LOCUS       NM_001162947            1989 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Mus musculus NIMA (never in mitosis gene a)-related expressed
            kinase 3 (Nek3), transcript variant 1, mRNA.
ACCESSION   NM_001162947
VERSION     NM_001162947.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1989)
  AUTHORS   Chang J, Baloh RH and Milbrandt J.
  TITLE     The NIMA-family kinase Nek3 regulates microtubule acetylation in
            neurons
  JOURNAL   J Cell Sci 122 (Pt 13), 2274-2282 (2009)
   PUBMED   19509051
  REMARK    GeneRIF: Data show that Nek3 influences neuronal morphogenesis and
            polarity through effects on microtubules.
REFERENCE   2  (bases 1 to 1989)
  AUTHORS   Ballif BA, Villen J, Beausoleil SA, Schwartz D and Gygi SP.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   3  (bases 1 to 1989)
  AUTHORS   Hamatani T, Falco G, Carter MG, Akutsu H, Stagg CA, Sharov AA,
            Dudekula DB, VanBuren V and Ko MS.
  TITLE     Age-associated alteration of gene expression patterns in mouse
            oocytes
  JOURNAL   Hum Mol Genet 13 (19), 2263-2278 (2004)
   PUBMED   15317747
REFERENCE   4  (bases 1 to 1989)
  AUTHORS   Guipponi M, Tapparel C, Jousson O, Scamuffa N, Mas C, Rossier C,
            Hutter P, Meda P, Lyle R, Reymond A and Antonarakis SE.
  TITLE     The murine orthologue of the Golgi-localized TPTE protein provides
            clues to the evolutionary history of the human TPTE gene family
  JOURNAL   Hum Genet 109 (6), 569-575 (2001)
   PUBMED   11810268
REFERENCE   5  (bases 1 to 1989)
  AUTHORS   Chen A, Yanai A, Arama E, Kilfin G and Motro B.
  TITLE     NIMA-related kinases: isolation and characterization of murine nek3
            and nek4 cDNAs, and chromosomal localization of nek1, nek2 and nek3
  JOURNAL   Gene 234 (1), 127-137 (1999)
   PUBMED   10393247
REFERENCE   6  (bases 1 to 1989)
  AUTHORS   Tanaka K and Nigg EA.
  TITLE     Cloning and characterization of the murine Nek3 protein kinase, a
            novel member of the NIMA family of putative cell cycle regulators
  JOURNAL   J Biol Chem 274 (19), 13491-13497 (1999)
   PUBMED   10224116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117665.6.
            
            [WARNING] On Sep 13, 2023 this sequence was replaced by
            NM_001162947.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF093416.1, SRR7345562.929021.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AC117665.6         129687-129857       c
            172-259             AC117665.6         127733-127820       c
            260-357             AC117665.6         127555-127652       c
            358-441             AC117665.6         125990-126073       c
            442-509             AC117665.6         124513-124580       c
            510-596             AC117665.6         124339-124425       c
            597-651             AC117665.6         117224-117278       c
            652-852             AC117665.6         115846-116046       c
            853-925             AC117665.6         114294-114366       c
            926-975             AC117665.6         110253-110302       c
            976-1078            AC117665.6         100356-100458       c
            1079-1228           AC117665.6         99413-99562         c
            1229-1360           AC117665.6         98569-98700         c
            1361-1484           AC117665.6         96708-96831         c
            1485-1989           AC117665.6         95649-96153         c
FEATURES             Location/Qualifiers
     source          1..1989
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 11.07 cM"
     gene            1..1989
                     /gene="Nek3"
                     /note="NIMA (never in mitosis gene a)-related expressed
                     kinase 3"
                     /db_xref="GeneID:23954"
                     /db_xref="MGI:MGI:1344371"
     exon            1..171
                     /gene="Nek3"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1590
                     /gene="Nek3"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein kinase Nek3; nimA-related protein
                     kinase 3; never in mitosis A-related kinase 3;
                     NIMA-related expressed kinase 3"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Nek3 isoform 1"
                     /protein_id="NP_001156419.1"
                     /db_xref="CCDS:CCDS52519.1"
                     /db_xref="GeneID:23954"
                     /db_xref="MGI:MGI:1344371"
                     /translation="MDNYTVLRVIGQGSFGRALLVLQESSNQTFAMKEIRLLKSDTQT
                     SRKEAVLLAKMKHPNIVAFKESFEAEGYLYIVMEYCDGGDLMQRIKQQKGKLFPEDTI
