LOCUS       NM_001039094            5002 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus neuronal growth regulator 1 (Negr1), transcript
            variant 1, mRNA.
ACCESSION   NM_001039094 XM_992112
VERSION     NM_001039094.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5002)
  AUTHORS   Singh,K., Jayaram,M., Hanumantharaju,A., Tonissoo,T., Jagomae,T.,
            Mikheim,K., Muthuraman,S., Gilbert,S.F., Plaas,M., Schafer,M.K.E.,
            Innos,J., Lillevali,K., Philips,M.A. and Vasar,E.
  TITLE     The IgLON family of cell adhesion molecules expressed in developing
            neural circuits ensure the proper functioning of the sensory system
            in mice
  JOURNAL   Sci Rep 14 (1), 22593 (2024)
   PUBMED   39349721
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5002)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5002)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 5002)
  AUTHORS   Lee,J., Kim,S., Lee,B., Kim,Y.B., Kim,K.H., Chung,G., Lee,S.J.,
            Lee,S., Sun,W., Park,H.K. and Choi,S.Y.
  TITLE     Major depression-related factor NEGR1 controls salivary secretion
            in mouse submandibular glands
  JOURNAL   iScience 26 (5), 106773 (2023)
   PUBMED   37216094
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5002)
  AUTHORS   Yoo,A., Joo,Y., Cheon,Y., Lee,S.J. and Lee,S.
  TITLE     Neuronal growth regulator 1 promotes adipocyte lipid trafficking
            via interaction with CD36
  JOURNAL   J Lipid Res 63 (6), 100221 (2022)
   PUBMED   35526561
  REMARK    GeneRIF: Neuronal growth regulator 1 promotes adipocyte lipid
            trafficking via interaction with CD36.
REFERENCE   6  (bases 1 to 5002)
  AUTHORS   Mattar,P., Britz,O., Johannes,C., Nieto,M., Ma,L., Rebeyka,A.,
            Klenin,N., Polleux,F., Guillemot,F. and Schuurmans,C.
  TITLE     A screen for downstream effectors of Neurogenin2 in the embryonic
            neocortex
  JOURNAL   Dev Biol 273 (2), 373-389 (2004)
   PUBMED   15328020
REFERENCE   7  (bases 1 to 5002)
  AUTHORS   Funatsu,N., Inoue,T. and Nakamura,S.
  TITLE     Gene expression analysis of the late embryonic mouse cerebral
            cortex using DNA microarray: identification of several region- and
            layer-specific genes
  JOURNAL   Cereb Cortex 14 (9), 1031-1044 (2004)
   PUBMED   15142957
REFERENCE   8  (bases 1 to 5002)
  AUTHORS   Quwailid,M.M., Hugill,A., Dear,N., Vizor,L., Wells,S., Horner,E.,
            Fuller,S., Weedon,J., McMath,H., Woodman,P., Edwards,D.,
            Campbell,D., Rodger,S., Carey,J., Roberts,A., Glenister,P.,
            Lalanne,Z., Parkinson,N., Coghill,E.L., McKeone,R., Cox,S.,
            Willan,J., Greenfield,A., Keays,D., Brady,S., Spurr,N., Gray,I.,
            Hunter,J., Brown,S.D. and Cox,R.D.
  TITLE     A gene-driven ENU-based approach to generating an allelic series in
            any gene
  JOURNAL   Mamm Genome 15 (8), 585-591 (2004)
   PUBMED   15457338
REFERENCE   9  (bases 1 to 5002)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   10 (bases 1 to 5002)
  AUTHORS   Marg,A., Sirim,P., Spaltmann,F., Plagge,A., Kauselmann,G., Buck,F.,
            Rathjen,F.G. and Brummendorf,T.
  TITLE     Neurotractin, a novel neurite outgrowth-promoting Ig-like protein
            that interacts with CEPU-1 and LAMP
  JOURNAL   J Cell Biol 145 (4), 865-876 (1999)
   PUBMED   10330412
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147253.1 and CA884108.1.
