LOCUS       NM_008691               3244 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus neurofilament, medium polypeptide (Nefm), mRNA.
ACCESSION   NM_008691
VERSION     NM_008691.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3244)
  AUTHORS   Curran,B.M., Nickerson,K.R., Yung,A.R., Goodrich,L.V., Jaworski,A.,
            Tessier-Lavigne,M. and Ma,L.
  TITLE     Multiple guidance mechanisms control axon growth to generate
            precise T-shaped bifurcation during dorsal funiculus development in
            the spinal cord
  JOURNAL   Elife 13, 94109 (2024)
   PUBMED   39159057
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3244)
  AUTHORS   Erickson,A.G., Motta,A., Kastriti,M.E., Edwards,S., Coulpier,F.,
            Theoulle,E., Murtazina,A., Poverennaya,I., Wies,D., Ganofsky,J.,
            Canu,G., Lallemend,F., Topilko,P., Hadjab,S., Fried,K.,
            Ruhrberg,C., Schwarz,Q., Castellani,V., Bonanomi,D. and Adameyko,I.
  TITLE     Motor innervation directs the correct development of the mouse
            sympathetic nervous system
  JOURNAL   Nat Commun 15 (1), 7065 (2024)
   PUBMED   39152112
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3244)
  AUTHORS   Zhang,J., Li,H. and Niswander,L.A.
  TITLE     m5C methylated lncRncr3-MeCP2 interaction restricts
            miR124a-initiated neurogenesis
  JOURNAL   Nat Commun 15 (1), 5136 (2024)
   PUBMED   38879605
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3244)
  AUTHORS   Zaninello,M., Schlegel,T., Nolte,H., Pirzada,M., Savino,E.,
            Barth,E., Klein,I., Wustenberg,H., Uddin,T., Wolff,L., Wirth,B.,
            Lehmann,H.C., Cioni,J.M., Langer,T. and Rugarli,E.I.
  TITLE     CLUH maintains functional mitochondria and translation in
            motoneuronal axons and prevents peripheral neuropathy
  JOURNAL   Sci Adv 10 (22), eadn2050 (2024)
   PUBMED   38809982
REFERENCE   5  (bases 1 to 3244)
  AUTHORS   Masuda,A., Nishida,K., Ajima,R., Saga,Y., Bakhtan,M., Klar,A.,
            Hirata,T. and Zhu,Y.
  TITLE     A global gene regulatory program and its region-specific regulator
            partition neurons into commissural and ipsilateral projection types
  JOURNAL   Sci Adv 10 (21), eadk2149 (2024)
   PUBMED   38781326
REFERENCE   6  (bases 1 to 3244)
  AUTHORS   Shneidman,P.S., Bruce,J., Schwartz,M.L. and Schlaepfer,W.W.
  TITLE     Negative regulatory regions are present upstream in the three mouse
            neurofilament genes
  JOURNAL   Brain Res Mol Brain Res 13 (1-2), 127-138 (1992)
   PUBMED   1315909
REFERENCE   7  (bases 1 to 3244)
  AUTHORS   Chisaka,O., Musci,T.S. and Capecchi,M.R.
  TITLE     Developmental defects of the ear, cranial nerves and hindbrain
            resulting from targeted disruption of the mouse homeobox gene
            Hox-1.6
  JOURNAL   Nature 355 (6360), 516-520 (1992)
   PUBMED   1346922
REFERENCE   8  (bases 1 to 3244)
  AUTHORS   Boisseau,S., Nedelec,J., Poirier,V., Rougon,G. and Simonneau,M.
  TITLE     Analysis of high PSA N-CAM expression during mammalian spinal cord
            and peripheral nervous system development
  JOURNAL   Development 112 (1), 69-82 (1991)
   PUBMED   1769342
REFERENCE   9  (bases 1 to 3244)
  AUTHORS   Whitlon,D.S. and Rutishauser,U.S.
  TITLE     NCAM in the organ of Corti of the developing mouse
  JOURNAL   J Neurocytol 19 (6), 970-977 (1990)
   PUBMED   2292721
REFERENCE   10 (bases 1 to 3244)
  AUTHORS   Wong,P.C. and Cleveland,D.W.
  TITLE     Characterization of dominant and recessive assembly-defective
            mutations in mouse neurofilament NF-M
  JOURNAL   J Cell Biol 111 (5 Pt 1), 1987-2003 (1990)
   PUBMED   2121743
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE986344.1, AK051696.1, AC154687.2 and BF466963.1.
