LOCUS       NM_021424               5701 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus nectin cell adhesion molecule 1 (Nectin1), transcript
            variant 1, mRNA.
ACCESSION   NM_021424
VERSION     NM_021424.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5701)
  AUTHORS   Tomioka,Y., Takeda,K., Ozaki,K., Inoue,H., Yamamoto,S., Takeuchi,T.
            and Ono,E.
  TITLE     Single amino acid mutation of nectin-1 provides remarkable
            resistance against lethal pseudorabies virus infection in mice
  JOURNAL   J Vet Med Sci 86 (1), 120-127 (2024)
   PUBMED   38030279
REFERENCE   2  (bases 1 to 5701)
  AUTHORS   Wu,C., Gong,Q., Xu,X., Fang,P., Wang,C., Yu,J.Y., Wang,X.X.,
            Fang,S.H., Chen,W.J., Lou,H.F., Liu,Y.H., Wang,L., Liu,Y.J.,
            Chen,W. and Wang,X.D.
  TITLE     Disrupted presynaptic nectin1-based neuronal adhesion in the
            entorhinal-hippocampal circuit contributes to early-life
            stress-induced memory deficits
  JOURNAL   Transl Psychiatry 12 (1), 141 (2022)
   PUBMED   35379771
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5701)
  AUTHORS   Chen,G., Yang,Y., Liu,W., Huang,L., Yang,L., Lei,Y., Wu,H., Lei,Z.
            and Guo,J.
  TITLE     EpCAM is essential for maintenance of the small intestinal
            epithelium architecture via regulation of the expression and
            localization of proteins that compose adherens junctions
  JOURNAL   Int J Mol Med 47 (2), 621-632 (2021)
   PUBMED   33416101
REFERENCE   4  (bases 1 to 5701)
  AUTHORS   Pang,J., Le,L., Zhou,Y., Tu,R., Hou,Q., Tsuchiya,D., Thomas,N.,
            Wang,Y., Yu,Z., Alexander,R., Thexton,M., Lewis,B., Corbin,T.,
            Durnin,M., Li,H., Ashery-Padan,R., Yan,D. and Xie,T.
  TITLE     NOTCH Signaling Controls Ciliary Body Morphogenesis and Secretion
            by Directly Regulating Nectin Protein Expression
  JOURNAL   Cell Rep 34 (2), 108603 (2021)
   PUBMED   33440163
REFERENCE   5  (bases 1 to 5701)
  AUTHORS   Tomorsky,J., Parker,P.R.L., Doe,C.Q. and Niell,C.M.
  TITLE     Precise levels of nectin-3 are required for proper synapse
            formation in postnatal visual cortex
  JOURNAL   Neural Dev 15 (1), 13 (2020)
   PUBMED   33160402
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5701)
  AUTHORS   Menotti,L., Avitabile,E., Dubreuil,P., Lopez,M. and
            Campadelli-Fiume,G.
  TITLE     Comparison of murine and human nectin1 binding to herpes simplex
            virus glycoprotein D (gD) reveals a weak interaction of murine
            nectin1 to gD and a gD-dependent pathway of entry
  JOURNAL   Virology 282 (2), 256-266 (2001)
   PUBMED   11289808
REFERENCE   7  (bases 1 to 5701)
  AUTHORS   Shukla,D., Dal Canto,M.C., Rowe,C.L. and Spear,P.G.
  TITLE     Striking similarity of murine nectin-1alpha to human nectin-1alpha
            (HveC) in sequence and activity as a glycoprotein D receptor for
            alphaherpesvirus entry
  JOURNAL   J Virol 74 (24), 11773-11781 (2000)
   PUBMED   11090177
REFERENCE   8  (bases 1 to 5701)
  AUTHORS   Suzuki,K., Hu,D., Bustos,T., Zlotogora,J., Richieri-Costa,A.,
            Helms,J.A. and Spritz,R.A.
