LOCUS       NM_010904               4004 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus neurofilament, heavy polypeptide (Nefh), mRNA.
ACCESSION   NM_010904 XM_354598
VERSION     NM_010904.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4004)
  AUTHORS   Sun,Y., Ren,M., Zhang,Y., Li,S., Luo,Z., Sun,S., He,S., Wang,G.,
            Zhang,D., Mansour,S.L., Song,L. and Liu,Z.
  TITLE     Casz1 is required for both inner hair cell fate stabilization and
            outer hair cell survival
  JOURNAL   Science, eado4930 (2025) In press
   PUBMED   39883789
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 4004)
  AUTHORS   N'Guetta,P.Y., McLarnon,S.R., Tassou,A., Geron,M., Shirvan,S.,
            Hill,R.Z., Scherrer,G. and O'Brien,L.L.
  TITLE     Comprehensive mapping of sensory and sympathetic innervation of the
            developing kidney
  JOURNAL   Cell Rep 43 (10), 114860 (2024)
   PUBMED   39412983
REFERENCE   3  (bases 1 to 4004)
  AUTHORS   Hayakawa-Yano,Y., Furukawa,T., Matsuo,T., Ogasawara,T., Nogami,M.,
            Yokoyama,K., Yugami,M., Shinozaki,M., Nakamoto,C., Sakimura,K.,
            Koyama,A., Ogi,K., Onodera,O., Takebayashi,H., Okano,H. and Yano,M.
  TITLE     Qki5 safeguards spinal motor neuron function by defining the motor
            neuron-specific transcriptome via pre-mRNA processing
  JOURNAL   Proc Natl Acad Sci U S A 121 (37), e2401531121 (2024)
   PUBMED   39226364
REFERENCE   4  (bases 1 to 4004)
  AUTHORS   Erickson,A.G., Motta,A., Kastriti,M.E., Edwards,S., Coulpier,F.,
            Theoulle,E., Murtazina,A., Poverennaya,I., Wies,D., Ganofsky,J.,
            Canu,G., Lallemend,F., Topilko,P., Hadjab,S., Fried,K.,
            Ruhrberg,C., Schwarz,Q., Castellani,V., Bonanomi,D. and Adameyko,I.
  TITLE     Motor innervation directs the correct development of the mouse
            sympathetic nervous system
  JOURNAL   Nat Commun 15 (1), 7065 (2024)
   PUBMED   39152112
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4004)
  AUTHORS   Li,W., Lipsius,K., Burns,N.G., Sato,R., Rehman,A., Xue,H.,
            Combs,C., Minichiello,L., Gangrade,H., Tampakakis,E. and
            Mukouyama,Y.S.
  TITLE     Vascular smooth muscle cell-derived nerve growth factor regulates
            sympathetic collateral branching to innervate blood vessels in
            embryonic skin
  JOURNAL   Biol Open 13 (5) (2024)
   PUBMED   38639409
REFERENCE   6  (bases 1 to 4004)
  AUTHORS   Kaupmann,K., Simon-Chazottes,D., Guenet,J.L. and Jockusch,H.
  TITLE     Wobbler, a mutation affecting motoneuron survival and gonadal
            functions in the mouse, maps to proximal chromosome 11
  JOURNAL   Genomics 13 (1), 39-43 (1992)
   PUBMED   1349581
REFERENCE   7  (bases 1 to 4004)
  AUTHORS   Shneidman,P.S., Bruce,J., Schwartz,M.L. and Schlaepfer,W.W.
  TITLE     Negative regulatory regions are present upstream in the three mouse
            neurofilament genes
  JOURNAL   Brain Res Mol Brain Res 13 (1-2), 127-138 (1992)
   PUBMED   1315909
REFERENCE   8  (bases 1 to 4004)
  AUTHORS   Whitlon,D.S. and Rutishauser,U.S.
  TITLE     NCAM in the organ of Corti of the developing mouse
  JOURNAL   J Neurocytol 19 (6), 970-977 (1990)
   PUBMED   2292721
REFERENCE   9  (bases 1 to 4004)
  AUTHORS   Lees,J.F., Shneidman,P.S., Skuntz,S.F., Carden,M.J. and
            Lazzarini,R.A.
