LOCUS       NM_178617               4936 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus N-terminal EF-hand calcium binding protein 1 (Necab1),
            mRNA.
ACCESSION   NM_178617
VERSION     NM_178617.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4936)
  AUTHORS   Udagawa,H., Funahashi,N., Nishimura,W., Uebanso,T., Kawaguchi,M.,
            Asahi,R., Nakajima,S., Nammo,T., Hiramoto,M. and Yasuda,K.
  TITLE     Glucocorticoid receptor-NECAB1 axis can negatively regulate insulin
            secretion in pancreatic beta-cells
  JOURNAL   Sci Rep 13 (1), 17958 (2023)
   PUBMED   37863964
  REMARK    GeneRIF: Glucocorticoid receptor-NECAB1 axis can negatively
            regulate insulin secretion in pancreatic beta-cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4936)
  AUTHORS   Hay,Y.A., Deperrois,N., Fuchsberger,T., Quarrell,T.M.,
            Koerling,A.L. and Paulsen,O.
  TITLE     Thalamus mediates neocortical Down state transition via
            GABAB-receptor-targeting interneurons
  JOURNAL   Neuron 109 (17), 2682-2690 (2021)
   PUBMED   34314698
REFERENCE   3  (bases 1 to 4936)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4936)
  AUTHORS   Hay,Y.A., Jarzebowski,P., Zhang,Y., Digby,R., Brendel,V.,
            Paulsen,O. and Magloire,V.
  TITLE     Cholinergic modulation of Up-Down states in the mouse medial
            entorhinal cortex in vitro
  JOURNAL   Eur J Neurosci 53 (5), 1378-1393 (2021)
   PUBMED   33131134
REFERENCE   5  (bases 1 to 4936)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4936)
  AUTHORS   Zimmermann,B., Girard,F., Meszar,Z. and Celio,M.R.
  TITLE     Expression of the calcium binding proteins Necab-1,-2 and -3 in the
            adult mouse hippocampus and dentate gyrus
  JOURNAL   Brain Res 1528, 1-7 (2013)
   PUBMED   23850650
  REMARK    GeneRIF: The genes for the three Necab's, including Necab-1, were
            expressed in specific, non-overlapping areas of the hippocampus.
REFERENCE   7  (bases 1 to 4936)
  AUTHORS   Sugita,S., Ho,A. and Sudhof,T.C.
  TITLE     NECABs: a family of neuronal Ca(2+)-binding proteins with an
            unusual domain structure and a restricted expression pattern
  JOURNAL   Neuroscience 112 (1), 51-63 (2002)
   PUBMED   12044471
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC067055.1.
            
            On Apr 22, 2009 this sequence version replaced NM_178617.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067055.1, AY278200.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4936              BC067055.1         1-4936
FEATURES             Location/Qualifiers
     source          1..4936
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 6.45 cM"
     gene            1..4936
                     /gene="Necab1"
                     /gene_synonym="1700003H21Rik; Efcbp1; STIP-1"
                     /note="N-terminal EF-hand calcium binding protein 1"
                     /db_xref="GeneID:69352"
                     /db_xref="MGI:MGI:1916602"
     exon            1..314
                     /gene="Necab1"
                     /gene_synonym="1700003H21Rik; Efcbp1; STIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            315..339
                     /gene="Necab1"
                     /gene_synonym="1700003H21Rik; Efcbp1; STIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..448
                     /gene="Necab1"
                     /gene_synonym="1700003H21Rik; Efcbp1; STIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..474
                     /gene="Necab1"
                     /gene_synonym="1700003H21Rik; Efcbp1; STIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..572
                     /gene="Necab1"
                     /gene_synonym="1700003H21Rik; Efcbp1; STIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..709
                     /gene="Necab1"
