LOCUS       NM_017464               4384 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus neural precursor cell expressed, developmentally
            down-regulated gene 9 (Nedd9), transcript variant 2, mRNA.
ACCESSION   NM_017464
VERSION     NM_017464.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4384)
  AUTHORS   Wong,W., Estep,J.A., Treptow,A.M., Rajabli,N., Jahncke,J.N.,
            Ubina,T., Wright,K.M. and Riccomagno,M.M.
  TITLE     An adhesion signaling axis involving Dystroglycan, beta1-Integrin,
            and Cas adaptor proteins regulates the establishment of the
            cortical glial scaffold
  JOURNAL   PLoS Biol 21 (8), e3002212 (2023)
   PUBMED   37540708
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4384)
  AUTHORS   Rusyn,L., Reinartz,S., Nikiforov,A., Mikhael,N., Vom Stein,A.,
            Kohlhas,V., Bloehdorn,J., Stilgenbauer,S., Lohneis,P., Buettner,R.,
            Robrecht,S., Fischer,K., Pallasch,C., Hallek,M., Nguyen,P.H. and
            Seeger-Nukpezah,T.
  TITLE     The scaffold protein NEDD9 is necessary for leukemia-cell migration
            and disease progression in a mouse model of chronic lymphocytic
            leukemia
  JOURNAL   Leukemia 36 (7), 1794-1805 (2022)
   PUBMED   35523865
  REMARK    GeneRIF: The scaffold protein NEDD9 is necessary for leukemia-cell
            migration and disease progression in a mouse model of chronic
            lymphocytic leukemia.
REFERENCE   3  (bases 1 to 4384)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4384)
  AUTHORS   Deneka,A.Y., Kopp,M.C., Nikonova,A.S., Gaponova,A.V.,
            Kiseleva,A.A., Hensley,H.H., Flieder,D.B., Serebriiskii,I.G. and
            Golemis,E.A.
  TITLE     Nedd9 Restrains Autophagy to Limit Growth of Early Stage Non-Small
            Cell Lung Cancer
  JOURNAL   Cancer Res 81 (13), 3717-3726 (2021)
   PUBMED   34006524
  REMARK    GeneRIF: Nedd9 Restrains Autophagy to Limit Growth of Early Stage
            Non-Small Cell Lung Cancer.
REFERENCE   5  (bases 1 to 4384)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4384)
  AUTHORS   Seo,S., Asai,T., Saito,T., Suzuki,T., Morishita,Y., Nakamoto,T.,
            Ichikawa,M., Yamamoto,G., Kawazu,M., Yamagata,T., Sakai,R.,
            Mitani,K., Ogawa,S., Kurokawa,M., Chiba,S. and Hirai,H.
  TITLE     Crk-associated substrate lymphocyte type is required for lymphocyte
            trafficking and marginal zone B cell maintenance
  JOURNAL   J Immunol 175 (6), 3492-3501 (2005)
   PUBMED   16148091
  REMARK    GeneRIF: Cas-L affects homeostasis of MZB cells and peripheral
            lymphoid organs, which is considered to be relevant to impaired
            lymphocyte migration and adhesion
REFERENCE   7  (bases 1 to 4384)
  AUTHORS   Abramova,N., Charniga,C., Goderie,S.K. and Temple,S.
  TITLE     Stage-specific changes in gene expression in acutely isolated mouse
            CNS progenitor cells
  JOURNAL   Dev Biol 283 (2), 269-281 (2005)
   PUBMED   15890332
REFERENCE   8  (bases 1 to 4384)
  AUTHORS   Cai,D., Felekkis,K.N., Near,R.I., O'Neill,G.M., van Seventer,J.M.,
            Golemis,E.A. and Lerner,A.
  TITLE     The GDP exchange factor AND-34 is expressed in B cells, associates
            with HEF1, and activates Cdc42
  JOURNAL   J Immunol 170 (2), 969-978 (2003)
   PUBMED   12517963
REFERENCE   9  (bases 1 to 4384)
  AUTHORS   Sakakibara,A. and Hattori,S.
  TITLE     Chat, a Cas/HEF1-associated adaptor protein that integrates
            multiple signaling pathways
  JOURNAL   J Biol Chem 275 (9), 6404-6410 (2000)
   PUBMED   10692442
REFERENCE   10 (bases 1 to 4384)
  AUTHORS   Kumar,S., Tomooka,Y. and Noda,M.