                     LNWFIQICLGVNHIHKRRVLHRDIKSKNVFLTHNGKVKLGDFGSARLLSSPMAFACTY
                     VGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCALKHPFQANSWKNLILKICQGPIH
                     PLPALYSCKLQGLVKQMLKRNPSHRPSATTLLCRGSLAPLVPKCLPPQIIREYGEQIL
                     DEIKISTPKNMKKQDSNRVRRALGEANSASMQEEERGRKCSHTELESTGTTPAGNALE
                     RAARGNPESGNPQEHGRHTSPASPHRPWWERHGPSSNVEALEKASILTSSFTAEDDRG
                     GSVIKYEENARRQWVREPPEALLSMLKDADLSQAFQTYTIYRPGAEGFLKGPLSEDTA
                     SDSVDGDLDSVMLDPERFEPRLDEEDTDFEEDNENPDWVSELKKHVGYGDGPGGQLLG
                     ERA"
     exon            172..259
                     /gene="Nek3"
                     /inference="alignment:Splign:2.1.0"
     exon            260..357
                     /gene="Nek3"
                     /inference="alignment:Splign:2.1.0"
     exon            358..441
                     /gene="Nek3"
                     /inference="alignment:Splign:2.1.0"
     exon            442..509
                     /gene="Nek3"
                     /inference="alignment:Splign:2.1.0"
     exon            510..596
                     /gene="Nek3"
                     /inference="alignment:Splign:2.1.0"
     exon            597..651
                     /gene="Nek3"
                     /inference="alignment:Splign:2.1.0"
     exon            652..852
                     /gene="Nek3"
                     /inference="alignment:Splign:2.1.0"
     exon            853..925
                     /gene="Nek3"
                     /inference="alignment:Splign:2.1.0"
     exon            926..975
                     /gene="Nek3"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1078
                     /gene="Nek3"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1228
                     /gene="Nek3"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1360
                     /gene="Nek3"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1484
                     /gene="Nek3"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1989
                     /gene="Nek3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgggagag ccagcagtga ctggaggggt agagcccagc tgtggctgcc cggcatggac
       61 aactacacag tcctgagagt gattggccag ggctccttcg gcagggctct tttggttctg
      121 caggaaagca gcaatcagac atttgccatg aaggaaatca gactgctcaa gtctgataca
      181 cagacttcta ggaaagaggc tgttctgctc gccaaaatga agcaccccaa tattgttgcc
      241 tttaaggagt catttgaagc tgaagggtac ctgtacattg tgatggagta ttgtgacgga
      301 ggggatctga tgcagaggat taaacagcaa aaagggaagt tattccctga agacacgata
      361 cttaattggt ttatacaaat ttgtcttgga gtaaatcaca ttcataagag acgtgtttta
      421 cacagagata tcaagtcgaa aaatgtcttc ctcacccaca atggaaaagt gaaattggga
      481 gattttggct ctgcccgtct tctctccagt cccatggcgt ttgcatgcac gtacgtggga
      541 acaccttatt atgtgcctcc agaaatctgg gagaacctgc cttacaacaa taaaagtgac
      601 atctggtcct tgggatgcat tctgtatgaa ctctgcgctc tgaagcatcc attccaggca
      661 aatagttgga aaaacctgat cctgaaaata tgccaggggc ccatccaccc gctgccggct
      721 ctgtactcct gcaagcttca gggcctggtc aagcagatgc tgaaaaggaa cccttcccac
      781 cgcccctccg ccacaaccct gctctgcagg ggtagcttgg ctccactggt cccgaagtgc
      841 ttgccccctc agatcatcag agaatatgga gaacagatat tagatgaaat caaaatatcc
      901 acgcctaaga atatgaaaaa acaggactcc aacagagtca ggagagctct gggagaagca
      961 aactctgcct ctatgcaaga ggaagaacgt ggtagaaagt gtagccatac tgaattggaa
     1021 agcactggta caaccccagc tgggaatgca ttggaaagag cagccagagg aaatccagaa
     1081 tcaggtaacc cacaggagca cgggaggcat accagtccgg caagtcctca caggccgtgg
     1141 tgggagagac acggtcccag ttccaatgtc gaagctttgg agaaagcatc tatccttacc
     1201 tccagtttca cggcagagga tgacagaggt gggtctgtga taaagtatga agaaaatgcc
     1261 cgaaggcagt gggtcagaga gccccctgag gccttgctgt caatgctgaa ggacgctgat
     1321 ctcagtcagg catttcagac atacacaata tatagaccag gtgcagaagg attcctgaaa
     1381 ggtccccttt ctgaagacac ggcatcggac agcgtcgacg gtgatctcga ttctgtcatg
     1441 ttagacccag agagatttga acctcggctg gatgaagaag acacggactt tgaggaagat
     1501 aacgaaaacc ctgattgggt gtcagaacta aagaagcacg taggatacgg ggatggacct
     1561 ggtggacaac tcctcggaga acgtgcctga gtcatggcaa gacactggcg agagacactg
     1621 gcgagagaca ctgatggctg ggaatggaag tgaggactga gaaaatgtat atcgcaagtt
     1681 tacaaagcaa tccagaaccc ttgcgagatt tcaacacaac ggaagtctag cagatgcttc
     1741 atgccttgtg ttccgacaga acggagatgc catgctcgtc tgccggccac catgtgtgtg
     1801 acactaggaa atgacttaac tcctttgatc ccaaatcttc tcaactatac aatgagagta
     1861 acaacgccta cctcatagga acactcacgg caacagttac agctgtccag tgcctgttat
     1921 ccccaattac catgtaacac tctcacattt cctaaaggtt taaggatcta aatacattaa
     1981 gctatggca
//