  TITLE     The structure and organization of the human heavy neurofilament
            subunit (NF-H) and the gene encoding it
  JOURNAL   EMBO J 7 (7), 1947-1955 (1988)
   PUBMED   3138108
REFERENCE   10 (bases 1 to 4004)
  AUTHORS   Julien,J.P., Meyer,D., Flavell,D., Hurst,J. and Grosveld,F.
  TITLE     Cloning and developmental expression of the murine neurofilament
            gene family
  JOURNAL   Brain Res 387 (3), 243-250 (1986)
   PUBMED   3103856
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645522.12, AK122388.1, CO426942.1 and BQ174087.1.
            
            On Jan 30, 2007 this sequence version replaced NM_010904.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.337918.1,
                                           SRR1660815.395888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1007              AL645522.12        61322-62328         c
            1008-1739           AK122388.1         910-1641
            1740-2213           CO426942.1         232-705
            2214-3692           AK122388.1         1954-3432
            3693-4004           BQ174087.1         1-312               c
FEATURES             Location/Qualifiers
     source          1..4004
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.12 cM"
     gene            1..4004
                     /gene="Nefh"
                     /gene_synonym="mKIAA0845; NF-H; NF200; Nfh"
                     /note="neurofilament, heavy polypeptide"
                     /db_xref="GeneID:380684"
                     /db_xref="MGI:MGI:97309"
     exon            1..1007
                     /gene="Nefh"
                     /gene_synonym="mKIAA0845; NF-H; NF200; Nfh"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..3403
                     /gene="Nefh"
                     /gene_synonym="mKIAA0845; NF-H; NF200; Nfh"
                     /note="neurofilament 200kDa; 200 kDa neurofilament
                     protein; neurofilament triplet H protein"
                     /codon_start=1
                     /product="neurofilament heavy polypeptide"
                     /protein_id="NP_035034.2"
                     /db_xref="CCDS:CCDS36099.1"
                     /db_xref="GeneID:380684"
                     /db_xref="MGI:MGI:97309"
                     /translation="MMSFGSADALLGAPFAPLHGGGSLHYSLSRKAGPGGTRSAAGSS
                     SGFHSWARTSVSSVSASPSRFRGAASSTDSLDTLSNGPEGCVVAAVAARSEKEQLQAL
                     NDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRAAMGELYEREVREMRGAVLRLGA
                     ARGQLRLEQEHLLEDIAHVRQRLDEEARQREEAEAAARALARFAQEAEAARVELQKKA
                     QALQEECGYLRRHHQEEVGELLGQIQGCGAAQAQAQAEARDALKCDVTSALREIRAQL
                     EGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALK
                     STKESLERQRSELEDRHQADIASYQDAIQQLDSELRNTKWEMAAQLREYQDLLNVKMA
                     LDIEIAAYRKLLEGEECRIGFGPSPFSLTEGLPKIPSISTHIKVKSEEMIKVVEKSEK
                     ETVIVEGQTEEIRVTEGVTEEEDKEAQGQEGEEAEEGEEKEEEEGAAATSPPAEEAAS
                     PEKETKSRVKEEAKSPGEAKSPGEAKSPAEAKSPGEAKSPGEAKSPGEAKSPAEPKSP
                     AEPKSPAEAKSPAEPKSPATVKSPGEAKSPSEAKSPAEAKSPAEAKSPAEAKSPAEAK
                     SPAEAKSPAEAKSPATVKSPGEAKSPSEAKSPAEAKSPAEAKSPAEAKSPAEVKSPGE
