LOCUS       NM_001347318            2300 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus NIMA (never in mitosis gene a)-related expressed
            kinase 5 (Nek5), transcript variant 2, mRNA.
ACCESSION   NM_001347318 XM_006509160
VERSION     NM_001347318.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2300)
  AUTHORS   Li,Y.Y., Guo,L., Li,H., Li,J., Dong,F., Yi,Z.Y., Ouyang,Y.C.,
            Hou,Y., Wang,Z.B., Sun,Q.Y., Lu,S.S. and Han,Z.
  TITLE     NEK5 regulates cell cycle progression during mouse oocyte
            maturation and preimplantation embryonic development
  JOURNAL   Mol Reprod Dev 86 (9), 1189-1198 (2019)
   PUBMED   31304658
REFERENCE   2  (bases 1 to 2300)
  AUTHORS   Potter,P.K., Bowl,M.R., Jeyarajan,P., Wisby,L., Blease,A.,
            Goldsworthy,M.E., Simon,M.M., Greenaway,S., Michel,V., Barnard,A.,
            Aguilar,C., Agnew,T., Banks,G., Blake,A., Chessum,L., Dorning,J.,
            Falcone,S., Goosey,L., Harris,S., Haynes,A., Heise,I., Hillier,R.,
            Hough,T., Hoslin,A., Hutchison,M., King,R., Kumar,S., Lad,H.V.,
            Law,G., MacLaren,R.E., Morse,S., Nicol,T., Parker,A., Pickford,K.,
            Sethi,S., Starbuck,B., Stelma,F., Cheeseman,M., Cross,S.H.,
            Foster,R.G., Jackson,I.J., Peirson,S.N., Thakker,R.V., Vincent,T.,
            Scudamore,C., Wells,S., El-Amraoui,A., Petit,C.,
            Acevedo-Arozena,A., Nolan,P.M., Cox,R., Mallon,A.M. and Brown,S.D.
  TITLE     Novel gene function revealed by mouse mutagenesis screens for
            models of age-related disease
  JOURNAL   Nat Commun 7, 12444 (2016)
   PUBMED   27534441
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2300)
  AUTHORS   Shimizu,K. and Sawasaki,T.
  TITLE     Nek5, a novel substrate for caspase-3, promotes skeletal muscle
            differentiation by up-regulating caspase activity
  JOURNAL   FEBS Lett 587 (14), 2219-2225 (2013)
   PUBMED   23727203
  REMARK    GeneRIF: Nek5 promotes myogenic differentiation through
            up-regulation of caspase-3 activity.
REFERENCE   4  (bases 1 to 2300)
  AUTHORS   Forrest,A.R., Taylor,D. and Grimmond,S.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Exploration of the cell-cycle genes found within the RIKEN FANTOM2
            data set
  JOURNAL   Genome Res 13 (6B), 1366-1375 (2003)
   PUBMED   12819135
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK054168.1, BC053516.1 and AK032672.1.
            
            On Jan 18, 2018 this sequence version replaced NM_001347318.1.
