis, NO, and cytokine production in murine macrophages and
            lymphocytes
  JOURNAL   J Leukoc Biol 81 (1), 344-354 (2007)
   PUBMED   17023558
  REMARK    GeneRIF: In conclusion, our data suggest that RelB is an important
            target for morphine modulation of proinflammatory and Th1
            cytokines. They also indicate that morphine uses multiple
            intracellular pathways to exert its generalized immunosuppression.
REFERENCE   7  (residues 1 to 582)
  AUTHORS   Guan,X., Liu,J., Ding,F., Gu,J. and Gu,X.
  TITLE     Expression and distribution of trihydrophobin 1 in postnatal
            developing mouse testis
  JOURNAL   Mol Cell Biochem 292 (1-2), 179-187 (2006)
   PUBMED   16786193
  REMARK    GeneRIF: The gene expression of TH1 in mouse testis and changes of
            TH1 protein during postnatal development, were analyzed.
REFERENCE   8  (residues 1 to 582)
  AUTHORS   Zanoni,I., Foti,M., Ricciardi-Castagnoli,P. and Granucci,F.
  TITLE     TLR-dependent activation stimuli associated with Th1 responses
            confer NK cell stimulatory capacity to mouse dendritic cells
  JOURNAL   J Immunol 175 (1), 286-292 (2005)
   PUBMED   15972660
REFERENCE   9  (residues 1 to 582)
  AUTHORS   Bonthron,D.T., Hayward,B.E., Moran,V. and Strain,L.
  TITLE     Characterization of TH1 and CTSZ, two non-imprinted genes
            downstream of GNAS1 in chromosome 20q13
  JOURNAL   Hum Genet 107 (2), 165-175 (2000)
   PUBMED   11030415
REFERENCE   10 (residues 1 to 582)
  AUTHORS   Deussing,J., von Olshausen,I. and Peters,C.
  TITLE     Murine and human cathepsin Z: cDNA-cloning, characterization of the
            genes and chromosomal localization
  JOURNAL   Biochim Biophys Acta 1491 (1-3), 93-106 (2000)
   PUBMED   10760573
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844534.4.
            
            On Jan 10, 2023 this sequence version replaced NP_065605.2.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006959.1, AJ238743.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..582
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 97.93 cM"
     Protein         1..582
                     /product="negative elongation factor D"
                     /note="TH1 homolog; TH1-like homolog; trihydrophobin 1
                     homolog; TH1-like protein"
                     /calculated_mol_wt=65349
     Region          2..579
                     /region_name="TH1"
                     /note="TH1 protein; pfam04858"
                     /db_xref="CDD:398497"
     CDS             1..582
                     /gene="Nelfcd"
                     /gene_synonym="2410003I03Rik; NELF-D; Th1; Th1l"
                     /coded_by="NM_020580.4:68..1816"
                     /db_xref="CCDS:CCDS38358.1"
                     /db_xref="GeneID:57314"
                     /db_xref="MGI:MGI:1926424"
ORIGIN      
        1 mgedyfgnas ewgeeadggq hqeddsgege ddaevqqecl hkfstrdyim epsifntlkr
       61 yfqaggspen viqllsenyt avaqtvnlla ewliqtgvep vqvqetvenh lksllikhfd
      121 prkadsifte egetpawleq miahttwrdl fyklaeahpd clmlnftvkl isdagyqgei
      181 tsvstacqql evfsrvlrts latildggee nleknlpefa kmvchgehty lfaqammsvl
      241 aqeeqggsav rrvaqevqrf aqekghdasq itlalgtaas ypracqalga mlsrgalnpa
      301 ditvlfkmft smdpppveli rvpafldlfm qslfkpgaki nqdhkhkyih ilayaasvve
      361 twkknkrvsi gkdelkstsk aietvhnlcc nenkgaselv aelstlyqci rfpvvamgvl
      421 kwvdwtvsep ryfqlqtdht pvhlalldei stchqllhpq vlqllvklfe tehsqldvme
      481 qlelkktlld rmvhllsrgy vlpvvsyirk clekldtdis liryfvtevl dviappytsd
      541 fvqlflpile ndsiagtika egehdpvtef iahcksnfiv vn
//