                     AKSPAEPKSPAEAKSPAEVKSPAEAKSPAEVKSPGEAKSPAAVKSPAEAKSPAAVKSP
                     GEAKSPGEAKSPAEAKSPAEAKSPIEVKSPEKAKTPVKEGAKSPAEAKSPEKAKSPVK
                     EDIKPPAEAKSPEKAKSPVKEGAKPPEKAKPLDVKSPEAQTPVQEEAKHPTDIRPPEQ
                     VKSPAKEKAKSPEKEEAKTSEKVAPKKEEVKSPVKEEVKAKEPPKKVEEEKTLPTPKT
                     EAKESKKDEAPKEAPKPKVEEKKETPTEKPKDSTAEAKKEEAGEKKKAVASEEETPAK
                     LGVKEEAKPKEKTETTKTEAEDTKAKEPSKPTETEKPKKEEMPAAPEKKDTKEEKTTE
                     SRKPEEKPKMEAKVKEDDKSLSKEPSKPKTEKAEKSSSTDQKESQPPEKTTEDKATKG
                     EK"
     exon            1008..1207
                     /gene="Nefh"
                     /gene_synonym="mKIAA0845; NF-H; NF200; Nfh"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1332
                     /gene="Nefh"
                     /gene_synonym="mKIAA0845; NF-H; NF200; Nfh"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..3994
                     /gene="Nefh"
                     /gene_synonym="mKIAA0845; NF-H; NF200; Nfh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3967..3972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nefh"
                     /gene_synonym="mKIAA0845; NF-H; NF200; Nfh"
                     /note="hexamer: AATAAA"
     polyA_site      3994
                     /gene="Nefh"
                     /gene_synonym="mKIAA0845; NF-H; NF200; Nfh"
                     /note="major polyA site"
ORIGIN      
        1 cccactgccg aggggccgga ccgggccacc gcggatataa aagagccgga gtcccagagc
       61 tgccgcagtg ctgcctgccc cgtcccagcc ccgcactccc gctccgctgg cggccgcacc
      121 tgctccggcc atgatgagct tcggcagcgc cgatgcgctg ctgggcgccc cgttcgcgcc
      181 gctgcacgga ggcggcagcc tgcactactc gctgagccgc aaggcaggcc cgggcggcac
      241 gcgctccgcg gccggctcct ccagcggctt ccactcgtgg gcgcggacgt ccgtgagctc
      301 cgtgtccgcc tcacccagcc gcttccgcgg cgccgcctcg agcaccgact cgctagacac
      361 cctaagcaac ggcccagagg gctgcgtggt ggcggcggtg gcggcgcgca gcgagaagga
      421 gcagctgcag gctctgaacg accgcttcgc gggctacatc gacaaggtga ggcagctcga
      481 ggcgcacaac cgcagcctgg agggcgaggc ggcggcgctg cggcagcagc aagccggccg
      541 cgccgccatg ggcgagctgt acgagcgcga ggtgcgcgag atgcgcggcg ccgtgctgcg
      601 cctcggggcg gcgcgcgggc agctgcgcct ggagcaggag cacctgctgg aggacatcgc
      661 tcacgtccgc cagcggctgg acgaggaggc ccggcagcgt gaggaggcgg aggcggcggc
      721 gcgcgccctg gcgcgcttcg cgcaggaggc ggaagcggcg cgcgtggagc tgcagaagaa
      781 ggcgcaggcg ctgcaggagg agtgcggcta cctgcggcgc caccaccagg aggaggtggg
      841 cgagctgctc ggtcagatcc agggctgcgg ggccgcgcag gcgcaggctc aggccgaggc
      901 tcgcgacgcc ctcaagtgcg acgtgacgtc ggcgctgcgg gagatccgcg cgcagctcga
      961 aggccacgcg gtgcagagca cgctgcagtc cgaggagtgg ttccgagtga ggttggaccg
     1021 actctcagag gcagccaaag tgaacacaga tgctatgcgc tcggcccaag aggagataac
     1081 tgagtaccgg cggcagctgc aagccaggac cacagagttg gaggccctga aaagcaccaa
     1141 ggagtcactg gagaggcagc gctctgagct agaggaccgt catcaggcag acattgcctc
     1201 ctaccaggac gctattcagc agctggacag tgagctgaga aacaccaagt gggagatggc
     1261 tgcacagctc cgagagtacc aggacctgct caacgtcaag atggccctgg acattgagat
     1321 tgccgcttac agaaagctcc tggaaggcga agagtgtcgg attggctttg gtccgagtcc
     1381 cttctctctt actgaaggac tcccaaaaat tccctccata tccacgcaca taaaagtcaa
