LOCUS       NM_201610               1914 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus nei like 2 (E. coli) (Neil2), mRNA.
ACCESSION   NM_201610 XM_356749
VERSION     NM_201610.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1914)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1914)
  AUTHORS   Zhou,Z., Yin,H., Suye,S., Ren,Z., Yan,L., Shi,L. and Fu,C.
  TITLE     Fance deficiency inhibits primordial germ cell proliferation
            associated with transcription-replication conflicts accumulate and
            DNA repair defects
  JOURNAL   J Ovarian Res 16 (1), 160 (2023)
   PUBMED   37563658
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1914)
  AUTHORS   Pan,L., Xue,Y., Wang,K., Zheng,X., Islam,A., Tapryal,N.,
            Chakraborty,A., Bacsi,A., Ba,X., Hazra,T.K. and Boldogh,I.
  TITLE     Nei-like DNA glycosylase 2 selectively antagonizes interferon-beta
            expression upon respiratory syncytial virus infection
  JOURNAL   J Biol Chem 299 (8), 105028 (2023)
   PUBMED   37423306
  REMARK    GeneRIF: Nei-like DNA glycosylase 2 selectively antagonizes
            interferon-beta expression upon respiratory syncytial virus
            infection.
REFERENCE   4  (bases 1 to 1914)
  AUTHORS   Hildrestrand,G.A., Rolseth,V., Kunath,N., Suganthan,R., Jensen,V.,
            Bugaj,A.M., Fernandez-Berrocal,M.S., Sikko,S.B., Vetlesen,S.,
            Kusnierczyk,A., Olsen,A.K., Gutzkow,K.B., Rowe,A.D., Wang,W.,
            Moldestad,O., Syrstad,M.D., Slupphaug,G., Eide,L., Klungland,A.,
            Saetrom,P., Luna,L., Ye,J., Scheffler,K. and Bjoras,M.
  TITLE     NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a
            cooperative manner in mice
  JOURNAL   Commun Biol 4 (1), 1354 (2021)
   PUBMED   34857879
  REMARK    GeneRIF: NEIL1 and NEIL2 DNA glycosylases modulate anxiety and
            learning in a cooperative manner in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1914)
  AUTHORS   Tapryal,N., Shahabi,S., Chakraborty,A., Hosoki,K., Wakamiya,M.,
            Sarkar,G., Sharma,G., Cardenas,V.J., Boldogh,I., Sur,S., Ghosh,G.
            and Hazra,T.K.
  TITLE     Intrapulmonary administration of purified NEIL2 abrogates
            NF-kappaB-mediated inflammation
  JOURNAL   J Biol Chem 296, 100723 (2021)
   PUBMED   33932404
  REMARK    GeneRIF: Intrapulmonary administration of purified NEIL2 abrogates
            NF-kappaB-mediated inflammation.
REFERENCE   6  (bases 1 to 1914)
  AUTHORS   Grin,I.R., Rieger,R.A. and Zharkov,D.O.
  TITLE     Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate
            reveals a loop important for substrate binding
  JOURNAL   Biochem Biophys Res Commun 394 (1), 100-105 (2010)
   PUBMED   20175991
  REMARK    GeneRIF: the beta2/beta3 loop where Lys50 is located in NEIL2 is
            important for DNA binding, presumably lies next to a
            phosphate-binding site, and may represent a target for regulation
            of the enzyme activity.
REFERENCE   7  (bases 1 to 1914)
  AUTHORS   Grin,I.R., Khodyreva,S.N., Nevinsky,G.A. and Zharkov,D.O.
  TITLE     Deoxyribophosphate lyase activity of mammalian endonuclease
            VIII-like proteins
  JOURNAL   FEBS Lett 580 (20), 4916-4922 (2006)
   PUBMED   16920106
  REMARK    GeneRIF: Results suggest a role for NEIL1 and 2 as backup
            deoxyribo-5'-phosphate lyases in mammalian cells.
REFERENCE   8  (bases 1 to 1914)
  AUTHORS   Tong,K.I., Katoh,Y., Kusunoki,H., Itoh,K., Tanaka,T. and
            Yamamoto,M.
