LOCUS       NM_021605               4290 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus NIMA (never in mitosis gene a)-related expressed
            kinase 7 (Nek7), transcript variant 1, mRNA.
ACCESSION   NM_021605
VERSION     NM_021605.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4290)
  AUTHORS   Hong,L., Zhuo,T. and Jing,S.
  TITLE     Silencing of METTL3 inhibits m6A methylation of NEK7 to suppress
            pyrolysis in an HT-22 cell-based model of intracerebral hemorrhage
  JOURNAL   Brain Res 1831, 148828 (2024)
   PUBMED   38408556
  REMARK    GeneRIF: Silencing of METTL3 inhibits m6A methylation of NEK7 to
            suppress pyrolysis in an HT-22 cell-based model of intracerebral
            hemorrhage.
REFERENCE   2  (bases 1 to 4290)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4290)
  AUTHORS   Zheng,S., Que,X., Wang,S., Zhou,Q., Xing,X., Chen,L., Hou,C.,
            Ma,J., An,P., Peng,Y., Yao,Y., Song,Q., Li,J., Zhang,P. and Pei,H.
  TITLE     ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7
            interaction and inflammasome activation
  JOURNAL   Mol Cell 83 (24), 4570-4585 (2023)
   PUBMED   38092000
  REMARK    GeneRIF: ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7
            interaction and inflammasome activation.
REFERENCE   4  (bases 1 to 4290)
  AUTHORS   Park,Y.J., Dodantenna,N., Kim,Y., Kim,T.H., Lee,H.S., Yoo,Y.S.,
            Heo,J., Lee,J.H., Kwon,M.H., Kang,H.C., Lee,J.S. and Cho,H.
  TITLE     MARCH5-dependent NLRP3 ubiquitination is required for mitochondrial
            NLRP3-NEK7 complex formation and NLRP3 inflammasome activation
  JOURNAL   EMBO J 42 (19), e113481 (2023)
   PUBMED   37575012
  REMARK    GeneRIF: MARCH5-dependent NLRP3 ubiquitination is required for
            mitochondrial NLRP3-NEK7 complex formation and NLRP3 inflammasome
            activation.
REFERENCE   5  (bases 1 to 4290)
  AUTHORS   Zhang,M., Zhi,D., Lin,J., Liu,P., Wang,Y. and Duan,M.
  TITLE     miR-181a-5p Inhibits Pyroptosis in Sepsis-Induced Acute Kidney
            Injury through Downregulation of NEK7
  JOURNAL   J Immunol Res 2022, 1825490 (2022)
   PUBMED   35991122
  REMARK    GeneRIF: miR-181a-5p Inhibits Pyroptosis in Sepsis-Induced Acute
            Kidney Injury through Downregulation of NEK7.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4290)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4290)
  AUTHORS   Morrish,T.A., Gilbert,N., Myers,J.S., Vincent,B.J., Stamato,T.D.,
            Taccioli,G.E., Batzer,M.A. and Moran,J.V.
  TITLE     DNA repair mediated by endonuclease-independent LINE-1
            retrotransposition
  JOURNAL   Nat Genet 31 (2), 159-165 (2002)
   PUBMED   12006980
REFERENCE   8  (bases 1 to 4290)
  AUTHORS   Feige,E. and Motro,B.
  TITLE     The related murine kinases, Nek6 and Nek7, display distinct
            patterns of expression
  JOURNAL   Mech Dev 110 (1-2), 219-223 (2002)
   PUBMED   11744387
  REMARK    GeneRIF: During early embryogenesis nek7 is expressed in the site
            of decidual reaction. Later in embryogenesis, nek7 is highly
            expressed in the dorsal thalamus.
REFERENCE   9  (bases 1 to 4290)
  AUTHORS   Kimura,M. and Okano,Y.
