LOCUS       NM_133666               1608 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase core subunit V1
            (Ndufv1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_133666
VERSION     NM_133666.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1608)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 1608)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1608)
  AUTHORS   Li,L., Zhang,L., Cao,Y., Chen,X., Gong,H., Ma,Y., Gui,Y., Xiang,T.,
            Liu,J. and Huang,X.
  TITLE     NDUFV1 attenuates renal ischemia-reperfusion injury by improving
            mitochondrial homeostasis
  JOURNAL   J Cell Mol Med 27 (10), 1341-1352 (2023)
   PUBMED   37029501
  REMARK    GeneRIF: NDUFV1 attenuates renal ischemia-reperfusion injury by
            improving mitochondrial homeostasis.
REFERENCE   4  (bases 1 to 1608)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1608)
  AUTHORS   Dieteren,C.E., Koopman,W.J., Swarts,H.G., Peters,J.G., Maczuga,P.,
            van Gemst,J.J., Masereeuw,R., Smeitink,J.A., Nijtmans,L.G. and
            Willems,P.H.
  TITLE     Subunit-specific incorporation efficiency and kinetics in
            mitochondrial complex I homeostasis
  JOURNAL   J Biol Chem 287 (50), 41851-41860 (2012)
   PUBMED   23038253
  REMARK    GeneRIF: The authors use green fluorescent-tagged complex I
            subunits to determine the kinetics of assembly. Tagged human NDUFV1
            can replace endogenous protein in the holo-complex I protein and
            was also found in complex I subassemblies, suggesting that NDUFV1
            may directly incorporate into the holo-enzyme and may also assemble
            into smaller complexes or in a monomer pool.
REFERENCE   6  (bases 1 to 1608)
  AUTHORS   Hoefs,S.J., Rodenburg,R.J., Smeitink,J.A. and van den Heuvel,L.P.
  TITLE     Molecular base of biochemical complex I deficiency
  JOURNAL   Mitochondrion 12 (5), 520-532 (2012)
   PUBMED   22820119
  REMARK    GeneRIF: The authors provide an overview of the function and
            assembly of human complex I, also known as NADH dehydrogenase
            (ubiquinone) 1 alpha subcomplex. They discuss its role in oxidative
            phosphorylation and the implications of complex I deficiency in
            disease.
            Review article
REFERENCE   7  (bases 1 to 1608)
  AUTHORS   Wirtz,S. and Schuelke,M.
  TITLE     Region-specific expression of mitochondrial complex I genes during
            murine brain development
  JOURNAL   PLoS One 6 (4), e18897 (2011)
   PUBMED   21556144
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1608)
  AUTHORS   Sultana,D.A., Tomita,S., Hamada,M., Iwanaga,Y., Kitahama,Y.,
            Khang,N.V., Hirai,S., Ohigashi,I., Nitta,S., Amagai,T.,
            Takahashi,S. and Takahama,Y.
  TITLE     Gene expression profile of the third pharyngeal pouch reveals role
            of mesenchymal MafB in embryonic thymus development
  JOURNAL   Blood 113 (13), 2976-2987 (2009)
   PUBMED   19164599
REFERENCE   9  (bases 1 to 1608)
  AUTHORS   Schuelke,M., Loeffen,J., Mariman,E., Smeitink,J. and van den
            Heuvel,L.
  TITLE     Cloning of the human mitochondrial 51 kDa subunit (NDUFV1) reveals
            a 100% antisense homology of its 3'UTR with the 5'UTR of the
            gamma-interferon inducible protein (IP-30) precursor: is this a
            link between mitochondrial myopathy and inflammation?
  JOURNAL   Biochem Biophys Res Commun 245 (2), 599-606 (1998)
   PUBMED   9571201
  REMARK    GeneRIF: The authors clone and characterize the human NADH
            dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial protein,
            also known as NDUFV1. They identify transcription factor binding
            sites as well as consensus motifs for NADH, flavin mononucleotide,
            and iron-sulfur binding sites. The human ortholog has high homology
            to the cow NDUFV1 protein.
