LOCUS       NM_021495               3085 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus nectin cell adhesion molecule 3 (Nectin3), transcript
            variant alpha, mRNA.
ACCESSION   NM_021495 XM_358989
VERSION     NM_021495.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3085)
  AUTHORS   Mohammad,R.Z., Murakawa,H., Svadlenka,K. and Togashi,H.
  TITLE     A numerical algorithm for modeling cellular rearrangements in
            tissue morphogenesis
  JOURNAL   Commun Biol 5 (1), 239 (2022)
   PUBMED   35304570
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3085)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3085)
  AUTHORS   Tomorsky,J., Parker,P.R.L., Doe,C.Q. and Niell,C.M.
  TITLE     Precise levels of nectin-3 are required for proper synapse
            formation in postnatal visual cortex
  JOURNAL   Neural Dev 15 (1), 13 (2020)
   PUBMED   33160402
  REMARK    GeneRIF: Precise levels of nectin-3 are required for proper synapse
            formation in postnatal visual cortex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3085)
  AUTHORS   Wang,H.L., Li,J.T., Wang,H., Sun,Y.X., Liu,R., Wang,X.D., Su,Y.A.
            and Si,T.M.
  TITLE     Prefrontal Nectin3 Reduction Mediates Adolescent Stress-Induced
            Deficits of Social Memory, Spatial Working Memory, and Dendritic
            Structure in Mice
  JOURNAL   Neurosci Bull 36 (8), 860-874 (2020)
   PUBMED   32385776
  REMARK    GeneRIF: Prefrontal Nectin3 Reduction Mediates Adolescent
            Stress-Induced Deficits of Social Memory, Spatial Working Memory,
            and Dendritic Structure in Mice.
REFERENCE   5  (bases 1 to 3085)
  AUTHORS   Li,T., Yao,J., Zhang,Q., Li,Q., Li,J., Wang,X., Li,W., Chen,A. and
            Yan,J.
  TITLE     Chronic stress impairs male spermatogenesis function and Nectin-3
            protein expression in the testis
  JOURNAL   Physiol Res 69 (2), 297-306 (2020)
   PUBMED   32324042
  REMARK    GeneRIF: Chronic stress impairs male spermatogenesis function and
            Nectin-3 protein expression in the testis.
REFERENCE   6  (bases 1 to 3085)
  AUTHORS   Takekuni,K., Ikeda,W., Fujito,T., Morimoto,K., Takeuchi,M.,
            Monden,M. and Takai,Y.
  TITLE     Direct binding of cell polarity protein PAR-3 to cell-cell adhesion
            molecule nectin at neuroepithelial cells of developing mouse
  JOURNAL   J Biol Chem 278 (8), 5497-5500 (2003)
   PUBMED   12515806
REFERENCE   7  (bases 1 to 3085)
  AUTHORS   Honda,T., Shimizu,K., Kawakatsu,T., Yasumi,M., Shingai,T.,
            Fukuhara,A., Ozaki-Kuroda,K., Irie,K., Nakanishi,H. and Takai,Y.
  TITLE     Antagonistic and agonistic effects of an extracellular fragment of
            nectin on formation of E-cadherin-based cell-cell adhesion
  JOURNAL   Genes Cells 8 (1), 51-63 (2003)
   PUBMED   12558799
REFERENCE   8  (bases 1 to 3085)
  AUTHORS   Ozaki-Kuroda,K., Nakanishi,H., Ohta,H., Tanaka,H., Kurihara,H.,
            Mueller,S., Irie,K., Ikeda,W., Sakai,T., Wimmer,E., Nishimune,Y.
            and Takai,Y.
  TITLE     Nectin couples cell-cell adhesion and the actin scaffold at
            heterotypic testicular junctions
  JOURNAL   Curr Biol 12 (13), 1145-1150 (2002)
   PUBMED   12121624
  REMARK    GeneRIF: nectin-afadin system plays essential roles in coupling
            cell-cell adhesion and the cortical actin scaffold in spermatids at
            Sertoli-spermatid junctions and in subsequent sperm morphogenesis
REFERENCE   9  (bases 1 to 3085)
  AUTHORS   Mizoguchi,A., Nakanishi,H., Kimura,K., Matsubara,K.,
            Ozaki-Kuroda,K., Katata,T., Honda,T., Kiyohara,Y., Heo,K.,
            Higashi,M., Tsutsumi,T., Sonoda,S., Ide,C. and Takai,Y.
  TITLE     Nectin: an adhesion molecule involved in formation of synapses
  JOURNAL   J Cell Biol 156 (3), 555-565 (2002)
   PUBMED   11827984
REFERENCE   10 (bases 1 to 3085)
  AUTHORS   Satoh-Horikawa,K., Nakanishi,H., Takahashi,K., Miyahara,M.,
            Nishimura,M., Tachibana,K., Mizoguchi,A. and Takai,Y.