  TITLE     Identification and assignment of the human NIMA-related protein
            kinase 7 gene (NEK7) to human chromosome 1q31.3
  JOURNAL   Cytogenet Cell Genet 94 (1-2), 33-38 (2001)
   PUBMED   11701951
REFERENCE   10 (bases 1 to 4290)
  AUTHORS   Kandli,M., Feige,E., Chen,A., Kilfin,G. and Motro,B.
  TITLE     Isolation and characterization of two evolutionarily conserved
            murine kinases (Nek6 and nek7) related to the fungal mitotic
            regulator, NIMA
  JOURNAL   Genomics 68 (2), 187-196 (2000)
   PUBMED   10964517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118216.15 and AC161436.4.
            
            On Oct 18, 2022 this sequence version replaced NM_021605.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149308.1, AK035502.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AC118216.15        189186-189377       c
            193-275             AC118216.15        131337-131419       c
            276-416             AC118216.15        113837-113977       c
            417-479             AC118216.15        103998-104060       c
            480-590             AC118216.15        102371-102481       c
            591-699             AC118216.15        86162-86270         c
            700-807             AC118216.15        85259-85366         c
            808-902             AC161436.4         11276-11370
            903-1016            AC161436.4         15252-15365
            1017-4290           AC161436.4         26831-30104
FEATURES             Location/Qualifiers
     source          1..4290
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 60.82 cM"
     gene            1..4290
                     /gene="Nek7"
                     /gene_synonym="2810460C19Rik"
                     /note="NIMA (never in mitosis gene a)-related expressed
                     kinase 7"
                     /db_xref="GeneID:59125"
                     /db_xref="MGI:MGI:1890645"
     exon            1..192
                     /gene="Nek7"
                     /gene_synonym="2810460C19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            193..275
                     /gene="Nek7"
                     /gene_synonym="2810460C19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..1127
                     /gene="Nek7"
                     /gene_synonym="2810460C19Rik"
                     /EC_number="2.7.11.34"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NIMA-related kinase 7; serine/threonine-protein kinase
                     Nek7; nimA-related protein kinase 7; never in mitosis
                     A-related kinase 7; NIMA-related expressed kinase 7"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Nek7 isoform 1"
                     /protein_id="NP_067618.1"
                     /db_xref="CCDS:CCDS15332.1"
                     /db_xref="GeneID:59125"
                     /db_xref="MGI:MGI:1890645"
                     /translation="MDEQSQGMQGPPVTQFQPQKALRPDMGYNTLANFRIEKKIGRGQ
                     FSEVYRASCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFI
                     EDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALDHMHSRRVMHR
                     DIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSD
                     IWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNICIN
                     PDPEKRPDIAYVYDVAKRMHACTAST"
     exon            276..416
                     /gene="Nek7"
                     /gene_synonym="2810460C19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            417..479
