LOCUS       NM_011849               4267 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus NIMA (never in mitosis gene a)-related expressed
            kinase 4 (Nek4), transcript variant 1, mRNA.
ACCESSION   NM_011849
VERSION     NM_011849.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4267)
  AUTHORS   Yang,Z.H., Cai,X., Zhang,C.Y., Zhang,Q., Li,M., Ding,Z.L., Guo,Y.,
            Ma,G., Yang,C.H., Guo,L., Chang,H., Wang,C., Li,M. and Xiao,X.
  TITLE     NEK4 modulates circadian fluctuations of emotional behaviors and
            synaptogenesis in male mice
  JOURNAL   Nat Commun 15 (1), 9180 (2024)
   PUBMED   39448584
  REMARK    GeneRIF: NEK4 modulates circadian fluctuations of emotional
            behaviors and synaptogenesis in male mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4267)
  AUTHORS   Doles,J. and Hemann,M.T.
  TITLE     Nek4 status differentially alters sensitivity to distinct
            microtubule poisons
  JOURNAL   Cancer Res 70 (3), 1033-1041 (2010)
   PUBMED   20103636
  REMARK    GeneRIF: Data show that after Taxol treatment, Nek4 promoted
            microtubule outgrowth, whereas Nek4 deficiency impaired G(2)-M
            arrest and decreased formation of mitotic-like asters.
REFERENCE   3  (bases 1 to 4267)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   4  (bases 1 to 4267)
  AUTHORS   Forrest,A.R., Taylor,D. and Grimmond,S.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Exploration of the cell-cycle genes found within the RIKEN FANTOM2
            data set
  JOURNAL   Genome Res 13 (6B), 1366-1375 (2003)
   PUBMED   12819135
REFERENCE   5  (bases 1 to 4267)
  AUTHORS   Hayashi,K., Igarashi,H., Ogawa,M. and Sakaguchi,N.
  TITLE     Activity and substrate specificity of the murine STK2
            Serine/Threonine kinase that is structurally related to the mitotic
            regulator protein NIMA of Aspergillus nidulans
  JOURNAL   Biochem Biophys Res Commun 264 (2), 449-456 (1999)
   PUBMED   10529384
REFERENCE   6  (bases 1 to 4267)
  AUTHORS   Chen,A., Yanai,A., Arama,E., Kilfin,G. and Motro,B.
  TITLE     NIMA-related kinases: isolation and characterization of murine nek3
            and nek4 cDNAs, and chromosomal localization of nek1, nek2 and nek3
  JOURNAL   Gene 234 (1), 127-137 (1999)
   PUBMED   10393247
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK078809.1, CN526970.1, AK149584.1 and BP762751.1.
            
            On Apr 29, 2015 this sequence version replaced NM_011849.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057939.1, AF099067.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1115              AK078809.1         2-1116
            1116-1758           CN526970.1         1-643
            1759-4242           AK149584.1         1532-4015
            4243-4267           BP762751.1         28-52               c
FEATURES             Location/Qualifiers
     source          1..4267
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.09 cM"
     gene            1..4267
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /note="NIMA (never in mitosis gene a)-related expressed
                     kinase 4"
                     /db_xref="GeneID:23955"
                     /db_xref="MGI:MGI:1344404"
     exon            1..342
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            343..609
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            610..807