  TITLE     Keap1 recruits Neh2 through binding to ETGE and DLG motifs:
            characterization of the two-site molecular recognition model
  JOURNAL   Mol Cell Biol 26 (8), 2887-2900 (2006)
   PUBMED   16581765
  REMARK    GeneRIF: Keap1 recruits NEH2 through binding to ETGE and DLG
            motifs.
REFERENCE   9  (bases 1 to 1914)
  AUTHORS   Conlon,K.A., Miller,H., Rosenquist,T.A., Zharkov,D.O. and
            Berrios,M.
  TITLE     The murine DNA glycosylase NEIL2 (mNEIL2) and human DNA polymerase
            beta bind microtubules in situ and in vitro
  JOURNAL   DNA Repair (Amst) 4 (4), 419-431 (2005)
   PUBMED   15725623
  REMARK    GeneRIF: Recombinant human DNA Polymerase beta and recombinant
            mpise NEIL2 associated with microtubules in situ and in vivo.
REFERENCE   10 (bases 1 to 1914)
  AUTHORS   Hailer,M.K., Slade,P.G., Martin,B.D., Rosenquist,T.A. and
            Sugden,K.D.
  TITLE     Recognition of the oxidized lesions spiroiminodihydantoin and
            guanidinohydantoin in DNA by the mammalian base excision repair
            glycosylases NEIL1 and NEIL2
  JOURNAL   DNA Repair (Amst) 4 (1), 41-50 (2005)
   PUBMED   15533836
  REMARK    GeneRIF: NEIL1 and NEIL2 are essential in the recognition of
            oxidized lesions arising from 8-oxoG and may play important roles
            in the repair of DNA damage induced by carcinogenic metals.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC115709.1 and AC090654.38.
            
            On Nov 17, 2006 this sequence version replaced NM_201610.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY518221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-938               BC115709.1         1-938
            939-1914            AC090654.38        182747-183722       c
FEATURES             Location/Qualifiers
     source          1..1914
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.24 cM"
     gene            1..1914
                     /gene="Neil2"
                     /gene_synonym="Gm1212; NEH2"
                     /note="nei like 2 (E. coli)"
                     /db_xref="GeneID:382913"
                     /db_xref="MGI:MGI:2686058"
     exon            1..102
                     /gene="Neil2"
                     /gene_synonym="Gm1212; NEH2"
                     /inference="alignment:Splign:2.1.0"
     exon            103..256
                     /gene="Neil2"
                     /gene_synonym="Gm1212; NEH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1108
                     /gene="Neil2"
                     /gene_synonym="Gm1212; NEH2"
                     /EC_number="4.2.99.18"
                     /note="endonuclease VIII-like 2; nei homolog 2; nei-like
                     protein 2; DNA glycosylase/AP lyase Neil2; DNA-(apurinic
                     or apyrimidinic site) lyase Neil2"
                     /codon_start=1
                     /product="endonuclease 8-like 2"
                     /protein_id="NP_963904.2"
                     /db_xref="CCDS:CCDS36949.1"
                     /db_xref="GeneID:382913"
                     /db_xref="MGI:MGI:2686058"
                     /translation="MPEGPSVRKFHHLVSPFVGQKVVKTGGSSKKLHPAAFQSLWLQD