            
            Transcript Variant: This variant (2) lacks an exon in the 3' coding
            region, which results in a frameshift compared to variant 1. The
            encoded isoform (2) has a distinct and longer C-terminus, compared
            to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053516.1, SRR13861889.97373.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AK054168.1         1-26
            27-2280             BC053516.1         1-2254
            2281-2300           AK032672.1         2387-2406
FEATURES             Location/Qualifiers
     source          1..2300
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.95 cM"
     gene            1..2300
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /note="NIMA (never in mitosis gene a)-related expressed
                     kinase 5"
                     /db_xref="GeneID:330721"
                     /db_xref="MGI:MGI:2142824"
     exon            1..82
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     exon            83..220
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     exon            221..305
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     exon            306..403
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     exon            404..487
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     exon            488..558
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     exon            559..645
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     exon            646..700
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     exon            701..901
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     exon            902..984
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1051
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1168
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1255
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1324
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1451
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1577
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1712
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1821
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..2300
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2258..2263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
                     /note="hexamer: AATAAA"
     polyA_site      2280
                     /gene="Nek5"
                     /gene_synonym="6530411J22"
ORIGIN      
        1 gtggccctgc ccctgcgtct gggaggctta gcggctggag caccgattct tccatgctca
       61 ctgcttaacg cccgccgagc aggaagttct gacgcctgga gccatggata actttcacct
      121 gattaagatc attggggaag gcacctttgg gaaggtgtac ttggctaaag ataaatcaga
      181 aagcagtcac tgtgtcataa aagaaatcag tttgacaaag gaaaaagagg cctcaaagaa
      241 cgaagtgatt cttctggcta ggatggagca tcccaatatc gtaaccttct tcagctcgtt
      301 tcaagagaac ggcaggctgt ttattgtaat ggaatactgt gatggagggg atctcatgca
      361 gaggatccag aggcagcggg gagtgatgtt cagcgaagac cagatcctgt gttggtttgt
      421 acagatttct ctaggactga agcatattca tgacaggaag attttacaca gggacataaa
      481 atctcagaat atttttctta gcaagaatgg aatggttgcc aagctcgggg actttggaac
      541 agcaagaaca ctgaatgact ccatggaact tgctcaaaca tgtgctggga caccttacta
      601 cctgtcccca gagatctgtc agaacaggcc atacaacaat aaaacggaca tctggtctct
      661 tggctgtgtc ttatatgagc tctgcacact caagcatcct tttgagagca acaacttcca
      721 ccatctggtt ctgaagattt gtcaaggacg tgttgctccc atatcacccc acttctctcg
      781 tgacctacag tccttgatac ctcagctctt cagagtgtct cctcaggacc ggccatccgt
      841 tacgtccctt ttgaaaagac cctttttaga aactctcatt gcccgatcct tgtatcctga
      901 ggtctgttca agaagaatcc agtcccacgc tcacatggag aacatggcca ttggccccac
      961 agcttgttgg agagttagtc catggtctgc tgcctacctt cagaggaaat ttgaagctca
     1021 gcaatataag ttaaaagtgg aaagacaatt gggtcttcgt ccatcttctg tggaaccaca
     1081 tccaaacgag ggagaaaagc tacaaagtca ttgggaggag actaaattcc aggagcttca
     1141 atacaggaag aacaaaatga aggaccagga atattggaaa cagctggaag aaatccgcca
     1201 acagtaccac aacgacatga aggaaattaa aaagaaaatg gggagagagc tgaagagagt
     1261 ggtaaagttt gaaatcagcc tagacaagtg tatttcagag gaagacaccg tccaggagaa
     1321 tgaggcagtg gataaactaa atgctacttt aagctttgaa gatggcacga agtttcagga
     1381 gcacagatgt aaggaggaac atgaagacta tacagacaga gcctttgaag aactctgtgg
     1441 cccagaagca gagggtttct ttcaggatgt cattgccgca gagaacagga ggcagtggga
     1501 tgccggggca cctcacactc tgctgcgaat aatggcaatg gcagatgtca cctccacctg
     1561 ccccaccatg ccggatgatg gccaagtgat tgtgatggaa ggcagtgtag agaatgggaa
     1621 gcagtggtgg ctggatgtgc cagggacccc gtgtgctttg gcagcagagt gtgcctgcag
     1681 tggctcattg tctgccagta aaggagaaac cgtaatgatc aaaccacagc ttcctaaaga
     1741 agaccaggaa aaggtagaaa tagccacggg catcatggtg gatgatgaac agctggaacc
     1801 aggatcggat gaagatgaca taaaatttga agaatctgaa gatgagctga ggagtgaaat
     1861 aatagaatcc ctagaaaaac ttgcagcttc cacagaagaa gcggaacagg ctcccagctc
     1921 ctctaagaat gcagaggagc caggagagaa agaaaagaca aacttgccag tcaagaaact
     1981 ccagtgaagg tctggacgct ggttttggcc tgtttgatct gtgtggctaa gaccaaggtt
     2041 catcaaatgc cagtcatgac gtgcaagtgt gaacaatctt ctgttcccca tgcgtgggga
     2101 tccatgtcct taaagaaaaa tccgctgtct tactgatttc acacacttcg tcctgtccat
     2161 gctcttgggg ggcaactctg atgaatgctg attttagctt tcattccatc tatcaaactg
     2221 aaacgctttg ttcttatttc catgtgtttg tcattagaat aaaactcata agaaaataaa
     2281 cagctctggc tttgtatggc
//
