LOCUS       NM_010888                526 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase core subunit S6
            (Ndufs6), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_010888 XM_354775
VERSION     NM_010888.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 526)
  AUTHORS   Zhang Y, Guo L, Han S, Chen L, Li C, Zhang Z, Hong Y, Zhang X, Zhou
            X, Jiang D, Liang X, Qiu J, Zhang J, Li X, Zhong S, Liao C, Yan B,
            Tse HF and Lian Q.
  TITLE     Adult mesenchymal stem cell ageing interplays with depressed
            mitochondrial Ndufs6
  JOURNAL   Cell Death Dis 11 (12), 1075 (2020)
   PUBMED   33323934
  REMARK    GeneRIF: Adult mesenchymal stem cell ageing interplays with
            depressed mitochondrial Ndufs6.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 526)
  AUTHORS   Signes A and Fernandez-Vizarra E.
  TITLE     Assembly of mammalian oxidative phosphorylation complexes I-V and
            supercomplexes
  JOURNAL   Essays Biochem 62 (3), 255-270 (2018)
   PUBMED   30030361
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 526)
  AUTHORS   Gomez-Velazquez M, Badia-Careaga C, Lechuga-Vieco AV,
            Nieto-Arellano R, Tena JJ, Rollan I, Alvarez A, Torroja C, Caceres
            EF, Roy AR, Galjart N, Delgado-Olguin P, Sanchez-Cabo F, Enriquez
            JA, Gomez-Skarmeta JL and Manzanares M.
  TITLE     CTCF counter-regulates cardiomyocyte development and maturation
            programs in the embryonic heart
  JOURNAL   PLoS Genet 13 (8), e1006985 (2017)
   PUBMED   28846746
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 526)
  AUTHORS   Forbes JM, Ke BX, Nguyen TV, Henstridge DC, Penfold SA, Laskowski
            A, Sourris KC, Groschner LN, Cooper ME, Thorburn DR and Coughlan
            MT.
  TITLE     Deficiency in mitochondrial complex I activity due to Ndufs6 gene
            trap insertion induces renal disease
  JOURNAL   Antioxid Redox Signal 19 (4), 331-343 (2013)
   PUBMED   23320803
  REMARK    GeneRIF: The studies identify for the first time that complex I
            deficiency as the result of interruption of Ndufs6 is an
            independent cause of renal impairment.
REFERENCE   5  (bases 1 to 526)
  AUTHORS   Ke BX, Pepe S, Grubb DR, Komen JC, Laskowski A, Rodda FA, Hardman
            BM, Pitt JJ, Ryan MT, Lazarou M, Koleff J, Cheung MM, Smolich JJ
            and Thorburn DR.
  TITLE     Tissue-specific splicing of an Ndufs6 gene-trap insertion generates
            a mitochondrial complex I deficiency-specific cardiomyopathy
  JOURNAL   Proc Natl Acad Sci U S A 109 (16), 6165-6170 (2012)
   PUBMED   22474353
  REMARK    GeneRIF: Data show that Ndufs6(gt/gt) mice are born healthy, attain
            normal weight and maturity, and are fertile, however, after 4 mo in
            males and 8 mo in females, Ndufs6(gt/gt) mice are at increased risk
            of cardiac failure and death.
REFERENCE   6  (bases 1 to 526)
  AUTHORS   Wirtz S and Schuelke M.
  TITLE     Region-specific expression of mitochondrial complex I genes during
            murine brain development
  JOURNAL   PLoS One 6 (4), e18897 (2011)
   PUBMED   21556144
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 526)
  AUTHORS   Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao
            H, Xiao L, Grishin NV, White M, Yang XJ and Zhao Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   8  (bases 1 to 526)
  AUTHORS   Watson JD, Beckett-Jones B, Roy RN, Green NC and Flynn TG.
  TITLE     Genomic sequence, structural organization and evolutionary
            conservation of the 13.2-kDa subunit of rat NADH:ubiquinone
            oxidoreductase
  JOURNAL   Gene 158 (2), 275-280 (1995)
   PUBMED   7607554
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154266.2, BG081040.2 and BC076501.1.
            
            [WARNING] On Aug 9, 2023 this sequence was replaced by NM_010888.3.
            
            On Feb 5, 2010 this sequence version replaced NM_010888.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the full-length protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK790167.1, BC086933.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC154266.2         124373-124382       c
            11-503              BG081040.2         1-493
            504-526             BC076501.1         535-557
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 39.69 cM"
     gene            1..526
                     /gene="Ndufs6"
                     /gene_synonym="IP13"
                     /note="NADH:ubiquinone oxidoreductase core subunit S6"
                     /db_xref="GeneID:407785"
                     /db_xref="MGI:MGI:107932"
     exon            1..144
                     /gene="Ndufs6"
                     /gene_synonym="IP13"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..387
                     /gene="Ndufs6"
                     /gene_synonym="IP13"
                     /note="NADH dehydrogenase [ubiquinone] iron-sulfur protein
                     6, mitochondrial; CI-13kD-A; complex I-13kD-A;
                     NADH-ubiquinone oxidoreductase 13 kDa-A subunit; NADH
                     dehydrogenase Fe-S protein 6; NADH dehydrogenase
                     (ubiquinone) Fe-S protein 6"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] iron-sulfur
                     protein 6, mitochondrial precursor"
                     /protein_id="NP_035018.1"
                     /db_xref="CCDS:CCDS26630.1"
                     /db_xref="GeneID:407785"
                     /db_xref="MGI:MGI:107932"
                     /translation="MAAVLTFRRLLTLPRAARGFGVQVSPSGEKITHTGQVYDEKDYR
                     RVRFVDRQKEVNENFAIDLIAQQPVNEVEHRIIACDGGGGALGHPKVYINLDKETKTG
                     TCGYCGLQFKQHHH"
     exon            145..198
                     /gene="Ndufs6"
                     /gene_synonym="IP13"
                     /inference="alignment:Splign:2.1.0"
     exon            199..321
                     /gene="Ndufs6"
                     /gene_synonym="IP13"
                     /inference="alignment:Splign:2.1.0"
     exon            322..506
                     /gene="Ndufs6"
                     /gene_synonym="IP13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttggtacgac gcgtggggtc aagggtcacc ggcaagatgg cggcggtgct gaccttccgc
       61 cggctgttga ctctccccag ggctgcacgg ggtttcgggg ttcaagtgtc gccgagcggg
      121 gaaaagatca cgcataccgg ccaggtgtat gatgaaaaag actacaggag ggttcgtttt
      181 gtagatcgtc agaaagaggt gaatgagaac tttgccattg atttgatagc acaacagcct
      241 gtgaatgagg tggagcaccg catcatagcc tgcgatggag gcggtggtgc cctgggccac
      301 cccaaggtgt acataaactt ggacaaagaa acaaaaacgg ggacatgtgg ctactgcggc
      361 ctgcagttca agcagcacca tcactagtgt gggctgtgtc ctggtcctct gactcctatg
      421 gaacatctcc acgctgggtg ttctgtgtga ggccactgct ctgtgaatgg tgtcccttgt
      481 tttgaataaa ggatgctccc accatgaaaa aaaaaaaaaa aaaaaa
//
