LOCUS       NM_146208               2271 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus nei like 3 (E. coli) (Neil3), mRNA.
ACCESSION   NM_146208
VERSION     NM_146208.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2271)
  AUTHORS   Bugaj,A.M., Kunath,N., Saasen,V.L., Fernandez-Berrocal,M.S.,
            Vankova,A., Saetrom,P., Bjoras,M. and Ye,J.
  TITLE     Dissecting gene expression networks in the developing hippocampus
            through the lens of NEIL3 depletion
  JOURNAL   Prog Neurobiol 235, 102599 (2024)
   PUBMED   38522610
  REMARK    GeneRIF: Dissecting gene expression networks in the developing
            hippocampus through the lens of NEIL3 depletion.
REFERENCE   2  (bases 1 to 2271)
  AUTHORS   Dickinson,K., Hammond,L., Akpa,M., Chu,L.L., Lalonde,C.T.,
            Goumba,A. and Goodyer,P.
  TITLE     WT1 regulates expression of DNA repair gene Neil3 during
            nephrogenesis
  JOURNAL   Am J Physiol Renal Physiol 324 (3), F245-F255 (2023)
   PUBMED   36546838
  REMARK    GeneRIF: WT1 regulates expression of DNA repair gene Neil3 during
            nephrogenesis.
REFERENCE   3  (bases 1 to 2271)
  AUTHORS   Lai,H.H., Hung,L.Y., Yen,C.J., Hung,H.C., Chen,R.Y., Ku,Y.C.,
            Lo,H.T., Tsai,H.W., Lee,Y.P., Yang,T.H., Chen,Y.Y., Huang,Y.S. and
            Huang,W.
  TITLE     NEIL3 promotes hepatoma epithelial-mesenchymal transition by
            activating the BRAF/MEK/ERK/TWIST signaling pathway
  JOURNAL   J Pathol 258 (4), 339-352 (2022)
   PUBMED   36181299
  REMARK    GeneRIF: NEIL3 promotes hepatoma epithelial-mesenchymal transition
            by activating the BRAF/MEK/ERK/TWIST signaling pathway.
REFERENCE   4  (bases 1 to 2271)
  AUTHORS   Egiazarian,M.A., Stromstad,S., Sakshaug,T., Nunez-Nescolarde,A.B.,
            Bethge,N., Bjoras,M. and Scheffler,K.
  TITLE     Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid
            pathology, adult neurogenesis, and memory in a mouse model of
            Alzheimer's disease
  JOURNAL   Free Radic Biol Med 193 (Pt 2), 685-693 (2022)
   PUBMED   36395955
REFERENCE   5  (bases 1 to 2271)
  AUTHORS   Huskova,A., Dinesh,D.C., Srb,P., Boura,E., Veverka,V. and Silhan,J.
  TITLE     Model of abasic site DNA cross-link repair; from the architecture
            of NEIL3 DNA binding domains to the X-structure model
  JOURNAL   Nucleic Acids Res 50 (18), 10436-10448 (2022)
   PUBMED   36155818
  REMARK    GeneRIF: Model of abasic site DNA cross-link repair; from the
            architecture of NEIL3 DNA binding domains to the X-structure model.
REFERENCE   6  (bases 1 to 2271)
  AUTHORS   Hildrestrand,G.A., Neurauter,C.G., Diep,D.B., Castellanos,C.G.,
            Krauss,S., Bjoras,M. and Luna,L.
  TITLE     Expression patterns of Neil3 during embryonic brain development and
            neoplasia
  JOURNAL   BMC Neurosci 10, 45 (2009)
   PUBMED   19426544
  REMARK    GeneRIF: NEIL3 is specifically expressed in brain areas where
            neurogenesis takes place during development and that its expression
            is tightly regulated both temporally and spatially. NEIL3 seems to
            be upregulated in tumor tissues compared to normal tissues.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2271)
  AUTHORS   Takao,M., Oohata,Y., Kitadokoro,K., Kobayashi,K., Iwai,S.,
            Yasui,A., Yonei,S. and Zhang,Q.M.