                     AQVHGKKLFLRFDPDEEMEPLNSSPQPIQGMWQKEAVDRELALGPSAQEPSAGPSGSG
                     EPVPSRSAETYNLGKIPSADAQRWLEVRFGLFGSIWVNDFSRAKKANKKGDWRDPVPR
                     LVLHFSGGGFLVFYNCQMSWSPPPVIEPTCDILSEKFHRGQALEALSQAQPVCYTLLD
                     QRYFSGLGNIIKNEALYRARIHPLSLGSCLSSSSREALVDHVVEFSKDWLRDKFQGKE
                     RHTQIYQKEQCPSGHQVMKETFGPPDGLQRLTWWCPQCQPQLSSKGPQNLPSS"
     exon            257..597
                     /gene="Neil2"
                     /gene_synonym="Gm1212; NEH2"
                     /inference="alignment:Splign:2.1.0"
     exon            598..794
                     /gene="Neil2"
                     /gene_synonym="Gm1212; NEH2"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1914
                     /gene="Neil2"
                     /gene_synonym="Gm1212; NEH2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggttaggaa acgctgtggc ctaagacttt ctcctggctc ctggagaaaa gggaccacgt
       61 cctgcgcagc ctggccacct caccctagcg acgaagccca agctttctac cggcagagat
      121 gccagaaggg ccatctgtga ggaagtttca ccatcttgtc tccccctttg tgggccagaa
      181 ggtggtcaag acggggggca gcagtaagaa gctccaccct gccgcctttc agtctctgtg
      241 gctccaggat gctcaggtgc atggaaaaaa attattcctt cggtttgatc cagatgagga
      301 gatggagcca ctcaacagca gcccacagcc tatacaggga atgtggcaga aagaggctgt
      361 ggaccgagag ctggccttgg gtcccagtgc tcaggaaccc tctgcaggtc cctctggatc
      421 tggggagcct gttcccagta gatctgctga aacatataat cttgggaaga tcccctcagc
      481 agatgcccag aggtggctgg aggtcaggtt tggtttattt ggcagtatct gggtgaatga
      541 cttctccaga gcaaagaaag ctaacaaaaa aggtgactgg agagacccag tgcccaggct
      601 ggtactccat tttagtggtg gtggcttcct ggtattttat aactgccaga tgtcatggag
      661 ccctccccca gtgattgagc ccacctgtga catattgtct gaaaagttcc atcgaggaca
      721 agccttggaa gctctaagcc aggctcagcc tgtgtgctac acactcttgg accagagata
      781 cttctcagga ttagggaaca tcataaagaa tgaagccttg tacagagcaa ggatccatcc
      841 cctctctctc ggttcatgcc tgagttcttc ctctcgggag gccctcgtgg atcacgtggt
      901 ggagttcagt aaggactggc ttcgggacaa attccaaggc aaggaacggc acacacagat
      961 ctaccagaag gaacaatgtc cttctggtca ccaggtcatg aaggagacat ttgggccccc
     1021 agatgggctc cagaggctca cctggtggtg ccctcaatgc cagccccagc tgtcctccaa
     1081 ggggccccag aatctcccgt cctcctaaaa catgtggcct ttgccgtggg gcttgtagcc
     1141 ttggagatcc aggtgctgtg tgtcctgaaa gaagggtgta ggcagggata gcattacaga
     1201 tcagggtaag gaagttcagg agagtcagta ttgctgacat tcatccgtag gattatgcct
     1261 caactgcagc tttcatagtg gttgataggt gctttccttt tctagttaat tctatgtaat
     1321 cccaccatgc tgtcaaaacc ctgacagtgg actggggaaa aactgcccgg agcagccgtg
     1381 agtctgaaaa gagcatgact ggtggtgtgc agcttctggg gggggggggg aacagctgga
     1441 ggagacagct gggggtgggg ccagcagagt gaacagctgg aggagacagc tgggggtggg
     1501 gtgggggtgg ggccagcaga gtgaacagct gggggatact ataatcccag gctaggttgc
     1561 ttatgcagtg ttttgagaac tggttgattt tgaggccctc taatttcttt cttcttttat
     1621 atagagggat caaggatgag ggcaaagctt caggaaggta gtgctaatca gcctacctgg
     1681 tgccctccca gtggctggag accccaggat ggacagggag gtgtgtccag ggtctgagaa
     1741 aagctggcta ttattttacc cctcaagttg ggcatttgtt gactgttgat gtttgaagaa
     1801 tttgcgtgtc tggggatgta aagaagcaat ctttcaggtt gttagtaaca gctttatgga
     1861 actggagtag caaatgaaaa taaaacggtg tggtattttc tgtggtcttc gtta
//
