LOCUS       NM_153064               1623 bp    mRNA    linear   ROD 23-DEC-2022
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase core subunit S2
            (Ndufs2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_153064
VERSION     NM_153064.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1623)
  AUTHORS   McElroy GS, Chakrabarty RP, D'Alessandro KB, Hu YS, Vasan K, Tan J,
            Stoolman JS, Weinberg SE, Steinert EM, Reyfman PA, Singer BD,
            Ladiges WC, Gao L, Lopez-Barneo J, Ridge K, Budinger GRS and
            Chandel NS.
  TITLE     Reduced expression of mitochondrial complex I subunit Ndufs2 does
            not impact healthspan in mice
  JOURNAL   Sci Rep 12 (1), 5196 (2022)
   PUBMED   35338200
  REMARK    GeneRIF: Reduced expression of mitochondrial complex I subunit
            Ndufs2 does not impact healthspan in mice.
            Erratum:[Sci Rep. 2022 May 17;12(1):8191. PMID: 35581238]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1623)
  AUTHORS   Gonzalez-Rodriguez P, Zampese E, Stout KA, Guzman JN, Ilijic E,
            Yang B, Tkatch T, Stavarache MA, Wokosin DL, Gao L, Kaplitt MG,
            Lopez-Barneo J, Schumacker PT and Surmeier DJ.
  TITLE     Disruption of mitochondrial complex I induces progressive
            parkinsonism
  JOURNAL   Nature 599 (7886), 650-656 (2021)
   PUBMED   34732887
  REMARK    Erratum:[Nature. 2022 Mar;603(7899):E1. PMID: 35149834]
REFERENCE   3  (bases 1 to 1623)
  AUTHORS   Parks C, Rogers CM, Prins P, Williams RW, Chen H, Jones BC, Moore
            BM 2nd and Mulligan MK.
  TITLE     Genetic Modulation of Initial Sensitivity to
            Delta9-Tetrahydrocannabinol (THC) Among the BXD Family of Mice
  JOURNAL   Front Genet 12, 659012 (2021)
   PUBMED   34367237
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1623)
  AUTHORS   Yang Y, Yang X, Lin Y, Yang G and Li L.
  TITLE     LASS2 regulates hepatocyte steatosis by interacting with
            NDUFS2/OXPHOS related proteins
  JOURNAL   Biochem Biophys Res Commun 526 (4), 871-879 (2020)
   PUBMED   32279995
  REMARK    GeneRIF: LASS2 regulates hepatocyte steatosis by interacting with
            NDUFS2/OXPHOS related proteins.
REFERENCE   5  (bases 1 to 1623)
  AUTHORS   Ruan QT, Yazdani N, Blum BC, Beierle JA, Lin W, Coelho MA, Fultz
            EK, Healy AF, Shahin JR, Kandola AK, Luttik KP, Zheng K, Smith NJ,
            Cheung J, Mortazavi F, Apicco DJ, Ragu Varman D, Ramamoorthy S, Ash
            PEA, Rosene DL, Emili A, Wolozin B, Szumlinski KK and Bryant CD.
  TITLE     A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced
            Reinforcement, Reward, and Dopamine Release and Increases
            Synaptosomal hnRNP H and Mitochondrial Proteins
  JOURNAL   J Neurosci 40 (1), 107-130 (2020)
   PUBMED   31704785
REFERENCE   6  (bases 1 to 1623)
  AUTHORS   Signes A and Fernandez-Vizarra E.
  TITLE     Assembly of mammalian oxidative phosphorylation complexes I-V and
            supercomplexes
  JOURNAL   Essays Biochem 62 (3), 255-270 (2018)
   PUBMED   30030361
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1623)
  AUTHORS   Arias-Mayenco I, Gonzalez-Rodriguez P, Torres-Torrelo H, Gao L,
            Fernandez-Aguera MC, Bonilla-Henao V, Ortega-Saenz P and
            Lopez-Barneo J.
  TITLE     Acute O2 Sensing: Role of Coenzyme QH2/Q Ratio and Mitochondrial
            ROS Compartmentalization
  JOURNAL   Cell Metab 28 (1), 145-158 (2018)
   PUBMED   29887397
REFERENCE   8  (bases 1 to 1623)
  AUTHORS   Brici D, Zhang Q, Reinhardt S, Dahl A, Hartmann H, Schmidt K,
            Goveas N, Huang J, Gahurova L, Kelsey G, Anastassiadis K, Stewart
            AF and Kranz A.
