LOCUS       NP_766049                628 aa            linear   ROD 08-FEB-2025
DEFINITION  serine/threonine-protein kinase Nek11 [Mus musculus].
ACCESSION   NP_766049
VERSION     NP_766049.2
DBSOURCE    REFSEQ: accession NM_172461.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 628)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 628)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (residues 1 to 628)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113016.7 and AC161250.2.
            
            On Aug 6, 2009 this sequence version replaced NP_766049.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030042.1, SRR17784651.234401.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..628
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 56.61 cM"
     Protein         1..628
                     /product="serine/threonine-protein kinase Nek11"
                     /EC_number="2.7.11.1"
                     /note="NIMA-related kinase 11; nimA-related protein kinase
                     11; never in mitosis A-related kinase 11"
                     /calculated_mol_wt=71517
     Region          29..288
                     /region_name="STKc_Nek11"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinase, Never In Mitosis gene A (NIMA)-related kinase 11;
                     cd08222"
                     /db_xref="CDD:270861"
     Site            order(36..40,44,60,62,93,109..112,116,118,159,161,
                     163..164,166,176,179,181,195..198)
                     /site_type="active"
                     /db_xref="CDD:270861"
     Site            order(36..37,39..40,44,60,62,93,110..112,116,164,166,181)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270861"
     Site            order(40,116,118,159,161,163,179,195..198)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270861"
     Site            175..198
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270861"
     Site            274
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CHEK1.
                     /evidence=ECO:0000250|UniProtKB:Q8NG66; propagated from
                     UniProtKB/Swiss-Prot (Q8C0Q4.2)"
     Region          452..475
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C0Q4.2)"
     CDS             1..628
                     /gene="Nek11"
                     /gene_synonym="4932416N14Rik"
                     /coded_by="NM_172461.4:220..2106"
                     /db_xref="CCDS:CCDS23464.1"
                     /db_xref="GeneID:208583"
                     /db_xref="MGI:MGI:2442276"
ORIGIN      
        1 mlkfqetakc vgrrptvipm yptaliarry vlqqklgsgs fgtvylvsdk kakpgeelkv
       61 lkeisvgeln pnetvqanve aqllsrlhhp aivrfhasfm eqetfciite ycegrdldyr
      121 iqeykeagkv faenqivewf iqlllgvdym herrilhrdl kskniflknn llkigdfgvs
      181 rllmgscela ttltgtphym spealkhqgy daksdiwsla cilyemccld hafagssfls
      241 vvlnivegkt pslpdrypre lntimermln kspslrpsaa dilkapymee qlqllmckyp
      301 emtledknsv cqkeaahtin avqkklhlqt lqalsdtqkt tprermwlrk lqaaderarr
      361 lkkiaeenyk endkrmqalr srnvgsvhah vlheldertl eslpepqslp cldldeleps
      421 ledtivdlgh yeipedplva eqyysdvfds csedseeqee emifseaggd tkeeespsvy
      481 rtnqqdsdta alvgclehvl gytsldtkti tnavtdmspg pmvfnsavar tkmkrmkesa
      541 vqklgmetfe evydylkrar hqnareaeiw ehletvvpra sdcfevdqll yfeellltme
      601 gkepslqnlp ceaaqkkpvk gthfcdnp
//