  TITLE     Mutations of PVRL1, encoding a cell-cell adhesion
            molecule/herpesvirus receptor, in cleft lip/palate-ectodermal
            dysplasia
  JOURNAL   Nat Genet 25 (4), 427-430 (2000)
   PUBMED   10932188
REFERENCE   9  (bases 1 to 5701)
  AUTHORS   Menotti,L., Lopez,M., Avitabile,E., Stefan,A., Cocchi,F.,
            Adelaide,J., Lecocq,E., Dubreuil,P. and Campadelli-Fiume,G.
  TITLE     The murine homolog of human Nectin1delta serves as a species
            nonspecific mediator for entry of human and animal alpha
            herpesviruses in a pathway independent of a detectable binding to
            gD
  JOURNAL   Proc Natl Acad Sci U S A 97 (9), 4867-4872 (2000)
   PUBMED   10781093
REFERENCE   10 (bases 1 to 5701)
  AUTHORS   Satoh-Horikawa,K., Nakanishi,H., Takahashi,K., Miyahara,M.,
            Nishimura,M., Tachibana,K., Mizoguchi,A. and Takai,Y.
  TITLE     Nectin-3, a new member of immunoglobulin-like cell adhesion
            molecules that shows homophilic and heterophilic cell-cell adhesion
            activities
  JOURNAL   J Biol Chem 275 (14), 10291-10299 (2000)
   PUBMED   10744716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162938.5, CB520822.1, AI853174.1 and BC060694.1.
            
            On Jun 20, 2018 this sequence version replaced NM_021424.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060694.1, AK147479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC162938.5         111026-111063       c
            39-528              CB520822.1         1-490
            529-622             AI853174.1         10-103
            623-5701            BC060694.1         1-5079
FEATURES             Location/Qualifiers
     source          1..5701
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.42 cM"
     gene            1..5701
                     /gene="Nectin1"
                     /gene_synonym="Cd111; HIgR; HveC; nectin-1; PRR; PRR1;
                     Pvrl1"
                     /note="nectin cell adhesion molecule 1"
                     /db_xref="GeneID:58235"
                     /db_xref="MGI:MGI:1926483"
     exon            1..769
                     /gene="Nectin1"
                     /gene_synonym="Cd111; HIgR; HveC; nectin-1; PRR; PRR1;
                     Pvrl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             691..2238
                     /gene="Nectin1"
                     /gene_synonym="Cd111; HIgR; HveC; nectin-1; PRR; PRR1;
                     Pvrl1"
                     /note="nectin-1 delta; nectin-1 alpha; poliovirus
                     receptor-related protein 1; herpes virus entry mediator C;
                     herpesvirus entry mediator C"
                     /codon_start=1
                     /product="nectin-1 precursor"
                     /protein_id="NP_067399.2"
                     /db_xref="CCDS:CCDS23092.1"
                     /db_xref="GeneID:58235"
                     /db_xref="MGI:MGI:1926483"
                     /translation="MARMGLAGAAGRWWGLALGLTAFFLPGTHTQVVQVNDSMYGFIG
                     TDVVLHCSFANPLPSVKITQVTWQKASNGSKQNMAIYNPTMGVSVLPPYEKRVEFLRP
