LOCUS       NM_008682               3542 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus neural precursor cell expressed, developmentally
            down-regulated gene 1 (Nedd1), mRNA.
ACCESSION   NM_008682
VERSION     NM_008682.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3542)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3542)
  AUTHORS   Muroyama,A., Seldin,L. and Lechler,T.
  TITLE     Divergent regulation of functionally distinct gamma-tubulin
            complexes during differentiation
  JOURNAL   J Cell Biol 213 (6), 679-692 (2016)
   PUBMED   27298324
REFERENCE   3  (bases 1 to 3542)
  AUTHORS   Marjanovic,M., Sanchez-Huertas,C., Terre,B., Gomez,R., Scheel,J.F.,
            Pacheco,S., Knobel,P.A., Martinez-Marchal,A., Aivio,S.,
            Palenzuela,L., Wolfrum,U., McKinnon,P.J., Suja,J.A., Roig,I.,
            Costanzo,V., Luders,J. and Stracker,T.H.
  TITLE     CEP63 deficiency promotes p53-dependent microcephaly and reveals a
            role for the centrosome in meiotic recombination
  JOURNAL   Nat Commun 6, 7676 (2015)
   PUBMED   26158450
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3542)
  AUTHORS   Fujita,T., Yanagihara,K., Takeshita,F., Aoyagi,K., Nishimura,T.,
            Takigahira,M., Chiwaki,F., Fukagawa,T., Katai,H., Ochiya,T.,
            Sakamoto,H., Konno,H., Yoshida,T. and Sasaki,H.
  TITLE     Intraperitoneal delivery of a small interfering RNA targeting NEDD1
            prolongs the survival of scirrhous gastric cancer model mice
  JOURNAL   Cancer Sci 104 (2), 214-222 (2013)
   PUBMED   23106787
  REMARK    GeneRIF: The mice treated with small interfering (si) RNA targeting
            NEDD1 by the atelocollagen-mediated delivery system showed a
            significantly prolonged survival.
REFERENCE   5  (bases 1 to 3542)
  AUTHORS   Machold,R., Klein,C. and Fishell,G.
  TITLE     Genes expressed in Atoh1 neuronal lineages arising from the
            r1/isthmus rhombic lip
  JOURNAL   Gene Expr Patterns 11 (5-6), 349-359 (2011)
   PUBMED   21440680
REFERENCE   6  (bases 1 to 3542)
  AUTHORS   Zhu,F., Lawo,S., Bird,A., Pinchev,D., Ralph,A., Richter,C.,
            Muller-Reichert,T., Kittler,R., Hyman,A.A. and Pelletier,L.
  TITLE     The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis
  JOURNAL   Curr Biol 18 (2), 136-141 (2008)
   PUBMED   18207742
REFERENCE   7  (bases 1 to 3542)
  AUTHORS   Desai,J., Shannon,M.E., Johnson,M.D., Ruff,D.W., Hughes,L.A.,
            Kerley,M.K., Carpenter,D.A., Johnson,D.K., Rinchik,E.M. and
            Culiat,C.T.
  TITLE     Nell1-deficient mice have reduced expression of extracellular
            matrix proteins causing cranial and vertebral defects
  JOURNAL   Hum Mol Genet 15 (8), 1329-1341 (2006)
   PUBMED   16537572
REFERENCE   8  (bases 1 to 3542)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   9  (bases 1 to 3542)
  AUTHORS   Kumar,S., Matsuzaki,T., Yoshida,Y. and Noda,M.
  TITLE     Molecular cloning and biological activity of a novel
            developmentally regulated gene encoding a protein with
            beta-transducin-like structure
  JOURNAL   J Biol Chem 269 (15), 11318-11326 (1994)
   PUBMED   8157664
REFERENCE   10 (bases 1 to 3542)
  AUTHORS   Kumar,S., Tomooka,Y. and Noda,M.
  TITLE     Identification of a set of genes with developmentally
            down-regulated expression in the mouse brain
  JOURNAL   Biochem Biophys Res Commun 185 (3), 1155-1161 (1992)
   PUBMED   1378265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK153746.1 and BC052430.1.
