LOCUS       NM_001357998            6388 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus neural precursor cell expressed, developmentally
            down-regulated 4 (Nedd4), transcript variant 2, mRNA.
ACCESSION   NM_001357998
VERSION     NM_001357998.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6388)
  AUTHORS   Meng,Y., Chen,L., Chai,Y., Meng,W., Yang,G., Ren,J., Li,H., Qi,P.,
            Chen,J. and Wang,N.
  TITLE     PUM2 promoted osteoarthritis progression through PTEN-mediated
            chondrocyte ferroptosis by facilitating NEDD4 mRNA degradation
  JOURNAL   Environ Toxicol 39 (9), 4318-4332 (2024)
   PUBMED   38733337
  REMARK    GeneRIF: PUM2 promoted osteoarthritis progression through
            PTEN-mediated chondrocyte ferroptosis by facilitating NEDD4 mRNA
            degradation.
REFERENCE   2  (bases 1 to 6388)
  AUTHORS   Ling,X., Xu,W., Tang,J., Cao,Q., Luo,G., Chen,X., Yang,S.,
            Reinach,P.S. and Yan,D.
  TITLE     The Role of Ubiquitination and the E3 Ligase Nedd4 in Regulating
            Corneal Epithelial Wound Healing
  JOURNAL   Invest Ophthalmol Vis Sci 65 (6), 29 (2024)
   PUBMED   38888282
  REMARK    GeneRIF: The Role of Ubiquitination and the E3 Ligase Nedd4 in
            Regulating Corneal Epithelial Wound Healing.
REFERENCE   3  (bases 1 to 6388)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6388)
  AUTHORS   Guo,Y., Wang,Y., Liu,H., Jiang,X. and Lei,S.
  TITLE     High glucose environment induces NEDD4 deficiency that impairs
            angiogenesis and diabetic wound healing
  JOURNAL   J Dermatol Sci 112 (3), 148-157 (2023)
   PUBMED   37932175
  REMARK    GeneRIF: High glucose environment induces NEDD4 deficiency that
            impairs angiogenesis and diabetic wound healing.
REFERENCE   5  (bases 1 to 6388)
  AUTHORS   You,J., Zhou,L., San,X., Li,H., Li,M. and Wang,B.
  TITLE     NEDD4 Regulated Pyroptosis Occurred from Co-infection between
            Influenza A Virus and Streptococcus pneumoniae
  JOURNAL   J Microbiol 61 (8), 777-789 (2023)
   PUBMED   37792248
  REMARK    GeneRIF: NEDD4 Regulated Pyroptosis Occurred from Co-infection
            between Influenza A Virus and Streptococcus pneumoniae.
REFERENCE   6  (bases 1 to 6388)
  AUTHORS   Gavva,N.R., Gavva,R., Ermekova,K., Sudol,M. and Shen,C.J.
  TITLE     Interaction of WW domains with hematopoietic transcription factor
            p45/NF-E2 and RNA polymerase II
  JOURNAL   J Biol Chem 272 (39), 24105-24108 (1997)
   PUBMED   9305852
REFERENCE   7  (bases 1 to 6388)
  AUTHORS   Hatakeyama,S., Jensen,J.P. and Weissman,A.M.
  TITLE     Subcellular localization and ubiquitin-conjugating enzyme (E2)
            interactions of mammalian HECT family ubiquitin protein ligases
  JOURNAL   J Biol Chem 272 (24), 15085-15092 (1997)
   PUBMED   9182527
REFERENCE   8  (bases 1 to 6388)
  AUTHORS   Kumar,S., Harvey,K.F., Kinoshita,M., Copeland,N.G., Noda,M. and
            Jenkins,N.A.
  TITLE     cDNA cloning, expression analysis, and mapping of the mouse Nedd4
            gene
  JOURNAL   Genomics 40 (3), 435-443 (1997)
   PUBMED   9073511
  REMARK    Erratum:[Genomics 1997 Aug 15;44(1):156]
REFERENCE   9  (bases 1 to 6388)
  AUTHORS   Staub,O., Dho,S., Henry,P., Correa,J., Ishikawa,T., McGlade,J. and
            Rotin,D.
  TITLE     WW domains of Nedd4 bind to the proline-rich PY motifs in the
            epithelial Na+ channel deleted in Liddle's syndrome
  JOURNAL   EMBO J 15 (10), 2371-2380 (1996)
   PUBMED   8665844
REFERENCE   10 (bases 1 to 6388)
  AUTHORS   Kumar,S., Tomooka,Y. and Noda,M.
  TITLE     Identification of a set of genes with developmentally
            down-regulated expression in the mouse brain
  JOURNAL   Biochem Biophys Res Commun 185 (3), 1155-1161 (1992)
   PUBMED   1378265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123683.6 and CT027588.10.