                     SFIDGTIRLSGLELEDEGMYICEFATFPTGNRESQLNLTVMAKPTNWIEGTRAVLRAR
                     KGQDDKVLVATCTSANGKPPSAVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSRE
                     AHRQSLACIVNYHLDRFRESLTLNVQYEPEVTIEGFDGNWYLQRTDVKLTCKADANPP
                     ATEYHWTTLNGSLPKGVEAQNRTLFFRGPITYSLAGTYICEATNPIGTRSGQVEVNIT
                     EFPYTPTPEHGRRAGQMPTAIIGGVAGSVLLVLIVVGGIIVALRRRRHTFKGDYSTKK
                     HVYGNGYSKAGIPQHHPPMAQNLQYPDDSDDEKKAGPLGGSSYEEEEEEEGGGGGERK
                     VGGPHPKYDEDAKRPYFTVDEAEARQDGYGDRTLGYQYDPEQLDLAENMVSQNDGSFI
                     SKKEWYV"
     exon            770..1120
                     /gene="Nectin1"
                     /gene_synonym="Cd111; HIgR; HveC; nectin-1; PRR; PRR1;
                     Pvrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1423
                     /gene="Nectin1"
                     /gene_synonym="Cd111; HIgR; HveC; nectin-1; PRR; PRR1;
                     Pvrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1541
                     /gene="Nectin1"
                     /gene_synonym="Cd111; HIgR; HveC; nectin-1; PRR; PRR1;
                     Pvrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1693
                     /gene="Nectin1"
                     /gene_synonym="Cd111; HIgR; HveC; nectin-1; PRR; PRR1;
                     Pvrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..5683
                     /gene="Nectin1"
                     /gene_synonym="Cd111; HIgR; HveC; nectin-1; PRR; PRR1;
                     Pvrl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5665..5670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nectin1"
                     /gene_synonym="Cd111; HIgR; HveC; nectin-1; PRR; PRR1;
                     Pvrl1"
                     /note="hexamer: AATAAA"
     polyA_site      5683
                     /gene="Nectin1"
                     /gene_synonym="Cd111; HIgR; HveC; nectin-1; PRR; PRR1;
                     Pvrl1"
                     /note="major polyA site"
ORIGIN      
        1 gagaggctgg atcggcgagt gagagaaaga gagggagagg agagagcgcg gctcgcctcg
       61 gcaccggggc agctccacat tgttgcggat cgcccgcacc gagcgcagcg gccgcggtgg
      121 ggacccgtgg cgcacccggc tcgctcccct cggtcctccg agaccgtgca gccccgagcc
      181 ccgcgggcag ctggccgccc tagccgcaca ccaccgcctg ggccccgagc cctccgcacc
      241 gcccggccac cctcggagaa cagccggcca tggacgcctg caagttggag ccgagcggga
      301 gggtgtgagc gcgcccaggg ccgggagcct gcgccgcgct agcccggtag ccgggcgcgc
      361 cgggggtggg tccctctccc cagccgggct ttgcgtggaa gaagagggcg gggaccgggg
      421 cgaggagaag agcggaggag gcgaaggggg catgactcgt gcaacttact gcgggcatct
      481 gccgaggctc tgagccggcg gcagccgggg accggattgc ggccgcgcgg atcccaccca
      541 gcccaccccg ccccgaccga cggctgcggc tgacctggat cctccgagcg cccgccaacc
      601 gccagcgatc cgccctcgtc ttccagactg gtttctggag cgcgaggagc gccctcctgg
      661 cagccccttt cgccggaccc ccaccccccg atggctcgga tggggcttgc gggcgccgct
      721 ggacgctggt ggggactcgc tctcggcttg accgccttct tcctcccagg cactcacacg