            
            On Apr 1, 2008 this sequence version replaced NM_008682.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052430.1, AK153746.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1186              AK153746.1         3-1188
            1187-3542           BC052430.1         1156-3511
FEATURES             Location/Qualifiers
     source          1..3542
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 47.25 cM"
     gene            1..3542
                     /gene="Nedd1"
                     /note="neural precursor cell expressed, developmentally
                     down-regulated gene 1"
                     /db_xref="GeneID:17997"
                     /db_xref="MGI:MGI:97293"
     exon            1..96
                     /gene="Nedd1"
                     /inference="alignment:Splign:2.1.0"
     exon            97..240
                     /gene="Nedd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2087
                     /gene="Nedd1"
                     /note="NEDD-1; neural precursor cell expressed
                     developmentally down-regulated protein 1"
                     /codon_start=1
                     /product="protein NEDD1"
                     /protein_id="NP_032708.2"
                     /db_xref="CCDS:CCDS24123.1"
                     /db_xref="GeneID:17997"
                     /db_xref="MGI:MGI:97293"
                     /translation="MQENLRFASSGDDVKIWDASFLTLVDKFNPHTSPHGISSICWSS
                     NNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVDLNSTSMYLASGGLNNTVN
                     IWDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPFGHG
                     SKQPIRHIKYSLFRKSLLGSVSDNGVVTLWDVNSQSSYHTFDSTHKAPASGICFSPVN
                     ELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLTAVDFMPDGATLAIGSSRGKIYQYD
                     LRMLKSPVKTISAHKTSVQCIAFQYSTSLTKASLSKGSSNKATAVNKRSVPVSSSSGA
                     AQNSGIVREAPSPSIATVLPQPVTTALGKGSGAAQDEAGLARSKSTDIFSKETDAGKS
                     QDFSSFDDTGKNSLGDMFSPIRDDAVVSKGGDESIGKGDGLDFLPQLNSVFPLRKNAG
                     ASSSLVLHSSPLNVLMGSSGKEENESHEPSAESKRAYLGKQEPKDAMKQFTKLISSGA
                     EPGILNTCPSSNQARNLEKFEKPEKDIEAQLIHEPSVNGSSTTVPKAASSVTAGVASS
                     LSEKIVDTLGNSRPGAPLTSVQIRFIQNMIQETLDDFREACHRDIVNLQVEMIKQFHI
                     QLNEMHSLLERYSVNEGLVAEIERLREENKRLRAHF"
     exon            241..335
                     /gene="Nedd1"
                     /inference="alignment:Splign:2.1.0"
     exon            336..452
                     /gene="Nedd1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..593
                     /gene="Nedd1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..823
                     /gene="Nedd1"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1025
                     /gene="Nedd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1221
                     /gene="Nedd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1350
                     /gene="Nedd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1398
                     /gene="Nedd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1601
                     /gene="Nedd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1758
                     /gene="Nedd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1915
                     /gene="Nedd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..1982
                     /gene="Nedd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..3533
                     /gene="Nedd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3509..3514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nedd1"
                     /note="hexamer: AATAAA"
     polyA_site      3533
                     /gene="Nedd1"
                     /note="major polyA site"
ORIGIN      
        1 cttccggccg cccaagttta acagtccagg cgggagccgg aagcgcagcg aggaacgggt
       61 ggagctgggc ctcccctgtg gccccacgct tgagaggccc agtcatgcag gaaaacctca
      121 gatttgcttc atcaggagat gacgttaaaa tatgggatgc ttcgttcctg acattggtgg
      181 ataaattcaa ccctcacacg tcaccgcatg gaatcagttc aatctgttgg agcagcaata
