LOCUS       NM_001271443             814 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase core subunit S8
            (Ndufs8), transcript variant 2, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001271443
VERSION     NM_001271443.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 814)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 814)
  AUTHORS   Xiong,Q.W., Jiang,K., Shen,X.W., Ma,Z.R., Yan,X.M., Xia,H. and
            Cao,X.
  TITLE     The requirement of the mitochondrial protein NDUFS8 for
            angiogenesis
  JOURNAL   Cell Death Dis 15 (4), 253 (2024)
   PUBMED   38594244
  REMARK    GeneRIF: The requirement of the mitochondrial protein NDUFS8 for
            angiogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 814)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 814)
  AUTHORS   Cheong,A., Archambault,D., Degani,R., Iverson,E., Tremblay,K.D. and
            Mager,J.
  TITLE     Nuclear-encoded mitochondrial ribosomal proteins are required to
            initiate gastrulation
  JOURNAL   Development 147 (10) (2020)
   PUBMED   32376682
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 814)
  AUTHORS   Moutaoufik,M.T., Malty,R., Amin,S., Zhang,Q., Phanse,S.,
            Gagarinova,A., Zilocchi,M., Hoell,L., Minic,Z., Gagarinova,M.,
            Aoki,H., Stockwell,J., Jessulat,M., Goebels,F., Broderick,K.,
            Scott,N.E., Vlasblom,J., Musso,G., Prasad,B., Lamantea,E.,
            Garavaglia,B., Rajput,A., Murayama,K., Okazaki,Y., Foster,L.J.,
            Bader,G.D., Cayabyab,F.S. and Babu,M.
  TITLE     Rewiring of the Human Mitochondrial Interactome during Neuronal
            Reprogramming Reveals Regulators of the Respirasome and
            Neurogenesis
  JOURNAL   iScience 19, 1114-1132 (2019)
   PUBMED   31536960
REFERENCE   6  (bases 1 to 814)
  AUTHORS   Signes,A. and Fernandez-Vizarra,E.
  TITLE     Assembly of mammalian oxidative phosphorylation complexes I-V and
            supercomplexes
  JOURNAL   Essays Biochem 62 (3), 255-270 (2018)
   PUBMED   30030361
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 814)
  AUTHORS   Inoue,M., Shima,Y., Miyabayashi,K., Tokunaga,K., Sato,T., Baba,T.,
            Ohkawa,Y., Akiyama,H., Suyama,M. and Morohashi,K.
  TITLE     Isolation and Characterization of Fetal Leydig Progenitor Cells of
            Male Mice
  JOURNAL   Endocrinology 157 (3), 1222-1233 (2016)
   PUBMED   26697723
REFERENCE   8  (bases 1 to 814)
  AUTHORS   Wirtz,S. and Schuelke,M.
  TITLE     Region-specific expression of mitochondrial complex I genes during
            murine brain development
  JOURNAL   PLoS One 6 (4), e18897 (2011)
   PUBMED   21556144
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 814)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135069.1, AK164901.1 and BP775598.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode
            the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK031157.1, AK135069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AK135069.1         2-25
            25-777              AK164901.1         2-754
            778-814             BP775598.1         26-62               c
FEATURES             Location/Qualifiers
     source          1..814
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.63 cM"
     gene            1..814
                     /gene="Ndufs8"
                     /gene_synonym="CI-23kD; TYKY"
                     /note="NADH:ubiquinone oxidoreductase core subunit S8"
                     /db_xref="GeneID:225887"
                     /db_xref="MGI:MGI:2385079"
     exon            1..65
                     /gene="Ndufs8"
                     /gene_synonym="CI-23kD; TYKY"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..704
                     /gene="Ndufs8"
                     /gene_synonym="CI-23kD; TYKY"
                     /EC_number="7.1.1.2"
                     /note="complex I-23kD; NADH-ubiquinone oxidoreductase 23
                     kDa subunit; NADH dehydrogenase (ubiquinone) Fe-S protein
                     8"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] iron-sulfur
                     protein 8, mitochondrial"
                     /protein_id="NP_001258372.1"
                     /db_xref="CCDS:CCDS29402.1"
                     /db_xref="GeneID:225887"
                     /db_xref="MGI:MGI:2385079"
                     /translation="MYRLSSSMLPRALAQAMRTGHLNGQSLHSSAVAATYKYVNKKEQ
                     ESEVDMKSATDNAARILMWTELIRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHA
                     LRRYPSGEERCIACKLCEAICPAQAITIEAEPRADGSRRTTRYDIDMTKCIYCGFCQE
                     ACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDKWEAEIAANIQADYLYR"
     exon            66..123
                     /gene="Ndufs8"
                     /gene_synonym="CI-23kD; TYKY"
                     /inference="alignment:Splign:2.1.0"
     exon            124..174
                     /gene="Ndufs8"
                     /gene_synonym="CI-23kD; TYKY"
                     /inference="alignment:Splign:2.1.0"
     exon            175..270
                     /gene="Ndufs8"
                     /gene_synonym="CI-23kD; TYKY"
                     /inference="alignment:Splign:2.1.0"
     exon            271..443
                     /gene="Ndufs8"
                     /gene_synonym="CI-23kD; TYKY"
                     /inference="alignment:Splign:2.1.0"
     exon            444..572
                     /gene="Ndufs8"
                     /gene_synonym="CI-23kD; TYKY"
                     /inference="alignment:Splign:2.1.0"
     exon            573..784
                     /gene="Ndufs8"
                     /gene_synonym="CI-23kD; TYKY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      762..767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufs8"
                     /gene_synonym="CI-23kD; TYKY"
                     /note="hexamer: AAGAAA"
     polyA_site      780
                     /gene="Ndufs8"
                     /gene_synonym="CI-23kD; TYKY"
                     /note="major polyA site"
ORIGIN      
        1 gagcttaggc tccgccttcc ggttgaaccg catctgggcc agggaaggag ccgcagcact
       61 tcaagatgta tcgcctgagc tcatcaatgc tgccacgggc cttggcccag gccatgcgca
      121 caggacatct taatggacaa agccttcata gcagcgcagt ggcggcaacg tacaagtatg
      181 tgaataagaa ggaacaggag tctgaggtgg acatgaagtc cgcaactgac aatgcagctc
      241 ggattctgat gtggacagaa ctcatccgag gactgggcat gaccctaagt tacctctttc
      301 gagagcctgc caccatcaac tacccctttg agaagggccc actgagtccg cgcttccgtg
      361 gggagcatgc actgcgccgc tacccatctg gagaggagcg ttgcattgcc tgcaaactct
      421 gtgaggccat ctgtcctgca caggccatca ccattgaggc tgagccaaga gccgatggca
      481 gccgccgaac gacacgctat gacatcgaca tgaccaagtg tatctactgt ggtttctgcc
      541 aggaagcctg ccctgttgat gccattgtgg agggccccaa cttcgagttc tccaccgaga
      601 cacacgagga gttgctgtac aacaaggaga agctactcaa caatggagac aagtgggagg
      661 ccgagatcgc tgccaacatc caggctgact acctgtaccg gtgaccagac cactggtgac
      721 cttggccacc tggctcagcc ttgtggcccc tttagcccat aaagaaacta tgatcccaca
      781 gctaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
