LOCUS       NM_172461               2924 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus NIMA (never in mitosis gene a)-related expressed
            kinase 11 (Nek11), mRNA.
ACCESSION   NM_172461
VERSION     NM_172461.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2924)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2924)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 2924)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113016.7 and AC161250.2.
            
            On Nov 9, 2022 this sequence version replaced NM_172461.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030042.1, SRR17784651.234401.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AC113016.7         41907-41986
            81-392              AC113016.7         44022-44333
            393-558             AC113016.7         89044-89209
            559-677             AC113016.7         113946-114064
            678-742             AC113016.7         122431-122495
            743-869             AC113016.7         123641-123767
            870-1019            AC113016.7         136782-136931
            1020-1098           AC113016.7         137042-137120
            1099-1184           AC113016.7         138818-138903
            1185-1304           AC113016.7         141689-141808
            1305-1398           AC113016.7         143433-143526
            1399-1513           AC113016.7         149436-149550
            1514-1674           AC113016.7         192758-192918
            1675-1735           AC161250.2         15226-15286
            1736-1832           AC161250.2         28951-29047
            1833-2924           AC161250.2         70590-71681
FEATURES             Location/Qualifiers
     source          1..2924
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 56.61 cM"
     gene            1..2924
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /note="NIMA (never in mitosis gene a)-related expressed
                     kinase 11"
                     /db_xref="GeneID:208583"
                     /db_xref="MGI:MGI:2442276"
     exon            1..80
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            81..392
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..2106
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /EC_number="2.7.11.1"
                     /note="NIMA-related kinase 11; nimA-related protein kinase
                     11; never in mitosis A-related kinase 11"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Nek11"
                     /protein_id="NP_766049.2"
                     /db_xref="CCDS:CCDS23464.1"
                     /db_xref="GeneID:208583"
                     /db_xref="MGI:MGI:2442276"
                     /translation="MLKFQETAKCVGRRPTVIPMYPTALIARRYVLQQKLGSGSFGTV
                     YLVSDKKAKPGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQ
                     ETFCIITEYCEGRDLDYRIQEYKEAGKVFAENQIVEWFIQLLLGVDYMHERRILHRDL
                     KSKNIFLKNNLLKIGDFGVSRLLMGSCELATTLTGTPHYMSPEALKHQGYDAKSDIWS
                     LACILYEMCCLDHAFAGSSFLSVVLNIVEGKTPSLPDRYPRELNTIMERMLNKSPSLR
                     PSAADILKAPYMEEQLQLLMCKYPEMTLEDKNSVCQKEAAHTINAVQKKLHLQTLQAL
                     SDTQKTTPRERMWLRKLQAADERARRLKKIAEENYKENDKRMQALRSRNVGSVHAHVL
                     HELDERTLESLPEPQSLPCLDLDELEPSLEDTIVDLGHYEIPEDPLVAEQYYSDVFDS
                     CSEDSEEQEEEMIFSEAGGDTKEEESPSVYRTNQQDSDTAALVGCLEHVLGYTSLDTK
                     TITNAVTDMSPGPMVFNSAVARTKMKRMKESAVQKLGMETFEEVYDYLKRARHQNARE
                     AEIWEHLETVVPRASDCFEVDQLLYFEELLLTMEGKEPSLQNLPCEAAQKKPVKGTHF
                     CDNP"
     exon            393..558
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            559..677
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            678..742
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            743..869
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1019
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1098
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1184
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1304
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1398
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1513
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1674
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1735
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1832