            
            Transcript Variant: This variant (2) lacks multiple 5' exons and
            contains an alternate 5' UTR and 5' coding region compared to
            variant 1. The encoded isoform (2) has a distinct N-terminus and is
            longer than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.11553.1,
                                           SRR10223971.9457.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1569              AC123683.6         155551-157119
            1570-1620           AC123683.6         171365-171415
            1621-1682           AC123683.6         172731-172792
            1683-1782           AC123683.6         174420-174519
            1783-1949           AC123683.6         180471-180637
            1950-2067           AC123683.6         183554-183671
            2068-2232           AC123683.6         183750-183914
            2233-2298           AC123683.6         187270-187335
            2299-2418           AC123683.6         188664-188783
            2419-2490           CT027588.10        158786-158857       c
            2491-2545           CT027588.10        158483-158537       c
            2546-2604           CT027588.10        158323-158381       c
            2605-2670           CT027588.10        157102-157167       c
            2671-2900           CT027588.10        154520-154749       c
            2901-3022           CT027588.10        152971-153092       c
            3023-3093           CT027588.10        152815-152885       c
            3094-3189           CT027588.10        150624-150719       c
            3190-3263           CT027588.10        150231-150304       c
            3264-3324           CT027588.10        149531-149591       c
            3325-3384           CT027588.10        148072-148131       c
            3385-3492           CT027588.10        146999-147106       c
            3493-3589           CT027588.10        146123-146219       c
            3590-3662           CT027588.10        143280-143352       c
            3663-6388           CT027588.10        139908-142633       c
FEATURES             Location/Qualifiers
     source          1..6388
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 40.08 cM"
     gene            1..6388
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /note="neural precursor cell expressed, developmentally
                     down-regulated 4"
                     /db_xref="GeneID:17999"
                     /db_xref="MGI:MGI:97297"
     exon            1..1569
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1620
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1682
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1782
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1949
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2067
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2232
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2298
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2418
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2490
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2545
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2604
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2670
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2900
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..3022
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3093
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3189
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3263
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3324
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..3384
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..3492
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3589
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3590..3662
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3663..6388
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4677..4682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /note="hexamer: TATAAA"
     polyA_site      4698
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