     1441 aagcgaagag atgataaagg tagtagagaa atccgagaag gaaactgtga ttgtagaagg
     1501 acagacagaa gagatccggg tgacggaagg agtgacagaa gaggaggaca aagaggccca
     1561 aggtcaggaa ggagaagaag cagaagaggg agaagaaaaa gaagaagagg aaggagcagc
     1621 agctacatct ccccctgcag aagaggctgc atctccagaa aaagaaacca agtctcgtgt
     1681 gaaagaagag gccaagtccc caggtgaggc caagtcccca ggtgaggcca agtccccagc
     1741 tgaggccaag tccccaggtg aggccaagtc cccaggtgag gccaagtccc caggtgaggc
     1801 caagtctcca gctgagccca agtctccagc tgagcccaag tctccagctg aggccaagtc
     1861 accagctgag cccaagtctc cagctacagt gaagtctcca ggtgaggcca agtcaccatc
     1921 tgaggccaaa tctccagctg aagccaaatc tccagctgag gccaaatctc cagctgaggc
     1981 caaatctcca gctgaggcca agtcaccagc tgaagccaag tcaccagctg aagccaaatc
     2041 tccagctaca gtgaagtctc caggtgaggc caagtcacca tctgaggcca aatctccagc
     2101 tgaagccaaa tctccagctg aggccaaatc tccagctgag gccaaatctc cagctgaggt
     2161 caagtcacca ggtgaggcca agtctccagc tgagcccaag tcaccagctg aggccaaatc
     2221 tccagctgag gtcaagtcac cagctgaggc caaatctcca gctgaggtca agtccccagg
     2281 tgaggccaag tctccagctg cagtgaagtc accagctgag gccaagtctc cagctgcagt
     2341 caagtcccca ggtgaggcca agtccccagg tgaggccaag tcaccagctg aggccaaatc
     2401 tccagctgag gccaagtcac caattgaggt aaaatctcca gagaaggcca agacccccgt
     2461 caaggaagga gcaaaatctc cagctgaggc caagtctcct gagaaggcca agtcccccgt
     2521 gaaggaagat atcaagcccc cagctgaggc gaaatcccct gagaaggcca agagccccgt
     2581 gaaggaagga gcaaagcctc ctgagaaggc caagcctcta gatgtgaagt ctccggaagc
     2641 ccagactcca gtacaggagg aagcgaagca ccccacagac atcagacccc ctgagcaggt
     2701 gaaaagtcct gccaaggaga aggccaagtc ccctgagaag gaagaagcca agacttctga
     2761 aaaggtggct cccaagaagg aagaggtgaa gtcccctgtg aaggaggagg taaaagccaa
     2821 agaaccccca aagaaggtag aagaagagaa gacactgcct acaccaaaga cagaggcgaa
     2881 ggagagtaag aaagacgaag ctcccaagga ggccccgaag cccaaggtgg aggagaagaa
     2941 ggaaactccc acggaaaagc ccaaggactc tacagcagaa gccaagaagg aagaggctgg
     3001 agagaagaag aaagccgtgg cctcagagga ggagactcct gccaagttgg gtgtgaagga
     3061 agaagctaaa cccaaagaga agacagagac aaccaagaca gaagcagaag acaccaaggc
     3121 caaagaacct agcaaaccca cagagacgga aaagccaaag aaagaggaga tgccagcggc
     3181 accagagaag aaagacacca aggaggagaa gaccacagag tccaggaagc ctgaggagaa
     3241 gcccaaaatg gaggccaagg tcaaggagga tgacaagagc ctttccaaag agcctagcaa
     3301 acccaagaca gaaaaggctg aaaaatcctc tagcacagac cagaaagaaa gccagccccc
     3361 agagaagacc acagaggaca aggccaccaa gggagagaag taagagaaca agagaaacac
     3421 ccagaatagc caaagaaact caggacggtc ccagtactca ggggtcggcg taataaattt
     3481 tatttcttcc tttccctccg taagaagaaa cactgcttag atggtgggcc tgccctcacc
     3541 aaacaggaat ttctattaag attaagttag caagagaaga taaccctgag ccttgtcccc
     3601 cacgccgaaa accctcccca ggtgatggac aattatgata gcttcttgta gccgaacgtg
     3661 atgtatgctg aacgctacgc gtaaaacacg cgtctaaaaa ctgccccctc ctttccaagt
     3721 aagtgcattt atttcctgta tgtccaactg acagatgacc gcaataatga atgagcagtt
     3781 agaaacgcat tatgcttgaa atgttgtaac ctattcctga atgccttctt gttttccaaa
     3841 ggagtggtca ggcccttgcc cagtacacgc tcctggaaga gctgcagcag gtgaggcagg
     3901 gcgctggcca ctgaaccacg ccagggtgta ctctccactg aagtccactt tcaattgctt
     3961 ccatgcaata aaaccaagtg cttctgaaat aaaaaaaaaa aaaa
//
