LOCUS       NM_028347               1883 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus nei endonuclease VIII-like 1 (E. coli) (Neil1),
            transcript variant 1, mRNA.
ACCESSION   NM_028347 XM_011242818
VERSION     NM_028347.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1883)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1883)
  AUTHORS   Cao,J.H., Cao,C.H., Lin,J.L., Li,S.Y., He,L.J., Han,K., Chen,J.W.,
            Li,S., Wang,X., Xie,D. and Wang,F.W.
  TITLE     NEIL1 drives the initiation of colorectal cancer through
            transcriptional regulation of COL17A1
  JOURNAL   Cell Rep 43 (1), 113654 (2024)
   PUBMED   38175757
  REMARK    GeneRIF: NEIL1 drives the initiation of colorectal cancer through
            transcriptional regulation of COL17A1.
REFERENCE   3  (bases 1 to 1883)
  AUTHORS   Vartanian,V., Krey,J.F., Chatterjee,P., Curtis,A., Six,M.,
            Rice,S.P.M., Jones,S.M., Sampath,H., Allen,C.N., Ryals,R.C.,
            Lloyd,R.S. and Barr-Gillespie,P.G.
  TITLE     Spontaneous allelic variant in deafness-blindness gene Ush1g
            resulting in an expanded phenotype
  JOURNAL   Genes Brain Behav 22 (4), e12849 (2023)
   PUBMED   37328946
REFERENCE   4  (bases 1 to 1883)
  AUTHORS   Hildrestrand,G.A., Rolseth,V., Kunath,N., Suganthan,R., Jensen,V.,
            Bugaj,A.M., Fernandez-Berrocal,M.S., Sikko,S.B., Vetlesen,S.,
            Kusnierczyk,A., Olsen,A.K., Gutzkow,K.B., Rowe,A.D., Wang,W.,
            Moldestad,O., Syrstad,M.D., Slupphaug,G., Eide,L., Klungland,A.,
            Saetrom,P., Luna,L., Ye,J., Scheffler,K. and Bjoras,M.
  TITLE     NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a
            cooperative manner in mice
  JOURNAL   Commun Biol 4 (1), 1354 (2021)
   PUBMED   34857879
  REMARK    GeneRIF: NEIL1 and NEIL2 DNA glycosylases modulate anxiety and
            learning in a cooperative manner in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1883)
  AUTHORS   Paluri,S.L., Burak,M., Senejani,A.G., Levinson,M., Rahim,T.,
            Clairmont,K., Kashgarian,M., Alvarado-Cruz,I., Meas,R.,
            Cardo-Vila,M., Zeiss,C., Maher,S., Bothwell,A.L.M., Coskun,E.,
            Kant,M., Jaruga,P., Dizdaroglu,M., Stephen Lloyd,R. and Sweasy,J.B.
  TITLE     DNA glycosylase deficiency leads to decreased severity of lupus in
            the Polb-Y265C mouse model
  JOURNAL   DNA Repair (Amst) 105, 103152 (2021)
   PUBMED   34186496
  REMARK    GeneRIF: DNA glycosylase deficiency leads to decreased severity of
            lupus in the Polb-Y265C mouse model.
REFERENCE   6  (bases 1 to 1883)
  AUTHORS   Miller,H., Fernandes,A.S., Zaika,E., McTigue,M.M., Torres,M.C.,
            Wente,M., Iden,C.R. and Grollman,A.P.
  TITLE     Stereoselective excision of thymine glycol from oxidatively damaged
            DNA
  JOURNAL   Nucleic Acids Res 32 (1), 338-345 (2004)
   PUBMED   14726482
  REMARK    GeneRIF: ability of Neil1 to discriminate between thymine glycol
            stereoisomers
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1883)
  AUTHORS   Rosenquist,T.A., Zaika,E., Fernandes,A.S., Zharkov,D.O., Miller,H.
            and Grollman,A.P.
  TITLE     The novel DNA glycosylase, NEIL1, protects mammalian cells from
            radiation-mediated cell death
  JOURNAL   DNA Repair (Amst) 2 (5), 581-591 (2003)
   PUBMED   12713815
  REMARK    GeneRIF: Neil1 is an essential component of base excision repair in
            mammalian cells; its presence may contribute to the redundant
            repair capacity observed in Ogg1 -/- and Nth1 -/- mice
REFERENCE   8  (bases 1 to 1883)
  AUTHORS   Carmell,M.A., Zhang,L., Conklin,D.S., Hannon,G.J. and
            Rosenquist,T.A.
