LOCUS       NM_008990               2735 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus nectin cell adhesion molecule 2 (Nectin2), transcript
            variant 1, mRNA.
ACCESSION   NM_008990 XM_987250
VERSION     NM_008990.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2735)
  AUTHORS   Shiotani,H., Miyata,M., Kameyama,T., Mandai,K., Yamasaki,M.,
            Watanabe,M., Mizutani,K. and Takai,Y.
  TITLE     Nectin-2alpha is localized at cholinergic neuron dendrites and
            regulates synapse formation in the medial habenula
  JOURNAL   J Comp Neurol 529 (2), 450-477 (2021)
   PUBMED   32452538
  REMARK    GeneRIF: Nectin-2alpha is localized at cholinergic neuron dendrites
            and regulates synapse formation in the medial habenula.
REFERENCE   2  (bases 1 to 2735)
  AUTHORS   Russo,E., Runge,P., Jahromi,N.H., Naboth,H., Landtwing,A.,
            Montecchi,R., Leicht,N., Hunter,M.C., Takai,Y. and Halin,C.
  TITLE     CD112 Regulates Angiogenesis and T Cell Entry into the Spleen
  JOURNAL   Cells 10 (1), 169 (2021)
   PUBMED   33467729
  REMARK    GeneRIF: CD112 Regulates Angiogenesis and T Cell Entry into the
            Spleen.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2735)
  AUTHORS   Landin Malt,A., Dailey,Z., Holbrook-Rasmussen,J., Zheng,Y.,
            Hogan,A., Du,Q. and Lu,X.
  TITLE     Par3 is essential for the establishment of planar cell polarity of
            inner ear hair cells
  JOURNAL   Proc Natl Acad Sci U S A 116 (11), 4999-5008 (2019)
   PUBMED   30814219
REFERENCE   4  (bases 1 to 2735)
  AUTHORS   Murter,B., Pan,X., Ophir,E., Alteber,Z., Azulay,M., Sen,R.,
            Levy,O., Dassa,L., Vaknin,I., Fridman-Kfir,T., Salomon,R.,
            Ravet,A., Tam,A., Levin,D., Vaknin,Y., Tatirovsky,E.,
            Machlenkin,A., Pardoll,D. and Ganguly,S.
  TITLE     Mouse PVRIG Has CD8+ T Cell-Specific Coinhibitory Functions and
            Dampens Antitumor Immunity
  JOURNAL   Cancer Immunol Res 7 (2), 244-256 (2019)
   PUBMED   30659055
REFERENCE   5  (bases 1 to 2735)
  AUTHORS   Shiotani,H., Miyata,M., Mizutani,K., Wang,S., Mizoguchi,A.,
            Mochizuki,H., Mandai,K. and Takai,Y.
  TITLE     Interaction of nectin-2alpha with the auxiliary protein of the
            voltage-gated A-type K+ channel Kv4.2 dipeptidyl
            aminopeptidase-like protein at the boundary between the adjacent
            somata of clustered cholinergic neurons in the medial habenula
  JOURNAL   Mol Cell Neurosci 94, 32-40 (2019)
   PUBMED   30408526
REFERENCE   6  (bases 1 to 2735)
  AUTHORS   Eberle,F., Dubreuil,P., Mattei,M.G., Devilard,E. and Lopez,M.
  TITLE     The human PRR2 gene, related to the human poliovirus receptor gene
            (PVR), is the true homolog of the murine MPH gene
  JOURNAL   Gene 159 (2), 267-272 (1995)
   PUBMED   7622062
REFERENCE   7  (bases 1 to 2735)
  AUTHORS   Aoki,J., Koike,S., Ise,I., Sato-Yoshida,Y. and Nomoto,A.
  TITLE     Amino acid residues on human poliovirus receptor involved in
            interaction with poliovirus
  JOURNAL   J Biol Chem 269 (11), 8431-8438 (1994)
   PUBMED   8132569
REFERENCE   8  (bases 1 to 2735)
  AUTHORS   Morrison,M.E. and Racaniello,V.R.
  TITLE     Molecular cloning and expression of a murine homolog of the human
            poliovirus receptor gene
  JOURNAL   J Virol 66 (5), 2807-2813 (1992)
   PUBMED   1560525
REFERENCE   9  (bases 1 to 2735)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     A molecular genetic linkage map of mouse chromosome 7
  JOURNAL   Genomics 8 (3), 525-535 (1990)
   PUBMED   1981054
REFERENCE   10 (bases 1 to 2735)
  AUTHORS   Mendelsohn,C., Johnson,B., Lionetti,K.A., Nobis,P., Wimmer,E. and
            Racaniello,V.R.
  TITLE     Transformation of a human poliovirus receptor gene into mouse cells
  JOURNAL   Proc Natl Acad Sci U S A 83 (20), 7845-7849 (1986)
   PUBMED   3020560
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149282.2 and BC046770.1.