REFERENCE   10 (bases 1 to 1608)
  AUTHORS   Fernandes,M., Lespinasse,F., Rotomondo,F., Poirier,C., Guenet,J.L.,
            Gaudray,P. and Carle,G.F.
  TITLE     Comparative mapping of two adjacent regions of MMU19 with their
            human counterpart on HSA11q13
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 237-246 (1998)
   PUBMED   9730611
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE863504.1, AK075692.1,
            AA223049.1 and AW113957.1.
            
            On Jun 4, 2013 this sequence version replaced NM_133666.2.
            
            Summary: This gene encodes a subunit of the NADH-ubiquinone
            oxidoreductase (complex I) enzyme, which is a large, multimeric
            protein. It is the first enzyme complex in the mitochondrial
            electron transport chain and catalyzes the transfer of electrons
            from NADH to the electron acceptor ubiquinone. The proton gradient
            created by electron transfer drives the conversion of ADP to ATP.
            This gene is a core subunit and is conserved in prokaryotes and
            eukaryotes. The human ortholog of this protein has been
            characterized. It has consensus motifs for NADH, flavin
            mononucleotide, and iron-sulfur binding sites and participates in
            the oxidation of NADH as part of the dehydrogenase module of
            complex I. In humans, deficiencies in complex I are associated with
            myopathies, encephalomyopathies, and neurodegenerative disorders.
            [provided by RefSeq, Jun 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014818.1, AK005021.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 23038253; reported by
                                                  MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BE863504.1         1-56
            57-1589             AK075692.1         2-1534
            1590-1597           AA223049.1         328-335
            1598-1608           AW113957.1         1-11                c
FEATURES             Location/Qualifiers
     source          1..1608
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.72 cM"
     gene            1..1608
                     /gene="Ndufv1"
                     /gene_synonym="CI-51kD"
                     /note="NADH:ubiquinone oxidoreductase core subunit V1"
                     /db_xref="GeneID:17995"
                     /db_xref="MGI:MGI:107851"
     exon            1..205
                     /gene="Ndufv1"
                     /gene_synonym="CI-51kD"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1528
                     /gene="Ndufv1"
                     /gene_synonym="CI-51kD"
                     /EC_number="7.1.1.2"
                     /note="NADH dehydrogenase [ubiquinone] flavoprotein 1,
                     mitochondrial; complex I-51kD; NADH-ubiquinone
                     oxidoreductase 51 kDa subunit; NADH dehydrogenase
                     flavoprotein 1; 24 kDa (FP); NADH dehydrogenase
                     (ubiquinone) flavoprotein 1"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] flavoprotein 1,
                     mitochondrial precursor"
                     /protein_id="NP_598427.1"
                     /db_xref="CCDS:CCDS29410.1"
                     /db_xref="GeneID:17995"
                     /db_xref="MGI:MGI:107851"
                     /translation="MLAARHFLGGLVPVRVSVRFSSGTTAPKKTSFGSLKDEDRIFTN
                     LYGRHDWRLKGALRRGDWYKTKEILLKGPDWILGEMKTSGLRGRGGAGFPTGLKWSFM
                     NKPSDGRPKYLVVNADEGEPGTCKDREIMRHDPHKLVEGCLVGGRAMGARAAYIYIRG
                     EFYNEASNLQVAIREAYEAGLIGKNACGSDYDFDVFVVRGAGAYICGEETALIESIEG
                     KQGKPRLKPPFPADVGVFGCPTTVANVETVAVSPTICRRGGTWFAGFGRERNSGTKLF
                     NISGHVNHPCTVEEEMSVPLKELIEKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCET