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            808..915
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1070
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1212
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1614
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1758
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1908
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..1975
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2109
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2198
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2401
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2535
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..4245
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3878..3883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /note="hexamer: AATACA"
     polyA_site      3900
                     /gene="Nek4"
                     /gene_synonym="Stk2"
     regulatory      4200..4205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /note="hexamer: AGTAAA"
     regulatory      4223..4228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /note="hexamer: AGTAAA"
     polyA_site      4223
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /note="major polyA site"
     polyA_site      4245
                     /gene="Nek4"
                     /gene_synonym="Stk2"
                     /note="major polyA site"
ORIGIN      
        1 aagcacgagg agcagctctg gccaccgcta ggtcgactct atggcgcgtc ttccaactct
       61 gagcatgcgc aggactaccc cgccagtatc gctatggtag cggcgtccgg gtgggccggg
      121 cctcgaagct cctgcccgcg gtgggccgcg tttatggagt acttcacctc ccgtctggca
      181 tgagcggggc ctcccgcagc cttacgcgcc gctgccacag cttcccgact gtaggcctcc
      241 ttcgggaaca tgccccaggc cgcatactgc tacatgcggg tcgtgggcag gggtagttac
      301 ggggaggtga cgctcgtgaa gcatcggcga gacggcaagc agtatgtcat caaaaagctg
      361 aacctccgaa atgcctccag ccgagagcgt cgagctgctg agcaggaagc tcagctccta
      421 tctcagttga agcaccccaa cattgtcacc tacaaagaat catgggaggg aggagacggt
      481 ctgctctaca ttgtcatggg cttctgcgaa ggaggtgatc tgtaccggaa gctcaaggag
      541 cagaaagggc agcttctgcc tgagagtcag gtggtggagt ggtttgtcca gatcgccatg
      601 gccttgcagt atttacatga gaaacacatc cttcatcgag atctgaaaac tcagaatgtc
      661 ttcttaacaa gaacaaacat catcaaagtg ggggacctag gaattgcccg cgtcttagag
      721 aatcacggtg acatggcgag caccctcatt ggcacaccct attacatgag ccctgagctg
      781 ttctccaaca aaccctacaa ctataagtcg gatgtttggg ctttgggatg ctgtgtatat
      841 gaaatggcca ccctgaagca cgcttttaat gcaaaagaca tgaattcttt agtttatcgg
      901 attattgaag gaaagttgcc gccaatgcca aaagtttaca gcacagagct ggctgagctg
      961 ataagaacaa tgctgagcag aaggcctgag gagaggccct ctgtgcggag catcctgagg
     1021 cagccctaca taaaacacca catctccttg ttcttggagg ccaccaaggc aaaaacttcc
     1081 aaaaataatg ttaaaaactg tgactccaga gccaagcctg ttgctgctgt agtttccaga
     1141 aaggaagaat caaatactga cgtgatacac taccagccac gctcttctga gggctctgct
     1201 ttgcatgtca tgggtgaaga taaatgtttg tcccaagaga aaccagtgga cattggtccc
     1261 ttgagatcac cggctagtct tgaaggccac actggcaaac aagacatgaa caatactggg
     1321 gagtcatgtg ccacaatcag taggataaat atcgatatct tacctgcaga aaggagggac
     1381 tcagcgaacg ctggtgtagt tcaggagagc caaccacaac acgtggatgc cgctgatgaa
     1441 gtagacagtc agtgcagtat ttctcaagag aaggagaggc tacagggcaa taccaagtcc
     1501 agtgatcagc ctggaaatct ccttcccaga cggtcctctg atggtggtga tggggaaggg