            
            On Apr 30, 2009 this sequence version replaced NM_008990.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046770.1, D26107.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC149282.2         154791-154894       c
            105-1630            BC046770.1         1-1526
            1631-2735           AC149282.2         121965-123069       c
FEATURES             Location/Qualifiers
     source          1..2735
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.94 cM"
     gene            1..2735
                     /gene="Nectin2"
                     /gene_synonym="Cd112; MPH; nectin-2; Pvr; Pvrl2; Pvs"
                     /note="nectin cell adhesion molecule 2"
                     /db_xref="GeneID:19294"
                     /db_xref="MGI:MGI:97822"
     exon            1..359
                     /gene="Nectin2"
                     /gene_synonym="Cd112; MPH; nectin-2; Pvr; Pvrl2; Pvs"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..1864
                     /gene="Nectin2"
                     /gene_synonym="Cd112; MPH; nectin-2; Pvr; Pvrl2; Pvs"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; poliovirus receptor-related protein 2; hveB;
                     mHveB; poliovirus receptor homolog; poliovirus
                     receptor-related 2; murine herpesvirus entry protein B;
                     herpesvirus entry mediator B; herpes virus entry mediator
                     B; murine herpes virus entry protein B; poliovirus
                     sensitivity"
                     /codon_start=1
                     /product="nectin-2 isoform 1 precursor"
                     /protein_id="NP_033016.3"
                     /db_xref="CCDS:CCDS20913.1"
                     /db_xref="GeneID:19294"
                     /db_xref="MGI:MGI:97822"
                     /translation="MARAAVLPPSRLSPTLPLLPLLLLLLQETGAQDVRVRVLPEVRG
                     RLGGTVELPCHLLPPTTERVSQVTWQRLDGTVVAAFHPSFGVDFPNSQFSKDRLSFVR
                     ARPETNADLRDATLAFRGLRVEDEGNYTCEFATFPNGTRRGVTWLRVIAQPENHAEAQ
                     EVTIGPQSVAVARCVSTGGRPPARITWISSLGGEAKDTQEPGIQAGTVTIISRYSLVP
                     VGRADGVKVTCRVEHESFEEPILLPVTLSVRYPPEVSISGYDDNWYLGRSEAILTCDV
                     RSNPEPTDYDWSTTSGVFPASAVAQGSQLLVHSVDRMVNTTFICTATNAVGTGRAEQV
                     ILVRESPSTAGAGATGGIIGGIIAAIIATAVAGTGILICRQQRKEQRLQAADEEEELE
                     GPPSYKPPTPKAKLEEPEMPSQLFTLGASEHSPVKTPYFDAGVSCADQEMPRYHELPT
                     LEERSGPLLLGATGLGPSLLVPPGPNVVEGVSLSLEDEEEDDEEEDFLDKINPIYDAL
                     SYPSPSDSYQSKDFFVSRAMYV"
     exon            360..722
                     /gene="Nectin2"
                     /gene_synonym="Cd112; MPH; nectin-2; Pvr; Pvrl2; Pvs"
                     /inference="alignment:Splign:2.1.0"
     exon            723..1019
                     /gene="Nectin2"
                     /gene_synonym="Cd112; MPH; nectin-2; Pvr; Pvrl2; Pvs"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1137
                     /gene="Nectin2"
                     /gene_synonym="Cd112; MPH; nectin-2; Pvr; Pvrl2; Pvs"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1286
                     /gene="Nectin2"
                     /gene_synonym="Cd112; MPH; nectin-2; Pvr; Pvrl2; Pvs"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1440
                     /gene="Nectin2"
                     /gene_synonym="Cd112; MPH; nectin-2; Pvr; Pvrl2; Pvs"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1504
                     /gene="Nectin2"
                     /gene_synonym="Cd112; MPH; nectin-2; Pvr; Pvrl2; Pvs"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1591
                     /gene="Nectin2"
                     /gene_synonym="Cd112; MPH; nectin-2; Pvr; Pvrl2; Pvs"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..2735
