LOCUS       NP_067470                549 aa            linear   ROD 12-JUN-2025
DEFINITION  nectin-3 isoform alpha [Mus musculus].
ACCESSION   NP_067470 XP_358989
VERSION     NP_067470.1
DBSOURCE    REFSEQ: accession NM_021495.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 549)
  AUTHORS   Clancy,S., Xie,N., Eluvathingal Muttikkal,T., Wang,J., Adylkhan,A.,
            Fateh,E., Smith,M., Wilson,P., Smith,M., Hogan,A., Sutherland,A.
            and Lu,X.
  TITLE     Rac1 and Nectin3 are essential for planar cell polarity-directed
            axon guidance in the peripheral auditory system
  JOURNAL   Development 152 (8) (2025)
   PUBMED   40207531
REFERENCE   2  (residues 1 to 549)
  AUTHORS   Mohammad,R.Z., Murakawa,H., Svadlenka,K. and Togashi,H.
  TITLE     A numerical algorithm for modeling cellular rearrangements in
            tissue morphogenesis
  JOURNAL   Commun Biol 5 (1), 239 (2022)
   PUBMED   35304570
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 549)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 549)
  AUTHORS   Tomorsky,J., Parker,P.R.L., Doe,C.Q. and Niell,C.M.
  TITLE     Precise levels of nectin-3 are required for proper synapse
            formation in postnatal visual cortex
  JOURNAL   Neural Dev 15 (1), 13 (2020)
   PUBMED   33160402
  REMARK    GeneRIF: Precise levels of nectin-3 are required for proper synapse
            formation in postnatal visual cortex.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 549)
  AUTHORS   Wang,H.L., Li,J.T., Wang,H., Sun,Y.X., Liu,R., Wang,X.D., Su,Y.A.
            and Si,T.M.
  TITLE     Prefrontal Nectin3 Reduction Mediates Adolescent Stress-Induced
            Deficits of Social Memory, Spatial Working Memory, and Dendritic
            Structure in Mice
  JOURNAL   Neurosci Bull 36 (8), 860-874 (2020)
   PUBMED   32385776
  REMARK    GeneRIF: Prefrontal Nectin3 Reduction Mediates Adolescent
            Stress-Induced Deficits of Social Memory, Spatial Working Memory,
            and Dendritic Structure in Mice.
REFERENCE   6  (residues 1 to 549)
  AUTHORS   Takekuni,K., Ikeda,W., Fujito,T., Morimoto,K., Takeuchi,M.,
            Monden,M. and Takai,Y.
  TITLE     Direct binding of cell polarity protein PAR-3 to cell-cell adhesion
            molecule nectin at neuroepithelial cells of developing mouse
  JOURNAL   J Biol Chem 278 (8), 5497-5500 (2003)
   PUBMED   12515806
REFERENCE   7  (residues 1 to 549)
  AUTHORS   Honda,T., Shimizu,K., Kawakatsu,T., Yasumi,M., Shingai,T.,
            Fukuhara,A., Ozaki-Kuroda,K., Irie,K., Nakanishi,H. and Takai,Y.
  TITLE     Antagonistic and agonistic effects of an extracellular fragment of
            nectin on formation of E-cadherin-based cell-cell adhesion
  JOURNAL   Genes Cells 8 (1), 51-63 (2003)
   PUBMED   12558799
REFERENCE   8  (residues 1 to 549)
  AUTHORS   Ozaki-Kuroda,K., Nakanishi,H., Ohta,H., Tanaka,H., Kurihara,H.,
            Mueller,S., Irie,K., Ikeda,W., Sakai,T., Wimmer,E., Nishimune,Y.
            and Takai,Y.
  TITLE     Nectin couples cell-cell adhesion and the actin scaffold at
            heterotypic testicular junctions
  JOURNAL   Curr Biol 12 (13), 1145-1150 (2002)
   PUBMED   12121624
  REMARK    GeneRIF: nectin-afadin system plays essential roles in coupling
            cell-cell adhesion and the cortical actin scaffold in spermatids at
            Sertoli-spermatid junctions and in subsequent sperm morphogenesis
REFERENCE   9  (residues 1 to 549)
  AUTHORS   Mizoguchi,A., Nakanishi,H., Kimura,K., Matsubara,K.,
            Ozaki-Kuroda,K., Katata,T., Honda,T., Kiyohara,Y., Heo,K.,
            Higashi,M., Tsutsumi,T., Sonoda,S., Ide,C. and Takai,Y.