            
            On Aug 16, 2006 this sequence version replaced NM_008691.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058333.1, AK051696.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               BE986344.1         1-161
            162-1687            AK051696.1         2-1527
            1688-2601           AC154687.2         126539-127452       c
            2602-3244           BF466963.1         1-643               c
FEATURES             Location/Qualifiers
     source          1..3244
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 35.46 cM"
     gene            1..3244
                     /gene="Nefm"
                     /gene_synonym="Nef3; NF-M; NF160; NF165; Nfm"
                     /note="neurofilament, medium polypeptide"
                     /db_xref="GeneID:18040"
                     /db_xref="MGI:MGI:97314"
     exon            1..1265
                     /gene="Nefm"
                     /gene_synonym="Nef3; NF-M; NF160; NF165; Nfm"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..2738
                     /gene="Nefm"
                     /gene_synonym="Nef3; NF-M; NF160; NF165; Nfm"
                     /note="neurofilament 3, medium; neurofilament protein M;
                     160 kDa neurofilament protein; neurofilament triplet M
                     protein; neurofilament-M"
                     /codon_start=1
                     /product="neurofilament medium polypeptide"
                     /protein_id="NP_032717.2"
                     /db_xref="CCDS:CCDS27233.1"
                     /db_xref="GeneID:18040"
                     /db_xref="MGI:MGI:97314"
                     /translation="MSYTLDSLGNPSAYRRVTETRSSFSRVSGSPSSGFRSQSWSRGS
                     PSTVSSSYKRSALAPRLAYSSAMLSSAESSLDFSQSSSLLNGGSGGDYKLSRSNEKEQ
                     LQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLE
                     MVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEESSMVKVEL
                     DKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLE
                     CHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRG
                     TKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMAL
                     DIEIAAYRKLLEGEETRFSTFSGSITGPLYTHRQPSVTISSKIQKTKVEAPKLKVQHK
                     FVEEIIEETKVEDEKSEMEETLTAIAEELAASAKEEKEEAEEKEEEPEAEKSPVKSPE
                     AKEEEEEGEKEEEEEGQEEEEEEDEGVKSDQAEEGGSEKEGSSEKDEGEQEEEEGETE
                     AEGEGEEAEAKEEKKIEGKVEEVAVKEEIKVEKPEKAKSPMPKSPVEEVKPKPEAKAG
                     KGEHKEEEKVEEEKKEVTKESPKEEKVEKKEEKPKDVADKKKAESPVKEKAVEEVITI
                     SKSVKVSLEKDTKEEKLQPQEKVKEKAEEEGGSEEEGSDRSPQESKKEDIAINGEVEG
                     KEEEEQETQEKGSGREEEKGVVTNGLDVSPAEEKKGEDSSDDKVVVTKKVEKITSEGG
                     DGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQGD"
     exon            1266..1390
                     /gene="Nefm"
                     /gene_synonym="Nef3; NF-M; NF160; NF165; Nfm"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..3230
                     /gene="Nefm"
                     /gene_synonym="Nef3; NF-M; NF160; NF165; Nfm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3206..3211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nefm"
                     /gene_synonym="Nef3; NF-M; NF160; NF165; Nfm"
                     /note="hexamer: AATAAA"
     polyA_site      3230
                     /gene="Nefm"
                     /gene_synonym="Nef3; NF-M; NF160; NF165; Nfm"
                     /note="major polyA site"
ORIGIN      
        1 cggccgctga atcaccgcaa ggcttgtctc ccccttcccc ccacccccgg cccggtaccc
       61 gcagtccccg cctcctcggc cgccgcctcc acggggcggg gccctggccc gggaccagct
      121 gctccgctat aaaggggctg cggcgaggcc ggcagaacgc tgtgacagcc acacacccca
      181 aggcctccaa gatgagctac acgctggact cgctgggcaa cccgtccgcc taccggcggg