  TITLE     Identification of a set of genes with developmentally
            down-regulated expression in the mouse brain
  JOURNAL   Biochem Biophys Res Commun 185 (3), 1155-1161 (1992)
   PUBMED   1378265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK033729.1, AK054179.1, AA762918.1, AA198880.1 and AV367231.2.
            
            On Dec 14, 2007 this sequence version replaced NM_017464.4.
            
            Transcript Variant: This variant (2) contains an alternate 5'-most
            exon and initiates translation at an alternate start codon,
            compared to variant 1. The encoded isoform (2) has a distinct
            N-terminus and is the same length as isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046357.1, AK054179.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2864              AK033729.1         2-2865
            2865-3182           AK054179.1         2861-3178
            3183-3482           AA762918.1         88-387
            3483-3921           AA198880.1         57-495
            3922-4384           AV367231.2         166-628
FEATURES             Location/Qualifiers
     source          1..4384
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 20.43 cM"
     gene            1..4384
                     /gene="Nedd9"
                     /gene_synonym="Cas-L; CasL; HEF1; MEF1; Nedd-9; p105"
                     /note="neural precursor cell expressed, developmentally
                     down-regulated gene 9"
                     /db_xref="GeneID:18003"
                     /db_xref="MGI:MGI:97302"
     exon            1..149
                     /gene="Nedd9"
                     /gene_synonym="Cas-L; CasL; HEF1; MEF1; Nedd-9; p105"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..2639
                     /gene="Nedd9"
                     /gene_synonym="Cas-L; CasL; HEF1; MEF1; Nedd-9; p105"
                     /note="isoform 2 is encoded by transcript variant 2;
                     enhancer of filamentation 1; Crk-associated substrate
                     lymphocyte-specific protein; CRK-associated
                     substrate-related protein"
                     /codon_start=1
                     /product="enhancer of filamentation 1 isoform 2"
                     /protein_id="NP_059492.3"
                     /db_xref="CCDS:CCDS36640.2"
                     /db_xref="GeneID:18003"
                     /db_xref="MGI:MGI:97302"
                     /translation="MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWW
                     LCSLHGRQGIVPGNRVKLLIGPVQETPGHEQPTPGPMHQTFGQQKLYQVPNSQAASRD
                     TIYQVPPSYQNQGIYQVPTGHGTPEQDVYQVPPSVQRNIGGTNGPLLSKKVITPVRTG
                     HGYVYEYPSRYQKDVYDVPPSHSTQGVYDIPPSSVKGPVFSVPVGEIKPQGVYDIPPT
                     QGVYAIPPSACRDEAGLREKEYDFPPPMKQDGKPDTRPEGVYDIPPTSTKTAGKDLHI
                     KFPCDAPGGVEPMARRHQSFSLHHAPSQLGQSGDTQSDAYDVPRGVQFLEVPTETSEK
                     ANPEERDGVYDVPLHNPADAKGSRDVVDGINRLSFSSTGSTRSNMSTSSTSSKESSLS
                     ASPSQDKRLRLDPDTAIEKLYRLQQTLEMGVCSLMSLVTTDWRCYGYMERHINEIRTA
                     VDKVELFLREYLHFAKGALANASCLPELVLHNKMKRELQRVEDSHQILSQTSHDLNEC
                     SWSLNILAINKPQNKCDDLDRFVMVAKTVPDDAKQLTTTISTYAETLFRADPANSHLK
                     NGPNSIMNSSEYTHPGSQMQPLHPGDYKAQVHSKPLPPSLSKDQPPDCGSSDGSERSW
                     MDDYDYVHLQGKEEFERQQKELLEKENIMKQSKAQLEHHQLSQFQLLEQEITKPVEND
                     ISKWKPSQSLPTTNNSVGAQDRQLLCFYYDQCETHFISLLNAIDALFSCVSSAQPPRI
                     FVAHSKFVILSAHKLVFIGDTLTRQVAAQDIRNKVRNSSNQLCEQLKTIVMATKMAAL