                     /gene="Nek7"
                     /gene_synonym="2810460C19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            480..590
                     /gene="Nek7"
                     /gene_synonym="2810460C19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            591..699
                     /gene="Nek7"
                     /gene_synonym="2810460C19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            700..807
                     /gene="Nek7"
                     /gene_synonym="2810460C19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            808..902
                     /gene="Nek7"
                     /gene_synonym="2810460C19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1016
                     /gene="Nek7"
                     /gene_synonym="2810460C19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..4290
                     /gene="Nek7"
                     /gene_synonym="2810460C19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3995..4000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nek7"
                     /gene_synonym="2810460C19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4015
                     /gene="Nek7"
                     /gene_synonym="2810460C19Rik"
                     /note="major polyA site"
     regulatory      4268..4273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nek7"
                     /gene_synonym="2810460C19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4290
                     /gene="Nek7"
                     /gene_synonym="2810460C19Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtttaccctc ctgacagccg cggccgccgg aggaggagcg gagccgggag gatgggccgc
       61 cgctaacctc gcagtgggaa gcgcgggccg agcagggtgg gagccggcgc ctgcagtggc
      121 gcggggagag gcgatcggcc ccggatcccg cagccctgca gcccgcgtag accgagctgc
      181 cccggcgccc cgaatcctga agtcccagtt gagtcagaat ggatgaacaa tcacaaggaa
      241 tgcaagggcc gcccgttact cagttccagc cacagaaggc attacggcca gatatgggct
      301 ataatacttt agccaacttc cgaatagaaa agaaaattgg tcgtggacaa tttagtgaag
      361 tttatagagc atcctgtctc ttggatggag tgccggtagc gttaaaaaaa gtacagatat
      421 ttgatttaat ggatgccaaa gcacgtgctg attgtatcaa agaaatagac ctccttaagc
      481 aactcaacca tccaaatgta attaaatact atgcatcatt cattgaggat aatgagctga
      541 acatagtttt ggagttagca gatgctggtg acctctccag aatgataaag cactttaaga
      601 aacaaaagag gctaatccct gagagaaccg tttggaaata cttcgttcag ctctgcagtg
      661 cactggacca catgcattct cgaagagtca tgcacagaga tataaaacca gctaatgtgt
      721 tcattacagc cactggggta gtaaaactcg gagaccttgg gcttggtcgg tttttcagct
      781 ccaaaaccac agctgcacat tctttagtgg gtacacctta ctacatgtct ccagagagaa
      841 tacatgaaaa tggatacaac ttcaagtctg acatctggtc tcttggctgt ctgctatatg
      901 agatggctgc actgcagagt cctttctacg gcgacaagat gaacttgtat tctctgtgta
      961 agaagataga gcagtgtgac tacccgcctc tcccgtcaga tcactattcg gaggagctac
     1021 gacagctagt taatatatgc atcaacccag atccagagaa gcgacccgac atcgcctatg
     1081 tttatgatgt ggcaaagagg atgcatgcat gtaccgcaag cacctaaact gtacaagatc
     1141 ctgaagacgg caaccaagat aacttaaaag tgtttttgtg cagatcatac ctccccgctt
     1201 atgtctgggt gttaagatta ctgtctcaga gctaatgcgc tttgaatcct taaccagttt
     1261 tcatatgagc ttcatttttc taccaggctc aatcaccttc ccaatccaca actttgggat
     1321 gctcagatgg caccaagaat gcaagcccaa caagagtttt tcgtttgaga attgtttcga
     1381 gtttctgctg atagactgtg tttatagata gtcagtgccc gatggtgaag cacacacaca
     1441 taggcacatg tccagagcga tgcagaacct gaggaaggac ctgggcattt gacttgtttg
