LOCUS       NM_080849               2832 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus NIMA (never in mitosis gene a)-related expressed
            kinase 8 (Nek8), mRNA.
ACCESSION   NM_080849
VERSION     NM_080849.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2832)
  AUTHORS   Djaziri,N., Burel,C., Abbad,L., Bakey,Z., Piedagnel,R. and
            Lelongt,B.
  TITLE     Cleavage of periostin by MMP9 protects mice from kidney cystic
            disease
  JOURNAL   PLoS One 18 (12), e0294922 (2023)
   PUBMED   38039285
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2832)
  AUTHORS   Claus,L.R., Chen,C., Stallworth,J., Turner,J.L., Slaats,G.G.,
            Hawks,A.L., Mabillard,H., Senum,S.R., Srikanth,S.,
            Flanagan-Steet,H., Louie,R.J., Silver,J., Lerner-Ellis,J.,
            Morel,C., Mighton,C., Sleutels,F., van Slegtenhorst,M., van Ham,T.,
            Brooks,A.S., Dorresteijn,E.M., Barakat,T.S., Dahan,K., Demoulin,N.,
            Goffin,E.J., Olinger,E., Larsen,M., Hertz,J.M., Lilien,M.R.,
            Obeidova,L., Seeman,T., Stone,H.K., Kerecuk,L., Gurgu,M., Yousef
            Yengej,F.A., Ammerlaan,C.M.E., Rookmaaker,M.B., Hanna,C.,
            Rogers,R.C., Duran,K., Peters,E., Sayer,J.A., van Haaften,G.,
            Harris,P.C., Ling,K., Mason,J.M., van Eerde,A.M. and Steet,R.
  CONSRTM   Genomics England Research Consortium
  TITLE     Certain heterozygous variants in the kinase domain of the
            serine/threonine kinase NEK8 can cause an autosomal dominant form
            of polycystic kidney disease
  JOURNAL   Kidney Int 104 (5), 995-1007 (2023)
   PUBMED   37598857
  REMARK    GeneRIF: Certain heterozygous variants in the kinase domain of the
            serine/threonine kinase NEK8 can cause an autosomal dominant form
            of polycystic kidney disease.
REFERENCE   3  (bases 1 to 2832)
  AUTHORS   Swenson-Fields,K.I., Ward,C.J., Lopez,M.E., Fross,S., Heimes
            Dillon,A.L., Meisenheimer,J.D., Rabbani,A.J., Wedlock,E.,
            Basu,M.K., Jansson,K.P., Rowe,P.S., Stubbs,J.R., Wallace,D.P.,
            Vitek,M.P. and Fields,T.A.
  TITLE     Caspase-1 and the inflammasome promote polycystic kidney disease
            progression
  JOURNAL   Front Mol Biosci 9, 971219 (2022)
   PUBMED   36523654
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2832)
  AUTHORS   Zhang,J.Q.J., Burgess,J., Stepanova,D., Saravanabavan,S.,
            Wong,A.T.Y., Kaldis,P. and Rangan,G.K.
  TITLE     Role of cyclin-dependent kinase 2 in the progression of mouse
            juvenile cystic kidney disease
  JOURNAL   Lab Invest 100 (5), 696-711 (2020)
   PUBMED   31915367
REFERENCE   5  (bases 1 to 2832)
  AUTHORS   Nakajima,Y., Kiyonari,H., Mukumoto,Y. and Yokoyama,T.
  TITLE     The Inv compartment of renal cilia is an intraciliary
            signal-activating center to phosphorylate ANKS6
  JOURNAL   Kidney Int 93 (5), 1108-1117 (2018)
   PUBMED   29395339
REFERENCE   6  (bases 1 to 2832)
  AUTHORS   Kuida,S. and Beier,D.R.
  TITLE     Genetic localization of interacting modifiers affecting severity in
            a murine model of polycystic kidney disease
  JOURNAL   Genome Res 10 (1), 49-54 (2000)
   PUBMED   10645949
REFERENCE   7  (bases 1 to 2832)
  AUTHORS   Iakoubova,O., Dushkin,H., Pacella,L. and Beier,D.R.
  TITLE     Genetic analysis of modifying loci on mouse chromosome 1 that
            affect disease severity in a model of recessive PKD
  JOURNAL   Physiol Genomics 1 (2), 101-105 (1999)
   PUBMED   11015567
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2832)
  AUTHORS   Iakoubova,O.A., Dushkin,H. and Beier,D.R.
