LOCUS       NM_026688                949 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase core subunit S3
            (Ndufs3), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_026688 XM_130347
VERSION     NM_026688.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 949)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 949)
  AUTHORS   Yuan,N., Shen,L., Peng,Q., Sha,R., Wang,Z., Xie,Z., You,X. and
            Feng,Y.
  TITLE     SRSF1 Is Required for Mitochondrial Homeostasis and Thermogenic
            Function in Brown Adipocytes Through its Control of Ndufs3 Splicing
  JOURNAL   Adv Sci (Weinh) 11 (21), e2306871 (2024)
   PUBMED   38569495
  REMARK    GeneRIF: SRSF1 Is Required for Mitochondrial Homeostasis and
            Thermogenic Function in Brown Adipocytes Through its Control of
            Ndufs3 Splicing.
REFERENCE   3  (bases 1 to 949)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 949)
  AUTHORS   Peralta,S., Pinto,M., Arguello,T., Garcia,S., Diaz,F. and
            Moraes,C.T.
  TITLE     Metformin delays neurological symptom onset in a mouse model of
            neuronal complex I deficiency
  JOURNAL   JCI Insight 5 (21), 141183 (2020)
   PUBMED   33148885
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 949)
  AUTHORS   Pereira,C.V., Peralta,S., Arguello,T., Bacman,S.R., Diaz,F. and
            Moraes,C.T.
  TITLE     Myopathy reversion in mice after restauration of mitochondrial
            complex I
  JOURNAL   EMBO Mol Med 12 (2), e10674 (2020)
   PUBMED   31916679
REFERENCE   6  (bases 1 to 949)
  AUTHORS   Peralta,S., Torraco,A., Wenz,T., Garcia,S., Diaz,F. and Moraes,C.T.
  TITLE     Partial complex I deficiency due to the CNS conditional ablation of
            Ndufa5 results in a mild chronic encephalopathy but no increase in
            oxidative damage
  JOURNAL   Hum Mol Genet 23 (6), 1399-1412 (2014)
   PUBMED   24154540
REFERENCE   7  (bases 1 to 949)
  AUTHORS   Wirtz,S. and Schuelke,M.
  TITLE     Region-specific expression of mitochondrial complex I genes during
            murine brain development
  JOURNAL   PLoS One 6 (4), e18897 (2011)
   PUBMED   21556144
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 949)
  AUTHORS   Yang,H., Brosel,S., Acin-Perez,R., Slavkovich,V., Nishino,I.,
            Khan,R., Goldberg,I.J., Graziano,J., Manfredi,G. and Schon,E.A.
  TITLE     Analysis of mouse models of cytochrome c oxidase deficiency owing
            to mutations in Sco2
  JOURNAL   Hum Mol Genet 19 (1), 170-180 (2010)
   PUBMED   19837698
REFERENCE   9  (bases 1 to 949)
  AUTHORS   Kruse,S.E., Watt,W.C., Marcinek,D.J., Kapur,R.P., Schenkman,K.A.
            and Palmiter,R.D.
  TITLE     Mice with mitochondrial complex I deficiency develop a fatal
            encephalomyopathy
  JOURNAL   Cell Metab 7 (4), 312-320 (2008)
   PUBMED   18396137
REFERENCE   10 (bases 1 to 949)
  AUTHORS   Ruivenkamp,C.A., van Wezel,T., Zanon,C., Stassen,A.P., Vlcek,C.,
            Csikos,T., Klous,A.M., Tripodis,N., Perrakis,A., Boerrigter,L.,
            Groot,P.C., Lindeman,J., Mooi,W.J., Meijjer,G.A., Scholten,G.,
            Dauwerse,H., Paces,V., van Zandwijk,N., van Ommen,G.J. and
            Demant,P.
  TITLE     Ptprj is a candidate for the mouse colon-cancer susceptibility
            locus Scc1 and is frequently deleted in human cancers
  JOURNAL   Nat Genet 31 (3), 295-300 (2002)
   PUBMED   12089527
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672241.6.