                     VLMDFDALVQAQTGLGTAAVIVMDRSTDIVKAIARLIEFYKHESCGQCTPCREGVDWM
                     NKVMARFVKGDARPAEIDSLWEISKQIEGHTICALGDGAAWPVQGLIRHFRPELEDRM
                     QRFAQQHRAWQAAS"
     exon            206..288
                     /gene="Ndufv1"
                     /gene_synonym="CI-51kD"
                     /inference="alignment:Splign:2.1.0"
     exon            289..459
                     /gene="Ndufv1"
                     /gene_synonym="CI-51kD"
                     /inference="alignment:Splign:2.1.0"
     exon            460..643
                     /gene="Ndufv1"
                     /gene_synonym="CI-51kD"
                     /inference="alignment:Splign:2.1.0"
     exon            644..833
                     /gene="Ndufv1"
                     /gene_synonym="CI-51kD"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1046
                     /gene="Ndufv1"
                     /gene_synonym="CI-51kD"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1213
                     /gene="Ndufv1"
                     /gene_synonym="CI-51kD"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1295
                     /gene="Ndufv1"
                     /gene_synonym="CI-51kD"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1441
                     /gene="Ndufv1"
                     /gene_synonym="CI-51kD"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1608
                     /gene="Ndufv1"
                     /gene_synonym="CI-51kD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1580..1585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufv1"
                     /gene_synonym="CI-51kD"
                     /note="hexamer: AACAAG"
     polyA_site      1607
                     /gene="Ndufv1"
                     /gene_synonym="CI-51kD"
                     /note="major polyA site"
ORIGIN      
        1 ctggacacgc cactggctgc ggatgtgtga cgcacttcct gtgcgctccc caccccgtgt
       61 gtttctgtcg cgccggtccc gcggttcgga gttgtgaagg tgacagccgg aggtgacccg
      121 tctggctccc gcgatgctag cggcacggca ttttctcggc gggttggttc ccgtgcgggt
      181 atctgtgcgt ttcagcagcg gcacgacagc acccaagaaa acctcatttg gctcactgaa
      241 ggatgaagac cggatcttta ccaacctgta tgggcgccat gactggaggc tgaaaggtgc
      301 cctgagacgg ggtgactggt acaagacaaa ggagatcctg ctgaaggggc ctgactggat
      361 cttgggtgag atgaagacat caggtttacg gggccgtggt ggtgctggct tccccactgg
      421 cctcaagtgg agcttcatga ataagccctc agatggcagg cccaagtatc tggtggtgaa
      481 tgctgacgag ggagagccag gcacctgtaa ggaccgagag atcatgcgtc atgaccctca
      541 caagctggtg gaaggctgcc ttgtgggagg ccgggccatg ggagcccggg ccgcctatat
      601 ctacatccga ggggaattct acaacgaggc ctccaatttg caggtagcta tccgagaggc
      661 ctatgaagca ggtctgattg gcaagaatgc ttgtggctcc gactatgatt ttgatgtgtt
      721 tgtggtgcgt ggggctgggg cctacatctg tggagaagag acggcactta ttgaatccat
      781 tgaaggcaag cagggaaagc cacgcctgaa gccgcccttt ccagcagatg tgggagtgtt
      841 tggatgcccc acaactgtgg ccaatgtgga gacagtggct gtgtccccca ccatttgccg
      901 tcgtgggggc acctggtttg ctggctttgg ccgagaacgc aattcaggta ccaaattgtt
      961 taacatctct ggccatgtca accacccctg cactgtggag gaagagatgt ctgtgccact
     1021 gaaagagctg attgagaaac atgctggtgg tgtcacaggt ggctgggaca acctccttgc
     1081 tgtgattcct ggtggctcat ctactccact gattcccaaa tctgtgtgtg agaccgtgct
     1141 aatggacttc gatgcactgg tgcaggctca gacaggcctg ggcacggctg cagttattgt
     1201 tatggatcgc tcgacagaca ttgtgaaagc catcgctcgt ctcattgagt tctacaagca
     1261 tgagagctgt ggccagtgta ccccgtgccg tgagggcgtt gactggatga acaaggtgat
     1321 ggcccgattt gtgaagggag atgcccggcc agctgagatt gactccctgt gggagatcag
     1381 caagcagata gaaggccaca ccatttgtgc tctgggtgat ggggctgcct ggccagtaca
     1441 gggtctgatc cgacatttca ggccagagct tgaggatcgg atgcaacgat ttgcccagca
     1501 gcaccgggcc tggcaggcag cctcgtgagt ccacacccta gcctgacaat ttctcatccc
     1561 tttgggaaac tggacaataa acaagtgctg tccactctcc aaccatag
//