            
            On Nov 15, 2013 this sequence version replaced NM_001039094.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147253.1, AK142298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4985              AK147253.1         2-4986
            4986-5002           CA884108.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..5002
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 80.6 cM"
     gene            1..5002
                     /gene="Negr1"
                     /gene_synonym="5330422G01Rik; KILON; Ntra"
                     /note="neuronal growth regulator 1"
                     /db_xref="GeneID:320840"
                     /db_xref="MGI:MGI:2444846"
     exon            1..559
                     /gene="Negr1"
                     /gene_synonym="5330422G01Rik; KILON; Ntra"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..1448
                     /gene="Negr1"
                     /gene_synonym="5330422G01Rik; KILON; Ntra"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; neurotractin; kindred of IgLON"
                     /codon_start=1
                     /product="neuronal growth regulator 1 isoform a precursor"
                     /protein_id="NP_001034183.1"
                     /db_xref="CCDS:CCDS17930.1"
                     /db_xref="GeneID:320840"
                     /db_xref="MGI:MGI:2444846"
                     /translation="MVLLAQGACCSNQWLAAVLLSLCSCLPAGQSVDFPWAAVDNMLV
                     RKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNV
                     DVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDISNDMTINEGTNVTLTCLATGKP
                     EPVISWRHISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVKKVRVIVNFA
                     PTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKRLFNGQQGIIIQNFSTRSIL
                     TVTNVTQEHFGNYTCVAANKLGTTNASLPLNPPSTAQYGITGSACDLFSCWSLALTLS
                     SVISIFYLKNAILQ"
     exon            560..792
                     /gene="Negr1"
                     /gene_synonym="5330422G01Rik; KILON; Ntra"
                     /inference="alignment:Splign:2.1.0"
     exon            793..918
                     /gene="Negr1"
                     /gene_synonym="5330422G01Rik; KILON; Ntra"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1050
                     /gene="Negr1"
                     /gene_synonym="5330422G01Rik; KILON; Ntra"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1171
                     /gene="Negr1"
                     /gene_synonym="5330422G01Rik; KILON; Ntra"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1323
                     /gene="Negr1"
                     /gene_synonym="5330422G01Rik; KILON; Ntra"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..5002
                     /gene="Negr1"
                     /gene_synonym="5330422G01Rik; KILON; Ntra"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4716..4721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Negr1"
                     /gene_synonym="5330422G01Rik; KILON; Ntra"
                     /note="hexamer: AATAAA"
     polyA_site      4742
                     /gene="Negr1"
                     /gene_synonym="5330422G01Rik; KILON; Ntra"
     regulatory      4960..4965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Negr1"
