LOCUS       NM_008683                580 bp    mRNA    linear   ROD 15-DEC-2024
DEFINITION  Mus musculus neural precursor cell expressed, developmentally
            down-regulated gene 8 (Nedd8), mRNA.
ACCESSION   NM_008683
VERSION     NM_008683.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 580)
  AUTHORS   Jiang,Y., Gao,S., Sun,H., Wu,X., Gu,J., Wu,H., Liao,Y., Ben-Ami,R.,
            Miao,C., Shen,R., Liu,J. and Chen,W.
  TITLE     Targeting NEDD8 suppresses surgical stress-facilitated metastasis
            of colon cancer via restraining regulatory T cells
  JOURNAL   Cell Death Dis 15 (1), 8 (2024)
   PUBMED   38177106
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 580)
  AUTHORS   Zhang,L., Jing,H., Li,H., Chen,W., Luo,B., Zhang,H., Dong,Z.,
            Li,L., Su,H., Xiong,W.C. and Mei,L.
  TITLE     Neddylation is critical to cortical development by regulating
            Wnt/beta-catenin signaling
  JOURNAL   Proc Natl Acad Sci U S A 117 (42), 26448-26459 (2020)
   PUBMED   33020269
REFERENCE   3  (bases 1 to 580)
  AUTHORS   Balasubramaniam,M., Parcon,P.A., Bose,C., Liu,L., Jones,R.A.,
            Farlow,M.R., Mrak,R.E., Barger,S.W. and Griffin,W.S.T.
  TITLE     Interleukin-1beta drives NEDD8 nuclear-to-cytoplasmic
            translocation, fostering parkin activation via NEDD8 binding to the
            P-ubiquitin activating site
  JOURNAL   J Neuroinflammation 16 (1), 275 (2019)
   PUBMED   31882005
  REMARK    GeneRIF: We present here the first evidence that the
            neuroinflammatory mediator IL-1beta facilitates ubiquitin ligase
            parkin/NEDD8 interactions
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 580)
  AUTHORS   Zou,J., Ma,W., Li,J., Littlejohn,R., Zhou,H., Kim,I.M.,
            Fulton,D.J.R., Chen,W., Weintraub,N.L., Zhou,J. and Su,H.
  TITLE     Neddylation mediates ventricular chamber maturation through
            repression of Hippo signaling
  JOURNAL   Proc Natl Acad Sci U S A 115 (17), E4101-E4110 (2018)
   PUBMED   29632206
REFERENCE   5  (bases 1 to 580)
  AUTHORS   Xie,P., Yang,J.P., Cao,Y., Peng,L.X., Zheng,L.S., Sun,R.,
            Meng,D.F., Wang,M.Y., Mei,Y., Qiang,Y.Y., Cao,L., Xiang,Y.Q.,
            Luo,D.H., Yun,J.P., Huang,B.J., Jia,L.J. and Qian,C.N.
  TITLE     Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves
            as a potential theranostic target
  JOURNAL   Cell Death Dis 8 (6), e2834 (2017)
   PUBMED   28569775
  REMARK    GeneRIF: Downregulation of NEDD8 enhanced the susceptibility of
            nasopharyngeal carcinoma cells to cisplatin and radiation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 580)
  AUTHORS   Hori,T., Osaka,F., Chiba,T., Miyamoto,C., Okabayashi,K.,
            Shimbara,N., Kato,S. and Tanaka,K.
  TITLE     Covalent modification of all members of human cullin family
            proteins by NEDD8
  JOURNAL   Oncogene 18 (48), 6829-6834 (1999)
   PUBMED   10597293
REFERENCE   7  (bases 1 to 580)
  AUTHORS   Singer,J.D., Gurian-West,M., Clurman,B. and Roberts,J.M.
  TITLE     Cullin-3 targets cyclin E for ubiquitination and controls S phase
            in mammalian cells
  JOURNAL   Genes Dev 13 (18), 2375-2387 (1999)
   PUBMED   10500095
REFERENCE   8  (bases 1 to 580)
  AUTHORS   Kamitani,T., Kito,K., Nguyen,H.P. and Yeh,E.T.
  TITLE     Characterization of NEDD8, a developmentally down-regulated
            ubiquitin-like protein
  JOURNAL   J Biol Chem 272 (45), 28557-28562 (1997)
   PUBMED   9353319
REFERENCE   9  (bases 1 to 580)
  AUTHORS   Kumar,S., Yoshida,Y. and Noda,M.
  TITLE     Cloning of a cDNA which encodes a novel ubiquitin-like protein
  JOURNAL   Biochem Biophys Res Commun 195 (1), 393-399 (1993)
   PUBMED   8395831
REFERENCE   10 (bases 1 to 580)
  AUTHORS   Kumar,S., Tomooka,Y. and Noda,M.
  TITLE     Identification of a set of genes with developmentally
            down-regulated expression in the mouse brain
  JOURNAL   Biochem Biophys Res Commun 185 (3), 1155-1161 (1992)
   PUBMED   1378265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146732.1 and AI847056.1.
            
            On Feb 5, 2019 this sequence version replaced NM_008683.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV661605.1, SRR7345562.4007404.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-576               AK146732.1         28-603
            577-580             AI847056.1         17-20               c
FEATURES             Location/Qualifiers
     source          1..580
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..580
                     /gene="Nedd8"
                     /gene_synonym="NEDD-8; Rub1"
                     /note="neural precursor cell expressed, developmentally
                     down-regulated gene 8"
                     /db_xref="GeneID:18002"
                     /db_xref="MGI:MGI:97301"
     exon            1..86
                     /gene="Nedd8"
                     /gene_synonym="NEDD-8; Rub1"
                     /inference="alignment:Splign:2.1.0"
     exon            87..134
                     /gene="Nedd8"
                     /gene_synonym="NEDD-8; Rub1"
                     /inference="alignment:Splign:2.1.0"
     exon            135..217
                     /gene="Nedd8"
                     /gene_synonym="NEDD-8; Rub1"
                     /inference="alignment:Splign:2.1.0"
     exon            218..580
                     /gene="Nedd8"
                     /gene_synonym="NEDD-8; Rub1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      561..566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nedd8"
                     /gene_synonym="NEDD-8; Rub1"
                     /note="hexamer: AATAAA"
     polyA_site      580
                     /gene="Nedd8"
                     /gene_synonym="NEDD-8; Rub1"
                     /note="major polyA site"
ORIGIN      
        1 agcggcagca gcgaccacag cgggagaagc agcactctag ccgcctgcaa ccccaacctg
       61 ggaagaagat gctaattaaa gtgaagacgc tgactgggaa ggagattgag atagacatcg
      121 aacccacaga caaggtggag cgaatcaagg agcgtgtgga agaaaaagaa gggattcccc
      181 cccagcagca gcggctcatc tacagtggca agcaaatgaa tgatgagaag acagcagctg
      241 attacaagat tctaggtggt tccgtcctcc acctggtgtt ggctcttaga ggaggaggtg
      301 gtcttgggca gtgaagaaac ttggttccgt ttacctcctt gccctgccaa tcataatgtg
      361 gcatcacata tcctctcact ctctgggaca ccagagccac tgccccctct cttggatgcc
      421 caatcttgtg tgtctactgg tgggagaatg tgaggacccc agggtgcagt gttcctggcc
      481 cagatggccc ctgctggcta ttgggtttta gtttgcagtc atgtgtgctt ccctgtctta
      541 tggctgtatc cttggttatc aataaaatat ttcctggcca
//
