LOCUS       NM_030087               1594 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase core subunit V3
            (Ndufv3), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_030087
VERSION     NM_030087.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1594)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 1594)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1594)
  AUTHORS   Signes,A. and Fernandez-Vizarra,E.
  TITLE     Assembly of mammalian oxidative phosphorylation complexes I-V and
            supercomplexes
  JOURNAL   Essays Biochem 62 (3), 255-270 (2018)
   PUBMED   30030361
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1594)
  AUTHORS   Guerrero-Castillo,S., Cabrera-Orefice,A., Huynen,M.A. and Arnold,S.
  TITLE     Identification and evolutionary analysis of tissue-specific
            isoforms of mitochondrial complex I subunit NDUFV3
  JOURNAL   Biochim Biophys Acta Bioenerg 1858 (3), 208-217 (2017)
   PUBMED   27988283
  REMARK    GeneRIF: Further mass spectrometric analyses of complex I from
            different murine and bovine tissues showed a tissue-specific
            expression pattern of NDUFV3-S and NDUFV3-L. Hence, NDUFV3-S was
            identified as the only isoform in heart and skeletal muscle,
            whereas in liver, brain, and lung NDUFV3-L was expressed as the
            dominant isoform, together with NDUFV3-S present in all tissues
            analyzed
REFERENCE   5  (bases 1 to 1594)
  AUTHORS   Wirtz,S. and Schuelke,M.
  TITLE     Region-specific expression of mitochondrial complex I genes during
            murine brain development
  JOURNAL   PLoS One 6 (4), e18897 (2011)
   PUBMED   21556144
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1594)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1594)
  AUTHORS   Davisson,M.T., Bechtel,L.J., Akeson,E.C., Fortna,A., Slavov,D. and
            Gardiner,K.
  TITLE     Evolutionary breakpoints on human chromosome 21
  JOURNAL   Genomics 78 (1-2), 99-106 (2001)
   PUBMED   11707078
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU555486.1, BY064612.1, AC166172.1, BF318157.1 and BU755401.1.
            
            On Apr 5, 2007 this sequence version replaced NM_030087.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013640.1, AK154477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BU555486.1         4-36
            34-399              BY064612.1         2-367
            400-1017            AC166172.1         38823-39440         c
            1018-1536           BF318157.1         42-560              c
            1537-1594           BU755401.1         1-58                c
FEATURES             Location/Qualifiers
     source          1..1594
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 16.64 cM"
     gene            1..1594
                     /gene="Ndufv3"
                     /gene_synonym="1500032D16Rik"
                     /note="NADH:ubiquinone oxidoreductase core subunit V3"
                     /db_xref="GeneID:78330"
                     /db_xref="MGI:MGI:1890894"
     exon            1..147
                     /gene="Ndufv3"
                     /gene_synonym="1500032D16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1506
                     /gene="Ndufv3"
                     /gene_synonym="1500032D16Rik"
                     /EC_number="7.1.1.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NADH-ubiquinone oxidoreductase flavoprotein 3; NADH
                     dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial;
                     CI-9kD; complex I-9kD; NADH-ubiquinone oxidoreductase 9
                     kDa subunit; NADH dehydrogenase (ubiquinone) flavoprotein