                     /gene_synonym="5330422G01Rik; KILON; Ntra"
                     /note="hexamer: TATAAA"
     polyA_site      4983
                     /gene="Negr1"
                     /gene_synonym="5330422G01Rik; KILON; Ntra"
                     /note="major polyA site"
ORIGIN      
        1 gggggccgcc ggccgctgct gcgccccgcg ctgcctgcgc cgcctcccgc gctctgctcg
       61 cagcctcgca ggacggtgtg cggccgccag ggattagcca cgctccggac gcggccgggc
      121 gccccgaagg aggtggagcg cggtgccagg gggcgggagg ggagggaggg aaggcaagct
      181 gcagaggagc agaaaggagg cgaggccggg gaaagaggga aactacgccc gacaactagg
      241 gagggggcga gaaagagaag aaacccaccc acccactcag aaaaaggaaa agaggaaaaa
      301 aaatctcgtg tggcgcgccg cctggttatc gggcagcctc gccagcagca gggggtggga
      361 gccgacgctg ccggagagcg agcagcctgg caggcacgga catggtgctc ctggcgcagg
      421 gcgcttgttg ctcgaaccag tggctggcgg cggtgcttct gagcctgtgc tcttgcctcc
      481 cggccgggca gagcgtggac ttcccttggg cggccgtgga caacatgctg gtgaggaaag
      541 gtgacacagc ggtgctcagg tgttacttgg aagatggagc atcaaagggt gcctggctca
      601 acaggtcaag tatcattttt gctggaggtg acaagtggtc agtggaccct cgagtttcca
      661 tttccacatt gaataaaaga gactacagcc tccagataca gaatgttgat gtaacagatg
      721 atggcccgta cacctgttct gtgcagaccc aacacacacc acggacaatg caggttcatc
      781 tcactgtgca agtcccaccg aaaatatacg acatctcaaa tgacatgacc atcaatgaag
      841 gaaccaatgt cacccttact tgtttggcca ctgggaagcc agagcctgtc atttcctgga
      901 ggcatatctc cccatcagca aaaccatttg aaaatggaca atatttggac atttatggaa
      961 ttacaaggga ccaggctggg gagtatgaat gcagtgcaga aaacgatgtg tcgttcccag
     1021 acgtgaagaa agtgagagtg atcgtgaact ttgcgcctac aattcaggaa attaaatctg
     1081 gcactgtgac ccctggacgc agtggactga tacgatgcga gggtgcaggt gtgccgccgc
     1141 cggccttcga gtggtacaaa ggagagaaga ggctcttcaa tggccaacaa ggaattatca
     1201 ttcagaattt tagcacaaga tccatcctca cagtgaccaa tgtgacgcag gagcacttcg
     1261 gcaactatac ttgtgtggct gccaacaagt tgggtacaac caacgcgagc ctgcccctca
     1321 accctccaag tacagcccag tatggaatta ctgggagtgc ctgcgacctc ttctcctgct
     1381 ggagccttgc gttgacacta tcttctgtca tcagtatatt ctacctgaag aatgctatcc
     1441 ttcaatgaat ctaaagaccc atgaaaggct tttaaggagt ctctgggagt gctgatggct
     1501 ggatccaatc tggtgcagtt agcttgaagc agcgtgggat acaatcggcc gtctgtacgc
     1561 gggtgacgcc ttttgtctgt ggaatcgctg gttgtgtaaa tactttcatt ctcctctcct
     1621 tttgattaga cacacgacct tgtgaagcac tgcacattgt ccctttttta agatgtgaaa
     1681 ggtctgaact tacttttaga ggatattaat tgtgatttca tgtttgtaat ctacaacttt
     1741 tcaaaagcat tcagtcgtgg tctgctaggc ttccggctgt agtttacata acaaatattg
     1801 cagtgaaccc ataattcttt aaggctgcaa tacaagggtt ccatgccctg tttcaataag
     1861 agtcaaccca catttacaaa gatgcatttt tttctttttt gataaaaatt caaataatat
     1921 tgccttcaga tcatttcttc aagatgtaac acatacctag acgtccctgc tcgcatgaca
     1981 tccaggtttt ggaaatgagc cttgtaatat aactcgctat gcttctcctt ctaatctcag
     2041 catgggtgtg ccttcataaa ataatctctt ggtctctgac aaatacataa tgttttccta
     2101 aaccttgcaa tctggaagca aaaaagtaaa ttacaccaat aagctaaact ccaccccact
     2161 ttggggggcg ccaagaagct attaggctgt gtctagtcat tacccattga gcctgagaac
     2221 tttgcccaca gcatctcagt tttcttgata aaacaattta ataacatgat tgaagttcag
     2281 gtttaatatt agtgccactg tgggaaaaca tagcccatca caggacagca cagcctgttc
     2341 aagagacccc tggtaaagca gcagtctcct gcactattca agttgatacc ctaacatagc