      241 tcaccgagac ccgctccagc ttcagccgcg tgagcggttc cccgtccagc ggcttccgct
      301 cgcagtcctg gtcccgcggc tcgcccagca ccgtgtcctc ctcctacaag cgcagcgcgc
      361 tcgccccgcg tctcgcctac agctcggcta tgctcagctc ggccgagagc agcctcgact
      421 tcagccagtc ctcgtcgctg ctcaacggcg gctccggcgg cgactacaaa ctgtcccgct
      481 ctaacgagaa agagcagctg caggggctga acgaccgctt cgccggctac atcgagaaag
      541 tgcactactt ggaacaacag aacaaggaga tcgaagcaga gatccaggca ctgcggcaga
      601 agcaggcctc gcacgcccag ctgggtgatg cttacgacca ggagatccga gagctgcgcg
      661 ccaccctcga gatggtgaac cacgagaagg ctcaagtgca gctggactcc gatcacttgg
      721 aggaagacat ccaccggctc aaggagcgct tcgaggagga ggcgcggctg cgggacgaca
      781 ccgaggctgc cattcgcgcg ctgcgcaaag acatcgaaga gtcgtcgatg gttaaggtgg
      841 agctggacaa gaaggtgcag tcgctgcagg atgaggtggc tttcctgcgg agcaatcacg
      901 aagaggaggt ggccgacctg ctggctcaga tccaggcgtc gcacatcacg gtagagcgca
      961 aagattacct gaagacagac atctccacgg cgctgaagga gatccgctcc cagctcgagt
     1021 gtcactcaga ccagaacatg caccaggccg aagagtggtt caaatgccgc tacgccaagc
     1081 tcaccgaggc ggccgagcag aacaaggagg ccattcgctc tgccaaggaa gagatcgccg
     1141 agtaccggcg ccagctgcag tccaagagca tcgagctcga gtcggtgcga ggcactaagg
     1201 agtccctgga gcggcagctc agcgacatcg aggagcgcca caaccacgac ctcagcagct
     1261 accaggacac catccagcag ttggaaaatg aacttcgggg aaccaagtgg gaaatggctc
     1321 gtcatttgcg agaataccag gatctcctta acgtcaagat ggccctggac atcgagatcg
     1381 ccgcgtacag gaaactccta gagggggaag agaccagatt tagcacattt tcaggaagca
     1441 tcaccgggcc tctgtacaca caccgacagc cctcagtcac aatatccagt aagattcaga
     1501 agaccaaagt cgaggccccc aagctcaagg tccaacacaa atttgtggag gagatcatcg
     1561 aagaaactaa agtggaagat gagaagtcag aaatggaaga aaccctcaca gccatcgcag
     1621 aggagttggc agcctccgcc aaagaggaga aggaagaggc cgaagaaaag gaggaggaac
     1681 cagaagccga aaagtctccc gtgaagtctc ctgaggctaa ggaagaggag gaggaagggg
     1741 aaaaggagga agaagaggaa ggccaggagg aagaagagga ggaagatgaa ggtgtcaagt
     1801 cagaccaggc agaagagggg ggatctgaga aggaaggctc cagtgaaaaa gatgaaggtg
     1861 agcaggaaga agaagaagga gaaaccgagg cagaaggtga aggagaggaa gcagaagcta
     1921 aggaggaaaa gaaaattgag ggaaaggttg aggaagtggc tgtcaaggag gaaatcaagg
     1981 tcgagaagcc tgagaaagcc aaatccccta tgcccaaatc acccgtggaa gaagtaaagc
     2041 caaaaccaga ggccaaggcc gggaagggtg agcacaagga ggaagagaaa gttgaggaag
     2101 agaagaagga agtcaccaaa gaatcaccca aggaagagaa ggtggagaaa aaggaggaga
     2161 agccaaaaga tgttgcagat aaaaagaagg ccgagtcccc ggtgaaagag aaggctgtgg
     2221 aggaggtgat caccatcagc aagtcggtaa aggtgagcct agagaaagac accaaagagg
     2281 agaagctgca gccgcaggag aaggtgaagg agaaggcaga ggaggagggg ggcagtgagg
     2341 aggaagggag tgaccgtagc ccgcaggagt ccaagaagga agacatagct atcaatgggg
     2401 aggtggaagg aaaagaggag gaggagcagg aaactcagga gaagggcagt gggcgggagg
     2461 aggagaaagg ggtggtcact aatggcttag atgtgagccc tgcagaggag aagaaaggag
     2521 aggatagcag tgatgataaa gtggtggtca ccaagaaggt agaaaagatc accagcgagg
     2581 ggggcgatgg tgctaccaaa tacatcacca aatctgtaac cgtcactcaa aaggttgaag
     2641 agcatgagga gacctttgag gagaagctgg tctcaactaa aaaggtagaa aaggtcactt
     2701 cacacgccat agtcaaggaa gtcacccagg gtgactaaga tcggagtccg ttgcaaaagg
     2761 ttaagccata cgacaatttc aaaatgcatg tgattgacag cttcaaaaca gaatgggttc
     2821 tcccatgggg gctccagaca ttgtattttc ctttgtgcaa tatgagggaa ctgcatgcaa
     2881 gctcagggtg cccccctcct cagtccttgg ggggaattca aatgcatgat cgtgtatgta
     2941 cctagggaat tcgccagttt cctgagctgt tggaagaggg gcactcgggg gggatgtctt
     3001 gagatgtatt atgcagagta ccaactgagc caaaaataat aagtgaaaca gaactctctt
     3061 agccttaaga aagctatata tgaatactta cgtttacctc actggtgcat ttaaaatgga
     3121 cttctgttca tgggagaacc ttgctgatct gcacagttcg caaccttatc ttgatcgatg
     3181 taaaatgtca cagcagtcct tgctcaataa aggtcatact ggaaacataa aaaaaaaaaa
     3241 aaaa
//