                     /gene="Nectin2"
                     /gene_synonym="Cd112; MPH; nectin-2; Pvr; Pvrl2; Pvs"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2718
                     /gene="Nectin2"
                     /gene_synonym="Cd112; MPH; nectin-2; Pvr; Pvrl2; Pvs"
                     /note="major polyA site"
ORIGIN      
        1 gagccctagg atcggcttgg cgaagagggg cggggcctgt gacgtcatga gtccggcccg
       61 ctggagctaa gcgaggggcc ggggggcgcg gatcctgaga gccaggcgag ggaaagctgg
      121 gccgaacgaa ctgatccggg gagccgtgag cggcggaagc cggcctggag ccggacactt
      181 cagacccctg actgccctcc cagccgatcg gtacacgaag agtggtccct aggcaccccc
      241 tgcccgggcc cagtccctcc ccgggccccc catggcccgg gccgcagtcc tcccgccgtc
      301 cagattgtca ccgacgctgc cgttgttgcc gctgctactg ctcctgcttc aggaaacagg
      361 agcccaagat gtgcgggtac gagtgcttcc cgaggtccgg ggccgcttgg gaggcaccgt
      421 ggagttaccg tgccacctgc tcccacccac gacggagcgc gtctctcagg tgacctggca
      481 gcgcctggat ggcacagttg tggctgcttt ccacccatcc ttcggagtgg atttccccaa
      541 ctctcagttc agcaaggacc gtctgtcctt tgtcagagcg agaccagaaa caaacgcaga
      601 cctgcgggat gccacactgg ccttccgggg actgagggta gaggacgagg gcaattacac
      661 ctgcgagttt gccacgtttc ccaacggtac ccgcaggggg gtgacctggc tcagagtcat
      721 agcccagcct gagaaccacg ctgaagccca ggaggtcaca attggccccc agtcggtggc
      781 tgtagcccgc tgtgtctcca ctgggggccg cccccctgcc cgaatcacct ggatctcatc
      841 tctgggtgga gaggccaaag atactcagga gccagggata caggctggca ccgtcactat
      901 catcagccga tactccttgg tgcccgtggg ccgagcggat ggcgtcaagg tcacgtgtag
      961 agtggaacac gagagcttcg aagagccgat cctgctgcca gtgaccctct ctgtgcgcta
     1021 ccctccagaa gtatccatct ccggctatga tgacaactgg taccttggcc gcagtgaggc
     1081 catactgacc tgtgatgtac gaagcaaccc agagcccaca gactatgact ggagcacgac
     1141 ctcgggcgtc ttcccagcct ctgcagtggc ccagggctct cagctgcttg tccactctgt
     1201 ggatcgaatg gtcaacacta ccttcatctg tacagccacc aacgctgtgg ggacaggccg
     1261 tgctgagcag gtcatcctgg tgcgagagtc acccagcaca gcaggagcag gggccactgg
     1321 tggcatcatt ggaggtatta tcgctgccat catcgccacc gcagtggctg gcacaggcat
     1381 cctcatctgc cgacaacagc ggaaggagca gaggcttcaa gctgcggatg aggaagaaga
     1441 actggaagga cctccctcct ataaaccacc caccccgaag gccaagctgg aggaaccaga
     1501 gatgccctct caactcttca ccttgggggc ctcagagcac agcccagtga agacgccata
     1561 ctttgatgct ggtgtctctt gtgctgatca ggagatgcct cggtatcacg agctgcccac
     1621 tctggaagag cggtcagggc ccctgctgtt gggggctaca ggcctgggac cttctcttct
     1681 ggtgcctcca ggacccaatg ttgtggaggg ggtttccctg agtctcgaag atgaggagga
     1741 agatgatgag gaggaagact tcctggataa aatcaaccct atttatgatg ccctgtccta
     1801 ccccagcccc tctgactcct accagagcaa agactttttt gtgtcacggg ccatgtatgt
     1861 gtgagggagg cacaggggct ctgacgtctc acctttcacc cttgacccat gagctttcca
     1921 ccagtaatct aggacactct gacttccagg cagaccaggg acaactatca cccattgcaa
     1981 tccacctgtg acttcttagt gactccacca tgacgtccaa tctatgatgt ctgaggcagg
     2041 caaacctgca caactggaaa cctggagatt tttatctccc ttggcaggga gctcaccata
     2101 tccttctgca ccacctgtga cccccccccc ccccccaagg actcctaaga ctacgaccct
     2161 ttgaccatgc cactcagtat ctcaagaacc cttaaagtcc caaaggaatc ggaccttgca
     2221 cttgtcctca ggcaatagag tccaacagat atgcaagaac gggatcaggg gctccctgtt
     2281 gctcagacct gagccctcca ggcagcagaa gctcacctga tccctcccca ccctgctccc
     2341 caaaggtgaa aaggagagga ttccccaatg taaggtagga cctccccatc tccacctact
     2401 cctgcaggca ggaatctcag gtttctcaca ccctctcctc agcacccagg ttcctgtctc
     2461 cagagcatga attccaggtc caatgctaga ggggagaacc taatgcaagt gtgccttgcc
     2521 accccaagtt tgggagactc tgctcttatc ctgaggacta ctgaattctt ttaaccccta
     2581 cccagtgaga tgagaactac atatccctct ttaggggatg gtgtgtgtat gtgtgtgtga
     2641 tggagaatct gggcatctgg gttgggaatt ttattttgta agcatttcct acataatatg
     2701 agtttctact ttgataaagt cttgtgtttt ctgtg
//