  TITLE     Germline transmission of RNAi in mice
  JOURNAL   Nat Struct Biol 10 (2), 91-92 (2003)
   PUBMED   12536207
  REMARK    GeneRIF: repression of Neil1 espression by RNA interference
REFERENCE   9  (bases 1 to 1883)
  AUTHORS   Morland,I., Rolseth,V., Luna,L., Rognes,T., Bjoras,M. and
            Seeberg,E.
  TITLE     Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an
            alternative pathway for the repair of 8-oxoguanine and other
            oxidation products in DNA
  JOURNAL   Nucleic Acids Res 30 (22), 4926-4936 (2002)
   PUBMED   12433996
REFERENCE   10 (bases 1 to 1883)
  AUTHORS   Takao,M., Kanno,S., Kobayashi,K., Zhang,Q.M., Yonei,S., van der
            Horst,G.T. and Yasui,A.
  TITLE     A back-up glycosylase in Nth1 knock-out mice is a functional Nei
            (endonuclease VIII) homologue
  JOURNAL   J Biol Chem 277 (44), 42205-42213 (2002)
   PUBMED   12200441
  REMARK    GeneRIF: NEIL1 is a back-up glycosylase for NTH1 with unique
            substrate specificity and tissue-specific expression.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC034873.1, AK013322.1 and AC132406.4.
            
            On or before Oct 27, 2017 this sequence version replaced
            XM_011242818.2, NM_028347.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034873.1, AK013322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               BC034873.1         1-181
            182-1275            AK013322.1         8-1101
            1276-1871           AK013322.1         1103-1698
            1872-1883           AC132406.4         24259-24270
FEATURES             Location/Qualifiers
     source          1..1883
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 30.89 cM"
     gene            1..1883
                     /gene="Neil1"
                     /gene_synonym="2810450N13Rik; NEH1; Nei1"
                     /note="nei endonuclease VIII-like 1 (E. coli)"
                     /db_xref="GeneID:72774"
                     /db_xref="MGI:MGI:1920024"
     exon            1..222
                     /gene="Neil1"
                     /gene_synonym="2810450N13Rik; NEH1; Nei1"
                     /inference="alignment:Splign:2.1.0"
     exon            223..679
                     /gene="Neil1"
                     /gene_synonym="2810450N13Rik; NEH1; Nei1"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1415
                     /gene="Neil1"
                     /gene_synonym="2810450N13Rik; NEH1; Nei1"
                     /EC_number="4.2.99.18"
                     /note="isoform 1 is encoded by transcript variant 1;
                     endonuclease 8-like 1; endonuclease VIII-like 1; nei
                     homolog 1; nei-like protein 1; DNA glycosylase/AP lyase
                     Neil1; DNA-(apurinic or apyrimidinic site) lyase Neil1"
                     /codon_start=1
                     /product="endonuclease 8-like 1 isoform 1"
                     /protein_id="NP_082623.1"
                     /db_xref="CCDS:CCDS23217.1"
                     /db_xref="GeneID:72774"
                     /db_xref="MGI:MGI:1920024"
                     /translation="MPEGPELHLASHFVNETCKGLVFGGCVEKSSVSRNPEVPFESSA
                     YHISALARGKELRLTLSPLPGSQPPQKPLSLVFRFGMSGSFQLVPAEALPRHAHLRFY
                     TAPPAPRLALCFVDIRRFGHWDPGGEWQPGRGPCVLLEYERFRENVLRNLSDKAFDRP
                     ICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARTVLEALQQCRPSPELTLSQKIKA
                     KLQNPDLLELCHLVPKEVVQLGGKGYGPERGEEDFAAFRAWLRCYGVPGMSSLRDRHG
                     RTIWFQGDPGPLAPKGGRSQKKKSQETQLGAEDRKEDLPLSSKSVSRMRRARKHPPKR
                     IAQQSEGAGLQQNQETPTAPEKGKRRGQRASTGHRRRPKTIPDTRPREAGESSAS"
     exon            680..799
                     /gene="Neil1"
                     /gene_synonym="2810450N13Rik; NEH1; Nei1"
                     /inference="alignment:Splign:2.1.0"
