LOCUS       NM_010887               1534 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase core subunit S4
            (Ndufs4), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_010887
VERSION     NM_010887.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1534)
  AUTHORS   Morishima,T., Fakruddin,M., Kanamori,Y., Masuda,T., Ogawa,A.,
            Wang,Y., Schoonenberg,V.A.C., Butter,F., Arima,Y., Akaike,T.,
            Moroishi,T., Tomizawa,K., Suda,T., Wei,F.Y. and Takizawa,H.
  TITLE     Mitochondrial translation regulates terminal erythroid
            differentiation by maintaining iron homeostasis
  JOURNAL   Sci Adv 11 (8), eadu3011 (2025)
   PUBMED   39983002
REFERENCE   2  (bases 1 to 1534)
  AUTHORS   Hernansanz-Agustin,P., Morales-Vidal,C., Calvo,E., Natale,P.,
            Marti-Mateos,Y., Jaroszewicz,S.N., Cabrera-Alarcon,J.L.,
            Acin-Perez,R., Lopez-Montero,I., Vazquez,J. and Enriquez,J.A.
  TITLE     A transmitochondrial sodium gradient controls membrane potential in
            mammalian mitochondria
  JOURNAL   Cell 187 (23), 6599-6613 (2024)
   PUBMED   39303716
REFERENCE   3  (bases 1 to 1534)
  AUTHORS   Nakai,R., Varnum,S., Field,R.L., Shi,H., Giwa,R., Jia,W.,
            Krysa,S.J., Cohen,E.F., Borcherding,N., Saneto,R.P., Tsai,R.C.,
            Suganuma,M., Ohta,H., Yokota,T. and Brestoff,J.R.
  TITLE     Mitochondria transfer-based therapies reduce the morbidity and
            mortality of Leigh syndrome
  JOURNAL   Nat Metab 6 (10), 1886-1896 (2024)
   PUBMED   39223312
REFERENCE   4  (bases 1 to 1534)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   5  (bases 1 to 1534)
  AUTHORS   Reynaud-Dulaurier,R., Clement,R., Yjjou,S., Cresson,C., Saoudi,Y.,
            Faideau,M. and Decressac,M.
  TITLE     The Blood-Brain Barrier Is Unaffected in the Ndufs4-/- Mouse Model
            of Leigh Syndrome
  JOURNAL   Int J Mol Sci 25 (9), 4828 (2024)
   PUBMED   38732047
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1534)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1534)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1534)
  AUTHORS   Papa,S., Scacco,S., Sardanelli,A.M., Vergari,R., Papa,F., Budde,S.,
            van den Heuvel,L. and Smeitink,J.
  TITLE     Mutation in the NDUFS4 gene of complex I abolishes cAMP-dependent
            activation of the complex in a child with fatal neurological
            syndrome
  JOURNAL   FEBS Lett 489 (2-3), 259-262 (2001)
   PUBMED   11165261
REFERENCE   9  (bases 1 to 1534)
  AUTHORS   Scacco,S., Vergari,R., Scarpulla,R.C., Technikova-Dobrova,Z.,
            Sardanelli,A., Lambo,R., Lorusso,V. and Papa,S.
  TITLE     cAMP-dependent phosphorylation of the nuclear encoded 18-kDa (IP)
            subunit of respiratory complex I and activation of the complex in
            serum-starved mouse fibroblast cultures
  JOURNAL   J Biol Chem 275 (23), 17578-17582 (2000)
   PUBMED   10747996
REFERENCE   10 (bases 1 to 1534)
  AUTHORS   Murdock,D.G., Boone,B.E., Esposito,L.A. and Wallace,D.C.
  TITLE     Up-regulation of nuclear and mitochondrial genes in the skeletal
            muscle of mice lacking the heart/muscle isoform of the adenine
            nucleotide translocator
  JOURNAL   J Biol Chem 274 (20), 14429-14433 (1999)
   PUBMED   10318868
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ041886.1, CJ073528.1, AK011124.1 and AK035175.1.