  TITLE     Nectin-3, a new member of immunoglobulin-like cell adhesion
            molecules that shows homophilic and heterophilic cell-cell adhesion
            activities
  JOURNAL   J Biol Chem 275 (14), 10291-10299 (2000)
   PUBMED   10744716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY713810.1, AK011949.1, BU701648.1, AC113113.18 and BQ174425.1.
            
            On May 3, 2011 this sequence version replaced NM_021495.3.
            
            Transcript Variant: This variant (alpha) represents the longest
            transcript and encodes the longest isoform (alpha).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011949.1, AF195833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-562               BY713810.1         1-562
            563-734             AK011949.1         563-734
            735-1336            BU701648.1         101-702
            1337-2421           AC113113.18        159226-160310       c
            2422-3085           BQ174425.1         1-664               c
FEATURES             Location/Qualifiers
     source          1..3085
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 30.48 cM"
     gene            1..3085
                     /gene="Nectin3"
                     /gene_synonym="2610301B19Rik; 3000002N23Rik;
                     4921513D19Rik; CD113; Pvrl3"
                     /note="nectin cell adhesion molecule 3"
                     /db_xref="GeneID:58998"
                     /db_xref="MGI:MGI:1930171"
     exon            1..353
                     /gene="Nectin3"
                     /gene_synonym="2610301B19Rik; 3000002N23Rik;
                     4921513D19Rik; CD113; Pvrl3"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1843
                     /gene="Nectin3"
                     /gene_synonym="2610301B19Rik; 3000002N23Rik;
                     4921513D19Rik; CD113; Pvrl3"
                     /note="isoform alpha is encoded by transcript variant
                     alpha; poliovirus receptor-related protein 3; poliovirus
                     receptor-related 3; nectin-3"
                     /codon_start=1
                     /product="nectin-3 isoform alpha"
                     /protein_id="NP_067470.1"
                     /db_xref="CCDS:CCDS28206.1"
                     /db_xref="GeneID:58998"
                     /db_xref="MGI:MGI:1930171"
                     /translation="MARTPGPAPLCPGGGKAQLSSAFPPAAGLLLPAPTPPPLLLLLI
                     PLLLFSRLCGALAGSIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSTQTV
                     AVHHPQYGFSVQGDYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQS
                     STTVTVLVEPTVSLIKGPDSLIDGGNETVAAVCVAATGKPVAQIDWEGDLGEMESSTT
                     SFPNETATIVSQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGY
                     DGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTVNYSG
                     VYVCKVSNSLGQRSDQKVIYISDPPTTTTLQPTVQWHSSPADVQDIATEHKKLPFPLS
                     TLATLKDDTIGTIIASVVGGALFLVLVSILAGVFCYRRRRTFRGDYFAKNYIPPSDMQ
                     KESQIDVLHQDELDSYPDSVKKENKNPVNNLIRKDYLEEPEKTQWNNVENLTRFERPM
                     DYYEDLKMGMKFVSDERYNESEDGLVSHVDGSVISRREWYV"
     exon            354..695
                     /gene="Nectin3"
                     /gene_synonym="2610301B19Rik; 3000002N23Rik;
                     4921513D19Rik; CD113; Pvrl3"
                     /inference="alignment:Splign:2.1.0"
     exon            696..992
                     /gene="Nectin3"
                     /gene_synonym="2610301B19Rik; 3000002N23Rik;
                     4921513D19Rik; CD113; Pvrl3"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1110
                     /gene="Nectin3"
                     /gene_synonym="2610301B19Rik; 3000002N23Rik;
                     4921513D19Rik; CD113; Pvrl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1262
                     /gene="Nectin3"
                     /gene_synonym="2610301B19Rik; 3000002N23Rik;
                     4921513D19Rik; CD113; Pvrl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..3070