     exon            800..863
                     /gene="Neil1"
                     /gene_synonym="2810450N13Rik; NEH1; Nei1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..963
                     /gene="Neil1"
                     /gene_synonym="2810450N13Rik; NEH1; Nei1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1091
                     /gene="Neil1"
                     /gene_synonym="2810450N13Rik; NEH1; Nei1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1119
                     /gene="Neil1"
                     /gene_synonym="2810450N13Rik; NEH1; Nei1"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1181
                     /gene="Neil1"
                     /gene_synonym="2810450N13Rik; NEH1; Nei1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1344
                     /gene="Neil1"
                     /gene_synonym="2810450N13Rik; NEH1; Nei1"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1883
                     /gene="Neil1"
                     /gene_synonym="2810450N13Rik; NEH1; Nei1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1862..1867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neil1"
                     /gene_synonym="2810450N13Rik; NEH1; Nei1"
                     /note="hexamer: AATAAA"
     polyA_site      1883
                     /gene="Neil1"
                     /gene_synonym="2810450N13Rik; NEH1; Nei1"
                     /note="major polyA site"
ORIGIN      
        1 gtcacctccg ggttacgcga ctgctccaaa gcttgcccaa cacccgggat tctcataaat
       61 aaggaactcc attccatact gcgccgcctg cctgagaaaa ctacatttcc cagcaggtac
      121 cagagtgtct ctagcctttc ccagcgtgct ctgaagttcg gcagactgct gggattaacc
      181 ccttactggc tgctgcctca ggttgagcag taaccagagc agggcccagc cattcctcct
      241 tcagaatgcc agagggccca gagctgcacc tggccagcca ctttgtgaat gagacatgta
      301 aggggctggt atttggtggg tgtgtggaga agtcctctgt cagccggaac ccggaggtgc
      361 cctttgagag cagtgcctac cacatctcag ctttagcccg aggcaaggag ctgcgcttga
      421 cattgagccc cctgcctggg tcccagcccc ctcagaagcc actgtccctt gtcttccgct
      481 ttgggatgtc aggatccttc cagctggtac ccgcagaggc actgccccgc cacgcccatc
      541 tacgttttta cacagcccca cctgctcccc ggcttgccct ttgcttcgta gacatccgtc
      601 gctttggcca ctgggatcct gggggtgaat ggcaaccagg ccgtggaccc tgtgtcttgc
      661 tggagtatga acggttcaga gagaacgtac ttcggaacct atcagacaaa gcctttgacc
      721 ggcccatctg tgaggccttg ttggaccaga ggttcttcaa tggcattggc aactatctgc
      781 gggcagagat cctgtaccgg ctgaagatcc ctccttttga gaaggctcgt acagttctag
      841 aggccctgca acagtgccgg ccgagcccag agctgaccct gagccagaag atcaaggcca
      901 aactacagaa cccagacctg ctggaactgt gtcacttggt gcccaaggaa gtggttcagc
      961 tggggggcaa aggctatggg ccagagcgtg gagaggagga ttttgctgcc tttcgagcct
     1021 ggcttcggtg ctatggtgtg ccaggcatga gctccctgcg agaccggcat ggccgtacca
     1081 tctggttcca gggtgatccc ggacccttgg cacccaaagg gggcagatcc caaaaaaaga
     1141 agtcacagga gacacagctg ggggctgagg acaggaaaga ggaccttcca ctttcaagca
     1201 agtccgtttc caggatgcgg agggccagga agcaccctcc taagagaata gctcaacagt
     1261 ctgaaggggc cggcctccaa caaaaccagg aaacccctac agctcctgag aaagggaaga
     1321 ggagggggca acgggcgagc acaggccacc gcagacgccc aaagactata cctgacaccc
     1381 gacccaggga ggctggggag agttcagctt catagatgga ggtctccttc cctgatgact
     1441 tgctgtgaat cctggggcat gtctgaatcc ctaaaagcag tatttgtagg gctgcatgcc
     1501 ctaggccccg tgacttttcc tgcataactg ttttttgggg gcagggcttt gtatgtccta
     1561 tccttgaacc catgtggatc tgaagatgac attgaactcc cgtttggtct ttctgctcca
     1621 tgtccatggt tgccggggtt acaggtgtga gccaagctgc cacactccac tcactgattt
     1681 gctgttgtct actttttcaa aacaagggtt tctctgtgta gccctggctg tcctggaact
     1741 cactctgtag accaagctgg cctcaaattc agagatctgc ctgcttctgc ctcccaaagt
     1801 gttggaaatg taagccatct tcaacatttt ttaaatccaa agtgaaaacc attattaaac
     1861 taataaattt gaacttcttg gta
//