  TITLE     Genetic analysis of a quantitative trait in a mouse model of
            polycystic kidney disease
  JOURNAL   Am J Respir Crit Care Med 156 (4 Pt 2), S72-S77 (1997)
   PUBMED   9351583
REFERENCE   9  (bases 1 to 2832)
  AUTHORS   Iakoubova,O.A., Dushkin,H. and Beier,D.R.
  TITLE     Localization of a murine recessive polycystic kidney disease
            mutation and modifying loci that affect disease severity
  JOURNAL   Genomics 26 (1), 107-114 (1995)
   PUBMED   7782068
REFERENCE   10 (bases 1 to 2832)
  AUTHORS   Atala,A., Freeman,M.R., Mandell,J. and Beier,D.R.
  TITLE     Juvenile cystic kidneys (jck): a new mouse mutation which causes
            polycystic kidneys
  JOURNAL   Kidney Int 43 (5), 1081-1085 (1993)
   PUBMED   8510385
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB646522.1, AF407579.1 and
            BC070457.1.
            
            On Jan 30, 2009 this sequence version replaced NM_080849.2.
            
            Summary: This gene encodes a NIMA-related kinase. Members of this
            serine/threonine protein kinase family are structurally-related to
            NIMA (never in mitosis, gene A) which controls mitotic signaling in
            Aspergillus nidulans. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070457.1, AK154358.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-484               BB646522.1         11-494
            485-2360            AF407579.1         435-2310
            2361-2832           BC070457.1         2310-2781
FEATURES             Location/Qualifiers
     source          1..2832
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..2832
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /note="NIMA (never in mitosis gene a)-related expressed
                     kinase 8"
                     /db_xref="GeneID:140859"
                     /db_xref="MGI:MGI:1890646"
     exon            1..107
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..2157
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /EC_number="2.7.11.1"
                     /note="nimA-related protein kinase 8; never in mitosis
                     A-related kinase 8; juvenile cystic kidney; NIMA-related
                     expressed kinase 8"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Nek8"
                     /protein_id="NP_543125.1"
                     /db_xref="CCDS:CCDS25091.1"
                     /db_xref="GeneID:140859"
                     /db_xref="MGI:MGI:1890646"
                     /translation="MEKYERIRVVGRGAFGIVHLCLRKADQKLVILKQIPVEQMTKEE
                     RQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEE
                     ETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKA
                     YTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSG
                     TFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLCIRALLNIHTDVGSVRMRR
                     AEKSLTPGPPIASGSTGSRATSARCRGVPRGPVRPAIPPPLSSVYAWGGGLSSPLRLP
                     MLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGTLLPGAVELPQPQFVSRFLE
                     GQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYE
                     MVQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVC
                     GIDSSMILTSPGRVLACGSNRFNKLGLDHLSLDEEPVPYQQVEEALSFTPLGSAPLDQ
                     EPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVMV
                     ACGDAFTVAVGAEGEVYSWGKGTRGRLGRRDEDAGLPRPVQLDETHPYMVTSVSCCHG
                     NTLLAVRSVTDEPVPP"
     exon            108..313
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /inference="alignment:Splign:2.1.0"
     exon            314..546
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /inference="alignment:Splign:2.1.0"
     exon            547..678
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /inference="alignment:Splign:2.1.0"
     exon            679..887
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /inference="alignment:Splign:2.1.0"
     exon            888..967
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1149
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1300
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1377
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1495
