LOCUS       NM_011914               2435 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus negative elongation factor complex member A, Whsc2
            (Nelfa), transcript variant 1, mRNA.
ACCESSION   NM_011914
VERSION     NM_011914.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2435)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2435)
  AUTHORS   Wu,B., Wang,Y., Wei,X., Zhang,J., Wu,J., Cao,G., Zhang,Y., Liu,J.,
            Li,X. and Bao,S.
  TITLE     NELFA and BCL2 induce the 2C-like state in mouse embryonic stem
            cells in a chemically defined medium
  JOURNAL   Cell Prolif 57 (2), e13534 (2024)
   PUBMED   37592709
  REMARK    GeneRIF: NELFA and BCL2 induce the 2C-like state in mouse embryonic
            stem cells in a chemically defined medium.
REFERENCE   3  (bases 1 to 2435)
  AUTHORS   Abe,K., Schauer,T. and Torres-Padilla,M.E.
  TITLE     Distinct patterns of RNA polymerase II and transcriptional
            elongation characterize mammalian genome activation
  JOURNAL   Cell Rep 41 (13), 111865 (2022)
   PUBMED   36577375
REFERENCE   4  (bases 1 to 2435)
  AUTHORS   Alikunju,S., Severinova,E., Yang,Z., Ivessa,A. and Sayed,D.
  TITLE     Acute NelfA knockdown restricts compensatory gene expression and
            precipitates ventricular dysfunction during cardiac hypertrophy
  JOURNAL   J Mol Cell Cardiol 142, 93-104 (2020)
   PUBMED   32278832
  REMARK    GeneRIF: Acute NelfA knockdown restricts compensatory gene
            expression and precipitates ventricular dysfunction during cardiac
            hypertrophy.
REFERENCE   5  (bases 1 to 2435)
  AUTHORS   Hu,Z., Tan,D.E.K., Chia,G., Tan,H., Leong,H.F., Chen,B.J.,
            Lau,M.S., Tan,K.Y.S., Bi,X., Yang,D., Ho,Y.S., Wu,B., Bao,S.,
            Wong,E.S.M. and Tee,W.W.
  TITLE     Maternal factor NELFA drives a 2C-like state in mouse embryonic
            stem cells
  JOURNAL   Nat Cell Biol 22 (2), 175-186 (2020)
   PUBMED   31932739
  REMARK    GeneRIF: Maternal factor NELFA drives a 2C-like state in mouse
            embryonic stem cells through Dux.
REFERENCE   6  (bases 1 to 2435)
  AUTHORS   Liu,N., Bezprozvannaya,S., Williams,A.H., Qi,X., Richardson,J.A.,
            Bassel-Duby,R. and Olson,E.N.
  TITLE     microRNA-133a regulates cardiomyocyte proliferation and suppresses
            smooth muscle gene expression in the heart
  JOURNAL   Genes Dev 22 (23), 3242-3254 (2008)
   PUBMED   19015276
REFERENCE   7  (bases 1 to 2435)
  AUTHORS   Care,A., Catalucci,D., Felicetti,F., Bonci,D., Addario,A.,
            Gallo,P., Bang,M.L., Segnalini,P., Gu,Y., Dalton,N.D., Elia,L.,
            Latronico,M.V., Hoydal,M., Autore,C., Russo,M.A., Dorn,G.W. 2nd,
            Ellingsen,O., Ruiz-Lozano,P., Peterson,K.L., Croce,C.M., Peschle,C.
            and Condorelli,G.
  TITLE     MicroRNA-133 controls cardiac hypertrophy
  JOURNAL   Nat Med 13 (5), 613-618 (2007)
   PUBMED   17468766
REFERENCE   8  (bases 1 to 2435)
  AUTHORS   Naf,D., Wilson,L.A., Bergstrom,R.A., Smith,R.S., Goodwin,N.C.,
            Verkerk,A., van Ommen,G.J., Ackerman,S.L., Frankel,W.N. and
            Schimenti,J.C.
  TITLE     Mouse models for the Wolf-Hirschhorn deletion syndrome
  JOURNAL   Hum Mol Genet 10 (2), 91-98 (2001)
   PUBMED   11152656
REFERENCE   9  (bases 1 to 2435)
  AUTHORS   Wright,T.J., Costa,J.L., Naranjo,C., Francis-West,P. and
            Altherr,M.R.
  TITLE     Comparative analysis of a novel gene from the
            Wolf-Hirschhorn/Pitt-Rogers-Danks syndrome critical region
  JOURNAL   Genomics 59 (2), 203-212 (1999)
   PUBMED   10409432
REFERENCE   10 (bases 1 to 2435)
  AUTHORS   Wright,T.J., Ricke,D.O., Denison,K., Abmayr,S., Cotter,P.D.,
            Hirschhorn,K., Keinanen,M., McDonald-McGinn,D., Somer,M.,
            Spinner,N., Yang-Feng,T., Zackai,E. and Altherr,M.R.