  TITLE     Human Nei-like protein NEIL3 has AP lyase activity specific for
            single-stranded DNA and confers oxidative stress resistance in
            Escherichia coli mutant
  JOURNAL   Genes Cells 14 (2), 261-270 (2009)
   PUBMED   19170771
REFERENCE   8  (bases 1 to 2271)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   9  (bases 1 to 2271)
  AUTHORS   Torisu,K., Tsuchimoto,D., Ohnishi,Y. and Nakabeppu,Y.
  TITLE     Hematopoietic tissue-specific expression of mouse Neil3 for
            endonuclease VIII-like protein
  JOURNAL   J Biochem 138 (6), 763-772 (2005)
   PUBMED   16428305
  REMARK    GeneRIF: NEIL3 is localized in the nuclei; Neil3 mRNA was
            selectively expressed in thymus, spleen and bone marrow
REFERENCE   10 (bases 1 to 2271)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108413.4, AK031027.1, DV646606.1, AI510383.1, BF714694.1 and
            BF714693.1.
            
            On Aug 25, 2009 this sequence version replaced NM_146208.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034753.1, AB072931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC108413.4         29633-29731
            100-784             AK031027.1         1-685
            785-1291            DV646606.1         232-738
            1292-1627           AI510383.1         164-499
            1628-2115           BF714694.1         23-510
            2116-2271           BF714693.1         1-156               c
FEATURES             Location/Qualifiers
     source          1..2271
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 29.14 cM"
     gene            1..2271
                     /gene="Neil3"
                     /note="nei like 3 (E. coli)"
                     /db_xref="GeneID:234258"
                     /db_xref="MGI:MGI:2384588"
     exon            1..310
                     /gene="Neil3"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1975
                     /gene="Neil3"
                     /EC_number="4.2.99.18"
                     /note="endonuclease VIII-like 3; nei endonuclease
                     VIII-like 3; nei-like protein 3; DNA glycosylase FPG2; DNA
                     glycosylase/AP lyase Neil3"
                     /codon_start=1
                     /product="endonuclease 8-like 3"
                     /protein_id="NP_666320.1"
                     /db_xref="CCDS:CCDS22305.1"
                     /db_xref="GeneID:234258"
                     /db_xref="MGI:MGI:2384588"
                     /translation="MVEGPGCTLNGEKIRARVLPGQAVTGVRGTALQSLLGPAMSPAA
                     SLADVATSAAPMNAKDSGWKLLRLFNGYVYSGVETLGKELFMYFGPRALRIHFGMKGS
                     ILINPREGENRAGASPALAVQLTRDLICFYDSSVELRNSVESQQRVRVMEELDICSPK
                     FSFSRAESEVKKQGDRMLCDVLLDQRVLPGVGNIIKNEALFDSGLHPAVKVCQLSDKQ
                     ACHLVKMTRDFSILFYRCCKAGSAISKHCKVYKRPNCDQCHSKITVCRFGENSRMTYF
                     CPHCQKENPQCVQVCQLPTRNTEISWTPRGEDCFTDSVARKSEEQWSCVVCTLINRPS
                     AKACDACLTTRPLDSVLKNRENSIAFNNLVKYPCNNFENTHTEVKINRKTAFGNTTLV
                     LTDLSNKSSALARKKRANHTIDGESQMFLPTDIGFSDSQHPSKEGINYITQPSNKVNI
                     SPTVCAQSKLFSSAHKKFKPAHTSATELKSYNSGLSNSELQTNRTRGHHSKSDGSPLC
                     KMHHRRCVLRVVRKDGENKGRQFYACSLPRGAQCGFFEWADLSFPFCRHGKRSIMKTV
                     LKIGPNNGKNFFVCPLEKKKQCNFFQWAENGPGMEIVPGC"
     exon            311..435
                     /gene="Neil3"
                     /inference="alignment:Splign:2.1.0"
     exon            436..570
                     /gene="Neil3"
                     /inference="alignment:Splign:2.1.0"
     exon            571..784
                     /gene="Neil3"
                     /inference="alignment:Splign:2.1.0"