                     /gene_synonym="1700003H21Rik; Efcbp1; STIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            710..831
                     /gene="Necab1"
                     /gene_synonym="1700003H21Rik; Efcbp1; STIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            832..908
                     /gene="Necab1"
                     /gene_synonym="1700003H21Rik; Efcbp1; STIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..962
                     /gene="Necab1"
                     /gene_synonym="1700003H21Rik; Efcbp1; STIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1075
                     /gene="Necab1"
                     /gene_synonym="1700003H21Rik; Efcbp1; STIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1153
                     /gene="Necab1"
                     /gene_synonym="1700003H21Rik; Efcbp1; STIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1245
                     /gene="Necab1"
                     /gene_synonym="1700003H21Rik; Efcbp1; STIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..4922
                     /gene="Necab1"
                     /gene_synonym="1700003H21Rik; Efcbp1; STIP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4894..4899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Necab1"
                     /gene_synonym="1700003H21Rik; Efcbp1; STIP-1"
                     /note="hexamer: AATAAA"
     polyA_site      4922
                     /gene="Necab1"
                     /gene_synonym="1700003H21Rik; Efcbp1; STIP-1"
                     /note="major polyA site"
ORIGIN      
        1 cacgggaagg gggcggcgag agctagcgtg ctgaagccta gaggcgggag agggaggaga
       61 gtccgcgcag agcagaggga ggcgcgcgct cagagcgaac acccacttgc atccgaccct
      121 ggtggcgcgg cgcggggagg cagcagctga gacagcacca ggtcagagcc tttgcatccc
      181 gcccagtctg cccgccagcg ccaggaccgc tgaggatgga ggattcccgg gagacttcgc
      241 cttcctccaa caactcctcg gaagagctca gctctaccct gcaactgtcc aagggcatgt
      301 ccatcttcct cgacattctg aggagagcag acaaaaatga tgatggaaaa ttgtcctttg
      361 aggaatttaa agcatatttt gcagatggag ttctcagtgg agaagaacta catgagctct
      421 tccacaccat tgacacacac aataccaaca atctcgacac agaagaacta tgcgaatatt
      481 tttctcagca cttgggtgaa tatgagaatg tactggccgc acttgaagac ctgaatctct
      541 ccatcctgaa ggcaatgggc aagacaaaga aagactacca agaagcttcc aatttggaac
      601 aatttgtcac tcgatttttg ttgaaggaga ccttgaatca gttgcagtct ctccagaact
      661 ctctggaatg tgccatggaa actactgaag agcaaacgcg tcaagaaagg caaggaccat
      721 ccaagccaga agtcctgtcc attcaatggc ctggaaagcg atccagccgc cgagtccaga
      781 gacacaatag tttctccccc aacagcccgc agttcaatgt cagcagtcca gcattgttag
      841 aagaagacaa ccagtggatg acccagataa acagactcca gaaattaatt gatagactgg
      901 aaaagaagga tctgaaactt gaacccctgg aagaagaaat tattgaagag aacactaaac
      961 ctcacatcat gcttgtgcag cgccagatgt ctgtgacaga agaggatctg gaagaattcc
     1021 agcttgctct gaagcactat gtggagagtg cttcagctca aagtggatgc ctgcgtatct
     1081 ctatacagaa gctctcaaac gaatctcgct acatgattta tgagttctgg gagaacagca
     1141 gtgtgtggaa ccgccacctc cagacgaatt acagcaagac gttccaaaga agcaacgtgg
     1201 atttcttgga aactccagag ctcacatcta ccatgctagt tcctgcttca tggtggatcc
     1261 tgaacaacaa ttagatgtcc ctacacaatg tctttattgt tccaagtgta agtgttctta
     1321 tctgaaacgt aaactgggaa gttctctgtg gtcgtcaatc agctgcatac ctttgttcac
     1381 tgtgtgttgg cacactcttt aaagtgtatt ctgcaaaatt gttgctcttg atatttgatg
     1441 gcaattgatc tgctacattg tgatcaatca ttataacaaa atccaaatat atgaaaatgg
     1501 tatataaata aagtaataaa atgtgataat tgtggtaaaa atgctaggtg agaacttcta
     1561 aaacataggc cagggtttgt aaactggcag tgttctcaac cttctgattg ctgcgaccct
     1621 ttaatacttt cctcatattg tgacaacccc aaccataaaa ttatttcatt gctacttcat
     1681 aactgtgatt ttgctactgt tatgaatcat aatgtaaata tctgatatgc agaatatctg
     1741 atatgctacc cccaaagaag ttgcaaccca cacattgaaa cccactgctc taaaggatta
     1801 catttgtgct ttgtgacttt tttcagtgac acatttttct gtgagagaaa cattcttttt