  TITLE     Setd1b, encoding a histone 3 lysine 4 methyltransferase, is a
            maternal effect gene required for the oogenic gene expression
            program
  JOURNAL   Development 144 (14), 2606-2617 (2017)
   PUBMED   28619824
REFERENCE   9  (bases 1 to 1623)
  AUTHORS   Fernandez-Aguera MC, Gao L, Gonzalez-Rodriguez P, Pintado CO,
            Arias-Mayenco I, Garcia-Flores P, Garcia-Perganeda A, Pascual A,
            Ortega-Saenz P and Lopez-Barneo J.
  TITLE     Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial
            Complex I Signaling
  JOURNAL   Cell Metab 22 (5), 825-837 (2015)
   PUBMED   26437605
  REMARK    GeneRIF: Ndufs2-null mice lose the hyperventilatory response to
            hypoxia, although they respond to hypercapnia. Ndufs2-deficient CB
            cells have normal functions and ATP content but are insensitive to
            changes in PO2.
REFERENCE   10 (bases 1 to 1623)
  AUTHORS   Wirtz S and Schuelke M.
  TITLE     Region-specific expression of mitochondrial complex I genes during
            murine brain development
  JOURNAL   PLoS One 6 (4), e18897 (2011)
   PUBMED   21556144
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY105246.1, AK078474.1 and AC084821.26.
            
            [WARNING] On May 18, 2023 this sequence was replaced by
            NM_153064.6.
            
            On Sep 1, 2015 this sequence version replaced NM_153064.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016097.1, AK078474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BY105246.1         2-11
            11-1616             AK078474.1         2-1607
            1617-1623           AC084821.26        110669-110675
FEATURES             Location/Qualifiers
     source          1..1623
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..1623
                     /gene="Ndufs2"
                     /gene_synonym="CI-49kD"
                     /note="NADH:ubiquinone oxidoreductase core subunit S2"
                     /db_xref="GeneID:226646"
                     /db_xref="MGI:MGI:2385112"
     exon            1..129
                     /gene="Ndufs2"
                     /gene_synonym="CI-49kD"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1426
                     /gene="Ndufs2"
                     /gene_synonym="CI-49kD"
                     /EC_number="7.1.1.2"
                     /note="NADH dehydrogenase [ubiquinone] iron-sulfur protein
                     2, mitochondrial; NADH-coenzyme Q reductase; complex
                     I-49kD; NADH-ubiquinone oxidoreductase 49 kDa subunit;
                     NADH dehydrogenase (ubiquinone) Fe-S protein 2"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] iron-sulfur
                     protein 2, mitochondrial precursor"
                     /protein_id="NP_694704.1"
                     /db_xref="CCDS:CCDS15484.1"
                     /db_xref="GeneID:226646"
                     /db_xref="MGI:MGI:2385112"
                     /translation="MAALRALRCLRGVGAPVLRPGSGIRLPSQPSRGARQWQPDIEWA
                     EQFSGAVMYPSKETAHWKPPPWNDVDILKEKAVTNMTLNFGPQHPAAHGVLRLVLELS
                     GEMVRKCDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMCNEQAYSIAVEKLLN
                     IQPPPRAQWIRVLFGEITRILNHIMAVTTHALDIGAMTPFFWMFEEREKMFEFYERVS
                     GARMHAAYIRPGGVHQDLPLGLLDDIYEFSKNFSLRIDEVEEMLTNNRIWRNRTVDIG
                     VVTAEDALNYGFSGVMLRGSGIQWDLRKTQPYDVYDQVEFDVPIGSRGDCYDRYLCRV
                     EEMRQSLRIIEQCLNKMPPGEIKVDDAKVSPPKRAEMKTSMESLIHHFKLYTEGYQVP
                     PGATYTAIEAPKGEFGVYLVSDGSSRPYRCKIKAPGFAHLAGLDKMSKGHMLADVVAI
                     IGTQDIVFGEIDR"
     exon            130..236
                     /gene="Ndufs2"
                     /gene_synonym="CI-49kD"