      781 caggtggtgc aggtgaacga ctccatgtat ggcttcatcg gcacagatgt ggtactgcac
      841 tgtagctttg ccaacccact gcccagtgtg aaaatcaccc aggtcacatg gcagaaggcc
      901 tccaatggct ccaaacagaa catggccatc tacaacccga ctatgggtgt gtccgtgctg
      961 cctccctacg agaaacgagt ggagttcctg cgaccctcct tcatcgacgg caccatccgc
     1021 ctctccggtc tggagctgga ggacgagggc atgtacatct gtgaatttgc caccttccct
     1081 acgggcaacc gtgaaagcca gctcaatctc actgtgatgg ccaaacccac caactggatt
     1141 gagggcaccc gggcggtgct tcgagccagg aagggacagg atgacaaggt tttggtggcc
     1201 acctgcacct cagccaatgg gaagcctccc agtgcggtgt cctgggaaac acggctaaag
     1261 ggcgaggcag agtaccagga aattcggaac cccaatggca ccgtgacagt catcagccgt
     1321 taccgtttgg tgcccagcag ggaagcccac cggcagtcgc tggcctgcat tgtcaactat
     1381 cacctggacc gcttcaggga gagccttacg ctcaacgtgc agtatgaacc tgaggtgacc
     1441 attgagggct ttgatggcaa ctggtacctg cagcggacag atgtgaagct cacgtgcaaa
     1501 gcggatgcta acccgccagc cactgagtac cactggacca cattgaatgg ctctctcccc
     1561 aagggtgtag aggcccagaa caggaccctc ttcttccggg gacctatcac ctacagcctg
     1621 gcaggaacct acatctgtga ggccaccaac cctattggca cccgatcggg ccaggtggag
     1681 gtcaatatca cagaattccc ctacaccccg actcctgaac acgggcggcg cgccgggcag
     1741 atgcccacag ccatcattgg gggcgtggca gggagtgtcc tgctggtgct gattgtggtc
     1801 ggagggatca tagtggccct gcgcaggcgc cggcacacct tcaagggtga ctacagcacc
     1861 aagaagcacg tgtacggcaa cggctacagc aaggcaggca tcccgcagca tcacccgccc
     1921 atggcacaga acctgcagta cccggatgac tcggatgatg aaaagaaggc cggcccattg
     1981 ggcgggagca gctatgagga ggaagaggag gaggagggcg gtggaggagg cgaacgtaag
     2041 gtgggcggcc cccaccccaa atatgacgag gacgccaaac ggccctactt cactgtggat
     2101 gaggctgagg cccgtcagga cggctatggg gaccggactc tgggctacca gtatgaccct
     2161 gaacagctgg acttggctga gaacatggtt tctcagaacg acgggtcttt catttccaag
     2221 aaagagtggt atgtgtagcc ccgccttctg gagcctctgt ctgtgcccac ttctcccagg
     2281 cccctacccg cacgcccccc tgcccacccc cacagcccac tgccctaaac cagccccaaa
     2341 ctcctgagga gccagaggag ctcagggcag accccacttg gcttcgtttt tttgtttttt
     2401 gtttgttttt tgtttttttt tttttaattt cctccctcac ccacccttcc ccctggtgtt
     2461 gtgttcgacc gtggctttgg tgttgctgta cctttccttt aaggacccct tccactgccc
     2521 tgtgtgtagg gagccctgtt cttgtcttgt gtacttgggc atccctccag ggtttgggga
     2581 gccagtcctc tcccaccccc ccacccccat cccccaacac tggaatttgt ttgtgttctc
     2641 tccgttggga atggagggca aagggagctt cgagatggag agcaccctca cccccacccg
     2701 atatgctgct cctcttctca gaaagatgta acccaagccc ccactaagct gatgcagtca
     2761 gtgcacctaa gaggttttag aggagttctc cgtggtaccc aggggagtct tgtgtgggga
     2821 ataatggagc tgagggttct gctggggtcc tgggcagtgt gttttcctgg tgagggtggt
     2881 tttatgtttt cttttttttt ttctttctgg ccccccaaat ggagttggcg tagctctcat
     2941 atacccctct ctgttaacgc ccagtccgtt ctgtacacag tgggtgaccc caggtggatt
     3001 ctacccacag ttcctatatg cctctgccaa catatgcaca catatccatg cacacatccc
     3061 tgggcctatg ccaacctctc acgccctgcc caggctgaac actgcccgag gcccaaccct
     3121 ctgctccacc tcttacccgt tcccagctca ggaagggatc agcccacaga agcattcaga
     3181 gtcagctagg atgaacctcc cgcacccacc cacccacccc caaagccact ctacaatttc