                     /gene="Nectin3"
                     /gene_synonym="2610301B19Rik; 3000002N23Rik;
                     4921513D19Rik; CD113; Pvrl3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggcatcg gcgacggcgg agtcgaggca gccgcgagcg ctcggccgag tggcggcggg
       61 cggcgacggc gcaggagccg ggggttgagg acacgcgcgc tggcccttcc gcgccgcggc
      121 cgccgccgcc gccgccaccc agagcctgag gcgccggggc gcgggcgagc gggtgggccg
      181 gggcaaggcg ggcatggcgc ggaccccggg cccggccccg ttgtgtcctg gaggcggcaa
      241 agcacaactt tcctcggcgt ttcctcccgc ggccggactg ctgctgccgg ccccgacgcc
      301 gccgccgctg ctgctgctgc ttattcccct gcttctcttc tcccggctct gtggtgcctt
      361 agctggatca attattgtgg agccacatgt cacagcagtg tggggaaaga atgtttcatt
      421 gaagtgttta attgaagtga atgaaactat aacccagatc tcatgggaga agatacatgg
      481 caaaagtaca cagactgttg cagttcatca tcctcagtat ggattctctg ttcaaggaga
      541 ttatcaggga agagtcttgt ttaaaaacta ttcacttaat gatgcaacaa ttactctgca
      601 taacataggc ttctcagatt ctggaaaata tatatgcaaa gccgttacat tcccacttgg
      661 aaatgctcag tcctctacaa cagtgactgt gttagttgaa cccacagtga gcctgataaa
      721 agggccggat tctttaattg atggagggaa tgagacagta gcagccgttt gtgtagcagc
      781 cactggaaag ccagtcgcac agattgactg ggaaggtgat cttggtgaaa tggaatctag
      841 tacaacttct tttcctaatg aaacagcaac gattgtcagc caatacaagc tgtttcccac
      901 aagatttgct cgaggaaggc gaattacttg tgttgtaaaa catccagcct tagaaaagga
      961 cattcgctac tctttcatac tagacataca gtatgctcct gaagtttcag taacaggata
     1021 tgatggaaat tggttcgtgg gaagaaaagg tgttaacctc aagtgtaatg ctgatgcaaa
     1081 ccctccaccc ttcaagtccg tgtggagcag gttggatgga caatggcctg atggtttatt
     1141 ggcgtcagat aatactcttc attttgtcca tccattgact gtcaattatt ctggcgttta
     1201 tgtctgtaaa gtatcaaatt cccttggtca aagaagtgat caaaaggtta tctacatttc
     1261 agatcctcct accaccacca cccttcagcc gacagttcag tggcattcct cacctgctga
     1321 cgtccaggat atagcaacag agcataaaaa attgcccttt cctttgtcaa ctttggcaac
     1381 acttaaggat gacacaattg gcaccatcat tgctagtgta gtgggtgggg ctctcttctt
     1441 agtgcttgtg agcattttag ctggggtatt ctgctatagg agacgacgga cgtttcgtgg
     1501 agactacttt gccaaaaact acattccacc atcagacatg cagaaagaat cacagattga
     1561 tgttcttcac caggatgagc tggattctta cccagacagt gtaaaaaagg aaaacaaaaa
     1621 tccagtaaac aacctgatcc gcaaagacta cttagaggag cctgagaaaa ctcagtggaa
     1681 taatgtagag aacctcacta ggtttgaaag accgatggat tactatgaag atctaaaaat
     1741 gggaatgaag tttgtcagtg atgaacgcta caatgaaagt gaagatggtt tggtttctca
     1801 tgtagatggc tccgtaattt ccaggaggga gtggtatgtc taacagccac tgacgcgact
     1861 tcactatgta caaggtttca ttcacactag ttgaccattt tcagattgtt catacttttt
     1921 cttgaggaag aataagcttt ttcaagttga tttcgagctt actttttata ttctgatctg
     1981 acaaatgaaa atgtaaaacc tgggttcaat gtatctgagc tgctttacag ttttcactgc
     2041 tatactactg tctcaagatt taaattctaa tgcagagtac tttattggtc tgaggcacac
     2101 aggtaagaaa gatgtcaacg ttaaatgtat gacgtttttg gtacaaaaat taaaaacaga
     2161 aaaaaaagaa actaccttgg cattgtgtat taaatattta cctaagacta taatctcaag
     2221 tataatgatt gtgtaacata tacctctcaa aacttatcac cactaagaat actccatcaa
     2281 aattgacagt aaaacccatc caagaaatgc ttatatattt ttagtatact aaaatcatcc
     2341 atcctgatgg agtatcttct catcgtcaac cattcttttc taagtttcta tagagatagg
     2401 atctttacct ctgcatttaa atgagccttg ccataattac tgtagagtgg cttttcaaag
     2461 atattttgtt gcactaaaac tgtggccata aactaagtga acacgatgtg tggaagagca
     2521 taactagctg ttcaatattt ttgtctaaaa cacatgcaag agtaataaaa tatatgcctc
     2581 ctgacacaat aattactaat tttttcatct ctggaagaaa attgttcagt tgttttgtga
     2641 atgtggcttt ggtacacaaa gcattaacct tatcttaatg ctttatttgc taagcagatg
     2701 aatagtgatg caagcgcggt acaggacaga gaggggattt gagtctgctt gtgtgccaga
     2761 gttagacatg agctgctcca gccaggaacc tatacgaaga gttttctaat cttcttgttt
     2821 tagttattta atgttggtat tgttcaaacg ggtacatgta caaaacaata ttaaaataag
     2881 ctttgaagct tgaggtttct ttagagaaat ctgaattaca gaaccagtca ttgataacac
     2941 ttgctgatga atgttggcaa tcccttcctg ttttcttcat ttctcctaaa tgtatgtata
     3001 tgtttcaagc tttttttgtt tgtttatttg tttggttttt tcaaattaaa actggaaaca
     3061 tatcatgaga aaaaaaaaaa aaaaa
//