     exon            785..859
                     /gene="Neil3"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1026
                     /gene="Neil3"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1196
                     /gene="Neil3"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1617
                     /gene="Neil3"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1792
                     /gene="Neil3"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..2253
                     /gene="Neil3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2232..2237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neil3"
                     /note="hexamer: AATAAA"
     polyA_site      2253
                     /gene="Neil3"
                     /note="major polyA site"
ORIGIN      
        1 ggggtttgct ggtgggcaag cctaggctgg gcggggcggg gcgcgcggga gatttgaact
       61 tcccgcccag tgtgggtcag caggaaagtg aagttgcctg gttgttttcc agtcaggcct
      121 tgcaactagc aggggttccg ggcgggctac agagatggtg gaagggccag ggtgtacact
      181 gaatggagag aagatccggg cacgagtgct accggggcag gcggtgactg gtgtgcgggg
      241 cacagctctg cagagcctcc tgggccctgc catgtcccct gccgcctccc tggctgatgt
      301 cgctacctcg gctgctccaa tgaatgctaa ggattctggc tggaaactct tgagactgtt
      361 taatggatat gtttacagtg gcgtggaaac cttagggaag gagctgttta tgtactttgg
      421 ccccagagct ttacggattc atttcggaat gaaaggctcc atcttgatta acccacggga
      481 gggtgagaac agagctgggg cttctccagc cttggcggtg cagctcacca gagacttgat
      541 ctgcttctat gactcttcag tagaactcag aaattcggtg gaaagccaac agagagtcag
      601 agtgatggaa gagttggata tatgttcacc aaagttcagt ttctcaagag cagagagtga
      661 agtgaaaaag cagggagatc ggatgctgtg tgatgtgttg ctggatcaga gggtgttgcc
      721 tggcgtgggc aacatcatca aaaatgaagc actctttgac agtggtcttc atccggctgt
      781 taaggtgtgt caactatcag acaaacaggc ctgtcacctt gtgaagatga ctcgggattt
      841 cagcattctc ttctacaggt gctgtaaagc aggatctgcc atttctaaac actgtaaggt
      901 ttacaagcgt cctaactgtg atcagtgcca cagcaaaatt actgtgtgtc gctttgggga
      961 gaacagcagg atgacatatt tctgtcctca ctgtcagaaa gaaaaccctc aatgtgttca
     1021 agtatgccag ctgccaacaa gaaacactga aatcagctgg actcctaggg gagaggattg
     1081 ctttacggac tcagtggctc ggaagtctga agagcagtgg tcctgtgtgg tttgtactct
     1141 cataaacaga ccctcggcta aggcctgtga tgcttgcttg accacaaggc ctctggattc
     1201 agtgctcaag aatagagaaa attccattgc cttcaacaac ttagtgaagt acccttgtaa
     1261 taactttgag aacacacaca ctgaagtaaa gatcaacagg aaaactgcgt ttggaaatac
     1321 gacccttgtt ttgactgatt taagcaataa atccagtgct ttggccagaa agaaaagagc
     1381 aaaccacaca atagatgggg aatctcaaat gtttctccct acagacatag gttttagtga
     1441 ttcacagcac ccctccaaag aaggaataaa ctatataact caaccatcca ataaggtaaa
     1501 catatcacct acagtttgtg cccagtctaa attatttagt tcagcacata aaaaattcaa
     1561 accagctcac acttctgcaa cagaacttaa aagttacaac tctggacttt ctaacagtga
     1621 actccaaacc aataggacac gtggccatca ttccaaaagt gatggcagcc ctctgtgcaa
     1681 gatgcaccac cgccgttgtg ttctccgagt tgtgaggaaa gatggagaaa acaaggggag
     1741 gcagttttat gcctgttctc tgccgagagg agcacagtgc ggattttttg aatgggcaga
     1801 cctgtccttc ccgttctgca gacatggcaa gcgctccatt atgaaaactg tgctgaagat
     1861 tggacctaat aatgggaaga atttttttgt atgtcctttg gagaaaaaaa agcagtgtaa
     1921 ttttttccag tgggccgaaa atggaccagg aatggaaatt gttccaggat gctaatagtt
     1981 ttctcttttt aaagaatgcc cgtctcataa actcatcaaa ctcatagcat tcagtcccct
     2041 ttgtttaata gaaaacttat agaacacctg ttgtacatac acattaagaa cctgtagtat
     2101 ttgagacata ttttttttca cttaactatg tgatcttcac agtttttgtt gtaataatga
     2161 acacactatt tcaccagagg cacagtccat tctctttgaa atgcatattc aatatagtta
     2221 ataatgatgt caataaagta ctcttagaat gttaaaaaaa aaaaaaaaaa a
//