     1861 ccatatggtc ctccaactat ttgctttata attcctttaa tattaacata aatgcataaa
     1921 acagcctagg ctatagccta tagaagctct gtctatctct catgttgtaa agtggtattt
     1981 tacaagtgaa caatctatag taacttaggg catttactaa tgtaaaacct ttatttgtaa
     2041 gtattatgat tctcatatat aagctagaca ttattgagca aagaggagag ctttacttca
     2101 gggaaattaa agtttatgtc agaaggcttt ggtatgcgac ccatataaat agctattctt
     2161 ataaaaaatg agcacttgaa tttaaatgaa gatttttaaa ttcagaactt taaatagagt
     2221 agaacttcaa ctcaaatgaa taaagaaatt aaaacaagca caaaagttta caactgaata
     2281 cacctatttt gtaaactttc ctaaggcaac taagataaac tatccccctt atctactctt
     2341 ccctagaggt tctgcttata gactctgcta caaaaataca catgcaacta ctatcacgtg
     2401 atgctctcat acaaatgctt ataaatctct gagtcttaag ggaaaatata cataaaatgt
     2461 tttttaacag ttggaatacc tagggaaata gagagtttga atgaaaattt catttcataa
     2521 ctatgagatg agaataccat ctctaagtac tttgtggaat agttttgtat attcaatcct
     2581 cataaatcga tgtaaaattt catagctgtt agacactagc aatttttaca cgcacacatg
     2641 cactgcattc agattgcaag ggggcaagca gtatgaagca gagcttgccg cagctcttct
     2701 gtcacaggtg tgcaagacaa gacatcactg gagttatctg atggctgctg agacttcctg
     2761 tccatcgtgg gaaagggaag gggacagcag agctctccta cagcacaggg gacgtactgt
     2821 ggtctctgtg ataagctctg aagcgcagga ggctgtaatc acacatgctt ctggaaaatc
     2881 ctgggataaa tgctttcaca atgaggactg caaccaatcg caatgctgtc ctaactggtt
     2941 cacttcatat ctaacccaaa aattctatca agtgttttgt acactaggta gtttttcaaa
     3001 gtaggagtta gtctactgaa aagtagagta gtcgaactga aaagggcgct cttcccagaa
     3061 acagagtttg gagaaaggcc ctctggttac aaatttgaat gaggtctgta aatatattaa
     3121 agtagaatca aaaggacctg agggaaaaca gcaaataatt aacttgtaga actctgctaa
     3181 ttctgatctc agctattatg caaatatgta tggtttaagt gtgtgtgtgt tagattatgt
     3241 atgaaaattc atacaatact ggatcctatg actaaaatga aaatagtagg agcagcacac
     3301 acaatcacac aatagcccta tagaatgtct cattttcaaa caaacaataa acttatgcct
     3361 aatgaagggg tatttctccc tattaaaaac caaccctttc tctgagaatc cacgtaatga
     3421 acaagagtct actgaaaggc caagctggga catcgactgt ggactgaatg ttaggatctg
     3481 ggcaagcatc cccacagcag caagcaagag gcactgggtt tagaacttca cattcaggaa
     3541 gagacgacat ttctgtgaac tgtggccttg aatgaccttc tcgtgatccc aagacacaaa
     3601 tgaataaaag tagtgagctt atatttactt accttactgt ctgcaggatt tctgacacat
     3661 tatatgcagt ttattgcatt aaaaccccta ataattaaaa acttaagcct ctaaattctt
     3721 tatgaggaat gacggaatcg aaacttaatt tgcctctatt tgcagcctgg atttttcctc
     3781 ttttggagtc aatttcaatt ttatttcccc accgtgtgac tctcgatcat ataatctgat
     3841 gaagaacatc aagctacttt ccacctgttc atgagtacct ctcaattacg aacctttgca
     3901 gattgctcac tgctagtagg tgtgaccgac cctaaggcca tattgttaag aacccagtga
     3961 atcaatcatg tttgtgaaag cctcccctac ccctgccgtt gacaactatg ctttgaatac
     4021 cagaatcatt ctgggctctg cagacatcat agtcctggtc aggtgctgat gtacaatcag
     4081 tggggaaaag accgagtgac tgacgttaag ggcaacaaaa attctgtacc atatatacat
     4141 catagcaaat actttatatt tgagaatctt tacagcttac atttccattc cattattaca
     4201 agtggtgaga aacaagaatt gcaagtagca tgcaaattat aatacagtct tcccacttca
     4261 ccaacaacat ccccactttc gagtgttatt tcccaatttt tgcaggaact gcctgcaaag
     4321 ctgaaactga ttagaaaaat tctttatact ttaaaatatc tctttctcct tttatgagaa
     4381 gccaaatagc caaccatcaa aagtaaaaat aaattgaatc gtcacagtcc attagttatt
     4441 gtactaggtc cacttcattt gcaggtgtcc aaaatataaa atgaataatt ctttatcttc
     4501 aaattcatct gttcttaaaa tgctacttaa aactttggtt gttttcctgt aatatagaag
     4561 aaagacaatt tatcaattag actaccgttt tcacaactta gcttattcaa ccaaatggta
     4621 tgaatctact tctatctaaa tgcatgttac tatagaaact attaaagtga ctggaactat
     4681 caaatacact tgtgtttcag gaaacctgtg tagtccattc ttaaaaatag taaactgtat
     4741 tccaagtctg tgttctattc ctgtggtgcc tagttttata aatgttgtta atgtataaag
     4801 caaaagtaag caattctaat gtatgtttac tcaaaagaag tttgtcaagc tcttattagc
     4861 aaaataaagt gtcaatgaat tatttaagcc tgaaataaaa agtgatcatg ctttatgtat
     4921 aaaaaaaaaa aaaaaa
//