            
            On Apr 25, 2018 this sequence version replaced NM_026688.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088337.1, BC027270.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AL672241.6         52637-52774         c
            139-204             AL672241.6         52476-52541         c
            205-302             AL672241.6         50900-50997         c
            303-452             AL672241.6         50416-50565         c
            453-578             AL672241.6         46690-46815         c
            579-698             AL672241.6         46437-46556         c
            699-949             AL672241.6         42680-42930         c
FEATURES             Location/Qualifiers
     source          1..949
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.44 cM"
     gene            1..949
                     /gene="Ndufs3"
                     /gene_synonym="0610010M09Rik; CI-30kD"
                     /note="NADH:ubiquinone oxidoreductase core subunit S3"
                     /db_xref="GeneID:68349"
                     /db_xref="MGI:MGI:1915599"
     exon            1..138
                     /gene="Ndufs3"
                     /gene_synonym="0610010M09Rik; CI-30kD"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..866
                     /gene="Ndufs3"
                     /gene_synonym="0610010M09Rik; CI-30kD"
                     /EC_number="7.1.1.2"
                     /note="NADH dehydrogenase [ubiquinone] iron-sulfur protein
                     3, mitochondrial; complex I-30kD; NADH-ubiquinone
                     oxidoreductase 30 kDa subunit"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] iron-sulfur
                     protein 3, mitochondrial precursor"
                     /protein_id="NP_080964.1"
                     /db_xref="CCDS:CCDS16418.1"
                     /db_xref="GeneID:68349"
                     /db_xref="MGI:MGI:1915599"
                     /translation="MAAAAARVWCRGLLGAASVGRGAGRPSVLWQHVRRESAAADKRP
                     TVRPRSDVTHKQLSAFGEYVAEILPKYVQQVQVSCLDELEICIHPDGVIPTLTFLRDH
                     TNAQFKSLADLTAVDVPTRQNRFEIVYNLLSLRFNSRIRVKTYADELTPIDSIVSVHI
                     AANWYEREVWDMFGVFFFNHPDLRRILTDYGFEGHPFRKDFPLTGYVELRYDDEVKRV
                     VAEPVELAQEFRKFDLNSPWEAFPAYRQPPESLKLEAGDKKPETK"
     exon            139..204
                     /gene="Ndufs3"
                     /gene_synonym="0610010M09Rik; CI-30kD"
                     /inference="alignment:Splign:2.1.0"
     exon            205..302
                     /gene="Ndufs3"
                     /gene_synonym="0610010M09Rik; CI-30kD"
                     /inference="alignment:Splign:2.1.0"
     exon            303..452
                     /gene="Ndufs3"
                     /gene_synonym="0610010M09Rik; CI-30kD"
                     /inference="alignment:Splign:2.1.0"
     exon            453..578
                     /gene="Ndufs3"
                     /gene_synonym="0610010M09Rik; CI-30kD"
                     /inference="alignment:Splign:2.1.0"
     exon            579..698
                     /gene="Ndufs3"
                     /gene_synonym="0610010M09Rik; CI-30kD"
                     /inference="alignment:Splign:2.1.0"
     exon            699..949
                     /gene="Ndufs3"
                     /gene_synonym="0610010M09Rik; CI-30kD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      920..925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufs3"
                     /gene_synonym="0610010M09Rik; CI-30kD"
                     /note="hexamer: AATAAA"
     polyA_site      940
                     /gene="Ndufs3"
                     /gene_synonym="0610010M09Rik; CI-30kD"
                     /note="major polyA site"
ORIGIN      
        1 acttccggtc cgtgcccttg gggctccgtg gcctgcgtgt gttctccggc tacttagtcg
       61 gcacactaag gaacatggcg gcggctgcag ccagggtctg gtgtcgtggg ctcttggggg
      121 ccgcttccgt aggcaggggg gctgggcgac cctccgtgct gtggcagcac gtaagaaggg
      181 agagcgcggc ggctgacaag cgccccactg tcagaccccg gagtgatgtg acccacaagc
      241 agctctcagc atttggagag tatgtggctg aaatcttacc caagtatgtc caacaagttc
      301 aggtgtcctg ccttgatgag ttagaaatct gtatccatcc cgatggagtc atcccaacgc
      361 tgacttttct cagggatcac accaatgcac aattcaaatc cttggctgac ttgacggcag
      421 tggatgtccc aactcggcag aaccgttttg agattgtcta caacctgctg tctctgcggt
      481 tcaactctag gattcgtgtg aagacctatg cagatgagct gacacccatt gactctatag
      541 tgtctgtgca catcgcggcc aattggtatg agagggaggt ctgggacatg tttggagttt
      601 tcttttttaa ccaccctgat ttaagaagga tcctgacaga ttatggcttc gagggacatc
      661 ctttccggaa agactttccc ctcactggct atgttgagct tcgttacgac gatgaggtaa
      721 agcgggtagt ggctgaacca gtggagctgg cacaagaatt ccgcaagttt gacctgaaca
      781 gcccctggga ggctttccct gcctatcgcc agcctcctga gagtctcaag ctcgaagctg
      841 gagacaagaa gcctgaaacc aagtaacttc aaaagcatgt agatcctaga ggaaaaggcc
      901 tcacctaagg ttgtctgtaa ataaactcca atggacattc tctccttcc
//