                     HYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF"
     exon            150..593
                     /gene="Nedd9"
                     /gene_synonym="Cas-L; CasL; HEF1; MEF1; Nedd-9; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            594..695
                     /gene="Nedd9"
                     /gene_synonym="Cas-L; CasL; HEF1; MEF1; Nedd-9; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            696..797
                     /gene="Nedd9"
                     /gene_synonym="Cas-L; CasL; HEF1; MEF1; Nedd-9; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            798..2039
                     /gene="Nedd9"
                     /gene_synonym="Cas-L; CasL; HEF1; MEF1; Nedd-9; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2129
                     /gene="Nedd9"
                     /gene_synonym="Cas-L; CasL; HEF1; MEF1; Nedd-9; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..4384
                     /gene="Nedd9"
                     /gene_synonym="Cas-L; CasL; HEF1; MEF1; Nedd-9; p105"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4290..4295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nedd9"
                     /gene_synonym="Cas-L; CasL; HEF1; MEF1; Nedd-9; p105"
                     /note="hexamer: ATTAAA"
     polyA_site      4317
                     /gene="Nedd9"
                     /gene_synonym="Cas-L; CasL; HEF1; MEF1; Nedd-9; p105"
                     /note="major polyA site"
ORIGIN      
        1 tcagagactc cgcagtgcgc gggaggcgaa ggcttctcat ttccatccag cccagcgctc
       61 aatggagggg cggactctgc agtgcctcac tcactgtgtg attcgatagg accagggctc
      121 atcagatcac cgccgagatg aagtacaaga atcttatggc aagggccttg tatgacaacg
      181 tccctgagtg tgctgaggag ctggccttcc gcaagggaga catcttaact gtcatagagc
      241 agaacacagg agggcttgag ggatggtggc tgtgttccct ccacggtcgc caaggcattg
      301 tcccagggaa ccgggtgaag cttctgattg gtccagtgca agagaccccc ggtcatgagc
      361 agcctactcc tggacctatg catcagacct ttggccaaca gaaactctat caagtgccaa
      421 attcccaggc agcatctcgg gataccatct accaagtgcc accctcctac cagaatcagg
      481 gaatttacca agtacccact ggccatggca ctccagaaca agatgtatat caagtaccac
      541 catcagttca gaggaacatt ggcggcacta atggacccct tctaagcaaa aaggtgatca
      601 ccccagtgag gacgggccat ggctatgtgt acgagtaccc atccagatac caaaaggatg
      661 tctacgatgt ccctccttcc cacagcactc aaggggtata tgacatccct ccttcctcag
      721 taaaaggccc tgtgttttca gttccagtgg gagagataaa acctcaaggg gtatatgaca
      781 ttccccccac ccaaggggtc tatgccattc caccatcggc ttgccgagat gaggcagggc
      841 tcagggaaaa ggaatatgat ttccctcctc caatgaagca agatggaaaa ccagacacca
      901 gacctgaggg ggtttatgac atccctccaa ccagcaccaa gacagcaggc aaggaccttc
      961 acatcaaatt cccctgtgat gctccaggag gtgtcgaacc aatggcacga agacaccaga
     1021 gcttttccct gcaccatgca ccctctcagc tgggacagtc tggggacact cagagtgatg
     1081 cctatgatgt cccccgggga gttcagtttc tggaggtacc aacagaaacc agtgaaaagg
     1141 caaatccgga ggaaagagac ggtgtctacg atgtccctct gcacaaccca gcagatgcca
     1201 aaggctctcg ggacgtggta gatgggatca acagactgtc tttctccagc actggcagta
     1261 ccaggagtaa catgtccacc tcttccacct cctcaaagga gtcttcactg tcagcctccc
     1321 cgtctcaaga caaaaggctc cgactggacc cagacacagc catagagaag ctctatcggc
     1381 tccagcagac cctggagatg ggtgtgtgca gcctcatgtc actggtcacc acagactgga
     1441 ggtgctacgg atacatggaa aggcacatca atgagatccg caccgcggtg gacaaagtag
     1501 agctgttctt acgagaatac ctccattttg ccaagggagc tttagccaat gcctcctgcc