     1561 agtgaactgg tgaagccatt gtatccctca aataaagacc aaaagccaga ccaggatcaa
     1621 gttactggta ttatagaaaa tcaggacagc atccacccaa gatcccagcc acacagctct
     1681 atgtctgaac cttctttgtc ccggcagcga aggcagaaaa aaagggaaca gactgcccat
     1741 agtcgtacaa agagccagtt ccaagaatta ccccctcggc ttttgccttc ttatcctggt
     1801 attgggaaag tggatatcat agcaacacag caaaatgatg gaaaccaagg tggacctgtg
     1861 gctgggtgtg taaacagttc aaggaccagc tcaacagcat cagcaaagga tcgaccatta
     1921 tcagccagag agaggagacg gctaaagcag tcacaggagg agatgctgcc ctcaggccct
     1981 gcagttcaga gaactccaag tgcagttgag ccactgaaac cacaggaaga agaccaaccc
     2041 atccctgccc aacgattctc ttctgactgc agcatcactc agatgaatca cacactcccg
     2101 agggaaaagg agaagaggct gatgcatggc ctgtctgagg atgagttaag ctcttctaca
     2161 agctcaactg ataagtcaga tggggattcc agggagggga agagtcatac aaatgaaatg
     2221 aaagacttgg tacagctgat gactcagact ctgaggctgg aagctaagga gagctgtgaa
     2281 gatctccagg tcctaaaccc agggtcagaa ttcagacttc atcgaaagta tcgagacacg
     2341 ctggtgcttc atggcaaggt tgcagaagag gtggaacccc actgtacgga gctgcctacg
     2401 ggtatcatac caggttctga aaagatcagg agaatcgttg aagtcttaag agctgatgta
     2461 atccagggcc tggggattca actcttagag caggtgtttg atcttttggg agaggaagat
     2521 gagttggaga gagaggcacg attacaggag cacatgggag acaagtatac aacttactgt
     2581 gtgaaagctc gccaattgaa attttttgaa gaaaatgtga gtttttgaga tttgttctaa
     2641 catgctgcca gaactaaaga tctattttca aaagtttttc atcttaaaaa aaacaccacc
     2701 accaccatca ccaaccctgt tccagtcatt cagaggctgg tcaccgccat cctttgcttg
     2761 atatctcctt ggagtcctct tactataaag aactggagag cagactaatg cgaaacaagt
     2821 tcacaaaaga aaaaaaaact ttgaatatca tatgtttatg aggaaaaatg ttatatcttt
     2881 gttactgttt actgagcctt aagacaactt tatatttagt ttatttttta aaagatagta
     2941 actagcttga catggggcca gaaaacatgg gattaaattg tactacagtg atagaagcaa
     3001 caagagaaag gaacgatgtc tcatgctgat gcttgctgcc attagtaacc ttagcaagta
     3061 gttggtgttc attctctaat atcaattcac tcttctggga atagatttaa agaacatgag
     3121 gttctatgtt gcattcaaac aactgttatt gttttctttt tacacatcag tggactttta
     3181 atattttgat ttattctgaa ccttagtgag gctgtcttta gacccttaga actcttgttc
     3241 aacctaacgt atagctttgt aagtcactgt gacttgacat gtttgacttc tttttcccat
     3301 cagcaaaaac attcttttaa acatgagttc ctttttcaat taagcagtgt ctaagtccag
     3361 gttcttagtc ctattggatg taagtgatgc ttttttttgt tttgttttgt tttttaaaga
     3421 gatgcattta ttgtatgtat atgagtacac tggagctgtc ttcagacaca ccagaagagg
     3481 gcatcagatc tcattacaaa tggttgtgag ccaccatgtg gttgctggga tttgaactca
     3541 ggacctctgg aagtgcagtc agtgctctta accactgagc catctctcca gcccccgcaa
     3601 gtgatgtttg tctttatgta caataaagtg tcaactgagt tcccatattt taaatatgta
     3661 gctgtaaggc tggatgcaat agttcacact tgtaatcctg gcacctgaga accagaggcg
     3721 gtgggtcatg agttcagtgc tagtctggat gacagagtga aatcaggggc agctcagact
     3781 acagagaccc tcgtctcaaa aaagtcctga ttgtatatca catgttgtgt taattattta
     3841 ataagaaatg tccatctaga aagattttta taaataaaat acaagttgtg gtggtttgaa
     3901 tatgtttggc ccagggagtg acactatttg gagatgtggc cctgttggag tgggtgtggc
     3961 ttttttagag gaagtgtgtc actatgggtg tgggctttgg gaccctcttc ctagcttcct
     4021 ggaagccagt gttctcctag cagccttcag atgaagatgt agaactctca gctcctcctg
     4081 caccatgcct gctcggatgc tgccatgttc ccgccttaat gataatggac tgaacctctg
     4141 aacctctaag ccagccccaa ttaagagttg ccttggtcat ggtgttgtct gttcatagca
     4201 gtaaaaccct aactaaaaca caagtaaatt ttcacttatg attaaaaaaa aaaaaaaaaa
     4261 aaaaaaa
//