                     3"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] flavoprotein 3,
                     mitochondrial isoform 1"
                     /protein_id="NP_084363.2"
                     /db_xref="CCDS:CCDS37549.1"
                     /db_xref="GeneID:78330"
                     /db_xref="MGI:MGI:1890894"
                     /translation="MAVSLLLRGGRIRALKAVLLEARVFPGELVSVVRLSTESEKSAK
                     EKELHPKTQSVLKDVGAEERGKLLTAHTAAALSKNSPPPSSYPSVENTGGAVAGPHPG
                     GSLLPTDEGLPKHLSRKTLVAFPQKVMPPPQARGSDSKAQGHVQKVTNDSSSSSSSSS
                     SDSDSDGEEHDSDRAPRVASKGKAGSSKPEASRPLTTGAPKITVSAKEKAKVQKPPTD
                     VTYPEKTLQPKKKWTKPVEDSKEARSKPVTSRPQSSEMLEQNVKEEHQRGKPRPDKTG
                     KESAKPCEAEGILPSHGKVRVPTQPTSGPVPTTQIQEASAEHPPAVAPRKGARYPEPK
                     VPEPGWKTSSPLLRKESAEKQVPEGGSQVQEVLEDQKPVSYSKTLPVQEKDTVEESAR
                     PHLEGRFQVAVEAPPTDAVLPQEAPADTQEPEPTDTTTYKNLQHHDYNTYTFLDLNLD
                     LSKFRLPQPSSGRESPRH"
     exon            148..271
                     /gene="Ndufv3"
                     /gene_synonym="1500032D16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            272..1363
                     /gene="Ndufv3"
                     /gene_synonym="1500032D16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1580
                     /gene="Ndufv3"
                     /gene_synonym="1500032D16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1560..1565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufv3"
                     /gene_synonym="1500032D16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1580
                     /gene="Ndufv3"
                     /gene_synonym="1500032D16Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcgattggtg aacgtggacg cggggcggag cctggggtgg tgcgtgtgca caagtaggtc
       61 acgtacctaa gtgcgacctc cgctcttggc atttgtgcca tggcggtctc tctcctcctg
      121 cggggaggac ggatccgggc gctgaaggct gtgctcctgg aggcaagggt gttcccggga
      181 gaactggttt ctgtagtgag gctgtctaca gagtcagaga agagtgcaaa ggagaaagag
      241 ctacatccca agacacaaag tgtgctcaaa gatgtgggag cagaggagag gggcaagctc
      301 ctaaccgcgc acacagcagc ggcactgtcc aaaaactcac ctccacccag ttcttaccca
      361 tcagtggaga acacaggtgg ggctgtggca ggcccgcacc ctggcggcag cctgctgccc
      421 acagatgaag ggcttccgaa gcatttgtca agaaagactt tggtagcgtt tcctcagaaa
      481 gttatgcctc caccccaagc acggggttct gactcaaagg ctcaggggca cgtgcagaaa
      541 gtgacaaacg attcatcttc atcttcctca tccagctcct cagattcaga ttctgatggg
      601 gaggaacatg actcagaccg tgctccccga gtggcaagca aaggcaaggc agggtcttcc
      661 aaaccggagg cctcccggcc cttgacgact ggagccccta aaatcacagt ttctgcaaaa
      721 gagaaggcca aggtccaaaa gccacccaca gatgtcacct acccagagaa gaccctgcag
      781 cctaagaaga aatggaccaa gcctgtagaa gacagcaaag aagccaggtc caagcccgtg
      841 acatccaggc cacagtccag tgagatgttg gagcaaaacg tgaaggaaga acaccaacgg
      901 gggaaaccga gaccagacaa gacaggaaag gaaagcgcaa agccatgtga agctgaagga
      961 atcttaccca gccacgggaa agtcagagta cccacacagc ccactagtgg gccagtgccc
     1021 acaacgcaaa tacaagaggc cagtgcagaa catccgccag ccgttgcccc caggaaggga
     1081 gctagatatc cggaaccaaa agtgccagag cccggatgga agacctcttc tcccctgctc
     1141 agaaaagaaa gcgcagagaa gcaggtgcca gaaggaggct cccaggtcca ggaggtcttg
     1201 gaagatcaga aaccagtgag ctattcgaag acacttcctg ttcaggagaa agatactgtt
     1261 gaagagagtg ccagaccaca tctggagggg aggttccagg tggcagtcga agccccaccc
     1321 actgatgcag tcctacccca ggaagccccg gccgacacac aggagcccga gccgactgac
     1381 accaccacct acaagaacct gcagcaccat gactacaaca catacacctt cctggacctg
     1441 aacctggacc tctccaaatt caggctgcca cagccgtctt caggacgaga gtcacctcgg
     1501 cactgagctc agctcagggt agaccccgat gttggttccc atgaatcctt gcctgtgaga
     1561 ataaaaggca gagtcacaaa aaaaaaaaaa aaaa
//