  TITLE     A transcript map of the newly defined 165 kb Wolf-Hirschhorn
            syndrome critical region
  JOURNAL   Hum Mol Genet 6 (2), 317-324 (1997)
   PUBMED   9063753
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163329.6.
            
            On Jan 6, 2023 this sequence version replaced NM_011914.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146185.1, AK019191.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               AC163329.6         70608-70853
            247-418             AC163329.6         84862-85033
            419-580             AC163329.6         86226-86387
            581-670             AC163329.6         103419-103508
            671-801             AC163329.6         105004-105134
            802-871             AC163329.6         105222-105291
            872-960             AC163329.6         105600-105688
            961-1072            AC163329.6         106355-106466
            1073-1344           AC163329.6         107326-107597
            1345-1444           AC163329.6         107768-107867
            1445-2435           AC163329.6         107970-108960
FEATURES             Location/Qualifiers
     source          1..2435
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.83 cM"
     gene            1..2435
                     /gene="Nelfa"
                     /gene_synonym="Whsc2; Whsc2h"
                     /note="negative elongation factor complex member A, Whsc2"
                     /db_xref="GeneID:24116"
                     /db_xref="MGI:MGI:1346098"
     exon            1..246
                     /gene="Nelfa"
                     /gene_synonym="Whsc2; Whsc2h"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1629
                     /gene="Nelfa"
                     /gene_synonym="Whsc2; Whsc2h"
                     /note="isoform 1 is encoded by transcript variant 1;
                     negative elongation factor A; Wolf-Hirschhorn syndrome
                     candidate 2 homolog"
                     /codon_start=1
                     /product="negative elongation factor A isoform 1"
                     /protein_id="NP_036044.1"
                     /db_xref="CCDS:CCDS19208.1"
                     /db_xref="GeneID:24116"
                     /db_xref="MGI:MGI:1346098"
                     /translation="MASMRESDTGLWLHNKLGATDELWAPPSIASLLTAAVIDNIRLC
                     FHRLSSAVKLKLLLGTLHLPRRTVDEMKAALMDIIQLATLDSDPWVLMVADILKSFPD
                     TGSLNLDLEEQNPNVQDILGELREKVSECEASAMLPLECQYLNKNALTTLAGPLTPPV
                     KHFQLKRKPKSATLRAELLQKSTETAQQLKRSAGVPFHAKGRGLLRKMDTTTPLKGIP
                     KQAPFRSPTTPSVFSPSGNRTPIPPSRTPLQKERGVKLLDISELNTVGAGREAKRRRK
                     TLDTEVVEKPTKEETVVENATPDYAAGLVSTQKLGSLNSEPTLPSTSYLPSTPSVVPA
                     SSYIPSSETPPAPPSREASRPPEEPSAPSPTLPTQFKQRAPMYNSGLSPATPAPAAPT
                     SPLTPTTPPAVTPTAQTPPVAMVAPQTQAPAPVQQQPKKNLSLTREQMFAAQEMFKTA
                     NKVTRPEKALILGFMAGSRENPCPEQGDVIQIKLSEHTEDLPKADGQGSTTMLVDTVF
                     EMNYATGQWTRFKKYKPMTNVS"
     exon            247..418
                     /gene="Nelfa"
                     /gene_synonym="Whsc2; Whsc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            419..580
                     /gene="Nelfa"
                     /gene_synonym="Whsc2; Whsc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            581..670
                     /gene="Nelfa"
                     /gene_synonym="Whsc2; Whsc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            671..801
                     /gene="Nelfa"
                     /gene_synonym="Whsc2; Whsc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            802..871
                     /gene="Nelfa"
                     /gene_synonym="Whsc2; Whsc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            872..960
                     /gene="Nelfa"
                     /gene_synonym="Whsc2; Whsc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1072
                     /gene="Nelfa"
                     /gene_synonym="Whsc2; Whsc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1344