            
            On Dec 23, 2009 this sequence version replaced NM_010887.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB236740.1, AK011124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                CJ041886.1         167-187
            22-388              CJ073528.1         21-387
            389-905             AK011124.1         377-893
            906-1534            AK035175.1         359-987
FEATURES             Location/Qualifiers
     source          1..1534
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 64.12 cM"
     gene            1..1534
                     /gene="Ndufs4"
                     /gene_synonym="6720411N02Rik; C1-18k"
                     /note="NADH:ubiquinone oxidoreductase core subunit S4"
                     /db_xref="GeneID:17993"
                     /db_xref="MGI:MGI:1343135"
     exon            1..136
                     /gene="Ndufs4"
                     /gene_synonym="6720411N02Rik; C1-18k"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..566
                     /gene="Ndufs4"
                     /gene_synonym="6720411N02Rik; C1-18k"
                     /note="CI-AQDQ; CI-18 kDa; complex I-AQDQ; complex I-18
                     kDa; NADH-ubiquinone oxidoreductase 18 kDa subunit"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] iron-sulfur
                     protein 4, mitochondrial"
                     /protein_id="NP_035017.2"
                     /db_xref="CCDS:CCDS49368.1"
                     /db_xref="GeneID:17993"
                     /db_xref="MGI:MGI:1343135"
                     /translation="MAAVSMSVSLRQAMLGRRAMATAAVSVCRVPSRLLSTSTWKLAD
                     NQTRDTQLITVDEKLDITTLTGVPEEHIKTRKVRIFVPARNNMQSGVNNTKKWKMEFD
                     TRERWENPLMGWASTADPLSNMVLTFSAKEDAIAFAEKNGWSYDVEEKKVPKPKSKSY
                     GANFSWNKRTRVSTK"
     exon            137..215
                     /gene="Ndufs4"
                     /gene_synonym="6720411N02Rik; C1-18k"
                     /inference="alignment:Splign:2.1.0"
     exon            216..388
                     /gene="Ndufs4"
                     /gene_synonym="6720411N02Rik; C1-18k"
                     /inference="alignment:Splign:2.1.0"
     exon            389..462
                     /gene="Ndufs4"
                     /gene_synonym="6720411N02Rik; C1-18k"
                     /inference="alignment:Splign:2.1.0"
     exon            463..1534
                     /gene="Ndufs4"
                     /gene_synonym="6720411N02Rik; C1-18k"
                     /inference="alignment:Splign:2.1.0"
     regulatory      658..663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufs4"
                     /gene_synonym="6720411N02Rik; C1-18k"
                     /note="hexamer: AATAAA"
     polyA_site      681
                     /gene="Ndufs4"
                     /gene_synonym="6720411N02Rik; C1-18k"
                     /note="major polyA site"
     regulatory      1507..1512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufs4"
                     /gene_synonym="6720411N02Rik; C1-18k"
                     /note="hexamer: AATAAA"
     polyA_site      1526
                     /gene="Ndufs4"
                     /gene_synonym="6720411N02Rik; C1-18k"
ORIGIN      
        1 ggatccgtac tcgcatcctg gcgtttgcct acaggaagat ggcggcggtc tcaatgtcag
       61 tgtcgctgag acaggcgatg ttggggcgaa gggcaatggc tacagctgcc gtttccgtct
      121 gtagagttcc atccaggttg ttgagcacat ccacttggaa gctggcagac aaccagactc
      181 gggacacaca gcttataaca gttgatgaga aactggatat cacaacttta actggtgttc
      241 cagaagagca catcaaaacc agaaaggtca gaatctttgt tcctgctcgc aataacatgc
      301 agtctggagt aaataacaca aagaaatgga agatggagtt tgataccaga gagagatggg
      361 aaaatccttt gatgggttgg gcatcaaccg ctgaccccct ctccaacatg gttctgacct
      421 tcagtgccaa agaagatgca attgcctttg cagaaaaaaa cggatggagc tatgatgtgg
      481 aagagaagaa ggttccgaaa cccaagtcca agtcttatgg tgcaaacttt tcttggaaca
      541 aaagaacaag agtgtctaca aaataggttg gagctggcta catctctgct tgactgtgac
      601 tgaagtgtca gctgtgcact atttatagtc catggataat gcacctctta atctcctaat
      661 aaatgtgacc tttaaactac aggtacactt ggcagtttct attttaagtg tttttgatgt
      721 cttacattga acatattaca gttccctgca cagacagatt tgagacattc accgctctac
      781 gaaatcagag cacttagagt ttaccaatgt gagtgcctgg aatcagctgc agcctaggtg
      841 gtttctggtt gctttttata gccactcaag tcaatgccat gcataaactc caagccatcc
      901 ttactaaacc actctcaggg aaattctttt gtcatgggta gaaaaggaca tggctgtact
      961 acaacccaat gactctcaac ttaattccct tatagccaac gatttcctgt ctgactggag
     1021 atttgtattt cctcggtgtt tatgaacaga aaaggattta tctgtacaag ttaagcccgt
     1081 tcttccccgt cccatgctcc caaaaataag gctcagtctc aatatatatt tacagatacc
     1141 ttggccatat tgctaggctt ttctctgact agaccatagc ttaaatcatc ccatttattc
     1201 taatctacat tctgccatgt ggctgattac ttgtgctcag gtaccatatg tctgtttcct
     1261 cacctcttcc tgggagaatc ttccttgcct ggctttatcc cagaattctt tctgcctccc
     1321 agatgtccac cttctagtcc accttttcct ataggccata ggctttttaa ttgacaagtg
     1381 atgcatccgt acaacacata aaatattctc tctacagttg tccataccag ttctgcctta
     1441 tgcatctgct gattgtgaga acttccaatg gagatctttt attcttagga aataagttca
     1501 atacaaaata aaaacaagtg tttggagacc ttta
//