     3241 agtgtagctc caacctttcc tgacaatgta catgtttctc ggatttctcc ttatctgtca
     3301 agtgctagca acacttgact cttctggaaa gtcagggctg ggatcccagg aaggaatgcg
     3361 aggcacagaa ttattgagac ggagaaggct gctttgtgga aactgcaaac acaattgaag
     3421 ggggactgct agcgtctcat atgggaaggc tggcctagat gtgtctcggg tctcaaagaa
     3481 agtgcagggg caccggggac ctgctgcgta tccacagact gacccctgct cactctctcc
     3541 tggtgccaga ctggcaagat ggccgtgtag aagggccttt gcatgcagtc tccctctttg
     3601 aatgggattc tggctttgtc agccgttcgg ggctgggcct tcccttgagt gcatggaaaa
     3661 aggtctcccc accccacctc accccagccc tctgtcccca agctcaaagt gcctcggttt
     3721 ctccatctgt gcccccagat taccctcatt ctaaatgggc attcccaggg cctgcctgtc
     3781 aggatctcag ccaactcagc cctaagtgac actcgctgag ggatcacaaa cattggggag
     3841 agggaggcag accattctgt gccctacggg cactgaccca ccctgccata ggcttcctaa
     3901 gggagcccca gcccacaccc cactcctccc tggtgctgct attgagttcc cagtccaagc
     3961 gccatctctg gcacccctta ctcagcccac cagctggggc tcttctgcca ggccctcact
     4021 gccctagtcc cagcccaggc cgcccagtag ccacgtagca gaagtctgaa gccatgccag
     4081 ccctggggcg gctctccgtc ttggcattgg ggacactgga tggggtgaag tttggggaag
     4141 aaaattctgg ggcctttcta gccacaggga gaaggaagat ggaggagctg ggctgcttct
     4201 cccagaagta ttagtgtcct ttccatgtca cagctcatcc tgttcctcat accactctgc
     4261 ccctctcctt ggtccccctc ccccaccccc aaggcaggag gcagaaccct gactgcccca
     4321 gagtggtatt tctgtcccta tggggccata agactgaaag actcaccctc ccgagtctct
     4381 cgcacctttc acggtcatcc cctatcccct gtcttgtgat ggatcgagga ggccctgggc
     4441 ctggacaaag cacctaagct ccctgtacaa acctgcacgc ctttccccga agcaaagcac
     4501 aatttatagg gtccatgcag caggatctag gatccccagc cgtggcactg agcgcttcca
     4561 ggcggccgcc acctgggcta agaaaggaca ggagtcaggg gtcggtagct ggacccaagg
     4621 agaaggggct tttcttgccc tgtgtttgcg ggacagtgga cacagccagc tgacagtgtg
     4681 acagagcgga gggcattttg cttcaccttc atgccccccc cccccagcac agctgagctt
     4741 ctgccagact gcggagagta aacttggtgt gttacctgcc cagacccctc cggatgtcgt
     4801 ccctagctgc cctccccctc ctgtccctcc cctgcccctg gacccctgtt tccctacaga
     4861 ttttggtatt gttctggtgt gcaacaaccc tctgagtctc ttttaccaga aggacctgaa
     4921 atacagcaac acacaattag tgaacacacg cccagcacac caacacacgc cttccacaga
     4981 ccaagcacag gtgtgtgtgt gtgtgtgtgc acaagtacac acataaacga gaaacctgta
     5041 ttaattaatg ctcgggcccc aagccctggg aaggcgcacc ctctgccagc caccccagcg
     5101 tgccccagtc actggtgcaa taaccttcct gccatcgtcc aggtgggaga atcaggactc
     5161 acgtcaggtg ggtgaggcca cccctctgag cccagcagac actgcatcct ttcctgggag
     5221 gaggggggtg ctcccaggcc tctggaggag tccaggtaga gacttcccca agcctaactg
     5281 ccaactgaaa ccctctcctg gtgagggcag gtggctccag ctgacctggg ccggagacac
     5341 cgagaggtga ggaaccagcc tcgctgatgc tgctttctga ccccagctgt gaagagtggg
     5401 ctggggggaa gagggtgact tttttttttt ttaacaaatg gaaacaaaat ccaggagaag
     5461 ctgccaccct cgcctgagtg tgactaagct tcctttgctt cagtttctat gtcactgttt
     5521 tcctctttgg tcctggggac agcccagcag attcccctgg tcctgacctg gaggggggga
     5581 gtggttgccc cgcccccttt tacttgtatt aaaaaaaaaa gatgggttga aaatgtactg
     5641 agaaaaaaaa tgtacttttt tataaataaa gtgtttaaaa caaaaaaaaa aaaaaaaaaa
     5701 a
//