                     /gene="Nelfa"
                     /gene_synonym="Whsc2; Whsc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1444
                     /gene="Nelfa"
                     /gene_synonym="Whsc2; Whsc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..2435
                     /gene="Nelfa"
                     /gene_synonym="Whsc2; Whsc2h"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2154..2159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nelfa"
                     /gene_synonym="Whsc2; Whsc2h"
                     /note="hexamer: ATTAAA"
     polyA_site      2175
                     /gene="Nelfa"
                     /gene_synonym="Whsc2; Whsc2h"
                     /note="major polyA site"
     regulatory      2405..2410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nelfa"
                     /gene_synonym="Whsc2; Whsc2h"
                     /note="hexamer: AATAAA"
     polyA_site      2435
                     /gene="Nelfa"
                     /gene_synonym="Whsc2; Whsc2h"
ORIGIN      
        1 gtaagatgcc ggccgacgcg cgctgccgcc gccaagatgg cttccatgag ggagagtgac
       61 accggcctgt ggctgcacaa caagctgggc gccacggacg agctgtgggc gccacccagc
      121 atcgcgtccc tgctcaccgc cgcggtcatc gataacatcc gcctctgctt ccaccgcctc
      181 tcctcggccg tgaagctcaa gctactgctc gggacgctgc atctcccgcg ccgcaccgtg
      241 gacgagatga aggcggctct gatggatatc atccagctgg ccacgctgga ctcagacccc
      301 tgggtcctca tggttgctga cattctgaag tccttccctg acacgggctc cttgaatctg
      361 gaccttgagg aacagaaccc caatgttcaa gacatcttag gagaacttag agaaaaagtg
      421 agtgagtgcg aggcatctgc catgctacca ctggagtgcc agtacctgaa caagaatgcc
      481 ctgaccaccc ttgctgggcc cctcacccca ccagtcaagc attttcagct aaagcggaaa
      541 cctaagagtg ccacgctgcg ggcagaactg ctgcagaaat ctaccgagac agcccagcag
      601 ctgaagagaa gtgctggggt cccattccac gctaagggcc gggggctgct tcgaaagatg
      661 gacactacaa cccctctcaa aggcattccg aagcaagccc ccttccgaag tcccaccaca
      721 cccagcgtct tcagtccttc tgggaaccgg actccaatac caccttcgag gacgccactg
      781 cagaaagaaa ggggtgtgaa gctgctggat atttctgagc tgaatacagt tggtgctgga
      841 cgagaggcaa agaggaggag gaagacttta gacacagaag tggtagaaaa gcccaccaag
      901 gaagagacgg ttgttgaaaa cgctacccct gactatgctg ctggcctggt atccacacag
      961 aaacttgggt ctctgaacag tgagccaaca ctgccctcca caagttacct gccctctaca
     1021 cccagtgtgg tacctgcctc atcttacatc cccagctctg agactccccc agctccaccc
     1081 tctcgggaag ccagccggcc acctgaggaa cccagcgctc caagtcccac actgccaaca
     1141 cagtttaaac aaagggcacc tatgtataac agtggcctga gcccagctac accagcacct
     1201 gcagcaccta cctcacctct gacacctact actcccccag ctgtcactcc tactgctcag
     1261 acacctccag tggccatggt ggcccctcag acccaggctc cagcccctgt tcagcagcaa
     1321 cctaaaaaga acctgtccct cactagagaa cagatgtttg ctgcccagga gatgttcaag
     1381 acggcaaaca aggtcactcg gccggagaag gccctcatcc tgggcttcat ggctggctct
     1441 cgagagaacc catgcccgga gcagggggat gtgatccaga tcaagctcag tgaacacaca
     1501 gaggatctgc ccaaggcaga cggccagggc agtaccacca tgctagtgga cacagtgttc
     1561 gagatgaact acgccacagg ccagtggaca cgcttcaaga agtacaagcc tatgaccaat
     1621 gtgtcctaag tgccatctct gctgctgacc ctcatcagac cagaggacaa ggtttgctgg
     1681 ttgtgctgag tgacctgagc agataccgaa ggatgtgctc cacccagcac ctgtgatcca
     1741 caggctcctg ggcccagcca tttctctgga gagtttaggc ttatttttta tattctaatg
     1801 agttagtttt ctgtgtgatt aagatacttt tttttattca atattatgtt ttgaatgcaa
     1861 accaaaagtt acttcaaaat tttagtgcct gttcgacttt tacctttttt atttcttctt
     1921 taaaaaaaaa aaaaaagtac tggctgagag ggctttcttt ctctctcctt gtgcatgccc
     1981 tccctcatga ggttgagggg accaaaggtg acagctggaa agtctagggt gtgagggggg
     2041 ctatgaccag ccttgatgcc actatttacc agggatttgt atgtcttttg tacagttgta
     2101 aacatttcaa acctgtgtct gggttcttat tttcattgta aaatgacctg agtattaaag
     2161 tttagttttt ctaaagaaag cccacagagc tgtgtttcag gcgagcttga ctccctgctc
     2221 tgagaccaaa cccctgcata tacagctgtc agaacctggg agaggagagg cagggttgga
     2281 ggtaaggcta cctgaaaata aaggttggta aatgggtaga gcaactgtgg gcacccagga
     2341 agttgtggag tcagacacag ttacatatta aataagtgta agaaaaaggc ctttaaagtt
     2401 ttttaataaa aaaatactca ttacagtttt ccaaa
//