                     /inference="alignment:Splign:2.1.0"
     exon            237..427
                     /gene="Ndufs2"
                     /gene_synonym="CI-49kD"
                     /inference="alignment:Splign:2.1.0"
     exon            428..548
                     /gene="Ndufs2"
                     /gene_synonym="CI-49kD"
                     /inference="alignment:Splign:2.1.0"
     exon            549..736
                     /gene="Ndufs2"
                     /gene_synonym="CI-49kD"
                     /inference="alignment:Splign:2.1.0"
     exon            737..814
                     /gene="Ndufs2"
                     /gene_synonym="CI-49kD"
                     /inference="alignment:Splign:2.1.0"
     exon            815..900
                     /gene="Ndufs2"
                     /gene_synonym="CI-49kD"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1020
                     /gene="Ndufs2"
                     /gene_synonym="CI-49kD"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1150
                     /gene="Ndufs2"
                     /gene_synonym="CI-49kD"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1246
                     /gene="Ndufs2"
                     /gene_synonym="CI-49kD"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1330
                     /gene="Ndufs2"
                     /gene_synonym="CI-49kD"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1388
                     /gene="Ndufs2"
                     /gene_synonym="CI-49kD"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1623
                     /gene="Ndufs2"
                     /gene_synonym="CI-49kD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctctcctt cctacagtct gcagcccggt aaagatggcg gccctgaggg cgctgcgctg
       61 cctccgtggg gtcggagccc cggtgctgcg gcccgggtct gggatccgct tgccaagtca
      121 gcccagcaga ggtgctcggc agtggcagcc agatattgaa tgggcagagc agttttcggg
      181 agctgtcatg tacccctcca aggaaacagc ccactggaaa cctcctcctt ggaatgatgt
      241 ggacattttg aaggaaaaag cggtgaccaa catgaccctg aactttgggc cccagcaccc
      301 agcagcccac ggagtcctga gactcgtgct ggaactgagt ggagagatgg tgcggaaatg
      361 tgaccctcac atcgggctcc tgcaccgagg cacggagaag ctcattgagt acaagaccta
      421 tctgcaggcc cttccatact ttgaccggtt ggactatgtg tccatgatgt gtaatgaaca
      481 ggcctattcg atagctgtgg agaagttgct aaacatccaa cctcctcctc gggcacagtg
      541 gatccgagtg ctctttggag agatcacacg gattttaaac catatcatgg ctgtcaccac
      601 acatgccctg gacatcggtg ccatgactcc tttcttctgg atgtttgaag aaagagagaa
      661 gatgttcgag ttctatgagc gggtgtctgg ggcccggatg cacgcggcgt atatccgacc
      721 tggaggagtg caccaggacc tacctcttgg gcttctggat gacatttatg agttttccaa
      781 gaacttctct cttcggattg atgaggtgga ggagatgctg accaacaata gaatctggcg
      841 aaataggaca gtcgacattg gggttgtaac agcggaagac gcacttaact atggattcag
      901 tggggtgatg ctccgaggct caggcatcca gtgggacttg cggaagaccc agccctatga
      961 cgtttacgac caggtggagt ttgatgttcc tatcggttct cgaggggact gctacgatag
     1021 gtacctgtgt cgtgtggagg agatgcgcca gtccctgcga atcattgagc agtgtctgaa
     1081 caagatgcct cccggggaga tcaaggttga tgacgccaaa gtgtccccac cgaagcgagc
     1141 agagatgaag acgtccatgg agtcactaat tcatcacttt aagctgtata cagagggcta
     1201 ccaagttcct ccaggagcca catatactgc cattgaagct cctaagggag agtttggggt
     1261 atacttggta tccgatggca gcagccgccc ttatcggtgt aagatcaagg ctcccggttt
     1321 tgcccacctg gctggtttgg acaagatgtc taagggacac atgttggcag atgtcgtggc
     1381 catcataggt acccaggata ttgtgttcgg agaaatagac cgatgagcga aagcaccacc
     1441 ctcgagctgc cttgcctgtc agctgctcct tcgaggcctg tgtctggtgg gagacaaggc
     1501 tgtgtgtctc tgtgtgtgta aacaaacgtg cacgtgctcg cacttagctg cgcaggcttt
     1561 ctgtgcatga actagaaaag gagacattat attaaattag ccaccttttg gcccctaagc
     1621 tca
//