     1561 tcccagaact ggtcctccac aacaaaatga agcgggaact ccaaagagta gaagattccc
     1621 accagattct aagccaaacc agccatgact tgaatgaatg cagctggtcc ctgaatattt
     1681 tagctatcaa taagccccaa aataagtgtg atgacctaga ccggtttgtg atggtcgcca
     1741 agacagtgcc agacgacgcc aaacaactga ccaccaccat cagcacctac gcggagaccc
     1801 tctttagagc agatcctgcc aattcccatc tgaagaatgg gcccaacagc atcatgaact
     1861 caagcgagta cacacatccg ggctcccaga tgcagccact gcatcctggt gactacaaag
     1921 cccaggtcca cagtaagccg ttgcctccta gtctaagcaa ggaccagcca ccagactgcg
     1981 gtagcagtga cggttctgag cggagttgga tggatgatta tgattatgtt cacctacagg
     2041 gcaaggagga gtttgagcga cagcagaagg agctcttgga aaaggagaac atcatgaagc
     2101 agagtaaggc gcagctggag catcaccagc tgagtcagtt ccagctgttg gaacaagaga
     2161 tcaccaagcc tgtggagaat gacatctcta aatggaagcc ctctcagagc ctcccaacca
     2221 ccaacaacag tgtgggtgct caggataggc agttgctttg cttctactat gaccagtgcg
     2281 agacccattt catttcccta ctcaacgcca tcgacgccct cttcagctgc gtcagctcag
     2341 cccaaccccc acggatcttt gtggcgcaca gcaagtttgt cattcttagt gcgcacaaac
     2401 tggtgttcat tggagacact ctgacaaggc aggtggctgc ccaggacatt cgcaacaaag
     2461 tcaggaactc cagcaaccag ctctgcgaac agctcaagac gatagtgatg gcgaccaaaa
     2521 tggccgccct ccactacccc agtaccaccg ccttgcagga aatggtgcac caggtgacag
     2581 acctgtccag aaatgctcag ctgtttaagc gttccttgct ggagatggcc accttttgag
     2641 aagacaaaga agtggaagga actgggtgaa taattactaa ggaaaactgg aaatactatc
     2701 tagtttttgt aaatgctatc tatttttgta gatattttat atgaaattga aatatttcga
     2761 tgtttttgtg agttagtcga ttttcatcaa ttcagggagc tgaagcttgg atttattttg
     2821 tttcccctgt gtggttctga tataaacata taagtatcta agacataagt tgtacagaac
     2881 tgtgtccacg tttgtgtatg cctacatatc catatttgtt tatctgtgtg tctgatacag
     2941 cccattaaaa acatgaattg agaagcacct tagtgagcac cttctaatgc tgcattgttt
     3001 gggttttgta gaaaattata ccacttagtt gtaatattgc tcttcatgta gtagtagtcg
     3061 tctgagccca gcacacccaa ctttcttgtc tgaaacctct ttcaaacttg acttgtcttt
     3121 aacacggtgg taaatctgac caacttctgg ttgaaggggg gcagggaaag aaagaaagat
     3181 tcaaaaaata tattaaccta aggtttcagg tgctagagag aggcaaaaca tgtgtgctgt
     3241 actaagaggc catgtctaca gtagttattg tgttatttca attctgaaag gaactacaat
     3301 aaagagagaa cacttgtttc cctggggcta catttgtgag tgattcagtc atggttttct
     3361 gaaggatgtt tttagagttg aatttttttt taaaaaaaat tgcaacagga attcatgaag
     3421 atacatcaga actgtgattg tgggcaaaaa gaagggctgt ttccaacagg cagtagttaa
     3481 atcaagacct ctctaccctc attctctaat ggaaatggcc agttccttag tcactgaact
     3541 gtggaaccac cgggccctgt cctgctctcg cattgcttga tggatcctac accagtctaa
     3601 aaacttacat aagcagacca acactcaaaa cagctgccaa gagctgacct tcacgtccca
     3661 ctgtggctat ggaccttgtg gatgtcagct agtcacagcc atgatcgtgt ggtctgtccc
     3721 ttcacaccgg ctgtgtggat acagcccagg caccagattc atcgtgggca gataaactac
     3781 ttccctcttc ctttatgacc aactcaagaa atatagtagt ctctgatcta tttcattcca
     3841 gcctacttgg aaatgtgttt ttatttgtta tggatgtctt gactgagtta atgttatttg
     3901 ttttaaacaa ccaaattaca aaggcaagga ggggcttaag aaggacatgt gatctcaatg
     3961 tgattttttt ttaataaatg gaagatatca aaggaaaggt gcttttcaaa acaaactata
     4021 attgtaattc tcaaagttct acatcgccag aagatgaaca gctgagctat tggagagcaa
     4081 ttcactgtgt ctggcgtgtg gaagaagagg gtcctgaagc atcagtacca ttgcaggaag
     4141 tcaggaaggg tatgcttgta gatcttacta cacaatgtgt atatgttatg tgatggctgc
     4201 cttgtcctaa cctgattgat gacattccac attgtaaaaa ccaaactatt caatttctac
     4261 tgtttattgc catcttgtat atttaagcca ttaaatgttt ggatatttct ctttatagcc
     4321 actgggtttc ttttccttgt gtctctctta tcacagaatt aaatattgac ccatctgagt
     4381 ataa
//