     regulatory      6358..6363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /note="hexamer: AATAAA"
     polyA_site      6388
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /note="major polyA site"
ORIGIN      
        1 gttaaagacg cctccccacg agctttttca acaccgccga tggttttttc ctctggatgc
       61 agcacagctg cgctagcctg actacagaca gagctctttg ttttgactct cagccctgaa
      121 catgcttgga aatgagaaca aatggcacag agtttacgac tgcactttgc cgccagaaga
      181 agcaagactt accctctgtc ggaaccctct ggagatgact tggatagcca cgttgacaca
      241 cacggccaga ggcggccccg gatctcagtg gctagtgtgg ttcaaatgag gctgaccccc
      301 agacaggcgc cacaggctcc gtgggtagag catagatcct ctgaaagtac tgacaaaaag
      361 agcagctgcc tgcagatctc actgcagccc agatacggag ggtgtcttcc atctgacact
      421 gtcgtggctg atagggacag tacttcctct acctgtgctt caaaggatga tgtttgcagc
      481 agcagtggaa ttgacagtga gctggacaat ggcagcctca gtaacttctc agccagtgac
      541 agtgggtctt acagcagcag tggcagtgac tgtgggtctt gtgcaagcct cgcaagtgga
      601 ggctcctcca ccggcagtgg tgtcagcgac agtagtggct atgagacctt tttcagtgga
      661 aatttacctt ctgacaacgc ctccaacaga agcgtgccag tcgacactac accccgtgaa
      721 gttatgtgcg gaagtcccag tagacttccc tttgcccagg aggacctgga tcgtggagta
      781 gagattatga aactgccagt gagtaggaac gcaaagggtc cactgaagcg ctgcacgtct
      841 ttggtcattt tccccaggag tccttcaaac accccaccag catccccgac gagcagaggt
      901 gcctaccaga cctcacacca gttggttgta tcacctactg aaactgcaca tcatgaagat
      961 ggatctggca ccaaaggctt tctgtcaaca gctgtcaacg ggcttcgatt atctaaaatg
     1021 gtttgtactc ctggagaagt cagagatgta cggccactcc atgccaaggg ctcattgcaa
     1081 aagaaaattg tcatttcaaa taataggccc aaacaaactg tgtgtgagaa gttgccagaa
     1141 ggattttcct gtgtttccgt gcacttgacc caacaaaaac caacgacatc agattgtgca
     1201 aacccccgtg gtggctgcac atcagagagg ttagaacttc agctgcagtc tgatttggac
     1261 catggcatgc tcaaacagag ggcatcccct tgcttgccaa ccgcatcaga catgggttac
     1321 catttaaaca tccgtggaga gttggaaaga ccaaattcac cgataagcaa aggccatgct
     1381 gctttgcaaa gaagtgtttc gctgggtggg acatacccaa atatttcctg cttatccagc
     1441 ctgaagcaca attgttcaaa ggggggacca tctcagttgc tcattaagtt tgcatctggg
     1501 aatgatggta aagttgatag tttctggaga cagagagact tgacaaatga actgtctgat
     1561 gtttgtaaga caagagatga tttcctaggt caagtggatg tccctctcta tcctttaccg
     1621 actgaaaacc caagaatgga gagaccatat acatttaagg attttgttct tcatccaaga
     1681 agtcacaaat caagagttaa aggttatctg agattaaaaa tgacttattt acctaaaaat
     1741 ggctcagaag atgaaaatgc agaccaggct gaggagttag agcctggctg ggttgttttg
     1801 gaccaaccag atgctgccac tcatttgccg catccaccag aaccctctcc cctacctcca
     1861 ggatgggaag agaggcagga tgtccttgga aggacctact acgtaaacca tgaatctaga
     1921 agaacacagt ggaaaaggcc aagccctgac gatgacctca cggatgaaga caatgatgat
     1981 atgcagctgc aagcgcagcg agcattcacc accaggcggc agatatcgga ggatgtggat
     2041 ggccctgaca accgggagtc ccctgagaat tgggaaatcg tacgagaaga tgaaaacacc
     2101 gagtatagtg gtcaggctgt ccagtcacct ccatcgggtc acattgatgt gcagactcac
     2161 cttgcagaag agtttaatac cagacttgct gtgtgtggaa atccagccac cagccagccg
     2221 gttaccagct caaatcattc cagcagagga ggcagcttgc agacctgtat ctttgaggaa
     2281 cagcctacac ttcctgtgct tttgcctact tcatctggat tgccaccagg ttgggaagaa
     2341 aaacaagatg acagaggaag atcatactat gtagaccaca actctaaaac caccacatgg
     2401 tccaagccca ccatgcagga tgatccaaga tcgaaaatcc ctgctcatct gagaggaaag
     2461 actgactcca atgacctggg acccttacct ccaggctggg aagaaagaac ccacacagat
     2521 gggcgagtct tcttcataaa ccacaatata aagaagaccc agtgggaaga tcctcgcctg
     2581 cagaacgtgg caatcactgg accagcagtg ccctactcca gagattacaa gagaaagtac
     2641 gagttcttca gaaggaagct caagaagcag actgacattc caaacaaatt tgaaatgaag
     2701 cttcgccgcg caaacattct ggaggattct taccggagga ttatgggtgt gaagagagct
     2761 gacttgctca aggccagact ctggattgag tttgatggtg aaaagggcct tgactatgga
     2821 ggggttgcca gagagtggtt cttcctcatc tcgaaggaaa tgttcaaccc ttactacggc
     2881 ctgtttgaat attctgctac ggataattac accctacaga taaatcctaa ctcgggcttg
     2941 tgtaatgaag atcacctctc atacttcaag ttcattggcc gtgtggctgg gatggcagtt
     3001 tatcatggca agctgttgga tgggtttttc atccgtccgt tttacaagat gatgcttcag
     3061 aaactgataa cactgcacga catggagtcc gtggatagtg aatattacag ttctctgcga