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1646
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1810
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1969
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2128
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2800
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2782..2787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /note="hexamer: AATAAA"
     polyA_site      2800
                     /gene="Nek8"
                     /gene_synonym="4632401F23Rik; b2b1449Clo; jck"
                     /note="major polyA site"
ORIGIN      
        1 agatgggagg gtccgcgcac gcgccgcacc gggattccag aagcgtaact gagaaatgag
       61 atggagaagt acgagcggat ccgagtggtg ggaagaggtg ccttcgggat tgtgcacctg
      121 tgcctgcgaa aggccgacca gaagctggtg atcctcaagc agatcccagt ggaacagatg
      181 accaaagaag agaggcaggc ggcccagaac gagtgccagg tgctcaagct gctcaaccac
      241 cccaacgtca tcgagtacta tgagaatttc ctagaggaca aggccctcat gattgctatg
      301 gagtacgcac caggtggcac cttggccgag ttcatccaga agcgctgcaa ctctctgcta
      361 gaggaggaga cgatccttca cttctttgtg cagatcctgc tggctctgca tcacgtgcac
      421 acacatctca tcctgcatcg ggacctcaag acacagaaca tccttcttga caaacaccgc
      481 atggtggtca agatcggtga ctttggcatc tctaagatcc tcagcagcaa gagcaaggcc
      541 tacacggtgg tgggtacacc ctgctacatc tcccctgagc tgtgtgaggg caaaccctac
      601 aaccagaaga gtgacatctg ggctctgggc tgtgtcttat atgagctggc cagcctcaag
      661 agggccttcg aggctgcaaa cttgccagcc ctggtgctga agatcatgag tggcaccttc
      721 gcacccatct ctgaccggta cagccctgag cttcgccagc tcgtcctgag tctgcttagc
      781 ctggaacctg cacagaggcc acccctcagc cacatcatgg cgcagcccct ctgcatccgg
      841 gccctactca acatccacac cgatgtgggc agcgtgcgca tgcggagggc agagaagtcc
      901 ctgaccccag gaccacctat agcctctggc agcacaggga gcagggccac cagtgcccga
      961 tgtaggggtg tcccccgggg acctgtgaga ccggctatcc caccgccact gtcttcggtc
     1021 tacgcttggg gtggtggcct tagcagtccc ctgaggttgc caatgctcaa cacggaggtg
     1081 gtccaggtag ccgctgggcg cacgcagaag gctggcgtta cgcgctctgg acgcctcatc
     1141 ctgtgggagg ccccacccct gggagctgga ggcggcacac tccttcctgg agccgtggag
     1201 ctgcctcagc cccagtttgt ctctcgtttc ctggaaggcc agtcaggtgt gaccatcaag
     1261 catgtggcct gcggggacct gttcaccgct tgcttgacag accgaggcat tatcatgacg
     1321 ttcggcagtg gcagcaatgg gtgtttaggt cacggcaacc tgactgacat cagccagccc
     1381 accattgtag aagccttgct gggctatgag atggtgcagg tggcctgtgg ggcctctcat
     1441 gtgctggccc tgtccacaga tggagagtta ttcgcctggg gcagaggaga tggtggtaga
     1501 ctgggactag gcaccaggga gtcccataac tgccctcagc aggtgcctgt ggccccagga
     1561 caggaagctc agagagttgt ctgtggtatt gactcttcca tgatcctcac ctctccaggc
     1621 agggtcctgg cctgtggaag taacaggttc aacaagctag gcttggacca cctatccctg
     1681 gacgaggagc ctgttcccta ccagcaagtg gaggaggccc tgagcttcac accactgggc
     1741 tctgcacctc tggaccagga gcccctgctg tgtgtggacc ttggcactgc tcattcagct
     1801 gctatcactg cttctgggga ctgctatact tttggcagca atcaacatgg acagctgggc
     1861 accagttccc gcagggtcag cagggcaccc tgtcgggtcc aaggcctgga gggcatcaag
     1921 atggtgatgg tggcctgcgg ggatgccttc actgtggccg ttggggcaga gggggaagtg
     1981 tattcttggg gcaaaggaac ccgaggccga ctgggaagga gggatgagga tgcggggctg
     2041 cctaggccag tgcagctgga tgagactcat ccttacatgg tgacttcagt gtcctgctgc
     2101 catgggaaca ctctgctggc tgttcgatca gtcacagatg aaccagttcc cccctgaggc
     2161 gacaggatga tccaagagac cacctttgag tattctgaaa aatgcaggtg cccgaggaat
     2221 gactgttgtc agcgtcctgg attgtgtcgt caatggggta gaaaggccag tgaagtctac
     2281 tctgttcccc caagtccctg tctccaaagc tctttatctt agtaaatatc tgcaaggctc
     2341 cagtctggca ggggtcaaca gaaggacggc cttcaaaacc tttgctaaaa aaaaaaaacg
     2401 cacctttctc caaccaccct cagcccagtt agaaagtaag tccctgacgg tgtcctcttg
     2461 gagactcatg ccatgctttg gaatagggca agccagggct tgtttggact ggtcattagg
     2521 ctagcctaat ctctgcatag cttgcagctg ataggttgga gggagccccc ttttctatct
     2581 taccctgagg caagggtttg cacaacccct gcgaaggcac ccctccccac acacacctct
     2641 tagggagggg gtgctggagc tatttttttg tttgctgagg agatactgct gaaaggttgc
     2701 cctttcccca ggctattcac cagacctaga ctggggagaa aggtaacccg accaatttct
     2761 caaaggtttc aaagtatcac taataaaaat atcaaatgcc aaaaaaaaaa aaaaaaaaaa
     2821 aaaaaaaaaa aa
//