     1501 cttttaagtc acttaatgga cgttgtagtg gacatgattg tgaacttctg atttttttct
     1561 tttaagtttc aagtacatgt tttagttctt agcattagag atctcaaata taattcttat
     1621 aagacatgca gacataaact ttttgagaaa gatttaaaat ttttagttta tacattcaaa
     1681 atgcaactat taaatgtgaa agcatagagg tcaaaatgtg agttggacac tgaagtctat
     1741 gttttaatgc ctttgaaagc ctttttttgt gtgtgtttaa atggtataaa tgaacccatt
     1801 ttaaaacgtg gttaaggact tgtttgcctg gcgtgatagt catgtttaac atgcacaagg
     1861 ctttgtgttt ttattgtaca tttgaagaat attcttggaa taatcttgca gtagttatag
     1921 ttcaatttct ttacaaatct aaatacactt aactcataac tatacactgt aatgcaagca
     1981 tatattgtta ttcatatatt gaagttttga tcagttcctc ttcagaatct tttttatcca
     2041 agttactttc ttatttatat tgtgtgtgca tttcatccat taaatgtttc agattttctg
     2101 agaatgagtt ccctttttaa aatatatttg gtatgccaac acttttttag gattgaaaaa
     2161 aaattttttt aaatgtttgg gtcattctag gtgcatctgt tttctcttgt tagaaagaaa
     2221 aggtgtgtgt taaaatgtgc ctgtgaatgt cgatattgtt tggcagggtt ataattttag
     2281 agtatgctct agagtatgtt gaacagcgtg aagactggcc cttactgaag acagaactgt
     2341 tccaagagca gcattcccgt tgagatgctt tggagtaaag tactgtgtat gacgatgaca
     2401 gacattttag ttaagggggt gaaaaaaaaa ggaggggtat ttaggaaacc ctgaggtgga
     2461 attttggtga atgtcttcat cttaatacca gccaattcct tcagagaatt gtggagccaa
     2521 agaacagagt aatcgtggct gttgcagaac acggtgtgcc atggtagagc attgggaagg
     2581 ctcatcctgc cggtgggtcg gtcagacagc cctgtgttgg ggagcttgta ctctggccca
     2641 cagagctcct gggttgattt tcttacagag tattctttct acagttattt tcaagtaatt
     2701 gtaaattttc aaagtaatat ctcatctttt aattcactat gtatgctgtc gtagacaaag
     2761 gaaatctggg tttttttttg tttttgtttt tgtttttttt tgtcttgaag gctgaactgg
     2821 gtacatccca gatcttagtg gctcatagga tatacccaga ggcatgaaga aatggcttcc
     2881 ggtgaccatt tgtgttgtgt tatatccatt gtaatgtcac aggactgatt gagatgaaac
     2941 atccccttcc tacaagagtt gttttctttc catatttaaa aacatgaggt tctgcctggc
     3001 agtgatggta cacaccttta atcccagcac ccgggaggca gaggcaggag gatttctgag
     3061 ttcgaggcca gcctggtcta caaagtgagt tccaggacag ccaggactac acagagaaat
     3121 cctgtctcaa aaaaccaaaa ctaaatgaaa atacaaggct tctccccttg tagtgacttt
     3181 gctttatgaa tttgtctcaa aaaaaaaaaa aatagagctg gagggcttac tggtcaggga
     3241 tggtcacttt aactttgtac aagaagaaac tttctttcaa atactttaag tccctcagtt
     3301 catatccacc ctcccccacc aaaataaaga atccattgtg tagaaacaaa ttcagtgtga
     3361 tgtttgcaag tggttatgga attgattaaa agttctaatc ttaacaatca cctataaaat
     3421 attctcttta tatttctgtt tatgagtaaa ttttatatga cgttaaatat tggaactgat
     3481 ttccgtaaca ggtcaaatta aaggtacggc tgatttgaaa cgttatttaa acactggtac
     3541 tagttatcca ggagagaatg tgcagtaacg ttggttggta tgctgaggtg tgggggtggt
     3601 gaatgaaggg taccctacct gcagtgctca agaatgtcca atgattgtaa agttactgag
     3661 atgtcaccgg caagttgcga gcgctctgct gttccttagt gtgtccttta caaaacgcct
     3721 gtcttatatc atgtactcca ggttttgctc tgaactttgt ctctatttat tataaccaag
     3781 aagctgttac tcacacaaat gtttattctt ttcaattgaa tgtactgttt ataacccaca
     3841 aatgcgcact ctttgcctcc aattcccgta gtactgtaat aatatgaatt tttttgtgaa
     3901 atactttcta ttttgttatg ctttaaatat acatgcaaaa gaattctgtt attagcttca
     3961 aaaactgtac agtatcttaa tataaatata taaaaataaa agatgagtac tgtaagtttt
     4021 agtatctatc aggtcccctc ccttttacct ctccaaatcg cccattgcta tgcttggcac
     4081 ccaacctaca gaaacagttc ttacccagtt ccaggacttt gctatcttga agaaacccga
     4141 aacagtgaga cagtcaaaag tgacaacctc tctggaggct ctgcggtttt atggcttggt
     4201 tttgaatgtg cgttatatca taaaacacag ctcactagtc tcttcaatgt ctccctttct
     4261 gtcgttgaat aaaaggcatc caaacagtca
//