     3121 tggattcttg aaaatgaccc gacggagctg gacctgagat ttatcataga tgaagaactt
     3181 tttggacaga cacatcagca cgaactgaaa accggaggat cagagattgt tgtcaccaat
     3241 aagaacaaaa aggagtatat ctaccttgta atacaatggc gatttgtgaa ccgtatccag
     3301 aagcaaatgg cagcttttaa agagggattt tttgaactga taccacagga tctcatcaag
     3361 atatttgatg aaaatgagct agagcttctc atgtgtggtc tgggagatgt ggatgtgaac
     3421 gactggcggg aacacacaaa atacaaaaat ggctacagca tgaaccacca ggtcatccac
     3481 tggttctgga aggctgtttg gatgatggat tcggaaaaaa gaatacgctt acttcagttt
     3541 gtcactggca catcccgtgt gccgatgaat gggtttgctg aactctatgg ctcgaatgga
     3601 ccacaatcct tcacagtgga acaatggggc acccctgata agctgccaag agcacacacc
     3661 tgcttcaatc gcctggacct gccaccctac gaatcctttg acgaactctg ggataaactt
     3721 cagatggcaa ttgagaacac acagggcttt gatggcgttg attagattac aaaaaaaaac
     3781 aagctgtggt gtcttgtaca ccatagtttc taagcaaaag caaaaacaaa atcacatttt
     3841 aacattttcc agatagtttc taaaagatgg tcactggctc ttcccaccga gaccagagga
     3901 cagtttatcc atgatttagc caccaccatg ctgacctgtt cacttgtcca gttactttgt
     3961 ccagttgttg gggttcatgt gtacggcagg atgtgagtcc tgtacgcctg agttctgacc
     4021 ctatctcatc ttgctaggca catccttctg aaactactga gattccaact gtgaaatatc
     4081 tgtaatgagt agctggtggg aaaaatttga tgctttttaa agatgaaatt tggacaaaga
     4141 aagtctttaa tgattagtat actgcgacat acttagtacc acatgtcgct acttattctg
     4201 tagacctgcc tagtgtacct tatcgcctag aaccttgaag ccgctttgga agatgtatca
     4261 cacgtgtttt tagtcactta agtcactagt gtttaaaaaa aaaatgtact cttcacttgg
     4321 gaagtatttc acgtttgtta gcatgcagct tgagccttac aggcgattct ggagacaagt
     4381 ggagcaagct tttattgcag tgtgtagtga gtcttaggcc tcctttttgc ctgtgcatcc
     4441 taaggctaga gtcattatgt gttagtgcgt tagaattcct tcaaacacga aacaagctcc
     4501 acaacgcagt gtttctaagc atgccgtgaa gaaccgagtt ccatgtatga cttgccctta
     4561 ccagccactc ttcacgcttg cagtcacgta gtacatacgt gtttacggag ttcattatgt
     4621 ttacagatta agcgaatttc tgtagttgca tttttatatt tttagtatca cgttagtata
     4681 aaaatttgtt taaaataacc aaagagtagt tcaatgcata atttgtatga atttgttacc
     4741 aagtttctta tgctttctaa aaaaatactg tttcctatga aaattatgtt taatcaaaag
     4801 tcaagaaccc ttggggcaaa atgctacagg tggagtccca ccatagtcac ctttgaggca
     4861 caggaagagg ttccatgcat gaatctgcac acatgagcag tgctggctgc tgtgcaccgg
     4921 gcccttggga tgaagccatc agcactgaca tccagccccg tcttcatcct caggcttaga
     4981 aacaagtggg atggtgactt tacagtcagt gggaagtaag agcccgcaga ataacaaagg
     5041 cagaaggaca ggaaagcgag gtccgagtcc gactgcgagg tcatatctgc caaggctcct
     5101 tctagtcagc ttacactggt gattatacgg aaaatgctct tagatatgag aaaagcaatg
     5161 tggcatgtaa tgagttagtg taagcttgtg ttataaactt tccgaatgct tataagtagc
     5221 ctgtgggagc tgtaagaaat acttggggcc attgatttaa gcttgttggc tctaacatga
     5281 ctaatacctg tcagcccatg gtagggattt cagtgacagt agtggaaacg ctttccacag
     5341 accacaccac tatgttgatc ggtgaaagac acccccaggc cagtgcatgc ttccagagtg
     5401 tcctgatcag tcagccaggc atggccaccg tccagtgttg atttttatca ttagccagct
     5461 gagcctgcag cacggggctc atttccccgt ctggcagatg tggatagctg ggcccactca
     5521 ttctgtctct caaggctatg gtaagttctt aaaggggtac ttttctgcaa gccaccagag
     5581 tctgagtcag ctgtcccctc ccagtaagca tgttcaccta aagtgattta gcctaggcga
     5641 ggaggatccc tactacgtgc tggattatgt gtgtgttcat gtaaggattt cagcgtcaaa
     5701 agttcacttc ctccatagtg gcaaaataac actaatatgg gctggtgtgt tatctggagt
     5761 gcccccattg tgtggaacta agggtgaaaa cagaactgta cacggttgtt cagtgtcgtc
     5821 cccagaactc atccccagca gggcttagaa aacacgagct tccttcctcc ttcacactca
     5881 ttttcctttg gatgattcag tgacatcaca gaacctggtg tccccctccc taccccaggt
     5941 gtgtagtaat ggtccgaagg gaccctggct ggaacaccac agccccccat gctagtgcat
     6001 gaaaacatct cgttcatatt ctaccactgg ggcattgtgg agtcacattc acgaaacacg
     6061 aagaccttgt acttctctag aaaagtgttt tagcctactt tttctctaat ccccacccca
     6121 acaaatgaaa cacaaaattg cattacaaaa gcaaacccaa atggtatttg ttttcgattt
     6181 tatttatacc gctcgagtta ttccttatac gtatcaagtt aaactcaatt ggttttaatg
     6241 ataagctatt tgacattgtt tttaaatttt ttcttatatg gtaaatgtat atccagatta
     6301 aggtatcgaa atttattgca taaactataa aatcattttc aaaatctcaa ttccacaaat
     6361 aaagttctat tctgatttta aaaacaaa
//