  TITLE     Nectin: an adhesion molecule involved in formation of synapses
  JOURNAL   J Cell Biol 156 (3), 555-565 (2002)
   PUBMED   11827984
REFERENCE   10 (residues 1 to 549)
  AUTHORS   Satoh-Horikawa,K., Nakanishi,H., Takahashi,K., Miyahara,M.,
            Nishimura,M., Tachibana,K., Mizoguchi,A. and Takai,Y.
  TITLE     Nectin-3, a new member of immunoglobulin-like cell adhesion
            molecules that shows homophilic and heterophilic cell-cell adhesion
            activities
  JOURNAL   J Biol Chem 275 (14), 10291-10299 (2000)
   PUBMED   10744716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY713810.1, AK011949.1, BU701648.1, AC113113.18 and BQ174425.1.
            
            On Dec 17, 2003 this sequence version replaced XP_358989.1.
            
            Transcript Variant: This variant (alpha) represents the longest
            transcript and encodes the longest isoform (alpha).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011949.1, AF195833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..549
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 30.48 cM"
     Protein         1..549
                     /product="nectin-3 isoform alpha"
                     /note="poliovirus receptor-related protein 3; poliovirus
                     receptor-related 3; nectin-3"
                     /calculated_mol_wt=60452
     Region          58..167
                     /region_name="IgV_1_Nectin-3_like"
                     /note="First immunoglobulin variable (IgV) domain of
                     nectin-3 (also known as poliovirus receptor related
                     protein 3), and similar domains; cd05887"
                     /db_xref="CDD:409470"
     Region          58..81
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409470"
     Region          58..62
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409470"
     Region          64..68
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409470"
     Site            order(72..79,86..94,101..113,131..137,142..156,159..167)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:409470"
     Region          73..81
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409470"
     Region          82..86
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409470"
     Region          87..93
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409470"
     Region          88..93
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409470"
     Region          94..113
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409470"
     Region          103..108
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409470"
     Region          110..114
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409470"
     Region          114..152
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409470"
     Region          121..125
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409470"
     Region          130..137
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409470"
     Region          144..152
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409470"
     Region          153..156
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409470"
     Region          156..166
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409470"
     Region          157..167
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409470"
     Region          170..265
                     /region_name="IgC1_2_Nectin-3-4_like"
                     /note="Second immunoglobulin (Ig) domain of nectin-3 and
                     nectin-4 (poliovirus receptor related protein 4), and
                     similar domains; member of the C1-set of Ig superfamily
                     (IgSF) domains; cd07704"
                     /db_xref="CDD:409501"
     Region          170..176
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409501"
     Region          189..196
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409501"
     Region          201..207
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409501"
     Region          209..211
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409501"
     Region          213..220
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409501"
     Region          225..233
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409501"
     Region          243..250
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409501"
     Region          256..262
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409501"
     Region          269..355
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          287..291
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          301..305
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          320..325
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          335..340
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          350..353
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          402..432
                     /region_name="TM_EGFR-like"
                     /note="Transmembrane domain of the Epidermal Growth Factor
                     Receptor family of Protein Tyrosine Kinases; cd12087"
                     /db_xref="CDD:213052"
     Site            order(403..404,407..408,410..412,414..415,418)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:213052"
     CDS             1..549
                     /gene="Nectin3"
                     /gene_synonym="2610301B19Rik; 3000002N23Rik;
                     4921513D19Rik; CD113; Pvrl3"
                     /coded_by="NM_021495.4:194..1843"
                     /note="isoform alpha is encoded by transcript variant
                     alpha"
                     /db_xref="CCDS:CCDS28206.1"
                     /db_xref="GeneID:58998"
                     /db_xref="MGI:MGI:1930171"
ORIGIN      
        1 martpgpapl cpgggkaqls safppaagll lpaptpppll llliplllfs rlcgalagsi
       61 ivephvtavw gknvslkcli evnetitqis wekihgkstq tvavhhpqyg fsvqgdyqgr
      121 vlfknyslnd atitlhnigf sdsgkyicka vtfplgnaqs sttvtvlvep tvslikgpds
      181 lidggnetva avcvaatgkp vaqidwegdl gemessttsf pnetativsq yklfptrfar
      241 grritcvvkh palekdirys fildiqyape vsvtgydgnw fvgrkgvnlk cnadanpppf
      301 ksvwsrldgq wpdgllasdn tlhfvhpltv nysgvyvckv snslgqrsdq kviyisdppt
      361 tttlqptvqw hsspadvqdi atehkklpfp lstlatlkdd tigtiiasvv ggalflvlvs
      421 ilagvfcyrr rrtfrgdyfa knyippsdmq kesqidvlhq deldsypdsv kkenknpvnn
      481 lirkdyleep ektqwnnven ltrferpmdy yedlkmgmkf vsderynese dglvshvdgs
      541 visrrewyv
//