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..2924
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2576..2581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /note="hexamer: ATTAAA"
     regulatory      2594..2599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      2599
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /note="major polyA site"
     polyA_site      2616
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
     regulatory      2905..2910
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /note="hexamer: CATAAA"
     polyA_site      2924
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
ORIGIN      
        1 aaacaaccac gccctccgag gcagcgagct ctaggctgac ggaggcttgg ccgggcgccg
       61 caggctgggg acctgtaaag ttgcttttag acacgatttg tggagttccc atatatctgg
      121 catcaatcaa cacttcccgt ttgacttttc aaacatcagc tcggatgccc aactgttgtt
      181 tctgtgaatg aacaagccag ttttatcttg tttggagcaa tgctgaaatt ccaagagact
      241 gcgaagtgtg tgggcagaag acccacagtc atccccatgt acccgaccgc tttgattgca
      301 agaagatatg ttcttcagca gaaacttggc agtggaagtt ttggaactgt ctatctggtg
      361 tcagacaaga aagccaaacc tggagaggag ctaaaggtac tgaaggaaat ctctgttggc
      421 gaattaaatc caaatgagac cgtgcaggcc aatgtggaag ctcagctcct ctccaggctc
      481 catcatcctg ccattgtcag attccatgca agcttcatgg agcaggagac tttttgcatt
      541 atcacggaat actgtgaggg ccgagatctg gactatagaa tccaggaata taaagaagct
      601 gggaaagtct tcgctgaaaa tcagatagta gaatggttta tccagctgtt gcttggagtt
      661 gactacatgc atgagaggag aatacttcat cgagacttga aatcaaagaa tatatttctg
      721 aaaaataatc tactcaaaat cggggatttt ggagtttctc ggctgctaat gggttcatgt
      781 gagctggcta caactctaac cgggaccccc cattatatga gtcccgaggc cctgaagcac
      841 caaggctatg atgccaagtc tgacatctgg tcactggcat gcattttata tgagatgtgt
      901 tgcctggatc atgcatttgc tggctccagt ttcttgtctg tggttttgaa tattgttgaa
      961 ggtaaaacac cttcactccc ggacagatat ccacgagaac taaacaccat catggaacgc
     1021 atgttgaaca agagtccttc attgagaccg tcggctgcag acattttaaa agccccttac
     1081 atggaagagc agcttcagct cctgatgtgt aaatacccag agatgacact ggaagacaag
     1141 aactcagttt gtcagaagga ggctgctcat acgattaatg ccgtgcagaa aaagcttcac
     1201 ctgcagactc tgcaagcctt gtctgacacg cagaaaacga ctcccagaga acggatgtgg
     1261 ctgaggaagc tgcaggcagc cgatgagaga gccaggaggc tgaaaaagat tgctgaagaa
     1321 aactataaag aaaatgacaa aaggatgcag gccctgagat cccggaatgt ggggtccgtg
     1381 catgcccatg tgctccatga actagatgaa cggactttgg agagcctgcc tgagcctcag
     1441 tcccttccgt gcctggacct cgatgaactt gagcccagtt tagaggacac cattgttgac
     1501 ctcggacatt atgagatccc agaagaccca cttgttgctg aacaatatta ttccgatgtc
     1561 tttgattcct gttctgaaga cagcgaggag caggaggaag aaatgatatt ctcagaagca
     1621 ggaggagaca cgaaagagga ggaatcccca tctgtgtaca gaacaaacca acaggacagt
     1681 gatactgccg cgctggttgg gtgtttggaa catgtcctgg gttacacctc tctagacaca
     1741 aagactatta ccaatgcagt gacagacatg tctcctggac caatggtttt caacagtgca
     1801 gtggctcgga ccaagatgaa gcgcatgaag gaatcagctg tacagaagct aggaatggaa
     1861 acgtttgagg aggtctacga ttacctcaag agagcaaggc accagaatgc cagagaagca
     1921 gagatctggg agcatctgga gacggtggtt cctcgggcca gtgactgctt tgaagttgac
     1981 cagctcctct attttgagga gttgctgctg accatggaag gaaaagagcc ctctctccag
     2041 aacctgccct gtgaagctgc ccagaagaag ccggtcaagg gcactcattt ctgtgacaat
     2101 ccatgatgtt taccctctgg acataactgg aaccactacc gttccctttg gctcctggtc
     2161 agatgtaagg atgtctatgg aaaggaaagc actcagctgc ctgccggggc atggagtcac
     2221 aggtcaaggt catagatgaa gtctggcatc ctgaaagctt tccctcagac gtacagccct
     2281 cggggtttcc agtatgctgg gagcactctg aagacacagg cactcagtac tgcgtccatc
     2341 cagggcaagc ccagtgcctg accagtgtga gctccaggga ctatggctag ctggcttgtg
     2401 acagcttgga caccagcctg gacaatggcc tgttcatctc caatgatgta tttttgatca
     2461 acactttttt cttcctgtga ccacatacaa gcaatacata aatctaaggg cctggattga
     2521 aaatccccaa agtgtttccc tcctgtgatc tattcccaac actcactcat ggagcattaa
     2581 agccttgatt cagagtaaat actgatttca tcgttatatg acaaatctcc tattttatct
     2641 ttttcttagc taacagtgtt tctcaacctg tgggtcatga cccctttggg gctgcctatt
     2701 ggatatcctg catatcagat atttacatta cagttcataa cagtagcaaa attacagtta
     2761 tgaggtagaa gtaaaatgac tttatggtta aaggtcacca caacatgagg aactgtgtta
     2821 aagggtcaca gcataggaag gttgagagtc actgttatat aatcatgtat gctttgtttt
     2881 gtttgctgtt tgttacaact gaaacataaa aagttacaca taaa
//