     2401 ttctttgcat agaccacagc cctgccaccc aagagacatg aggtggcgag tgctcagatt
     2461 aggctttgac atcagtaagt tactgtgaca gaaaccctgc agatttccat ctgattctcc
     2521 gtctttggtt gataggaatg catcttatgt tccttacaat tccaaaatgt gttttaacaa
     2581 atattgggca tccatgcata acagatcagc cctgaagtaa ctaattcttc accaaaatct
     2641 tgttagtcat taccactcaa attgatgcca aaactgaaga ctcaccatgt ttcactgcat
     2701 cttacaggac atatgtgaga tgcaaccaaa tggacacacc agaaggaggg catcatggga
     2761 tatgttaatc actcaatgat tgtgaatatt acattttttc tattcaagaa gcaaaactac
     2821 atttttgaag gaaaatgctg ttagtctaac tactatatta caggaatagg ctcatggtct
     2881 tgcttttgac caaagaaaag accagagcct tgaaagccat ttttcaggtc tgatgaagtt
     2941 gccaatttca gcacgcctag gtttctacag tgaccttctg cacaccctaa ataaagacct
     3001 actctcaaaa ctacacccaa ggacttttac agtgattatt ttaggtagtt catgttttgc
     3061 cctggaagga tggctttaaa tttttgattc ttttctaaac aaattttaga cccaaaagac
     3121 accataaatc tattttaatt aggaaaatga atcataagtg aggagacata aatacatagt
     3181 cttcctatga aatggcaata atgtggcata atgctatgaa atttactagc tgtaataaat
     3241 ttatgtcatt ttgattgata tattaaaaat gaattttgaa aattatggca tctaaatttc
     3301 taggtgattt gatactaaaa atgttctttg tggaattagt gagcaaacaa cagaattatt
     3361 tttctttgta ttgcagcttt aaagtagcac actccacaat aacctacttt tagagatagc
     3421 ggtgctacca tggagtgttg gccacctgaa ccgctgtttg gggagagaag cagttggaga
     3481 atgcgtattc tacagtgacc gtttccctag agttaaaaat gcctcctctg tgtaaggtgt
     3541 gtagggtaca tgtgaggtaa actgaggtat aaaatacaga tgaaccaaat aattagttct
     3601 aagtgttgtc atgattccga attcgtggag tccggtgttt ttccatagag tgtgacaaag
     3661 gacagtcata gctcagtagc tacatgtatt tgcctttatg ttagaagaga ctttcttgag
     3721 tgacatttta atagaggagg catccgctat gtttttctgt attacagcag catagtcctt
     3781 aggcgcctgg acagagtgaa accatgagta tttatgagtt cagtattgtt caaataaggc
     3841 tacagtattt gcttttttgt gtgaatgtat tgcatataat gttcaagtag gtgattttac
     3901 attgacgggc atctgaaatg tctgattact ccattttatc agtcctgact gtacaagatt
     3961 gttgcaattt cagaatagca gtcttatgaa gttaatttat cttttgattt acaacaattt
     4021 ctttagctat tcatttcagc gttatgtttt ccacaatatc catttgtggg attccttttg
     4081 ttgcccctaa atttttaaag aaagaaggaa aaaatgatga tagagaaagg agaatgtgaa
     4141 aatggagaaa aggaaaaaag agtatggggg ataaacagaa atgactgaag gaagcgaaga
     4201 ggttgggagg gagagtgggg gagagctgga atcttctgct gatgagccta ttggactgca
     4261 ttcttggttt aactgcaaat ggccgaattt tttcccaatg atcttattct acacctaagt
     4321 cctgctatac cctgtggtcc tgctgggcag aatttattga atgattccac tgcccaggcc
     4381 acagtactga gtgctttttg cagacactga gattgagaga gagcatttca aacataaagt
     4441 cactttgggg ttcacagctt cactgaaaaa ttatcttctc ataacattta tgatatgtct
     4501 agaaagtaga ctggaaagct aagaatcacc cggataattc aggacaaaac tgcacacata
     4561 tagagaagta cccccaatct gtgaagtatg aacactctga gcaactgaac tatcaaagtc
     4621 aaccaatggt attgatcaaa ttactgaata attgttaatt tacccattgt gcttagcttt
     4681 gtaacacagc tgaaagttac ctatttaatc ttttcaataa aaattgtttt ttttgaaatc
     4741 cagaaatgat tttaaaaaga ggtcaggttt ctaactattt attgaagtgt gtgggtgtac
     4801 agtatttcaa tagatatgaa tatggataag tggtattgcc ttaagatcct ctgaaatgta
     4861 cttactttaa agactggaaa acacccttcc tgtctttagt aaaacatcca tatttcataa
     4921 tctgatgtaa aatatgttgt actgtttcca ataggtgaat ataaagtcag tttatcaatt
     4981 aaagtatgta tttgactcat tt
//