      241 ataactttct agtgacagct tcttccagtg gtgacaaaat agtggtgtca agttgcaaat
      301 gtaagcccgt tccacttttg gagcttgcgg aagggcaaaa gcagacatgt gtcgatttaa
      361 attctacatc aatgtatttg gcaagtggag gcctaaataa cactgttaat atttgggatt
      421 taaagtccaa acgacttcat cggtctctta aggatcataa atgtgaagta acttgtgtgg
      481 catacaattg gaatgactgt tacattgctt ctgggtctct cagtggtgag attatcttac
      541 acagtgtaac cactaataca tccagcacac cttttggcca tgggagtaag cagcctatcc
      601 ggcacatcaa gtactcattg tttaggaagt ctctcttggg cagcgtttcg gataatggag
      661 tagtgactct ctgggatgtg aacagtcaga gttcatacca cacctttgac agtacacaca
      721 aagccccagc ttcaggcatc tgcttctctc ctgtcaatga actgctgttt gtaaccatag
      781 gcctggataa aagaatcatc ctctatgata cttcaagtaa gaagctagtg aaaactttag
      841 tggccgacac ccccctgact gcagtagatt ttatgccgga tggagccact ttggctattg
      901 gatcttcccg tgggaaaata tatcagtatg acttaaggat gctgaaatct cccgtgaaaa
      961 ccatcagtgc ccacaagaca tctgtgcagt gtatagcatt tcagtactcc acatctctga
     1021 cgaaggcaag tttaagcaaa ggcagctcaa ataaggccac agcagtgaac aaacggagtg
     1081 ttcctgtgag cagcagcagt ggggctgccc agaattctgg aattgtcaga gaagcaccca
     1141 gcccttccat tgccacagtt ctcccacagc ccgtgacaac agctctgggc aaaggatcag
     1201 gggctgctca ggacgaagca ggtttggctc gaagcaaaag tacagatatt ttctctaagg
     1261 aaacagatgc tggaaaaagt caggatttct ccagctttga tgatactggg aaaaatagtt
     1321 taggtgacat gttctcacca atcagagatg atgctgtagt cagcaaagga ggtgatgaat
     1381 ctataggcaa aggagatggc cttgactttc taccacagct aaactcagtg ttccctctga
     1441 ggaagaatgc aggtgcctcc agcagtctgg tgctgcactc cagccctctt aatgtcctca
     1501 tgggatcttc agggaaagaa gagaatgaaa gccatgagcc gtcagctgag tctaaaagag
     1561 catacctagg gaagcaggaa cctaaggacg ccatgaagca gtttacaaag ttgatctcct
     1621 ctggtgctga acctggaatt ctaaatacct gtccatcgtc taaccaagca agaaatcttg
     1681 aaaaatttga aaagccagaa aaagatattg aagcccagtt gatacatgaa ccctcagtca
     1741 acggctcctc aactacagta ccaaaggcag catcctccgt cactgctgga gtggccagtt
     1801 cactctcaga gaaaatagtc gatacccttg ggaacagtcg gccaggggcg ccgcttacct
     1861 cagtccagat ccgcttcatt cagaacatga tacaagaaac actggatgac ttcagggaag
     1921 cttgccatag agacattgtg aatctgcaag tggaaatgat taaacagttt catatacagc
     1981 tgaatgaaat gcactctttg ctggaaagat actccgtgaa tgaaggctta gtggctgaga
     2041 tcgaaaggct gcgagaagaa aacaaaaggc tgcgggccca tttctgaaga ctctgggcac
     2101 cttgatttgt tatgagttag gatgtttctg gcaactataa tacacggaat cagtattgtt
     2161 tgcatggcct tgaaagtgga ttttgcagca cgcactattc catctctgtc agacatttat
     2221 atttttatat taaaactgca cagaatacca atcttcctag tggggaagtc aacaggatct
     2281 ttattttctg aatgccttag ctatacacta agtgcccttt tcctaaaaga agaaaatgtt
     2341 cataagaata ggtttatgtt ttgtaaatga cttttaaaaa tagatatatt tttgatggac
     2401 aaattgtatt ccaaattttt ttaggtagcc aacttttaaa acctcggtat accttctatt
     2461 ttataaagaa ataattgtaa agtggcaatt ggattttttc acagtttagt aattattttg
     2521 ttaacatgat gacatcaggt atgccttatt tatttagtgt atatgtaata catttttgaa
     2581 actttgcatt gtacagatac atggtacctt tgttctggtt acctaatttt atatatatat
     2641 aattttttta agggtttgga agattcaagg gctatatatc tgctgattgt ctaatgaatt
     2701 tactatgtgc aaaatcatta ctataagatt ttcatcactc aacttaggat cagtgaaatt
     2761 ttcttatact aactaaatat tagaatattg ttgccatttt ttccctcaca agtaacaggc
     2821 atagattatt tcttctgtgt tgtgtatcat taactttctc taattacagt gtgctgtgaa
     2881 cagcactttc tatccttagc cttaccataa tatttataaa ggttcatcat gcagagaatg
     2941 tacatgttgg cggagctggc cgtgttcatc tgcctgctgg aacctacact ttgatagggc
     3001 tggactaggg gctactcacc gtttatattc ttgtcgcctc ttgcccaaag atctcaactg
     3061 tgtactttat atgtacatct gttccccact tttgctttcc aggatcaaga tgtttactaa
     3121 aatgtagctt agattgataa ctttaagtgt ttctaaagag atagaatctg taagggtgta
     3181 tttaataaat ataaacctat gaataattat ctccaaaagt ggaacaggag taagactttt
     3241 ccaagtgact cagaaagtct gtttgtgtgt caagtttctg tggccttttc ttggcagcta
     3301 tggccgcatt atgacttgta acaagtcccc ttacatgtca ctcaaacaac gttaaaatgc
     3361 agacgtcttt tgtctatata ctacatttta acctattaat attttcctat ttcctttttt
     3421 ctataggtgt atatattgtg tattaaaaag ggtctgatag agcatgtata taggtaaaac
     3481 acttgtcatg gatttaagca ctgagtacaa taaattttca cattcaaaat gtaaaaaaaa
     3541 aa
//
